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All Journal International Journal of Public Health Science (IJPHS) Biology, Medicine, & Natural Product Chemistry CERATA Jurnal Ilmu Farmasi Community Empowerment Jurnal Farmasi Sains dan Praktis Urecol Journal. Part C: Health Sciences Urecol Journal. Part D: Applied Sciences Urecol Journal. Part G: Multidisciplinary Research Prosiding University Research Colloquium Borobudur Pharmacy Review CERATA
Setiyo Budi Santoso
Universitas Muhammadiyah Magelang, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Online Home Pharmacy Care Prototype Putri Diana Savita; Dwiky Miftahuda; Winda Alawiyah Safi'a; Prasojo Pribadi; Setiyo Budi Santoso
Prosiding University Research Colloquium Proceeding of The 15th University Research Colloquium 2022: Mahasiswa (Student Paper Presentation) B
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (155.702 KB)

Abstract

This article presents the design of an online pharmacy service application at home. Development of application workflows using software in the draw.io network. The development includes a consultation menu, ordering medication/prescription redemption, camera features to take pictures (prescriptions), payments, and delivery messages.
Hubungan tingkat pengetahuan terhadap perilaku penggunaan antibiotik masyarakat Esah Meinitasari; Fitriana Yuliastuti; Setiyo Budi Santoso
Borobudur Pharmacy Review Vol 1 No 1 (2021): January-June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v1i1.4869

Abstract

Tingginya kejadian infeksi menyebabkan antibiotik menjadi pilihan pertama dalam mengatasi infeksi yang akan berdampak pada meningkatnya angka penggunaan antibiotik di masyarakat luas. Penggunaan antibiotik yang tidak tepat dapat menurunkan efektivitas antibiotik yang akan menyebabkan resiko buruk seperti resistensi antibiotik. Tujuan penelitian ini untuk mengetahui tingkat pengetahuan dan tingkat perilaku penggunaan antibiotik, mengetahui hubungan karakteristik sosio-demografi responden terhadap tingkat pengetahuan antibiotik, serta mengetahui ada tidaknya hubungan antara tingkat pengetahuan terhadap perilaku penggunaan antibiotik. Sampel dalam penelitian ini adalah 124 masyarakat dusun batur. Metode Penelitian menggunakan pendekatan cross sectional Study. Pengumpulan data dilakukan dengan cara memberikan kuesioner tertutup. Hasil penelitian menunjukkan mayoritas masyarakat di Dusun Batur memiliki tingkat pengetahuan antibiotik dalam kategori kurang (50,0%). Tingkat perilaku penggunaan antibiotik termasuk kategori cukup (55,65%). Hasil uji Spearman Rank menunjukkan bahwa ada hubungan signifikan yang searah antara pendidikan terakhir terhadap tingkat pengetahuan dengan nilai signifikansi sebesar 0,001 dan arah korelasi positif sebesar 0,294. Sedangkan hasil uji Korelasi Pearson menunjukkan adanya hubungan signifikan yang searah antara tingkat pengetahuan terhadap perilaku penggunaan antibiotik Masyarakat Dusun Batur dengan nilai signifikansi sebesar 0,000 dan arah korelasi positif sebesar 0,528.
The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate Deksa Yudha Syach Putra; Setiyo Budi Santoso; Heni Lutfiyati
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.169-173

Abstract

Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine days of hyperglycemia modeling; alloxan (Groups A and D), streptozotocin (Group B and E), dextrose monohydrate (Groups C and F). On preclinical research animals modelling related to obesity-associated hyperglycemia in mice, dextrose monohydrate induction was most successful than streptozocotin and alloxan induction, which performed best during the induction period (31% weight growth) and after metformin intervention (36% weight growth). Overall, dextrose monohydrate is most suitable to be used for modeling type 2 diabetes mellitus test animals rather than alloxan and streptozocotin.
Hubungan kepatuhan pengobatan dan riwayat hipertensi dengan tindakan pengendalian tekanan darah pada pasien hipertensi di puskesmas Kabupaten Magelang Viantika Meiliana Wulandari; Widarika Santi Hapsari; Setiyo Budi Santoso
Borobudur Pharmacy Review Vol 3 No 1 (2023): January- June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v3i1.5721

Abstract

Hipertensi adalah faktor primer ketiga yang menyebabkan 7 juta lebih kematian dini di setiap tahunnya. Hasil riskesdas tahun 2018 menunjukkan prevalensi terjadinya hipertensi sebesar 34,1%, angka tersebut mengalami peningkatan cukup tinggi dibandingkan hasil riskesdas tahun 2013. Kepatuhan pengobatan penderita hipertensi adalah hal yang penting karena penyakit hipertensi adalah penyakit yang tidak dapat disembuhkan namun harus terkontrol atau dikendalikan. Penggunaan antihipertensi saja ternyata tidak cukup untuk mendapatkan efek pengontrol tekanan darah dalam jangka panjang apabila tidak didukung dengan kepatuhan penggunaan obat antihipertensi. Tujuan penelitian ini untuk menganalisis hubungan kepatuhan pengobatan dan riwayat hipertensi dengan tindakan pengendalian tekanan darah pada pasien hipertensi di Puskesmas Kabupaten Magelang. Penelitian merupakan jenis penelitian observasional dengan pendekatan cros sectional. Pengumpulan data dilakukan menggunakan kuesioner. Kuesioner diberikan kepada pasien yang memenuhi kriteria inklusi. Sampel dalam penelitian ini adalah 166 orang. Hasil yang didapat yakni pasien hipertensi memiliki tingkat kepatuhan dengan kategori sedang sebesar 89,2%. Sedangkan tindakan pengendalian dalam kategori cukup sebesar 53,6%. Analisis dilakukan menggunakan chi square, dengan hasil nilai p=0,745 untuk kepatuhan dengan tindakan pengendalian dan p=0,153 untuk riwayat hipertensi dengan tindakan pengendalian. Kesimpulan dalam penelitian ini adalah tidak terdapat hubungan antara kepatuhan dengan tindakan pengendalian serta tidak terdapat hubungan antara riwayat hipertensi dengan tindakan pengendalian
MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS Setiyo Budi Santoso; Widarika Santi Hapsari; Renny Setyowati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8463

Abstract

Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid reference for researchers. This investigation aimed to establish a sustained dyslipidemia induction that persists after several days of intervention with a hypolipidemic agent. Six groups of mice, each consisting of five primary test animals and one reserve test animal, were used. After a seven-day acclimatization period, we induced each group for 14 days using three different methods: (1) 5% body weight of quail egg yolks (5% QEY), (2) 10% body weight of used cooking oil (10% UCOs), and (3) a combination of 5% QEY and 10% UCOs. Once all mice reached their peak lipid levels, we evaluated lipid performance through a seven-day intervention with simvastatin (0.026 mg/20-gram body weight) in one of the paired groups. A 14-day combined induction of 5% QEY and 10% UCOs resulted in a 39% elevation in mouse lipids compared to baseline levels. Our findings offer an alternative to traditional dyslipidemia models. However, the development of an animal model for dyslipidemia still poses challenges. Therefore, the identification of novel biomarkers capable of targeting dyslipidemia in humans is crucial.
Pharmacists' Efforts to Limit Interaction with Consumers During the Implementing Emergency Community Activity Restrictions Sania Husna Annavisa; Setiyo Budi Santoso
Urecol Journal. Part G: Multidisciplinary Research Vol. 1 No. 2 (2021): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujmr.119

Abstract

The spread of Corona Virus Disease 2019 (Covid-19) peaked on July 15, 2021 due to an uncontrollable spike since the previous month. The government responded by implementing Emergency Community Activity Restrictions (ECAR). However, pharmacies can still operate normally at that time. This article presents the efforts of pharmacists in limiting interactions with pharmacy consumers during ECAR. This study involved two pharmacies in the Temanggung Regency, Central Java. Observation activities took place from June to July 2021. Researchers collected 100 samples of interactions that took place between pharmacists and patients, by recording all conversations that occurred. Researchers classify the nodes of conversation (utterances) in two communication functions; therapeutic and social functions. The research data are presented in descriptive form. In emergency ECAR situations, pharmacy staff have tried to limit interaction with pharmacy consumers, by shortening the face-to-face duration. Within the limited duration of interaction, pharmacists are more dominant in conveying information exchange, and prioritizing information on the therapeutic aspect. The results of this study confirm to all parties that efforts to prevent the spread of the Covid-19 virus also include effectiveness in health services. Although there are restrictions on interactions in pharmaceutical services, health service providers still prioritize the fulfillment of the quality of information exchange to patients.
Psychological and Environmental Support: An Important Complement to Controlled Antiretroviral Therapy for HIV Patients Setiyo Budi Santoso; Heni Lutfiyati; Ulfahishofi Hanifah Afifi; Shellyta Ratnafuri
Urecol Journal. Part C: Health Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujhs.13

Abstract

This article presents a quality of life profile for HIV patients who have undergone controlled antiretroviral therapy. Specifically, researchers reviewed the unique needs of research subjects for psychological and environmental support. The research took place at the Regional General Hospital KRT Setjonegoro Wonosobo, involving 68 research subjects. All study subjects were HIV patients undergoing controlled antiretroviral therapy (outpatient) with a duration of more than six months and were aged more than 15 years. Investigation of the quality of life profile used the Indonesian version of the WHOQOL-HIV Bref questionnaire. The results showed that HIV patients who underwent controlled therapy had a higher quality of life score than general HIV patients. Antiretroviral treatment has helped them have physical qualities, independence, spiritual side, and social abilities in living life. Even so, they need psychological intervention and environmental support to have consistent quality of themselves. Health workers involved in managing HIV patients need to provide professional interventions to improve their ability to concentrate and ensure that they are always comfortable with their physical condition. Further, there is a need for cooperation by relationships (family, friends, community) and health workers to ensure that HIV patients do not experience financial difficulties, enjoy time in a relaxed manner, and feel safe as part of the environment society in general.
Profile of Therapy Adherence-Prolanis Related to Sociodemography: A Literature Review Dhea Salsa Bella; Setiyo Budi Santoso; Elmiawati Latifah
Urecol Journal. Part C: Health Sciences Vol. 1 No. 2 (2021): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujhs.75

Abstract

The results of this literature review present a profile of measuring adherence to therapy in prolanis member. More specifically, the authors explored the adherence related to the sociodemographic variants. The literature search utilizes the Google Scholar data storage base. Researchers used two variants of keywords; (1) “prolanis” and “drug”, (2) “prolanis” and “pharmaceutical”. The literature search is limited to the results of publications during the years 2010-2020. Literature review studies only involve research results that meet the following inclusion criteria; (1) scientific articles published after going through the peer review process, (2) research involving sociodemographic variables and therapy adherence index, (3) research involving only prolanis participants, and (4) research results showing correlation values between variables. A total of 9 articles met the inclusion criteria according to the research objectives. This literature review involved 644 respondents from 12 health centers and 1 treatment center as subjects in this study. The results of our literature review confirm that prolanis participants need family support and adequate knowledge, in order to adhere to therapy. In addition, we also conclude that there is no relationship between gender differences and adherence to therapy. Based on these conclusions, we recommend community pharmacy practitioners, to optimize educational services and provide basic information about drugs, both to prolanis participants and their families. We note that researchers have not mutually agreed on the relationship between therapy adherence with age, education, type of work and home pharmacy care services in prolanis. The exploration of sociodemographic variables, which is still a matter of debate, is a priority for further research to identify adherence to prolanis therapy. We also suggest to future researchers to avoid the use of MMAS-8. The use of questionnaires without permission from the inventor is prone to licensing problems.
Hepatotoxicity Risk Profile of Indonesian Due to Polymorphism of NAT2 and CYP2E1 in Isoniazid Metabolism Setiyo Budi Santoso; Puji Umi Chabibah; Prasojo Pribadi
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.11

Abstract

This article presents data on drug-induced liver injury events' risk profile due to NAT2 and CYP2E1 polymorphisms in isoniazid metabolism in Indonesian populations among various populations of several countries. The research took place through a review of the literature obtained from google scholar. The library search uses three variants of the keyword: (1) "pharmacogenomic and tuberculosis and INH and NAT2 and CYP2E1 and polymorphism", (2) "isoniazid and hepatotoxicity and polymorphism and N-acetyltransferase," (3) "isoniazid and hepatotoxicity and polymorphism and CYP2E1". Analysis of hepatotoxic risk based on the odds ratio (confidence interval) using Stata MP 14th edition software. The study of drug-induced liver injury events' risk based on various NAT2 acetylation rates involved 2,140 populations from 8 countries, while the risk analysis based on CYP2E1 allele variety involved 1,530 populations from 5 countries. The literature review shows that the Indonesian population's isoniazid-induced liver injury events' risk with slow acetylator NAT2 enzymes and people with CYP2E1*c1/c2 is three times higher than other populations in various countries. Further, people who have the combination slow acetylator NAT2 and CYP2E1*c1/c2 have more drug-induced liver injury events' risk.
Kesiapan Apoteker dalam Memberikan Layanan Medication Therapy Management Heni Lutfiyati; Prasojo Pribadi; Setiyo Budi Santoso
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i1.74

Abstract

Optimizing the implementation of the referral program is one of BPJS 'top programs. BPJS Health implements a referral program based on Medication Therapy Management. Medication therapy management interventions can reduce the frequency of drug-related problems, including non-compliance, and reduce health care costs. The purpose of this study was to evaluate the readiness of pharmacists in providing medication therapy management services This research uses a descriptive method by using a questionnaire as an instrument for data retrieval. The sampling technique is convenience sampling. The population is pharmacists who practice pharmaceutical services and are willing to fill out questionnaires. The result most pharmacists feel they have enough clinical knowledge and experience to provide MTM services. There are still many pharmacist workplaces (Puskesmas, Pharmacies and hospitals) that have not yet prepared to provide MTM services. Pharmacists think they have a desire to provide MTM services and have sufficient access to information in designing appropriate MTM services and pharmacists should be involved in providing MTM services. The obstacles faced by pharmacists in providing MTM services are insufficient time, insufficient human resources, limited space, limited information regarding MTM services, and the costs needed to implement MTM. Pharmacists are willing to provide Medication Therapy Management services but many obstacles remain. Training is needed so that pharmacists become more confident in providing clinical services
Co-Authors Ahmad Faiz Makarim Deksa Yudha Syach Putra Dhea Salsa Bella Dwiky Miftahuda Esah Meinitasari Fitriana Yuliastuti Heni Lutfiyati Nesya Jeihan Daniswara Ngesti Rahayu Nur Reviana Majid Nurul Umi Salamah Prasojo Pribadi Puji Umi Chabibah Putri Diana Savita Renny Setyowati Sania Husna Annavisa Shellyta Ratnafuri Shellyta Ratnafuri Shelvia Lharas Anggitha Ulfahishofi Hanifah Afifi Ulfahishofi Hanifah Afifi Viantika Meiliana Wulandari Widarika Santi Hapsari Winda Alawiyah Safi'a