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Ayu Wulandari
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Ekstrak Etanol Daun Etlingera comosa terhadap penurunan kadar glukosa darah dan gambaran histopatologi pankreas tikus putih jantan Faikah Dyah Utami; Nur Ramadhani; Ayu Wulandari; Syafika Alaydrus; Resa Aprilia Herlin Molano
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1081

Abstract

Etlingera comosa is a unique and newly discovered endemic plant species from Central Sulawesi, Indonesia, specifically originating from Tentena. Plants belonging to the Etlingera genus have been reported to possess considerable potential as natural antioxidants. This study aimed to evaluate the effect of the ethanol extract of E. comosa on blood glucose reduction and pancreatic histopathological changes in male white rats. A completely randomized design with a one-way treatment pattern was employed. Thirty male white rats (Rattus norvegicus) were randomly divided into six groups (n = 5 per group): normal control, positive control, negative control, and treatment groups receiving E. comosa ethanol extract at doses of 100, 200, and 400 mg/kg body weight (BW). All groups, except the normal control, were induced with streptozotocin. Blood glucose levels were measured using a glucometer, while pancreatic histopathological damage was evaluated using hematoxylin and eosin (H&E) staining. The results demonstrated significant differences in blood glucose levels throughout the treatment period, as well as significant differences in pancreatic histopathological damage scores among the experimental groups. Administration of the ethanol extract at a dose of 400 mg/kg BW produced a hypoglycemic effect that was not significantly different from the positive control (p > 0.05) but was significantly different from the negative control (p < 0.05). Similarly, the pancreatic damage score in the 400 mg/kg BW group was comparable to the positive control and significantly improved compared with the negative control. These findings indicate that the ethanol extract of E. comosa effectively reduces blood glucose levels and ameliorates pancreatic histopathological damage in streptozotocin-induced diabetic rats, with the most effective dose being 400 mg/kg BW.
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Co-Authors Faikah Dyah Utami Halik Alamsyah Joni Tandi Kevin Maengko Muthmainah Tuldjanah Nur Ramadhani Recky Patala Resa Aprilia Herlin Molano Rezky Yanuarty Siti Nurhaliza Syafika Alaydrus