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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian
Rezky Yanuarty
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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EVALUATION OF APHRODISIAC ACTIVITY OF ETHYL ACETATE FRACTION OF CLOVE LEAVES (Syzygium aromaticum L.) IN MALE WHITE RATS (Rattus norvegicus) Muthmainah Tuldjanah; Rezky Yanuarty; Agung; Ayu Wulandari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.918

Abstract

Clove leaves contain antioxidant compounds such as saponins, flavonoids, tannins, sterols, and essential oils. Among those chemical constituents, eugenol, eugenol acetate, caryophyllene, and sesquiterpenes were believed to have aphrodisiac activity. This study aims to investigate the potential aphrodisiac effects of the ethyl acetate fraction of clove leaves (Syzygium aromaticum L) administered at a dose of 250 mg/kg BW. The research employed an experimental method with a modified post-test randomized controlled group design and utilized a total of 45 white rats, consisting of 15 males and 30 females, divided into three treatment groups in a 1:2 ratio. Each group consisted of 5 male rats and 10 female rats. The three groups included the healthy control group (Na-CMC 0.5%), the positive control group (treated with X-Gra 52.5 mg/kg body weight) and the treatment group receiving clove leaf extract samples at a dosage of 250 mg/kg BW. The results indicate that the ethyl acetate fraction of clove leaves contains steroids and alkaloids with mount latency (ML), intromission latency (IL) ejaculation latency (EL), mount frequency (MF), intromission frequency (IF) and ejaculation frequency (EF) of 11.40 s, 15.80 s, 6.228 s, 23.60, 14.60, and 1.60 s, respectively. Based on these findings, it can be concluded that it has the potential to be used as an aphrodisiac agent. Keywords: Aphrodisiac, Syzygium Aromaticum L., ethyl acetate fraction, clove leaves, ejaculation frequency
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Potensi Gastroprotektif Fraksi Etil Asetat Daun Cincau Hijau (Cyclea barbata Miers) terhadap Lambung Tikus yang Diinduksi Etanol Dyah Ratna Ayu Puspita Sari; Rezky Yanuarty
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 19 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v19i2.13624

Abstract

Tukak lambung merupakan penyakit saluran cerna dengan prevalensi tinggi. Tukak lambung ditandai oleh adanya kerusakan mukosa lambung. Salah satu tanaman yang berpotensi sebagai gastroprotektor adalah daun cincau hijau (Cyclea barbata Miers). Tujuan penelitian adalah mengevaluasi efek gastroprotektif dari fraksi etil asetat daun cincau hijau terhadap lambung tikus yang diinduksi etanol 80%. Hewan uji yang digunakan sebanyak 36 tikus jantan yang dibagi kedalam 6 kelompok. kelompok I merupakan kontrol normal, kelompok II (Na CMC 0,5%), kelompok III (ranitidin 13,5 mg/kg BB), kelompok IV, V, VI diberikan fraksi etil asetat daun cincau hijau 100 mg/kg BB, 200 mg/kg BB, dan 400 mg/kg BB. Perlakuan diberikan selama 14 hari dan pada hari ke 15 dilakukan pembedahan. Parameter pengukuran yang digunakan adalah jumlah tukak, keparahan tukak, dan indeks tukak yang terbentuk. Hasil penelitian menunjukkan bahwa dosis 400 mg/kg BB fraksi etil asetat daun cincau hijau dapat menurunkan jumlah tukak, keparahan dan indeks tukak lebih baik dibandingkan kelompok lainnya. Hasil statistik juga menunjukkan skor jumlah dan keparahan tukak pada kelompok VI berbeda nyata dari kelompok kontrol negatif (P<0.05).
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Co-Authors Agung Ayu Wulandari Ayu Wulandari Dyah Ratna Ayu Puspita Sari Halik Alamsyah Joni Tandi Kevin Maengko Muthmainah Tuldjanah Recky Patala Siti Nurhaliza