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All Journal Farmaka Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research Indian Journal of Forensic Medicine & Toxicology

Rano K. Sinuraya

Unknown Affiliation

Author-ID : 2425056

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Articles

NSAID-Induced Adverse Drug Reaction: Mechanism and Management Katherine A.Tjenggal; Rano K. Sinuraya; Cherry Rahayu; Rizky Abdulah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14308

Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs to reduce pain or swelling. The use of these drugsin high doses or long-term can cause side effects or hypersensitivity problems, also known as Adverse DrugReaction (ADR). A literature review was carried out using the PubMed database by inserting the keywords‘NSAID’, ‘adverse drug reaction’, and ‘hypersensitivity’. All studies related to NSAIDs and their adversedrug reactions were included in this review, while genetic or pharmacogenomics studies and NSAIDs’effectiveness were excluded. The results showed that gastrointestinal (GI) problems such as duodenal ulcersor erosive gastritis are the most common diclofenac effects (2.05%). Cardiovascular issues, such as acutemyocardial infarction, were mostly caused by rofecoxib (2.12%). Hypersensitivity, both respiratory andskin, is commonly caused by ibuprofen with prevalence 50% and 67%, respectively. The most frequentkidney problem related to NSAIDs use is acute kidney injury. In comparison, the common hypersensitivityproblems are asthma, urticaria, and angioedema. Adverse drug reactions can be prevented or treated bylowering the dose, reducing the duration of treatment, adding companion drugs, or changing the type ofNSAID. In conclusion, it can be seen that ibuprofen severely caused kidney problems and hypersensitivity.On the other hand, diclofenac caused digestive issues, and rofecoxib caused cardiovascular problems.

Association of Genetic Polymorphisms with Risperidone Treatment Response in Schizophrenia: A Review Gina Sabila; Rano K. Sinuraya
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14735

Background: Schizophrenia is a severe mental disorder characterized by positive, negative, and cognitivesymptoms that affect the quality of life. Risperidone is widely known as second-generation antipsychoticthat is effective to treat schizophrenia. Unlike the first-generation antipsychotic, risperidone has a lowerimpact on the extrapyramidal adverse effect. However, individually, the risperidone treatment response maybe different caused by the genetic polymorphisms. This review aims to examine the association of geneticpolymorphisms with risperidone treatment response in schizophrenia.Method: The review was conducted using the Pubmed database and 49 articles included in this reviewamong 80 articles obtained in an initial search. The result showed genetic polymorphisms which affectsrisperidone therapy include DRD2, genetic polymorphisms on serotonin, cytochrome P450, BDNF, COMT,and ABCB1. Those polymorphisms might increase or decrease pharmacokinetics and pharmacodynamicprofile of risperidone. In addition, genetic polymorphisms also contributed to the risk of metabolic syndromeand hyperprolactinemia induced by risperidone treatment.Conclusion: Based on those findings, several genetic polymorphisms had an association with therapeuticoutcomes and side effect after risperidone treatment. Genetic polymorphisms screening may be useful fordrug choices or dosage adjustment that safer and effective for patients.

Risiko Peningkatan Efek Samping Terhadap Interaksi Obat Warfarin dan Antibiotik NAELI FARHATY; Rano K. Sinuraya
Farmaka Vol 16, No 2 (2018): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Interaksi obat adalah salah satu permasalahan utama bagi pasien yang menerima terapi polifarmasi. Adanya interaksi antar obat menyebabkan terjadinya peningkatan risiko terjadinya efek samping dan rawat inap di rumah sakit. Salah satu interaksi obat yang sering terjadi yaitu obat warfarin dan antibiotik. Interaksi kedua obat tersebut dapat menyebabkan terjadinya peningkatan risiko pendarahan. Antibiotik kuinolon, sulfonamid, dan makrolida dianggap memiliki risiko tinggi terhadap peningkatan toksisitas warfarin, sedangkan amoksisilin dan sefaleksin diyakini memiliki risiko yang lebih kecil. Umumnya, mekanisme interaksi antara kedua obat tersebut dapat melalui penghambatan enzim hati CYP2C9 dan menghambat sintesis vitamin K dari flora normal usus. Agar efektifitas dari kedua obat tetap sesuai maka diperlukan penyesuaian dosis dan pemantauan INR (International Normalized Ratio).

Utilization of Indonesia’ Natural Resources as Raw Materials in Pharmaceutical Industries for the Treatment of Degenerative Diseases AGI MEISARANI; Rano K. Sinuraya
Farmaka Vol 16, No 2 (2018): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

In Indonesia, health problems such as treatment of degenerative diseases are still not be handled properly. The common degenerative diseases in Indonesia are diabetes mellitus and hypertension. Generating qualified medicines with lower cost for degenerative disease are still be a major problem because Indonesia has not been independent in pharmaceutical raw materials. Raw materials are important part in the production process of pharmaceutical preparations. Indonesia obtained raw materials by importing from various countries. By looking at the various potentials of natural resources that can be used as a source of raw material in pharmaceutical industries, both active pharmaceutical ingredients (API) and excipients, Indonesia will be able to independently produce the pharmaceutical raw materials. To achieve independency of pharmaceutical raw materials, the appropriate processing methods to produce quality raw materials is needed. Based on this issue, a review of various studies was performed including the processing of API and pharmaceutical excipients raw materials of plant and animal body parts. “Kayu Manis” (Cinnamomum burmanii) and “Brotowali” (Tinospora cripa L.) which can be utilized as raw material pharmaceutical ingredient for the treatment of diabetes mellitus and “Mengkudu" (Morinda citrifolia L.) which can be used for the treatment of hypertension disease. Meanwhile, some natural resources that can be used as excipients are gelatin from the skin and fish bones (as a binder in the preparation of tablets), carrageenan from seaweed (emulsifier and suspending agent) and the Mimosa “Putri Malu” (Mimosa pudica L.) mucilago seed (as an alternative to polymer as buchoadhesive agent, disintegrator and binder)

Review: Penggunaan Obat Off-label pada Anak-Anak FEBBY VALENTINE PURWADI; Rano K. Sinuraya
Farmaka Vol 16, No 1 (2018): Farmaka (Juni)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Hingga saat ini pengujian klinis pada populasi pediatrik masih terbilang sedikit dibandingkan dengan pengujian klinis pada populasi dewasa. Hal ini berdampak pada ketersediaan informasi mengenai efikasi dan keamanan obat untuk populasi pediatrik. Alhasil, dokter dengan terpaksa harus mengambil keputusan untuk memberikan obat secara off-label. Penggunaan obat off-label dapat meningkatkan insiden terjadinya Medication error dan Adverse drug reaction (ADR), sehingga penggunaannya memunculkan kekhawatiran sebagaimana risiko tersebut dapat terjadi. Review ini bertujuan untuk memberikan gambaran mengenai pengguanaan obat off-label dan keamanan penggunaan obat off-label pada populasi pediatrik.

Analisis Minimalisasi Biaya Penggunaan Antibiotik Meropenem dan Ceftazidime pada Terapi Febrile Neutropenia Rizky Abdulah; Raine D. Kumamba; Rano K. Sinuraya; Cherry Rahayu; Melisa I. Barliana
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Universitas Padjadjaran

Antibiotik dibutuhkan sebagai salah satu terapi dalam menunjang keberhasilan terapi febrile neutropenia. Beragamnya alternatif terapi antibiotik, menjadikan studi farmakoekonomi diperlukan agar didapatkan terapi yang efektif dan efisien. Tujuan penelitian ini adalah untuk mengetahui antibiotik yang lebih efisien dari segi biaya, yang digunakan dalam terapi febrile neutropenia di salah satu rumah sakit rujukan di kota Bandung selama periode 2011–2013. Penelitian ini merupakan studi observasi analisis, dengan pengambilan data secara retrospektif yang dilakukan pada bulan Februari 2014, melalui data rekam medis pasien rawat inap febrile neutropenia yang mendapatkan terapi antibiotik meropenem atau ceftazidime. Hasil penelitian menunjukkan bahwa walaupun secara statistik tidak menunjukkan perbedaan bermakna, rata-rata total biaya terapi menggunakan antibiotik meropenem adalah sebesar Rp11.094.147, sedangkan rata-rata biaya total perawatan kelompok antibiotik ceftazidime sebesar Rp7.082.523. Hasil penelitian ini diharapkan dapat membantu tenaga profesional kesehatan dalam manajemen terapi febrile neutropenia.Kata kunci: Ceftazidime, farmakoekonomi, febrile neutropenia, meropenemCost Minimization Analysis of the Use of Meropenem and Ceftazidime in Febrile Neutropenia Therapy Use of antibiotics is required in febrile neutropenia therapy. The variety choice on the use of antibiotics has increased the role of pharmacoeconomics study to determine the most effective and efficient antibiotic in a specific area. The purpose of this study was to investigate the lowest cost antibiotic between meropenem and ceftazidime that were used as one of febrile neutropenia treatments at one of referral hospitals in West Java province during 2011–2013. This study was a retrospective, observational and analytical study that was performed on February 2014 by collecting medical record data related to febrile neutropenia inpatient who received meropenem or ceftazidime therapy. The result showed that although it was not statistically significant, the total cost for ceftazidime therapy was IDR7,082,523, which was lower than meropenem therapy (IDR11,094,147). Hopefully, this result can assist the health professionals in the management of febrile neutropenia therapy.Keywords: Ceftazidime, febrile neutropenia, meropenem, pharmacoeconomics

Evaluation of Medication Use Patterns among Geriatric Patients using World Health Organization Prescribing Indicators Irma M. Puspitasari; Ani Hanifah; Rano K. Sinuraya
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Geriatrics patients are paticularly suceptible to medication error due to complex clinical problems and multiple treatment. World Health Organization (WHO) published a set of prescribing indicators to promote rationale use of drug. This study aimed to evaluate medicine use pattern in geriatric patients at a primary care facility in Bandung, Indonesia, using WHO indicators. This research was conducted using cross sectional design with retrospective data collection. Medical presciption from geriatric patients aged 60-74 years old visiting primary care facility during 2013-2015 were selected. A total of 103.292 prescriptions were obtained in this study. The average number of drugs per encounter was 2.1 (optimal range=1.6-1.8). Vast majority (99.41%) of the drugs prescribed were generic drugs (optimal value=100%). The encounters with an antibiotics prescribed were 7.4% (optimal range=20.0-26.8%). Very few parenteral drugs were prescribed in this study setting (0.04%) (optimal range=13.4-24.1%). The drugs prescribed from essential drug list were 72.83% (optimal value=100%). The most commonly prescribed drugs were paracetamol 500 mg, chlorpheniramine maleat 4 mg, amlodipine 5 mg, vitamin B complex, and glyceryl guaiacolat. The most frequently prescribed antibiotics were amoxicillin, cloramphenicol, cyprofloxacin, clindamycin, and oxytetracyclin. In conclusion, the medication use pattern in this study was below the WHO requirement. This finding called for a strategy to promote rational prescribing of medicines. Keywords: geriatrics, WHO prescribing indicators, drug use patterns

Co-Authors AGI MEISARANI Ani Hanifah Cherry Rahayu Cherry Rahayu FEBBY VALENTINE PURWADI Gina Sabila Irma M. Puspitasari Katherine A.Tjenggal Melisa I. Barliana NAELI FARHATY Raine D. Kumamba Rizky Abdulah

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