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All Journal Jurnal Kedokteran JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ners Jurnal Medika Hutama Majalah Biomorfologi (Biomorphology Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Yoga Dan Kesehatan Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Physical Therapy Journal of Indonesia GEMBIRA (Pengabdian Kepada Masyarakat) Folia Medica Indonesiana
Mohammad Fathul Qorib
Airlangga University
Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure David Setyo Budi; Reny I`tishom; Alphania Rahniayu; Mohammad Fathul Qorib
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14699

Abstract

Background: Disruption to healing process results on longer healing duration from the timeline. Povidoneiodine and tulle are common management in wound care. The advance of industry in health sector andthe availability of natural ingredients in Indonesia provide opportunities for developing alternatives forwound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial,and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan canmaintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potentialof turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with“post-test only control group design”. The sample consisted of 30 mice which were assigned into 5 groups.Result: All experimental groups experienced a gradual decrease in wound length. The statistical test resultsfor groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group Idid not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but ithad significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate thereduction of wound length.
Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi Mohammad Fathul Qorib
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.868

Abstract

Siklooksigenase (COX) merupakan enzim yang sangat penting dalam menjaga homeostasis organ tubuh manusia. Enzim ini berperan pada kondisi fisiologis dan patologis khususnya saat terjadi inflamasi. Enzim ini memiliki 3 isoform yaitu Cox1, Cox2, dan Cox3. Isoform yang banyak diteliti dan terbukti sangat berperan dalam tubuh manusia adalah Cox1 dan Cox2, sedangkan Cox3 masih banyak perbedaan pendapat. Ekpresi Cox1 dan Cox2 dapat ditemukan pada berbagai organ dalam tubuh manusia, akan tetapi dalam naskah ini akan dibatasi pembahasannya pada lambung, ginjal, saraf, kardiovaskular, dan platelet. Hal ini dikaitkan dengan peran Cox sebagai target pengobatan nyeri dan inflamasi serta resiko efek samping yang mungkin ditimbulkannya. Perbedaan struktur kimia, karakter, serta perannya dalam menjaga homeostasis sangat perlu dipahami sebagai dasar penyusunan strategi pengobatan dan kewaspadaan terhadap efek samping yang dapat ditimbulkannya.
IN VITRO ANTIBACTERIAL ACTIVITY OF EUCALYPTUS (Melaleuca leucadendra) OIL AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) Constantia Lidwina Targanski; Wiwin Retnowati; Mohammad Fathul Qorib; Manik Retno Wahyunitisari; Wilda Mahdani
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.59-67

Abstract

Highlights The use of eucalyptus oil is natural and risk-free. It has a lengthy history of use as a traditional medicine in Asia, including Indonesia. It has been demonstrated that eucalyptus oil possesses antibacterial activity against MRSA, and this activity was controlled by the oil's concentration. Abstract Background: Eucalyptus (Melaleuca leucadendra) oil is used by Indonesians as an herbal medicine. Eucalyptus containing 1,8-cineol at 72.30% is expected to be used as an antibacterial.  Objective: The study aimed to assess the antibacterial activity of eucalyptus oil against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria in vitro. Material and Method: The materials used were eucalyptus oil (M. leucadendra) in various concentrations with ethyl acetate as solvent. The research method used was the agar-well diffusion assay. The MRSA was suspended to 0.5 McFarland turbidity. The MRSA suspension was thoroughly swabbed onto the surface of the Mueller-Hinton agar plate. The wells were made with a diameter of 0.6 mm on Muller-Hinton agar aseptically and 100 µl of eucalyptus oil was put into the well using a micropipette and incubated for 24 hours at 37°C. The diameter of the inhibition zone was measured with a caliper. Statistical analysis using the SPSS software edition 23. Result: Eucalyptus oil solution starting from a concentration of 10% to 100% had an antibacterial response, which could be seen by the formation of a bacterial inhibition zone around the eucalyptus oil (M. leucadendra) wells. The inhibition ability of eucalyptus oil against MRSA bacteria was greatest at a concentration of 90% with an inhibition zone of 31.26 mm. It was found that the concentration of eucalyptus oil affected the diameter of the bacterial inhibition area. Conclusion: Eucalyptus oil has been shown to have antibacterial activity against MRSA and was influenced by the concentration of the oil.
Mental Health Status and Literacy of Adolescent in Rural Area of Mojokerto, East Java, Indonesia Ardana, Arin Aurilia; d'Arqom, Annette; Puteri, Fira Adilah; Indiastuti, Danti Nur; Nasution, Mhd Zamal; Hasanatuludhhiyah, Nurina; Qorib, Mohammad Fathul; Setiawati, Yuani; Junaidah Yusof
Jurnal Psikiatri Surabaya Vol. 14 No. 2 (2025): November
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v14i2.64237

Abstract

Introduction: Adolescence is a crucial period for the development of mental health. Enhancing mental health literacy can reduce stigma and support early intervention and treatment. This study aims to examine the mental health status and mental health literacy among middle and late adolescents in a rural area of Mojokerto District, East Java, Indonesia. Methods: A total of 81 high school students from Mojokerto District participated in the study. The Depression Anxiety Stress Scale – Youth version (DASS-Y) was used to assess symptoms of depression, anxiety, and stress. Mental health literacy was measured using the Adolescent Mental Health Literacy Questionnaire (AMHL). The validity of the AMHL was tested on 30 students using Pearson correlation. Descriptive statistics were used to analyze the prevalence of mental health conditions and levels of mental health literacy. Inferential statistics were applied to explore associations between mental health status, literacy, and sociodemographic variables. Results: The results showed that 53% of students experienced symptoms of mental health problems. While most students demonstrated moderate to satisfactory mental health literacy, significant gaps remain. Enhancing literacy may help reduce stigma and improve knowledge and attitudes toward mental health. Sociodemographic factors and mental health literacy showed limited influence on mental health status. However, sex was significantly associated with both mental health literacy and mental health status (p = 0.016 and p = 0.032, respectively). Conclusion: Mental health during adolescence significantly influences adult well-being. Improving adolescent mental health literacy is crucial for early recognition, stigma reduction, and better access to mental health care.
Comparison Of The Effectiveness Of Remdesivir And Favipiravir In Moderate To Critical Covid-19 Patients Filhi Rihmayuwainilla; Irmi Syafa'ah; Mohammad Fathul Qorib
Jurnal Medika Hutama Vol. 7 No. 1 Oktober (2025): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

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Abstract

Introduction: COVID-19 is a respiratory disease outbreak that caused a pandemic in late 2019. COVID-19 causes infected patients to experience mild, moderate, severe to critical respiratory diseases that cause death. However, until now there has been no specific therapy for COVID-19. The most currently used therapy is using antivirals, such as remdesivir and favipiravir. This study aims to analyze the effectiveness of antivirals remdesivir and favipiravir in improving symptoms and duration of treatment of moderate to critical COVID-19 patients at Airlangga University Hospital in May-June 2021. Methods: Observational analytic study with retrospective cohort method obtained from the medical records of moderate to critical COVID-19 patients who used remdesivir and favipiravir antivirals at Universitas Airlangga Hospital. Data were collected using total sampling technique and tested with Mann-Whitney. The parameters used in this study were age, gender, comorbidities, severity, antiviral drugs, and duration of treatment. Results: Of the 130 study subjects, 27 patients used remdesivir and 103 patients used favipiravir. The test results obtained as follows, the test between antivirals and symptom improvement time found p = 0.015 (p < 0.05) which means significant, the test between antivirals and length of treatment found p = 0.018 (p < 0.05) which means significant. Conclusion: There is a significant difference in effectiveness between the use of remdesivir and favipiravir on symptom improvement time and length of treatment for moderate to critical COVID-19 patients at Airlangga University Hospital.
Perbandingan Efektivitas Remdesivir dan Favipiravir sebagai Terapi Antivirus pada Pasien COVID-19 Derajat Sedang hingga Kritis Filhi Rihmayuwainilla; Irmi Syafa'ah; mohammad Fathul Qorib
Jurnal Yoga dan Kesehatan Vol 8 No 2 (2025)
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/jyk.v8i2.5339

Abstract

COVID-19 merupakan wabah penyakit pernapasan yang menjadi pandemi pada akhir tahun 2019. Wabah tersebut menyebabkan pasien yang terinfeksi mengalami penyakit pernapasan baik yang ringan, sedang, berat, hingga kritis yang dapat menyebabkan kematian. Namun, hingga saat ini belum ada terapi spesifik untuk mengatasinya. Terapi yang paling banyak digunakan saat ini adalah antivirus, seperti remdesivir dan favipiravir. Penelitian ini bertujuan untuk menganalisis efektivitas antivirus remdesivir dan favipiravir dalam memperbaiki gejala dan durasi perawatan pasien COVID-19 derajat sedang hingga kritis di Rumah Sakit Universitas Airlangga pada bulan Mei-Juni 2021. Metode penelitian ini menggunakan studi analitik observasional dengan metode kohort retrospektif. Ini diperoleh dari rekam medis pasien COVID-19 derajat sedang hingga kritis yang menggunakan antivirus remdesivir dan favipiravir di RS Universitas Airlangga. Data dikumpulkan menggunakan teknik total sampling dan diuji dengan Mann-Whitney. Parameter yang digunakan dalam penelitian ini adalah usia, jenis kelamin, komorbiditas, tingkat keparahan, obat antivirus, dan lama pengobatan. Dari 130 subjek penelitian, 27 pasien menggunakan remdesivir dan 103 pasien menggunakan favipiravir. Hasil uji menunjukkan bahwa uji antara antivirus dan waktu perbaikan gejala menunjukkan p = 0,015 (p < 0,05) yang berarti signifikan, sedangkan uji antara antivirus dan lama pengobatan menunjukkan p = 0,018 (p < 0,05) yang berarti signifikan. Jadi, kesimpulannya adalah terdapat perbedaan efektivitas yang signifikan antara penggunaan remdesivir dan favipiravir terhadap waktu perbaikan gejala dan lama pengobatan pasien COVID-19 derajat sedang hingga kritis.
Selection of Medical Therapy in Glaucoma Patients in the Outpatient Eye Clinic Soetomo General Academic Hospital Surabaya Praba, Venansya Maulina; Primitasari, Yulia; Qorib, Mohammad Fathul; Loebis, Rozalina
Folia Medica Indonesiana Vol. 57, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlight: • Medical therapy selection in the outpatient eye clinic were determined. • Treatment of prostaglandin analogue therapyfor primary open angle glaucoma was the most common glaucoma type. Abstract: Glaucoma is the second leading cause of blindness and the third cause of visual impairment. Glaucoma management includes medical therapy, laser, and incisions. This study aims to determine the selection of medical therapy in the outpatient eye clinic Soetomo General Academic Hospital Surabaya. This study was a retrospective descriptive study. The variables were type of glaucoma, visual acuity, intraocular pressure, and drug therapy. Data processing was done by collecting, grouping, and describing data. Glaucoma was mostly common in 50-64 years old (37.66%), male (50.65%), most patients lived in Surabaya (53.68%), the most common type was Primary Open-Angle Glaucoma (32.90%), the most medical therapy given in the first visit in 2019 was single medical therapy (67.97%), the most single drug therapy was latanoprost (49.68%), the most drugs combination was timolol maleat with acetazolamide (35.14%), the most commonly drugs class were prostaglandin analogues (48.48%), most of the visual acuity values were 6/6 - 6/18 (1,00 – 0,33) (37.88%), most intraocular pressure was in the 11-21 mmHg (62.55%). The most common type of glaucoma was primary open angle glaucoma with the most therapy given was prostaglandin analogue.
DAMPIT ROBUSTA COFFEE EFFECT ON THE CREATININE KINASE LEVELS AND MUSCLE PAIN SCALES AMONG SPORT ENTHUSIAST Salamy, M. Fath Alhaqqi Sanis; Qorib, Mohammad Fathul; Herawati, Lilik; Darmawan, Rizky; Mujahiddin, M. Izzul; Salamun, Salamun; Salamy, Ahmed Zaiyan Nahel; Salamy, Achmad Yarziq Mubarak Salis; Mohamed, Moh Nahar Azmi; Ramadhan, Ain Darojah Siddiq Ramadhan
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Excessive eccentric exercise often results in muscle injury, reflected by elevated serum creatine kinase (CK) levels and delayed onset muscle soreness (DOMS). In Indonesia, coffee consumption after exercise has increased, with Dampit Robusta Coffee (DRC)—a local variety rich in caffeine and antioxidants considered a potential aid for recovery. This study evaluated the effect of DRC consumption on biomarkers of muscle damage and perceived soreness. A single-blind randomized controlled trial was conducted on 20 healthy untrained men aged 20–25 years, allocated into treatment (n = 10) and control (n = 10) groups. The treatment group consumed brewed DRC (≈200 mg caffeine/day) for five consecutive days, while the control group received placebo (coffee-flavored water). All participants performed a modified YMCA step test as an eccentric exercise protocol. Serum CK levels were measured at 2 and 24 hours post-exercise, and muscle soreness was assessed using a visual analogue scale (VAS). At both 2 and 24 hours, mean CK levels were lower in the DRC group compared with control, but differences were not significant (p > 0.05). However, analysis of CK change (ΔCK) showed a significant between-group difference, with CK decreasing in the DRC group but increasing in the control group (p = 0.031). VAS scores decreased significantly over time within both groups (p = 0.05), but between-group differences remained nonsignificant (p > 0.05). In conclusion, DRC consumption attenuated CK elevation after eccentric exercise, suggesting a protective effect against muscle injury, although its effect on soreness was inconclusive. Further studies with larger and more diverse samples are needed.
Effects of Minocycline as a Neuroprotective Agent for Stroke on Mmp-9 Levels, Functional Outcome, and Mortality Nisa, Ayu Imamatun; Damayanti, Arlia Ayu; Nagasastra, Jeffri; Machin, Abdulloh; Qorib, Mohammad Fathul; , Retnaningsih; Hamidi, Baarid Luqman
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. As minocycline plays an important role in stroke microglia activation and iron chelation, it is important to further analyze its effects on stroke treatment. 2. This meta-analysis revealed a significant effect of minocycline therapy, as evidenced by improved functional outcomes and inhibited matrix metalloproteinase-9 (MMP-9) activity. Abstract Stroke is the most common and devastating cerebrovascular disease. Many neuroprotective medications, such as scale and minocycline, have been developed to help the nervous system recover or regenerate after a stroke. However, it remains unclear whether minocycline provides a beneficial effect on stroke. We conducted this systematic review and meta-analysis to synthesize the effects of minocycline in stroke treatment. The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42023485168. The quality of the eligible studies was assessed using the Jadad scale. This systematic review included three ischemic stroke trials, seven intracerebral hemorrhage trials, and one study on acute stroke. There was a significant association between minocycline intervention and stroke severity according to the National Institute of Health Stroke Scale (NIHSS), with a pooled mean difference (MD) of -1.92, a 95% confidence interval (CI) of -3.39 to -0.45, and a value of p=0.01. In the subgroup of ischemic stroke, the modified Rankin Scale (mRS) was significantly lower in the minocycline treatment group compared to the control group (MD=-0.89, 95% CI=-1.54 to -0.25, p=0.007). Additionally, matrix metalloproteinase-9 (MMP-9) levels for the intracerebral hemorrhage subgroup were significantly lower in the minocycline treatment group compared to the control group (MD=-19.93, 95% CI=-36.9 to -2.96, p=0.02). The analysis revealed that minocycline intervention was not significantly associated with hematoma volume, mortality, or stroke recurrence. Our findings indicate that minocycline supplementation is a potential intervention strategy for treating ischemic stroke and intracerebral hemorrhage.
PENINGKATAN PENGETAHUAN TATA KELOLA NYERI SENDI PADA TENAGA KESEHATAN DASAR DI KECAMATAN JETIS KABUPATEN MOJOKERTO Kusuma Eko Purwantari; Prasetiowati , Lucky; Indiastuti , Danti Nur; Qorib, Mohammad Fathul
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 06 (2025): DESEMBER 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

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Abstract

Nyeri sendi termasuk salah satu keluhan yang sering didapatkan pada lansia. Adanya anggapan yang salah di masyarakat bahwa keluhan nyeri sendi disebabkan oleh kelainan kadar asam urat dan kolesterol. Hal ini juga didukung kurang tepatnya diagnosa yang ditegakkan oleh tenaga kesehatan, selanjutnya berakibat penanganan yang salah. Tenaga kesehatan yang meliputi dokter umum, bidan desa dan perawat merupakan lini terdepan,sebagai tempat pilihan lansia untuk mendapatkan pelayanan kesehatan. Tujuan pengabdian masyarakat ini untuk meningkatkan pengetahuan tenaga kesehatan tentang nyeri sendi sehingga terwujud penatalaksanaan yang tepat. Selain itu tenaga kesehatan diharapkan  mampu menjadi jembatan untuk meluruskan pemahaman yang salah di masyarakat. Kegiatan berupa penyuluhan dan pelatihan yang dilanjutkan dengan diskusi. Materi yang disampaikan meliputi anatomi klinik nyeri sendi, pemeriksaan dasar sendi dan tata laksana nyeri sendi baik farmakologi dan non farmakologi. Evaluasi pelaksanaan kegiatan ini menggunakan metode pre test dan post test. Hasil dari pre test dan post test dilakukan uji paired t- test, dengan hasil signifikan apabila p > 0,05. Hasil yang diperoleh, terdapat peningkatan rerata nilai yaitu rerata pre test sebesar 1,15 ± 6,19 dan rerata post test sebesar  72,41 ± 37,87, dengan  nilai p = 0.000, menunjukkan beda signifikan. Hal ini menggambarkan adanya peningkatan pengetahuan peserta yang meliputi gejala, pemeriksaan dasar dan tata laksana nyeri sendi. Pengetahuan mengenai gejala klinis dan pemeriksaan dasar sendi diperlukan untuk menegakkan diagnosa. Diagnosa yang tepat sangat diperlukan agar penderita mendapat penanganan yang tepat.  
Co-Authors , Retnaningsih Achmad Yarziq Mubarak Salis Salamy Alphania Rahniayu Annette d’Arqom, Annette Anny Setijo Rahaju, Anny Setijo Ardana, Arin Aurilia Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Constantia Lidwina Targanski Damayanti, Arlia Ayu David Setyo Budi Devin Hernando Fatimah, Nurmawati Filhi Rihmayuwainilla Hamidi, Baarid Luqman Harzat HERAWATI, LILIK I'tishom, Reny Indiastuti , Danti Nur Indiastuti, Danti Nur Irmi Syafa'ah Istiani, Hari Ghanesia I’tishom, Reny Jeffri Nagasastra Junaidah Yusof Kohar Hari Santoso Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh ManikRetno Wahyunitisari Martinez, Oscar Fidel Antunez Maulydia Maulydia Mhd Zamal Nasution Mohamed, Moh Nahar Azmi Muhammad Axel Arsyad Mujahiddin, M. Izzul Nagasastra, Jeffri Nisa, Ayu Imamatun Nur Arfian, Nur Nur Eni Lestari Nurina Hasanatuludhhiyah Praba, Venansya Maulina Primitasari, Yulia Puteri, Fira Adilah Putri, Eka Arum Cahyaning Ramadhan, Ain Darojah Siddiq Ramadhan Retnaningsih Rifatus Solicha Rizky Darmawan, Rizky Rozalina Loebis, Rozalina Salamun Salamun Salamy, Ahmed Zaiyan Nahel Salamy, M. Fath Alhaqqi Sanis Sari, Gadis Meinar Shayla Kokomi Rishardy Wilda Mahdani Wiwin Retnowati Yuani Setiawati