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All Journal Folia Medica Indonesiana Jurnal Kedokteran Jurnal Medika Hutama Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Yoga Dan Kesehatan
Mohammad Fathul Qorib
Airlangga University
Religion Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure David Setyo Budi; Reny I`tishom; Alphania Rahniayu; Mohammad Fathul Qorib
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14699

Abstract

Background: Disruption to healing process results on longer healing duration from the timeline. Povidoneiodine and tulle are common management in wound care. The advance of industry in health sector andthe availability of natural ingredients in Indonesia provide opportunities for developing alternatives forwound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial,and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan canmaintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potentialof turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with“post-test only control group design”. The sample consisted of 30 mice which were assigned into 5 groups.Result: All experimental groups experienced a gradual decrease in wound length. The statistical test resultsfor groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group Idid not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but ithad significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate thereduction of wound length.
Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi Mohammad Fathul Qorib
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.868

Abstract

Siklooksigenase (COX) merupakan enzim yang sangat penting dalam menjaga homeostasis organ tubuh manusia. Enzim ini berperan pada kondisi fisiologis dan patologis khususnya saat terjadi inflamasi. Enzim ini memiliki 3 isoform yaitu Cox1, Cox2, dan Cox3. Isoform yang banyak diteliti dan terbukti sangat berperan dalam tubuh manusia adalah Cox1 dan Cox2, sedangkan Cox3 masih banyak perbedaan pendapat. Ekpresi Cox1 dan Cox2 dapat ditemukan pada berbagai organ dalam tubuh manusia, akan tetapi dalam naskah ini akan dibatasi pembahasannya pada lambung, ginjal, saraf, kardiovaskular, dan platelet. Hal ini dikaitkan dengan peran Cox sebagai target pengobatan nyeri dan inflamasi serta resiko efek samping yang mungkin ditimbulkannya. Perbedaan struktur kimia, karakter, serta perannya dalam menjaga homeostasis sangat perlu dipahami sebagai dasar penyusunan strategi pengobatan dan kewaspadaan terhadap efek samping yang dapat ditimbulkannya.
IN VITRO ANTIBACTERIAL ACTIVITY OF EUCALYPTUS (Melaleuca leucadendra) OIL AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) Constantia Lidwina Targanski; Wiwin Retnowati; Mohammad Fathul Qorib; Manik Retno Wahyunitisari; Wilda Mahdani
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.59-67

Abstract

Highlights The use of eucalyptus oil is natural and risk-free. It has a lengthy history of use as a traditional medicine in Asia, including Indonesia. It has been demonstrated that eucalyptus oil possesses antibacterial activity against MRSA, and this activity was controlled by the oil's concentration. Abstract Background: Eucalyptus (Melaleuca leucadendra) oil is used by Indonesians as an herbal medicine. Eucalyptus containing 1,8-cineol at 72.30% is expected to be used as an antibacterial.  Objective: The study aimed to assess the antibacterial activity of eucalyptus oil against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria in vitro. Material and Method: The materials used were eucalyptus oil (M. leucadendra) in various concentrations with ethyl acetate as solvent. The research method used was the agar-well diffusion assay. The MRSA was suspended to 0.5 McFarland turbidity. The MRSA suspension was thoroughly swabbed onto the surface of the Mueller-Hinton agar plate. The wells were made with a diameter of 0.6 mm on Muller-Hinton agar aseptically and 100 µl of eucalyptus oil was put into the well using a micropipette and incubated for 24 hours at 37°C. The diameter of the inhibition zone was measured with a caliper. Statistical analysis using the SPSS software edition 23. Result: Eucalyptus oil solution starting from a concentration of 10% to 100% had an antibacterial response, which could be seen by the formation of a bacterial inhibition zone around the eucalyptus oil (M. leucadendra) wells. The inhibition ability of eucalyptus oil against MRSA bacteria was greatest at a concentration of 90% with an inhibition zone of 31.26 mm. It was found that the concentration of eucalyptus oil affected the diameter of the bacterial inhibition area. Conclusion: Eucalyptus oil has been shown to have antibacterial activity against MRSA and was influenced by the concentration of the oil.
Effects of Minocycline as a Neuroprotective Agent for Stroke on Mmp-9 Levels, Functional Outcome, and Mortality Ayu Imamatun Nisa; Arlia Ayu Damayanti; Jeffri Nagasastra; Abdulloh Machin; Mohammad Fathul Qorib; Retnaningsih; Baarid Luqman Hamidi
Folia Medica Indonesiana Vol. 60 No. 2 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i2.58931

Abstract

Highlights:1. As minocycline plays an important role in stroke microglia activation and iron chelation, it is important to further analyze its effects on stroke treatment.2. This meta-analysis revealed a significant effect of minocycline therapy, as evidenced by improved functional outcomes and inhibited matrix metalloproteinase-9 (MMP-9) activity.   Abstract Stroke is the most common and devastating cerebrovascular disease. Many neuroprotective medications, such as scale and minocycline, have been developed to help the nervous system recover or regenerate after a stroke. However, it remains unclear whether minocycline provides a beneficial effect on stroke. We conducted this systematic review and meta-analysis to synthesize the effects of minocycline in stroke treatment. The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42023485168. The quality of the eligible studies was assessed using the Jadad scale. This systematic review included three ischemic stroke trials, seven intracerebral hemorrhage trials, and one study on acute stroke. There was a significant association between minocycline intervention and stroke severity according to the National Institute of Health Stroke Scale (NIHSS), with a pooled mean difference (MD) of -1.92, a 95% confidence interval (CI) of -3.39 to -0.45, and a value of p=0.01. In the subgroup of ischemic stroke, the modified Rankin Scale (mRS) was significantly lower in the minocycline treatment group compared to the control group (MD=-0.89, 95% CI=-1.54 to -0.25, p=0.007). Additionally, matrix metalloproteinase-9 (MMP-9) levels for the intracerebral hemorrhage subgroup were significantly lower in the minocycline treatment group compared to the control group (MD=-19.93, 95% CI=-36.9 to -2.96, p=0.02). The analysis revealed that minocycline intervention was not significantly associated with hematoma volume, mortality, or stroke recurrence. Our findings indicate that minocycline supplementation is a potential intervention strategy for treating ischemic stroke and intracerebral hemorrhage.
Comparison Of The Effectiveness Of Remdesivir And Favipiravir In Moderate To Critical Covid-19 Patients Filhi Rihmayuwainilla; Irmi Syafa'ah; Mohammad Fathul Qorib
Jurnal Medika Hutama Vol. 7 No. 1 Oktober (2025): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: COVID-19 is a respiratory disease outbreak that caused a pandemic in late 2019. COVID-19 causes infected patients to experience mild, moderate, severe to critical respiratory diseases that cause death. However, until now there has been no specific therapy for COVID-19. The most currently used therapy is using antivirals, such as remdesivir and favipiravir. This study aims to analyze the effectiveness of antivirals remdesivir and favipiravir in improving symptoms and duration of treatment of moderate to critical COVID-19 patients at Airlangga University Hospital in May-June 2021. Methods: Observational analytic study with retrospective cohort method obtained from the medical records of moderate to critical COVID-19 patients who used remdesivir and favipiravir antivirals at Universitas Airlangga Hospital. Data were collected using total sampling technique and tested with Mann-Whitney. The parameters used in this study were age, gender, comorbidities, severity, antiviral drugs, and duration of treatment. Results: Of the 130 study subjects, 27 patients used remdesivir and 103 patients used favipiravir. The test results obtained as follows, the test between antivirals and symptom improvement time found p = 0.015 (p < 0.05) which means significant, the test between antivirals and length of treatment found p = 0.018 (p < 0.05) which means significant. Conclusion: There is a significant difference in effectiveness between the use of remdesivir and favipiravir on symptom improvement time and length of treatment for moderate to critical COVID-19 patients at Airlangga University Hospital.
Perbandingan Efektivitas Remdesivir dan Favipiravir sebagai Terapi Antivirus pada Pasien COVID-19 Derajat Sedang hingga Kritis Filhi Rihmayuwainilla; Irmi Syafa'ah; mohammad Fathul Qorib
Jurnal Yoga dan Kesehatan Vol 8 No 2 (2025)
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/jyk.v8i2.5339

Abstract

COVID-19 merupakan wabah penyakit pernapasan yang menjadi pandemi pada akhir tahun 2019. Wabah tersebut menyebabkan pasien yang terinfeksi mengalami penyakit pernapasan baik yang ringan, sedang, berat, hingga kritis yang dapat menyebabkan kematian. Namun, hingga saat ini belum ada terapi spesifik untuk mengatasinya. Terapi yang paling banyak digunakan saat ini adalah antivirus, seperti remdesivir dan favipiravir. Penelitian ini bertujuan untuk menganalisis efektivitas antivirus remdesivir dan favipiravir dalam memperbaiki gejala dan durasi perawatan pasien COVID-19 derajat sedang hingga kritis di Rumah Sakit Universitas Airlangga pada bulan Mei-Juni 2021. Metode penelitian ini menggunakan studi analitik observasional dengan metode kohort retrospektif. Ini diperoleh dari rekam medis pasien COVID-19 derajat sedang hingga kritis yang menggunakan antivirus remdesivir dan favipiravir di RS Universitas Airlangga. Data dikumpulkan menggunakan teknik total sampling dan diuji dengan Mann-Whitney. Parameter yang digunakan dalam penelitian ini adalah usia, jenis kelamin, komorbiditas, tingkat keparahan, obat antivirus, dan lama pengobatan. Dari 130 subjek penelitian, 27 pasien menggunakan remdesivir dan 103 pasien menggunakan favipiravir. Hasil uji menunjukkan bahwa uji antara antivirus dan waktu perbaikan gejala menunjukkan p = 0,015 (p < 0,05) yang berarti signifikan, sedangkan uji antara antivirus dan lama pengobatan menunjukkan p = 0,018 (p < 0,05) yang berarti signifikan. Jadi, kesimpulannya adalah terdapat perbedaan efektivitas yang signifikan antara penggunaan remdesivir dan favipiravir terhadap waktu perbaikan gejala dan lama pengobatan pasien COVID-19 derajat sedang hingga kritis.
Co-Authors Alphania Rahniayu Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Constantia Lidwina Targanski David Setyo Budi Filhi Rihmayuwainilla I'tishom, Reny Irmi Syafa'ah Jeffri Nagasastra Machin, Abdulloh ManikRetno Wahyunitisari Retnaningsih Wilda Mahdani Wiwin Retnowati