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All Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology Indonesian Journal of Biomedicine and Clinical Sciences
Mifetika Lukitasari
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Cardiac Fibrosis Attenuation by Chlorogenic Acid and Epigallocatechin-Gallate Mediated by Suppression of Galectin-3 Gene Expression and Collagen Deposition in Rat Metabolic Syndrome Model Indah Nur Chomsy; M. Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Husnul Khotimah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14759

Abstract

Objective: Metabolic syndrome (MetS) is a set cluster of risk factors for metabolic abnormalities thatcan develop cardiovascular disease (CVD), one of that is remodeling or cardiac fibrosis. Cardiac fibrosisidentified from the high levels of the profibrotic molecule; one of them is galectin-3. Aim: This studyintended to determine the effect of combination therapy of green coffee (CGA) and green tea (EGCG) oncardiac fibrosis by raise of the galectin-3 gene expression and collagen deposition in rat cardiac tissue inthe rat metabolic syndrome model. Methods: Twenty-four male MetS rats (Sprague-Dawley) divided intotwo control groups and three groups therapy (n=5) administration of the CGA 200mg/kgbw (body weightin kilograms) and EGCG 300mg/kgbw orally. After eight weeks of treatment, rats euthanized, then mRNAexpression of galectin-3 was measured. Furthermore, collagen deposition of cardiac tissue carried out inhistology slides. Results: Research reveals that the expression of galectin-3 decreased in the metabolicsyndrome model group, which given combination therapy compared with metabolic syndrome model micethat did not receive any therapy (P=0.000). Collagen deposition in cardiac tissue also found less than inthe therapy group compared with the group not treated with both compounds (P=0.000). The correlationbetween the two parameters shows a positive association with low strength. Conclusion: This study showsthat the combination therapy of CGA and EGCG is an engaging therapeutic candidate. It expected to reducethe progression of cardiac fibrosis in metabolic syndrome
Consumer Perceptions and Preferences of Beverage Products in Malang City Mohammad Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Nashi Widodo; Inggita Kusumastuty; Nur Ida Panca Nugrahini
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.3872

Abstract

This research aims to investigate the consumer perceptions and preferences of beverage products in Malang City, East Java. This study uses a Mixing theory approach, which analyzes research data quantitatively by using descriptive analysis, and qualitatively. The population is all consumers of beverage products in Malang city, where 220 consumers were selected as research samples through purposive random sampling. Primary data were collected using a questionnaire. Types of drinks that are commonly consumed by the local community include soft drinks, tea, milk, coffee, health drinks, and beverages included in "other" category. Furthermore, the most consumed beverage is coffee. The results demonstrate that the choice of beverage products is greater based on the health and refreshing benefits. In terms of purchasing methods, most consumers prefer buying directly at the nearest store. This finding is a strong signal for beverage producers to market the products widely to reach small stores in residential areas. Producers of beverages other than coffee are suggested to emphasize the refreshing or health benefits of the beverage products to gain consumers' preference.
Lipoprotein-Associated Phospholipase A2 Activity increase the Sensitivity of Framingham Score for detecting the incidence of Acute Myocardial Infarction in sub-population of Indonesian Male Patients Andi Wahjono; Saifur Rohman; Miryanti Cahyaningtias; Rina Yudha; Yanna Indrayana; Mifetika lukitasari; Rusdianto Rusdianto; Aditya Kurniawan; Djanggan Sargowo; Sasmojo Widito; Dadang Hendrawan; Jayarani Fatimah Putri; widodo Ph.D
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cardiovascular disease. Framingham score is currently a widely used risk stratification tool for detecting the incidence of acute myocardial infarction (AMI), although it is not very sensitive. Adding Lp-PLA2 to the Framingham score can raise the odds ratio (OR) for AMI, but requires further research.Objectives: In this study, we examine the role of Lp-PLA2 in increasing the sensitivity of the Framingham score for detecting the incidence of AMI.Methods: This study was a case-control study of 97 male patients, 60 of whom had AMI and were treated in the intensive care unit as test subjects, and 37 of whom were non-AMI patients with normal treadmill test used as controls.Results:Lp-PLA2 activity was found to be higher in the AMI group than that in the control group (83.97 ± 27.15 nmol/ml/min vs. 55.04 ± 31.99 nmol/ml/min). Eighteen patients (30%) with AMI were included in the high-risk category according to the Framingham score; this number increased to 36 patients after the addition of Lp-PLA2 activity to the Framingham score. Analysis using a receiver operating characteristic (ROC) showed a cut-off value for Lp-PLA2 activity associated with AMI of approximately 74.21 nmol/ml/min with an accuracy of 67%. The OR for detecting AMI incidence increased after the addition of Lp-PLA2 activity from 1:01 (CI 95%, 0.414–2.48) to 4.67 (CI 95%, 1.88-11.61).Conclusions:   The addition of Lp-PLA2 activity may increase the sensitivity of the Framingham score for detecting the incidence of AMI.
The effect of fluid restriction monitoring guidelines using the Heart Failure Self-Care Application (Aplikasi Perawatan Mandiri Heart Failure/ATRIA) on reducing risk of fluid retention in heart failure patients at Dr. Saiful Anwar Hospital Malang Ghazyarda Aqilah Setya; Mifetika Lukitasari; Suryanto; Ika Setyo Rini; Hikmawan Wahyu Sulistomo; Cholid Tri Tjahjono Candra; Mohammad Saifur Rohman; Ardian Rizal
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 4 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i4.13534

Abstract

Heart failure patients are often at risk of rehospitalization due to recurrent symptoms such as dyspnea, edema, pulmonary congestion, and rapid weight gain resulting from fluid retention. This study aimed to analyze the impact of guided fluid restriction using the ATRIA application on risk of fluid retention in heart failure patients. The quasi-experimental method was used with a posttestonly control group design. Simple random sampling was carried out to select respondents, with the intervention group given the ATRIA application and the control group receiving a booklet intervention. The study duration was four weeks, with 16 respondents in the intervention group and 15 respondents in the control from Dr. Saiful Anwar Hospital, Malang. Data analysis used an independent sample t-test to assess differences in body and weekly weight changes. The resultsshowed no significant difference in body weight between the intervention and control groups each week (p > 0.05). Similarly, there was no significant difference change in body weight between the two groups (p > 0.05). In conclusion, there is no distinction observed between the ATRIA application and booklet concerning fluid restriction guidelines for reducing risk of fluid retention in heart failure patients. The results suggested that nurses could provide educational services and monitor the condition of heart failure patients using either application or booklet. Future studies are recommended to analyze factors that might impact fluid retention in heart failure patient.
Co-Authors ADITYA KURNIAWAN Andi Wahjono Ardian Rizal Cholid Tri Tjahjono Candra Dadang Hendrawan Djanggan Sargowo Dwi Adi Nugroho Ghazyarda Aqilah Setya Hikmawan Wahyu Sulistomo HUSNUL KHOTIMAH Ika Setyo Rini Indah Nur Chomsy Inggita Kusumastuty Jayarani Fatimah Putri M. Saifur Rohman Miryanti Cahyaningtias Mohammad Saifur Rohman Nashi Widodo Nur Ida Panca Nugrahini Rina Yudha Rusdianto Rusdianto Saifur Rohman Sasmojo Widito Suryanto widodo Ph.D yanna indrayana