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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian MITRA: Jurnal Pemberdayaan Masyarakat Jurnal Biomedika Jurnal Abdimas Indonesia
Muhammad Dzakwan
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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FORMULASI TABLET HISAP EKSTRAK DAUN KELOR SEBAGAI SUMBER VITAMIN A Muhammad Dzakwan; Siti Aisiyah
Biomedika Vol 7 No 1 (2014): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14670.519 KB) | DOI: 10.31001/biomedika.v7i1.489

Abstract

Abstrak Tujuan penelitian ini adalah membuat bentuk sediaan tablet hisap ekstrak daun kelor sebagai sumber vitamin A. Penelitian ini dibuat tiga formula tablet hisap yang terbaik dengan variasi konsentrasi bahan pengikat gelatin yaitu 2%, 4% dan 6%. Tablet yang dibuat dievaluasi sifat fisis dan uji tanggapan rasa. Hasil penelitian ini selanjutnya dilakukan analisis data menggunakan metode analisa varian satu jalan ANOVA dengan taraf kepercayaan 95% untuk mendapatkan formula tablet hisap yang terbaik. Hasil penelitian ini pertama, ekstrak daun kelor dapat dibuat menjadi tablet hisap dengan metode granulasi basah.Kedua, Tablet hisap ekstrak daun kelor dapat dibuat dengan menggunakan bahan pengikat gelatin.Ketiga, Formula I dengan konsentrasi pengikatgelatin 2% merupakan formula terbaik dan memenuhi persyaratan uji mutu fisik tablet.Keempat, Formula I dengan konsentrasi pengikat gelatin 2% memenuhi uji tanggapan rasa yang terbaik. Kata kunci : Daun kelor, ekstrak, formulasi, tablet hisap, gelatin Abstract The aim of this research wasto create a tablet dosage form suction Moringa leaf extract. This study was made three lozenges of the best formulas with gelatin binder concentration variation is 2%, 4% and 6%. Tablets are made ​​and evaluated physical propertiestaste test. Analysis of research data using statistical methods variant one way ANOVA with a 95% confidence level. The results obtained extracts of Moringa leaves can be made ​​into lozenges with gelatin binder and has met the requirements of the physical quality test tablets and taste responses. Formula I with a concentration of 2% gelatin binder is the best formula and meet the requirements of the physical quality test tablet. Key words: Moringa leaf, extract, formulation, lozenges, gelatin
Increasing the Quality of Gendola Fruit Syrup as a Healthy Drink Nur Aini Dewi Purnamasari; Ganet Eko Pramukantoro; Muhammad Dzakwan
MITRA: Jurnal Pemberdayaan Masyarakat Vol 4 No 1 (2020): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v4i1.1066

Abstract

Gendola herbal syrup is a solution in the form of syrup containing gendola as an active substance that is dissolved in the syrup component. Gendola syrup has a high betalain antioxidant content, and is beneficial for improving health. Betalain antioxidant content is easily damaged due to the influence of air, humidity, and temperature, causing the red color of the gendola to fade. The implementation of this project aimed to help improve the quality of Gendola syrup and provide training to partners so that they were able to market Gendola syrup products online. This project was implemented in productive community groups, UDHerba Puspitasari in Mlandangan Rt 02 Rw 08, Mandan Village, Sukoharjo District Sukoharjo Regency to make them able to produce and market herbal processed products. Based on observations of the results achieved, our partners were able to produce herbal syrup, although it was still limited, the quality was not good, and it did not yield profits. The methods implemented in this program included: 1) provide training for making Gendola syrup with encapsulation methods; 2) provide equipment that can support the production process; 3) provide online marketing training. The results obtained in this community-service activity contributed siqnificantly to UD Herba Puspitasari in their efforts of producing high-quality Gendola syrup and marketing the products online.
Kegiatan Pemeriksaan Asam Urat Guna Mencegah Hiperurisemia Beserta Komplikasinya Pada Populasi Lanjut Usia Di Panti Werda Hana Robert Kosasih; Junius Kurniawan; Kenzie Rafif Ramadhani; Muhammad Dzakwan
jurnal ABDIMAS Indonesia Vol. 2 No. 2 (2024): Juni : Jurnal ABDIMAS Indonesia
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jurai.v2i2.1298

Abstract

Serum uric acid (SUA) is the end product of purine metabolism in humans. When the body makes too much uric acid and the kidneys don't get rid of it quickly enough, this is called hyperuricemia. This leads to gouty arthritis because monosodium urate crystals build up in the joints. Normal SUA levels are 3.5–7.0 mg/dL in men and 2.6–6.0 mg/dL in women, influenced by diet, genetics, kidney function and medications. The prevalence of hyperuricemia is increasing globally, both in developed and developing countries. Although often asymptomatic, elevated SUA can cause tissue damage and increase the risk of hypertension, dyslipidemia, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, and chronic kidney disease (CKD). This activity uses the PDCA (Plan-Do-Check-Action) method for early detection of hyperuricemia in the elderly at Hana Nursing Home, South Tangerang. Blood test results revealed hyperuricemia in 16 people (26.23%). Routine SUA screening helps identify individuals at risk and allows for preventive measures such as dietary changes and regular exercise.
Pengujian Sifat Anti-Inflamasi Ekstrak Bunga Chamomile dalam Nanopartikel Kristal Cair Lyotropik Secara In Vitro Widyan Muchzadi Akbar; Muhammad Dzakwan; Fransiska Leviana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17402

Abstract

Chamomile is renowned for its anti-inflammatory properties. Lyotropic Liquid Crystal Nanoparticle (LLCN) offers better enhancement of the bioavailability and efficacy of natural products. This study evaluated the LLCN system’s effectiveness in improving chamomile extract’s anti-inflammatory activity and compliance with nanoparticle standards. Chamomile 70% ethanol extract was prepared, and the total phenolic and flavonoid content was measured. The extract was formulated into LLCN, and the particle size, polydispersity index, zeta potential, stability, and entrapment efficiency were evaluated. Anti-inflammatory activity was tested in vitro using the protein denaturation inhibition method. The extract showed high phenolic and flavonoid content. The characterisation results demonstrated that the LLCN system met the required specifications, exhibiting particle size values of 230.366±3.412 nm, polydispersity index of 0.217±0.034, a zeta potential of -23.763±0.756 mV, and an entrapment efficiency of 84.060%±0.100. Stability testing indicated that storage at 4°C was more effective than room temperature, preserving a smaller particle size and improving overall stability. The LLCN system significantly enhanced the extract’s anti-inflammatory activity, as demonstrated by a lower IC50 value than the viscous extract. In conclusion, the LLCN system enhances the therapeutic potential of chamomile extract and represents a promising strategy for developing phytochemical-based anti-inflammatory formulations.
Co-Authors Fransiska Leviana Ganet Eko P Junius Kurniawan Kenzie Rafif Ramadhani Purnamasari, Nur Aini Dewi Robert Kosasih Siti Aisiyah Widyan Muchzadi Akbar