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AKTIVITAS PENURUNAN PARASITEMIA EKSTRAK KULIT BATANG MUNDU SEBAGAI ANTIPLASMODIUM SECAR in vivo DENGAN PARAMETER ED50 Mamik Ponco Rahayu; Reslely Harjanti; Gunawan Pamudji
Biomedika Vol 7 No 1 (2014): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13741.949 KB) | DOI: 10.31001/biomedika.v7i1.493

Abstract

Abstrak Pengobatan malaria di Indonesia saat ini di beberapa daerah masih menggunakan obat standar kloroquin dengan dosis 600 mg hari pertama dan kedua serta 300 mg hari ketiga. Efektivitas pemberian kloroquin saat ini sudah mulai diragukan karena telah banyak ditemukan resistensi terhadap obat ini. Salah satu usaha menemukan antimalaria baru adalah melalui penelitian terhadap tanaman obat yang digunakansecara tradisional oleh masyarakat untuk mengobati malaria. Tanaman mundu termasuk familia garcinia, Marga Garnicia diketahui kaya kandungan senyawa xanton dan menunjukkan aktivitas biologi termasuk antimalaria (Merza, et al.,).Penelitian ini bertujuan untuk mengetahui aktivitas antiplasmodium ekstrak etil asetat kulit batang mundu. Ekstraksi diperoleh secara maserasi bertingkat dengan pelarut n heksan dan etil asetat. Uji aktivitas antiplasmodium dilakukan secara in vivo pada mencit jantan galur Swiss yang diinduksi Plasmodium berghei dengan parameter pengujian persentase parasitemia, persentase penghambatan parasitemia dan penentuan dosis efektif 50% (ED50) menggunakan metode The 4-daySuppresive Test (Peters, 1970). Dosis yang diberikan ke hewan uji untuk ekstrak etil asetat kulit batang mundu yaitu 12,5; 25; 50; 100 mg/gr BB mencit Swiss. Dosis tablet klorokuin 5 mg/kg bb didapatkan 0.91 mg/ 20g bb dan sebagai kontrol normalCMC 0.5%. Pengujian aktivitas antiplasmodium ekstrak etil asetat kulit batang mundu diperoleh dosis ED50 adalah 5,01 mg/kg BB. Berdasarkan data tersebut, ekstrak etil asetat kulit batang mundu memiliki aktivitas antiplasmodium. Keywords: Antiplasmodium, ED50, Kulit batang mundu, etil asetat
Evaluasi Pengelolaan Obat Di Instalasi Farmasi Rumah Sakit Umum Daerah Provinsi NTB Tahun 2017 nur oktaviani; Gunawan Pamudji
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.612 KB) | DOI: 10.31001/jfi.v15i2.443

Abstract

IFRS is responsible for drug management, namely selection, planning and procurement, distribution and use. Preliminary observations indicate of drug management problems in IFRSUD Province NTB. The aim of the study was to evaluate of drug management in IFRSUD Province NTB. Descriptive research were taken retrospectively and concurrently. Data in the form of quantitative and qualitative, accompanied by interviews of related parties. All stages of drug management measured using the MOH RI indicator, Pudjaningsih, Permenkes and WHO then compared with the results of other studies. The results showed that the stage that did not meet the standards were: the stage of selection: conformity with the national formulary; procurement: percentage of available fund allocation, namely the frequency of incomplete SP / Invoice, percentage of available capital funds with the total needed, frequency of delay in payment by the hospital against the agreed time, the percentage of suitability between drug planning and the reality of each drug; distribution, the accuracy of the amount of drug data on the automatic stock card, Turn Over Ratio, percentage and value of drugs that were damaged / expired, percentage of dead stock; usage: number of drug items per recipe, percentage of antibiotic, and percentage of prescription injection drugs. The results are in accordance with the standards, the stage of selection suitability with hospital formulary; procurement: frequency of procurement of each drug item per year; distribution: namely drug availability level; use, percentage of prescription with a generic name, percentage of drugs that can submitted, percentage of drug that label, and the average time spent serving recipes
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN PELAWAN (Tristaniopsis obovate. Benn) DENGAN METODE PENANGKAPAN RADIKAL BEBAS 2,2’-DIFENIL-1-PIKRILHIDRAZIL Muhammad Farid Al Kadri; Titik Sunarni; Gunawan Pamudji; Irfan Zamzani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 2 No 2 (2019): March 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (873.755 KB)

Abstract

Radikal bebas merupakan salah satu penyebab terjadinya penyakit degenaratif, sehingga perlu adanya senyawa antioksidan lainnya untuk mengurangi radikal bebas yang dapat menyebabkan kerusakan sel. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan ektrak etanol daun pelawan (Tristaniopsis obovate. Benn) dibandingkan dengan senyawa rutin. Pengujian aktivitas antioksidan ekstrak daun pelawan menggunakan metode penangkapan radikal bebas 2,2’-difenil-1-pikrilhidrazil (DPPH) dan rutin sebagai pembanding. Hasil penelitian menunjukkan bahwa dengan peningkatan konsentrasi ekstrak etanol daun pelawan dan pembanding rutin maka semakin besar pula persen penangkapan radikal bebas DPPH. Hasil aktivitas antioksidan ekstrak etanol daun pelawan dengan IC50 sebesar 14,020 ppm dan standar rutin dengan IC50 sebesar 4,837 ppm. Free radical is one of the causes of degenerative diseases; therefore, it is needed another antioxidant to diminish cell damage. This research aims at investigating antioxidant activity of ethanol extract of Pelawan leaf (Tristaniopsis obovate. Benn) compared to regular substance. The testing of antioxidant activity of Pelawan leaf’s extract utilized the method of capturing 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical and regular substance as a standard of comparison. The result shows that the increase of concentration of ethanol extract impacted the high percentage of the capture of DPPH free radical. The result of antioxidant activity of Pelawan leaf’s extract with IC50 was14.020 ppm, and regular standard with IC50 was 4.837 ppm.
Co-Authors Mamik Ponco Rahayu Muhammad Farid Al Kadri Nur Oktaviani Reslely Harjanti Titik Sunarni Zamzani, Irfan