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All Journal Nusantara Medical Science Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Biomedika
Irawaty Djaharuddin
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Detection of LytA Genes in Streptococcus pneumoniae Isolated from sputum pneumonia patients Mustika Sari Hutabarat; Firdaus Hamid; Irawaty Djaharuddin; Alfian Zainuddin; Rossana Agus; Muhammad Nassrum Massi
Biomedika Vol 13 No 1 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i1.718

Abstract

Streptococcus pneumoniae (pneumococcus) is a Gram-positive facultative anaerobic bacterium that is a major cause of morbidity and mortality worldwide. But the lack of reporting of disease by this bacterium in Indonesia, one of the causes is because the diagnosis of pneumococcal infection is often clinically not typical and conventional methods which are still the standard gold method often give false-negative results. So the purpose of this study was to evaluate the performance of culture and molecular diagnostic methods using the Polymerase Chain Reaction (PCR) technique in detecting Streptococcus pneumoniae in sputum clinical samples using the Autolysin (LytA) gene which is a virulence factor of this bacterium. 57 isolates from 60 samples were confirmed as Streptococcus sp through microscopic identification, culture, and biochemical tests. Then the sensitivity test with an optochin test of 9 (9%) compared the results descriptively with the PCR technique using the Autolysin A (LytA) gene which was obtained more sensitive by 15 (25%).
Pulmonary Tuberculosis CT-Scan Features and Sputum Smear in Tertiary Referral Hospital Nur Amelia Bachtiar; Sri Asriyani; Bachtiar Murtala; Irawaty Djaharuddin; Andi Alfian Zainuddin; Nikmatia Latief
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.13489

Abstract

Introduction: Management of pulmonary tuberculosis (PTB) from primary and secondary health centers might affect the result of sputum acid-fast bacilli (AFB) smear and features of lung computed tomography scan (CT-scan) presented in tertiary hospitals. The study aims to investigate comparison between CT-scan features of PTB with sputum AFB smear in Wahidin Sudirohusodo Hospital as the top referral hospital in the Eastern part of Indonesia. Methods: This is a retrospective study of patients diagnosed as PTB by pulmonologist of nine months period. Patients with available CT-scan and sputum AFB smear results are included in the study. CT-scan features re-evaluated with RadiAnt DICOM viewer for standardized reading. The relationship between data obtained was analyzed with a chi-square test. Results: Sixty-one PTB patients were entered into the study. The three most common features found in CT were consolidation (93.4%) followed by Tree-in-bud (91.8%), and fibrosis calcification (85.2%). Relationship of CT features and sputum AFB smear was significant on cavity (p-value: 0.002) and pleural effusion (p-value: 0.020). However, unlike cavity (OR = 1.667), pleural effusion has opposite relationship (OR = 0.205) with sputum AFB smear. Conclusions: Pulmonary tuberculosis CT features seen in top referral hospitals can be very severe with consolidation and tree-in-buds as the most common features found in more than 90% of the cases. Feature of cavity may help radiologist to distinct highly active PTB with positive sputum AFB smear while presence of pleural effusion should raise the suspicion from pulmonologists to add further laboratory investigation.
Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD) Nurfajar Budi Mulya; Muhamad Ilyas; Erwin Arief; Irawaty Djaharuddin; Siti Nurisyah; Harry Akza Putrawan
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18850

Abstract

Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods:  This study was designed for a cross-sectional study. 65 acute exacerbation COPD patients were selected. The serum level of Interleukin-1β was recorded. Results:  Most of the subjects are men (95,4%), moderate smokers (41,5%), normal BMI (61,5%), more than 60 years old (73,8%), have more than 2 exacerbations in a year (67%), severe airway obstruction (41,5%) and mostly in group D (80%). The mean level of Interleukin-1β was 1.63 pg/ml range from 0,009-17,62 pg/ml. Kruskal Wallis analysis test noticed significant differentiation mean serum level of Interleukin-1β in several groups of GOLD. p<0,05. There was no correlation between serum level of IL-1β with the severity of airway obstruction (GOLD) p>0.05. Conclusions: there was no correlation between the severity of airway obstruction with serum level of IL-1β in acute exacerbation of COPD. there was a vicious trend of increasing IL-1β serum level according to the severity of airway obstruction mainly seen in GOLD 2, GOLD 3, and GOLD 4.
KARAKTERISTIK PASIEN TUBERKULOSIS PARU DI PUSKESMAS KOTA BAUBAU SULAWESI TENGGARA Wa Ode Nur Hikmah Arif; Elly Wahyudin; Irawaty Djaharuddin
Majalah Farmasi dan Farmakologi Vol. 26 No. 1 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i1.14759

Abstract

Tuberkulosis (TB) adalah salah satu penyakit infeksi menular melalui udara yang paling mematikan. Penyakit TB disebabkan terutama oleh bakteri patogen Mycobacterium tuberculosis (Mtb ). Penelitian ini bertujuan untuk mengetahui karakteristik pasien sebagai data pendukung untuk evaluasi tatalaksana terapi pada pasien TB paru. Penelitian ini merupakan penelitian deskriptif yang dilakukan di Puskesmas Kota Baubau Sulawesi Tenggara sejak Desember 2020-Februari 2021. Sampel Penelitian berjumlah 49 orang. Pengumpulan data dilakukan dengan bersumber dari data rekam medis, SITB (Sistem Informasi Tuberkulosis) dan kuesioner. Data penelitian kemudian dianalisis dengan menggunakan uji statistik SPSS. Hasil penelitian berupa data karakteristik pasien tuberkulosis paru di Puskesmas kota Baubau yang menunjukkan bahwa pasien tuberkulosis paru terbanyak pada jenis kelamin laki-laki (65,3%), umur 15-35 tahun (65,3%), pendidikan dasar dan menengah (73,5%), pekerjaan wiraswasta (51%), penghasilan >Rp 500.000 (75,5%), pemeriksaan akhir bulan ke enam BTA(-) (95,9%), pasien BTA(+) (4,1%), kepatuhan pasien (89,8%), pengetahuan responden tinggi (51%), efek samping obat terbanyak badan lemas (28,6%), mual (28,6%). Sebanyak (26,53%) pasien dengan penyakit penyerta dan 14,29% dengan keluhan gangguan asam lambung telah menerima Antasida.
Co-Authors Alfian Zainuddin Andi Alfian Zainuddin Bachtiar Murtala Bachtiar, Nur Amelia Elly Wahyudin Erwin Arief Firdaus Hamid Harry Akza Putrawan Latief, Nikmatia Muhamad Ilyas Muhammad Nassrum Massi Mustika Sari Hutabarat Nurfajar Budi Mulya Rossana Agus Siti Nurisyah Sri Asriyani Wa Ode Nur Hikmah Arif