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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology
Ira Humairah
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Prevention and Early Detection of Metabolic Syndrome in Household Community, Surabaya Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Siti Khaerunnisa; Gwenny Ichsan Prabowo; Suhartati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15747

Abstract

Introduction. Metabolic syndrome is a collection of factors believed to increase the risk of atherosclerosis and type 2 diabetes mellitus. The incidence of metabolic syndrome in young adults is increasing, especially in Asian countries. Therefore we need efforts to increase knowledge in society about this disease. Aim. We conducted a socialization program on prevention and early detection of metabolic syndrome in household community to increase public knowledge about this disease.Method. This program was conducted in August 2017 in Wonokromo District, Surabaya. The participants in the activity consisted of 32 people from household community. The activity consisted of blood sampling collection, body weight, and abdominal circumference measurement for risk factor assessment, pre-test, socialization of metabolic syndrome, and post-test.Results. From the results of the pre and post test, we found an increase knowledge of 76.9% participants. The laboratory test results for early detection of metabolic syndrome showed 37.5% of participants had metabolic syndrome. We also found a significant positive correlation between body weight and abdominal circumference (p = 0.000, r = 0.867). There was also a significant negative correlation between body weight and HDL (p = 0.004, r = -0.494), between abdominal circumference and HDL (p <0.05, r = -0.376), and between TG and HDL (p <0.05, r = -4.22).Conclusion. Socialization and early detection of metabolic syndrome can increase knowledge, awareness, and detection of metabolic syndrome in the household community.
SARI ETANOL, ETIL ASETAT ALANG-ALANG (IMPERATA CYLINDRICA) TERHADAP SUPEROXIDE DISMUTASE (SOD) St Khaerunnisa; Sutji Kuswarini; Suhartati Suhartati; Lina Lukitasari; Ira Humairah; Reza Arta BN; Gwenny IP
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1080

Abstract

Oxidative stress has been considered as a mechanism involved in the pathogenesis and progression of many diseases such as:hypercholesterolemia and atherosclerosis. The objective of this current study was to know the potential antioxidant role of ethanol andethyl acetate extract of reeds (Imperata cylindrica) by investigation in rats fed with a high-cholesterol diet. Imperata cylindrica is richin antioxidants and has a cholesterol-reducing effect. A group of twenty four male albino Wistar rats was divided into four subgroups: anormal diet group (K0), a high-cholesterol diet group (K1), the same diet with ethanol extract of Imperata cylindrica group (K2), and thesimilar diet with ethyl acetate fraction of Imperata cylindrica group (K3),. After the treatment period, the hepatic antioxidant enzymeactivity (Superoxide dismutase/SOD) was determined. The rats fed on high-cholesterol diet with supplementation exhibited a significantelevation in SOD activity (p<0. 05), 61.6±12.4% inhibition, compared to normal animals 37.44±12.2%. The treated animals withethanol and ethyl acetate extract of Imperata cylindrica showed a significantly reduced the level of SOD activity (p<0.05, 29.90±5.6%as well as a 33.49±7.4% inhibition). The level of SOD activity when restored was closer to that in normal animals, signifying reversalof the oxidative stress. The study results showed that the treatment with Imperata cylindrica positively changed the hepatic antioxidantenzyme activities in high fat-diet rats, and thus had potential hypocholesterolemic and antioxidant effects. Imperata cylindrica couldprotect against oxidative stress linked to atherosclerosis and also decrease the atherogenic index.
Co-Authors Gwenny IP Lukitasari, Lina Prabowo, Gwenny Ichsan Qurnianingsih, Ema Reza Arta BN Siti Khaerunnisa Siti Khaerunnisa Suhartati Suhartati Suhartati Sutji Kuswarini