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<![CDATA[KUALITAS LINGKUNGAN PERMUKIMAN KAWASAN PECINAN KOTA SEMARANG ]]>
<![CDATA[Yuliastuti, Nany]]>;
<![CDATA[Khaerunnisa, Isti]]>
<![CDATA[ TEKNIK Volume 32, Nomor 3, Tahun 2011 ]]>
Publisher : <![CDATA[Diponegoro University ]]>
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DOI: 10.14710/teknik.v32i3.1740
<![CDATA[Chinatown is a component of the urban area which has many unique possibilities and store a wide variety issuesrelated to its area development and social culture. Chinatown in Semarang is one area that has a specialtreatment from the local government of Semarang where it has a high commercial and cultural value. The areahas some issues that are often experienced by urban settlements in the high building density that causes thedifficulty of procuring open space and green open spaces, some of the environmental infrastructure damage suchas potholes, clogged channels to rubbish strewn everywhere. The purpose of this study was to assess theenvironmental quality of settlements in the Chinatown area of Semarang. General approach used in this study isa quantitative approach. While the analytical techniques used in this research is descriptive statistics, withdescriptive techniques of quantitative, qualitative and descriptive descriptive and comparative analysis ofweighting as an analytical tool used to support the analysis. The results of this study is the quality ofneighborhoods in the city of Semarang's Chinatown area belong to the category of Medium with a value of 50 inunits of percent. This value is derived from the analysis of public facilities and infrastructure conditions of theenvironment area, the analysis of the physical quality of the built environment, and public awareness of theenvironmental analysis has been done before, where all of the analysis is at a Moderate category. This indicatesthat the need to increase the quality of neighborhoods Chinatown area, in anticipation of a decline inenvironmental quality. A good public awareness of the environment in which they live will be able to preventdegradation of Semarang's Chinatown neighborhood area can even improve the quality of the settlements in theregion.]]>
<![CDATA[Pengaruh Variasi Dosis Ekstrak Terong Belanda Terhadap Konsentrasi Spermatozoa Pada Mus Muscullus Yang Dipapar Timbal Asetat ]]>
<![CDATA[Abadiyah Zakiah]]>;
<![CDATA[Reny I’tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020 ]]>
Publisher : <![CDATA[FORIKES ]]>
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DOI: 10.33846/sf11nk319
<![CDATA[Infertility is a 10-15% problem experienced by men around the world. One of the causes of infertility in men is caused by an increase in reactive oxygen species (ROS) by toxic substances such as heavy metal lead (Pb). This research was conducted to find the potential of Dutch eggplant fruit (Solanum betaceum) in various doses to increase the concentration of mice spermatozoa (Mus muscullus) exposed to lead acetate. Dutch eggplant has a good phenolic content as an antioxidant to prevent free radicals. The study design used was Posttest only control group design with a sample of 40 male mice. The treatment time in all groups is 35 days. Mice were divided into 5 groups that were given oral treatment. The control group was given 75 mg/kgBW of lead acetate treatment. The treatment group was given lead acetate 75mg / KgBB and Dutch eggplant extract at various doses of 100 mg/kgBW (P1), 200 mg/kgBW (P2), and 400 mg/kgBW (P3). The results showed that Dutch eggplant extract (Solanum betaceum) with various doses could significantly increase spermatozoa concentration. The optimal dose of Dutch eggplant extract (Solanum betaceum) in mice exposed to lead is 100 mg/kg/day in the treatment group (P1). Keywords: tamarillo; spermatozoa concentration ABSTRAK Infertilitas merupakan masalah 10-15% yang dialami pria di seluruh dunia. salah satu penyebab infertilitas pada pria disebabkan oleh peningkatan reactive oxygen species (ROS) oleh bahan toksik seperti logam berat timbal (Pb). Penelitian ini dilakukan untuk menemukan potensi buah terong belanda (Solanum betaceum) dalam berbagai dosis terhadap peningkatan konsentrasi spermatozoa mencit (Mus musculus) yang dipapar timbal asetat. Terong belanda mempunyai kandungan fenolik yang baik sebagai antioksidan untuk mencegah radikal bebas. Desain penelitian yang digunakan Posttest only control group design dengan sampel 40 mencit jantan. Waktu perlakuan pada semua kelompok yaitu 35 hari. Mencit dibagi menjadi 5 kelompok yang diberikan perlakuan secara oral. Kelompok kontrol diberikan perlakuan timbal asetat 75mg/KgBB. Kelompok perlakuan diberikan timbal asetat 75mg/KgBB dan ekstrak terong belanda dengan berbagai dosis 100mg/KgBB (P1), 200mg/KgBB (P2), dan 400mg/KgBB (P3). Hasil penelitian menunjukkan bahwa ekstrak terong belanda (Solanum betaceum) dengan berbagai dosis mampu meningkatkan konsentrasi spermatozoa secara signifikan. Dosis optimal pemberian ekstrak terong belanda (Solanum betaceum) pada mencit yang dipapar timbal adalah 100 mg/kgBB/hari pada kelompok perlakuan (P1). Kata kunci: terong belanda; konsentrasi spermatozoa]]>
<![CDATA[Potensi Ekstrak Solanum betaceum sebagai Agen Protektif Sel Leydig pada Mencit yang Dipapar Timbal Asetat ]]>
<![CDATA[Anak Agung Istri Dalem Cinthya Riris]]>;
<![CDATA[Reny I’tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020 ]]>
Publisher : <![CDATA[FORIKES ]]>
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DOI: 10.33846/sf11nk313
<![CDATA[Lead exposure as environmental pollution can cause male reproductive problems. Provision of natural antioxidants can be an alternative solution to protect male reproductive function. This research was conducted to investigate the potential of Solanum betaceum extract as a protective agent for Leydig cells in mice exposed to lead acetate. The entire research process with a replication unit of 40 male mice. Mice were divided into five groups with each treatment given orally. The negative control group (K0) only gets aquadest for 35 days, the positive control group (K1) gets aquadest day 1-3, day 4-35 get lead acetate at a dose of 0.075 mg/kg BW/day, the treatment group (P1), (P2 ), and (P3) only given Solanum betaceum extract at day 1-3 with sequential doses of 100 mg/ kg BW /day, 200 mg/ kg BW /day, and 400 mg/ kg BW /day, then 4-35 days were given Solanum extract betaceum and after 1 hour given lead acetate. The results of this study indicate that there were significant differences between groups with p]]>
<![CDATA[Ekstrak Solanum betaceum Mampu Meningkatkan Tebal Epitel dan Diameter Tubulus Seminiferus pada Mencit (Mus musculus) yang Terpapar Timbal Asetat ]]>
<![CDATA[Nurul Fatimah Susanti]]>;
<![CDATA[Reny I’tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020 ]]>
Publisher : <![CDATA[FORIKES ]]>
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DOI: 10.33846/sf11nk320
<![CDATA[One of the environmental factors that cause male infertility is heavy metal pollution such as lead. Lead can interfere with male fertility. Flavanoids are antioxidants that can prevent the negative effects caused by lead. The flavonoids contained in the Solanum betaceum extract have the potential to prevent the adverse effects of lead on the reproductive tract of mice because it can prevent oxidative stress. So it can affect the thickness of the seminiferous tubule epithelium and the diameter of the seminiferous tubules of mice exposed by lead acetat. The research method was a pure experimental laboratory (true experimental) randomized posttest only control group design approach. The total sample of 40 heads was divided into 5 groups. The study used 5 treatments. The concentration of Solanum betaceum for research group 100 mg/kg BW/day, 200 mg/kg BW/day, 400 mg/kg BW/day. Data analysis was performed analytically using One Way Anova. The results showed the mean ± standard deviation of the highest seminiferous tubular epithelium was highest 76.63 ± 7.17 and the mean ± standard deviation of the highest seminiferous tubule diameter was highest at 219.98 ± 17.06 in the P3 group. The results of this study indicate that there were significant differences between groups with p]]>
<![CDATA[Efektifitas Pemberian Ekstrak Terong Belanda (Solanum betaceum) Terhadap Peningkatan Berat Testis Mencit (Mus musculus) yang Dipapar Timbal Asetat ]]>
<![CDATA[Nurul Jannatul Wahidah]]>;
<![CDATA[Reny I'tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020 ]]>
Publisher : <![CDATA[FORIKES ]]>
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DOI: 10.33846/sf11nk318
<![CDATA[Male infertility with unknown definite etiology can be associated with lead exposure. Lead that accumulates in the body can cause oxidative stress and spermatogenesis disruption. To minimize the impact of lead exposure, it is necessary to use conventional methods with natural materials. One of them is the use of Solanum betaceum which have been proven to have secondary metabolic components that are antioxidants. This study aims to prove the effect of Dutch Eggplant (Solanum betaceum) extract to testicular weight of mice (Mus musculus) exposed to lead. This research was an true experimental research using male Mus musculus. Mice were 40 and divided into five groups randomly. Each group was consist of 8 mices. 1st group was negative control (K0), 2nd group was positive control (K1), 3rd group was exposed to lead + Solanum betaceum extract 100mg / KgBB (P1), 4th group was exposed to lead + Solanum betaceum extract 200mg / KgBB (P2), 5th group was exposed to lead + Solanum betaceum extract 400mg / KgBB (P3) for 35 days. Data were analyzed with One Way Anova and continued with T-Test. The results of this study prove that Dutch Eggplant (Solanum betaceum) extract significantly increase the testicular weight in mice exposed by lead acetate (p]]>
<![CDATA[Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review ]]>
<![CDATA[Anak Agung Istri Dalem Cinthya Riris]]>;
<![CDATA[Reny I'tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i1.4693
<![CDATA[The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function. Abnormal condition induced by reactive oxygen species reduce cell viability through lipid peroxidation and apoptotic pathway. Antioxidant ameliorate ROS elevation and prevent cell damage. Specifically, Leydig cells are vulnerable to ROS exposure and decline its function in mediating spermatogenesis. Therefore, it is needed to improve Leydig cells viability within antioxidant supplementation. This study aimed to determine the protective effect of antioxidant on Leydig cells induced by reactive oxygen species. This type of study is a literature review. Various studies have been reviewed through critical appraisal tool Olsen-Baisch Scoring for integrated review. Furthermore, this study highlighted the importance of the mechanism of antioxidant as protective agent of Leydig cells. Supplementation of antioxidant with the correct administration, dosage, and duration is potential to balance reactive oxygen species level and protect Leydig cells. Keywords : Leydig cell, antioxidant, reactive oxygen species, infertility]]>
<![CDATA[Solanum betaceum Extract as a Protective on Spermatozoa Morphology of Mice Exposed to Lead Acetate ]]>
<![CDATA[Rima Wirenviona]]>;
<![CDATA[Reny I'tishom]]>;
<![CDATA[Siti Khaerunnisa]]>;
<![CDATA[Anak Agung Istri Dalem Cinthya Riris]]>;
<![CDATA[Nurul Fatimah Susanti]]>;
<![CDATA[Nurul Jannatul Wahidah]]>;
<![CDATA[Abadiyah Zakiah Kustantina]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i1.4594
<![CDATA[Environmental pollution is one of the factors that contribute to the decline in male fertility. Lead is one of six air pollutants harmful to the reproductive system. One parameter of infertility in men is an increase in reproductive function observed with decreased morphological abnormalities of spermatozoa. The purpose is to analyze the effect of giving various dosages of Solanum betaceum extract on spermatozoa morphology of mice exposed to lead acetate. This study was true experimental using a randomized post-test only control group design. The total sample was 40 male mice Balb/ C taken by simple random sampling technique. Treatment and maintenance of experimental animals for 35 days. Statistical tests showed there were significant differences with p-value 0.005. Solanum betaceum extract can be used as a protective to improve the normal morphology spermatozoa of mice that exposed to lead acetate.]]>
<![CDATA[Ethanolic extract of Dutch eggplants (Solanum betaceum) protects spermatozoa motility exposed to lead acetate ]]>
<![CDATA[Rima Wirenviona]]>;
<![CDATA[Reny I'tishom]]>;
<![CDATA[Siti Khaerunnisa]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 4 (2020) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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DOI: 10.19106/JMedSci005204202002
<![CDATA[Lead is a toxic material that can have negative effects on reproductive organs. Lead exposure reduces the activity of endogenous antioxidant enzymes and increases the number of oxidants in the body. High free radicals will affect spermatogenesis and result in decreased motile spermatozoa. Antioxidants are known to protect the motility of spermatozoa, and adequate antioxidants can be found in Dutch eggplants (Solanumbetaceum). This study aimed to evaluate the effect of S. betaceum on spermatozoa motility after exposure to lead acetate. This study is a true experimental design with a randomized post-test-only control group design. Forty male Balb/C mice 12 weeks old were randomly divided into 5 groups: two control groups (C0, C1) and three treatment groups (T1, T2, T3).The C0 received distilled water, and the C1 received 75 mg/kg BW lead acetate. The T1, T2 and T3 received 100, 200 and 400 mg/kg BW of S. betaceum, respectively, an hour before exposed lead acetate. The data were analyzed using one-way ANOVA with a significant level of p <0.05. A significantly increasein the mean total motility of spermatozoa in T1, T2, and T3 was reported.This study indicates that S. betaceum have a protective effect on spermatozoa motility when exposed to lead acetate.]]>
<![CDATA[Maximizing Millennial Students Role in Combating COVID-19 Hoaxes and Myths ]]>
<![CDATA[Astri Dewayani]]>;
<![CDATA[Euvanggelia Dwilda Ferdinandus]]>;
<![CDATA[Rizki Putra Prastio]]>;
<![CDATA[Indah Fahmiyah]]>;
<![CDATA[Amila Sofiah]]>;
<![CDATA[Rodik Wahyu Indrawan]]>;
<![CDATA[Mochammad Nurul]]>;
<![CDATA[Gagas Gayuh Aji]]>;
<![CDATA[Nanda Rachmad Putra Gofur]]>;
<![CDATA[Siti Khaerunnisa]]>;
<![CDATA[Dewi Sriani]]>;
<![CDATA[Yankel Sena]]>
<![CDATA[ Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia ]]>
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DOI: 10.20473/bhsj.v4i1.26910
<![CDATA[Introduction: Since the outbreak of Corona Disease-19 (COVID-19) spreads all over the world, various ways of health attempts have been conducted. However, overflowed information intertwines with mis/disinformation could raise public anxiety and stigma-related diseases. We aimed to assess the help of the young generation of millennials and Gen-Z whom are active college students in debunking hoaxes and myths of COVID-19 into their community.Method: The selected students were given a short course on COVID-19 basic information, prevention, and circulated myths. Later, they become ambassadors and actively educated via offline and online platforms. The impact of outspread information on audiences was investigated through a qualitative survey.Result: The knowledge of students were measured by pre- and post-test within the short course. Prior knowledge showed the least understanding part was prevention and myth of COVID-19. There was a significant improvement of knowledge in post-test after receiving seminar (p=0.0002). There were 97 respondents who filled the online survey that predominantly in young adulthood age. Respondent's insight was enhanced and they likely intend to spread the actual information to their surroundings.Conclusion: Appointing student as the spokesperson for health education can raise their social responsibility. Clarifying misinformation and health behaviour could be more influential within the same sharing community. In addition, the use of various online platforms could efficiently reach massive target, especially young ages.]]>
<![CDATA[SARI ETANOL, ETIL ASETAT ALANG-ALANG (IMPERATA CYLINDRICA) TERHADAP SUPEROXIDE DISMUTASE (SOD) ]]>
<![CDATA[St Khaerunnisa]]>;
<![CDATA[Sutji Kuswarini]]>;
<![CDATA[Suhartati Suhartati]]>;
<![CDATA[Lina Lukitasari]]>;
<![CDATA[Ira Humairah]]>;
<![CDATA[Reza Arta BN]]>;
<![CDATA[Gwenny IP]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v20i2.1080
<![CDATA[Oxidative stress has been considered as a mechanism involved in the pathogenesis and progression of many diseases such as:hypercholesterolemia and atherosclerosis. The objective of this current study was to know the potential antioxidant role of ethanol andethyl acetate extract of reeds (Imperata cylindrica) by investigation in rats fed with a high-cholesterol diet. Imperata cylindrica is richin antioxidants and has a cholesterol-reducing effect. A group of twenty four male albino Wistar rats was divided into four subgroups: anormal diet group (K0), a high-cholesterol diet group (K1), the same diet with ethanol extract of Imperata cylindrica group (K2), and thesimilar diet with ethyl acetate fraction of Imperata cylindrica group (K3),. After the treatment period, the hepatic antioxidant enzymeactivity (Superoxide dismutase/SOD) was determined. The rats fed on high-cholesterol diet with supplementation exhibited a significantelevation in SOD activity (p<0. 05), 61.6±12.4% inhibition, compared to normal animals 37.44±12.2%. The treated animals withethanol and ethyl acetate extract of Imperata cylindrica showed a significantly reduced the level of SOD activity (p<0.05, 29.90±5.6%as well as a 33.49±7.4% inhibition). The level of SOD activity when restored was closer to that in normal animals, signifying reversalof the oxidative stress. The study results showed that the treatment with Imperata cylindrica positively changed the hepatic antioxidantenzyme activities in high fat-diet rats, and thus had potential hypocholesterolemic and antioxidant effects. Imperata cylindrica couldprotect against oxidative stress linked to atherosclerosis and also decrease the atherogenic index.]]>
