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All Journal ThufuLA: Jurnal Inovasi Pendidikan Guru Raudhatul Athfal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Griya Journal of Mathematics Education and Application Gudang Jurnal Ilmu Kesehatan
Siti Khaerunnisa
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health Other

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Molecular Docking Human Plasma Kallikrein to Prevent Acute Respiratory Distress Syndrome(ARDS) in COVID-19 Patient Feriawan Tan; Cindy ApriliaEkaPrasanty; Anna Surgean Veterini; YuaniSetiawati; Rizki Awaluddin; Fadilah Fadilah; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16860

Abstract

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation of the kallikreinkininsystem which produces bradykinin which is a potent proinflammatory mediator. This research is anin silico study which aims to determine the potential of active medicinal plant compounds in inhibiting thekallikrein-kinin system.Molecular docking in this study using Autodock 4.2 with Lamarckian GA criteria.Human plasma kallikrein (PDB ID: 5TJX) was docked with 70 compounds and one native ligandand analyzedusing Autodock 4.2.The smallest binding energy obtained from docking 5TJX with several compoundsin sequence, namely, xanthohumol, nafamostat, demethoxycurcumin, epicatechingallate, beta mangostin,alpha mangostin (-9.52, -9.35, -9.33, -9.28, -9.19, -9.06 kcal/mol). Therefore, the compound shows the bestpotential as a plasma kallikrein inhibitor. However, further research is still needed to determine the potentialof drugs and medicinal plant active compounds for medical treatment.
Swimming Improves Memory Function and Decreases N-Methyl-D-Aspartate in Ageing Rats Hanik Badriyah Hidayati; Purwo Sri Rejeki; Lilik Herawati; Susi Wahyuning Asih; Suhartati Suhartati; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16883

Abstract

A single Memory impairment substantially reduces the quality of life in the elderly. It is associated with thealteration of neurotrophic (NT) factors, such as brain-derived neurotrophic factor (BDNF) and glutamatereceptor N-methyl-D-aspartate (NMDA). Exercise is often used to reduce cognitive impairment. Previousstudies show that the benefits of aerobic exercises on such impairments are correlated with increasing BDNFand preventing the production of NMDA. However, some results remain controversial. Thus, the associationbetween exercise and Memory was addressed by examining increases in BDNF and the reduction of NMDAin ageing rats. The study used a randomized, post-test-only controlled group of 30 male one-year-old ageingRattus norvegicus divided into three groups, namely, K0 (control) and K1 and K2 (aerobic swimmingexercise). K1 and K2 animals differed in the frequency of exercise, which is three and four sessions perweek, respectively. Memory was assessed using Y-maze performance. BDNF and NMDA were analyzedusing enzyme-linked immunosorbent assays. A significant improvement in memory function and reductionin the NMDA level were observed in K1 and K2 group rats (p = 0.001; p = 0.041). No significant impact onthe BDNF levels was observed (p = 0.387). Swimming may boost Memory by reducing the NMDA levelbut not by increasing BDNF. Swimming is a promising method for preventing or delaying memory loss indegenerative brain diseases. Further investigation is needed to fully understand underlying mechanisms.
Prevention and Early Detection of Metabolic Syndrome in Household Community, Surabaya Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Siti Khaerunnisa; Gwenny Ichsan Prabowo; Suhartati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15747

Abstract

Introduction. Metabolic syndrome is a collection of factors believed to increase the risk of atherosclerosis and type 2 diabetes mellitus. The incidence of metabolic syndrome in young adults is increasing, especially in Asian countries. Therefore we need efforts to increase knowledge in society about this disease. Aim. We conducted a socialization program on prevention and early detection of metabolic syndrome in household community to increase public knowledge about this disease.Method. This program was conducted in August 2017 in Wonokromo District, Surabaya. The participants in the activity consisted of 32 people from household community. The activity consisted of blood sampling collection, body weight, and abdominal circumference measurement for risk factor assessment, pre-test, socialization of metabolic syndrome, and post-test.Results. From the results of the pre and post test, we found an increase knowledge of 76.9% participants. The laboratory test results for early detection of metabolic syndrome showed 37.5% of participants had metabolic syndrome. We also found a significant positive correlation between body weight and abdominal circumference (p = 0.000, r = 0.867). There was also a significant negative correlation between body weight and HDL (p = 0.004, r = -0.494), between abdominal circumference and HDL (p <0.05, r = -0.376), and between TG and HDL (p <0.05, r = -4.22).Conclusion. Socialization and early detection of metabolic syndrome can increase knowledge, awareness, and detection of metabolic syndrome in the household community.
Peran Guru dalam Menanamkan Nilai Karakter Peduli Sosial Siti Khaerunnisa; Muqowim Muqowim
ThufuLA: Jurnal Inovasi Pendidikan Guru Raudhatul Athfal Vol 8, No 2 (2020): ThufuLA: Jurnal Inovasi Pendidikan Guru Raudhatul Athfal
Publisher : PIAUD IAIN Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21043/thufula.v8i2.7636

Abstract

Tujuan penelitian ini yaitu untuk mengetahui peran guru dalam menanamkan nilai karakter peduli sosial di RA An Nawaa 3 Kota Cirebon. Penelitian ini dilatar belakangi oleh data hasil survey salah satu lembaga sosial di Indonesia yang menunjukkan bahwa kemampuan memiliki rasa empati pada anak muda menurun 40% selama 10 tahun terakhir, seiring dengan perkembangan teknologi dan internet. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Beberapa informan yang dijadikan sumber data yaitu kepala sekolah, guru kelas B1, B2, B3, A1, dan A2. Hasil penelitian menunjukkan bahwa guru telah menjalankan perannya dalam menanamkan nilai karakter peduli sosial pada anak. Beberapa peran guru tersebut diantaranya guru sebagai sumber belajar, fasilitator, pengelola, demonstrator, pembimbing, motivator, evaluator, dan mediator. Faktor pendukungnya adalah antusias belajar anak yang tinggi, pelaksanaan program sekolah, dan dukungan dari orang tua murid. Sedangkan faktor penghambatnya yaitu emosi anak yang belum stabil dan adanya kendala pada waktu pelaksanaan program sekolah.
In Silico Analysis Effect of Potential Antidiabetic from Dandang Gendis Extract on Aldose Reductase, Glucokinase, and GSK3β for Type 2 Diabetes Mellitus Safira Raissa Dwi Putri; Irda Bella; Siti Khaerunnisa; Nurlaili Susanti; Arifa Mustika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42288

Abstract

Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Various epidemiological studies have shown a trend of increasing incidence and prevalence of diabetes mellitus in various parts of the world. Therefore, diabetes mellitus is currently a global health threat. Dandang gendis (Clinacanthus nutans) is a widely used plant as a traditional herbal treatment in Indonesia, and it has been proven that the ethanol extract of dandang gendis leaves shows an antidiabetic effect. This research aims to determine the compatibility among the flavonoid compounds in C. nutans with Aldose reductase, glucokinase, and GSK3β target drugs for type 2 diabetes mellitus using in silico method.Methods: 45 compounds were obtained from multiple sources. The screening method used Lipinski’s rule of five and Pyrx until 8 compounds were selected. Avogadro, AutoDock 4.2, and Biovia Discovery Studio 2016 were used for molecular docking and visualization analysis.Results: Molecular docking results demonstrate that the ligand-protein interaction’s binding energy was -7.31 to 35.25 kcal/mol for 1AH3, -7.55 to 0.15 kcal/mol for 1V4S, and -7.99 to -2.85 kcal/mol for 3D0E.Conclusion: We can conclude that flavonoid compounds Apigenin, Vitexin, 3,3-di-O-Methylellagic Acid, and Clinacoside C show a high binding affinity with Aldose Reductase, Glucokinase, and GSK3β proteins and have the potential to be oral antidiabetic drug compounds for Diabetes Mellitus. However, its binding affinity has not been able to exceed that of the native ligand of the protein. Further research is needed to determine the significant efficacy and potential as an antidiabetic.
Pengaruh Model Discovery Learning Terhadap Kemampuan Berpikir Kritis Matematis Siswa Kelas VIII MTs NW Pringgabaya Tahun Ajaran 2024/2025 Siti Khaerunnisa; Azmi, Syahrul; Kurniawan, Eka
Griya Journal of Mathematics Education and Application Vol. 5 No. 3 (2025): September 2025
Publisher : Pendidikan Matematika FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/griya.v5i3.805

Abstract

This study aimed to determine the impact of implementing the discovery learning model on the critical thinking skills in class VIII at MTs NW Pringgabaya during the 2024/2025 school year. This research is a type of quasi-experiment. The study population consisted of VIII grade students at MTs NW Pringgabaya, divided into three classes. Cluster random sampling was used to select the sample, after conducting a homogeneity test on each population class. The experimental class, which applied the discovery learning model, was class VIII A, and the control class, which applied the direct learning model, was class VIII B. Data were collected using a critical thinking test and analyzed using an independent samples t-test. The results of the analysis showed that the , and the results of the calculation of effect size using Cohen's formula amounted to 0.51, therefore, it can be concluded that the application of the discovery learning model has an effect on the critical thinking skills of Class VIII students at MTs NW Pringgabaya.
Pengaruh Senam Hipertensi Dan Konsumsi Buah Semangka Terhadap Tingkat Pengetahuan Pada Penderita Hipertensi Okti Ariyani; Alfika Safitri; Sapii; Nurul Sapitri; Siti Diyani; Muhammad Miftahul Ilmi; Siti Khaerunnisa
Gudang Jurnal Ilmu Kesehatan Vol. 3 No. 2 (2025): GJIK - AGUSTUS s/d JANUARI
Publisher : PT. Gudang Pustaka Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/gjik.v3i2.1716

Abstract

Hipertensi adalah salah satu penyakit kronis yang umum terjadi di masyarakat dan menjadi faktor risiko utama bagi berbagai gangguan kardiovaskular. Pengelolaan hipertensi tidak hanya bergantung pada pengobatan medis, tetapi juga melibatkan pendekatan non-farmakologis seperti aktivitas fisik yang rutin dan pola makan sehat. Penelitian ini bertujuan untuk mengevaluasi dampak senam hipertensi dan konsumsi buah semangka terhadap penurunan tekanan darah pada individu yang menderita hipertensi. Metode yang digunakan ialah desain studi kasus deskriptif. Subjek pada penelitian ini ialah 23 penderita hipertensi di wilayah Kp. Bayur Rw 4 Kelurahan Periuk Jaya. Implementasi dilakukan 3 kali dalam 1 minggu dengan durasi 20 menit. Hasil didapatkan tingkat pengetahuan dengan kategori baik sebelum dilakukan pendidikan kesehatan tentang hipertensi sebanyak 3 orang (13%) dan tingkat pengetahuan dengan kategori baik sesudah dilakukan pendidikan kesehatan tentang hipertensi didapatkan sebanyak 23 orang (100%). Kesimpulan bahwa pendidikan kesehatan tentang hipertensi efektif meningkatkan tingkat pengetahuan responden. Sebelum intervensi, hanya 13% responden yang memiliki pengetahuan dalam kategori baik, sedangkan setelah diberikan pendidikan kesehatan, seluruh responden (100%) menunjukkan peningkatan pengetahuan ke kategori baik.
Co-Authors Alfika Safitri Anna Surgean Veterini Arifa Mustika Cindy ApriliaEkaPrasanty Fadilah Fadilah Feriawan Tan Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** HERAWATI, LILIK Ira Humairah Irda Bella Kurniawan, Eka Lukitasari, Lina Muhammad Miftahul Ilmi Muqowim, Muqowim Nurlaili Susanti Nurul Sapitri Okti Ariyani Prabowo, Gwenny Ichsan Qurnianingsih, Ema Rejeki, Purwo Sri Rizki Awaluddin Safira Raissa Dwi Putri Sapii Siti Diyani Suhartati Suhartati Suhartati Susi Wahyuning Asih Syahrul Azmi Yuani Setiawati