Article Per Year (5 Year)
p-Index From 2020 - 2025
1.006
P-Index
This Author published in this journals
All Journal Jurnal Analis Medika Biosains (JAMBS) Medical and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology
Edijanto, Soebagijo Poegoeh
Department Of Clinical Pathology, Faculty Of Medicine, Airlangga University/Dr. Soetomo Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search

 1 
PENETUAN FORMULA UNTUK MENETAPKAN ESTIMASI KOLESTEROL-LDL Nugraha, Gilang; Edijanto, Soebagijoh Poegoeh
Jurnal Ilmu Kesehatan dan Kesehatan Vol 2 No 2 (2018): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v2i2.587

Abstract

Abstract: Measurement LDL-Cholesterol (LDL-C) can be performed by estimating LDL-C (cLDL-C) inthe blood. In addition to the first proposed Friedewald formula, several new formulas that promise betterexamination in determining LDL-C levels, proposed by Anandaraja, Puavilai, Chen, Vujovic, deCordova and Dansethakul. The subjects of the study were patients who performed routine lipid profileexamination in Institution of Clinical Pathology of Gedung Pusat Diagnostik Terpadu RSUD Dr.Soetomo Surabaya who performs 10 to 12 hours of fasting with TG less than 400 mg / dL. The sampleconsisted of 41 men and 48 women with an average age of 52 years. The statistical test on each cLDLC gave the Friedewald -1.32% bias value; Anandaraja -3,92%; Puavilai 4.26%, Chen -2.19%; Vujovic-23.65%; de Cordova -0.91% and Dansethakul 4.45%. The correlation coefficient on Friedewald0.9509; Anandaraja 0.9013; Puavilai 0.9576, Chen 0.9585; Vujovic 0.8745; de Cordova 0.9300 andDansethakul 0.9505. The proposed cLDL-C formula Chen et al promises in determining the LDL-Cestimate and the Vujovic formula gives a poor result in this study. Validation methods should be appliedto each of the cLDL formulas if they are to be applied to clinical laboratories.
Effect of Dyslipidemia Therapy on Creatinine Kinase Activity Level in Patients with Heart Disease Sulistian, Waode Dila; Fuadi, Muhamad Ro’biul; Edijanto, Soebagijo Poegoeh; Yusuf, Mochammad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1631

Abstract

Cardiovascular disease remains a significant health problem in the Asia Pacific region. Several studies have found that dyslipidemia is a cause of morbidity and mortality and requires high medical costs. Dyslipidemia is a risk factor for atherosclerosis. The most widely used therapy for dyslipidemia is statins. Statins often cause muscle disorders such as myalgia, myopathy, and rhabdomyolysis, which can cause death. A prospective cohort study design was carried out at Airlangga University Hospital, Surabaya, from April to November 2019. A total of 26 sample pairs containing 13 samples were treated with Atorvastatin, and 13 samples were treated with Simvastatin. The subjects were examined for the creatinine kinase activity level using enzymatic methods. The mean creatinine kinase levels in the atorvastatin group before and after treatment was 105.71 IU/L and 100.03 IU/L, respectively, because the subjects were diagnosed with acute coronary syndromes and blood was collected during acute conditions. Median creatinine kinase levels in the Simvastatin group were 85.5 IU/L before therapy and 118.1 IU/L after therapy, indicating significant differences in creatinine kinase levels before and after treatment. Simvastatin is very susceptible to certain drug interactions that can increase the concentration of statins in the serum. There were differences in levels of creatinine kinase activity before and after Simvastatin therapy but not Atorvastatin.
Hypokalemic Periodic Paralysis and Renal Tubular Acidosis in Patient withHypothyroidism Laurensia Goretti; Soebagijo Poegoeh Edijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15832

Abstract

Hypokalemiaperiodic paralysis (HPP) is a rare disorder characterized by acute muscle paralysis. Basedon its etiology, HPP can be classified as primary and secondary types. One of the most common causes ofsecondary HPP is renal tubular acidosis (RTA) which may be also present in thyroid disease. We observed acase of a 48-year-old female, with complaints of weakness in both lower extremities for two days. Difficultiesin walking and weakness in both arms were also present. Patient also experienced nausea, vomiting, anddiarrhea 4 days before coming to the hospital. She had a history of thyroidectomy in 2009 and in 2019 wasadmitted for similar symptoms. Medication consumed by the patient were Euthyrox 100 mg one time dailyand KSR 600 mg three times daily. In the last week, Euthyrox was discontinued by the patient due to herdiarrhea. The patient’s general condition was weak and vital signs were BP 120/80 mmHg, pulse 84 bpm, RR18 times per minute and temperature was 36.6°C. Motoric strength was 4/4 in both arms and 3/3 in both legs.No pathological neurological reflexes were found during examination. Inverted T wave and prominent Uwave were seen on electrocardiogram (ECG) results.Laboratory results showed hypokalemia (2.0 mmol/L),Blood Gas Analysis: Metabolic Acidosis (pH 7.42, pCO2 32 mmHg, HCO3 20.8 mmol/L, BE -3.7 mmol/L)with anion gap of 14.2 meq/L. Urinalysis results were pH 8, urinary anion gap 18.29 mmol/h. Decreasedthyroid function was also shown in the endocrine laboratory panel FT4 0.57 ng/dl and TSH 32.097 IU/mL.HPP is a disorder characterized by muscle weakness and may be present in distal type RTA. Clinicalsymptoms of distal type RTA are hypokalemia, hyperchloremic metabolic acidosis, urinary pH <5.5. Distaltype RTA can be caused by endocrine disorder i.e., hypothyroidism. Observation of patient condition andlaboratory results lead to the conclusion that the patient is diagnosed with hypokalemic periodic paralysisand renal tubular acidosis based on hypokalemia, metabolic acidosis with normal anion gap, and alkalineurine with positive urinary anion gap.
PENETUAN FORMULA UNTUK MENETAPKAN ESTIMASI KOLESTEROL-LDL Gilang Nugraha; Soebagijoh Poegoeh Edijanto
Jurnal Ilmu Kesehatan dan Kesehatan Vol 2 No 2 (2018): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v2i2.587

Abstract

Abstract: Measurement LDL-Cholesterol (LDL-C) can be performed by estimating LDL-C (cLDL-C) inthe blood. In addition to the first proposed Friedewald formula, several new formulas that promise betterexamination in determining LDL-C levels, proposed by Anandaraja, Puavilai, Chen, Vujovic, deCordova and Dansethakul. The subjects of the study were patients who performed routine lipid profileexamination in Institution of Clinical Pathology of Gedung Pusat Diagnostik Terpadu RSUD Dr.Soetomo Surabaya who performs 10 to 12 hours of fasting with TG less than 400 mg / dL. The sampleconsisted of 41 men and 48 women with an average age of 52 years. The statistical test on each cLDLC gave the Friedewald -1.32% bias value; Anandaraja -3,92%; Puavilai 4.26%, Chen -2.19%; Vujovic-23.65%; de Cordova -0.91% and Dansethakul 4.45%. The correlation coefficient on Friedewald0.9509; Anandaraja 0.9013; Puavilai 0.9576, Chen 0.9585; Vujovic 0.8745; de Cordova 0.9300 andDansethakul 0.9505. The proposed cLDL-C formula Chen et al promises in determining the LDL-Cestimate and the Vujovic formula gives a poor result in this study. Validation methods should be appliedto each of the cLDL formulas if they are to be applied to clinical laboratories.
Correlation between Serum Endocan and HbA1c in Type 1 Diabetes Mellitus Patients Catur Suci Sutrisnani; Sidarti Soehita Satjadibrata; Soebagijo Poegoeh Edijanto; Anik Widijanti; Haryudi Aji Cahyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1676

Abstract

Endothelial dysfunction is a key mechanism in the pathogenesis of complications of cardiovascular disease in Diabetes Mellitus (DM) patients. One of the new biomarkers for inflammatory conditions and endothelial dysfunction is endocan. This study aimed to determine the correlation between endocan levels and HbA1c in type 1 DM patients. This study was an analytical observational study with a cross-sectional approach performed at the Dr. Saiful Anwar Hospital, Malang from May to August 2019. The research subjects were children aged 10-18 years with a diagnosis of type 1 DM who met the inclusion criteria. Students who underwent routine health checks participated as the control group. In both groups, serum endocan levels were measured using the ELISA method and HbA1c levels were measured by the HPLC method. Independent T-test analysis was used to determine the differences between both groups and the Pearson test was used to determine the correlation between serum endocan and HbA1c with SPSS version 23. In this study, there were 40 type 1 DM patients and 40 healthy controls with a mean age of 14.5 (3.16) years in the type 1 DM group and 14.7 (0.99) years in the healthy control group. There was a higher number of female subjects in both the type 1 DM group (57.5%) and the healthy control group (65%). The mean endocan level in the type 1 DM group was higher than the control group and was statistically significant with 1090.61 (150.84) pg/mL vs. 775.56 (8.91) pg/mL, p=0.000). The mean value for HbA1c levels in the type 1 DM group was also significantly higher compared to the control group 9.63 (2.22%) vs. 4.69 (0.251%), p <0.001), respectively. There was a significant positive correlation between endocan levels and HbA1c in DM patients (p=0.025, r=0.354). This study showed a correlation between serum endocan levels and HbA1c in patients with type 1 DM.
COMPARISON OF SDLDL-C ANALYSIS USING SRISAWASDI METHOD AND HOMOGENEOUS ENZYMATIC ASSAY METHOD ON HYPERTRIGLYCERIDEMIA CONDITION (Perbandingan Analisa sdLDL-C metode Srisawasdi dan Homogeneous Enzymatic Assay di Kondisi Hipertrigliseridemia) Gilang Nugraha; Soebagijo Poegoeh Edijanto; Edhi Rianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1188

Abstract

Small Dense Low Density Lipoprotein (sdLDL) merupakan fraksi terkecil dari partikel Low Density Lipoprotein (LDL) yang memilikidiameter ≤25,5 nm. Partikel sdLDL merupakan lipoprotein sangat aterogenik bahkan telah dilaporkan meningkatkan kebahayaanPenyakit Jantung Koroner (PJK) hingga tiga kali lipat. Pengukuran sdLDL dilakukan dengan alat dan teknik yang rumit sehinggakurang cocok diterapkan dalam praktek klinis sehari-hari. Tahun 2011, Srisawasdi dkk mengembangkan teknik pengukuran perkiraansdLDL-cholesterol (sdLDL-C) menggunakan persamaan dengan menghitung profil lipid rutin. Dilaporkan bahwa peningkatan kepekatantrigliserida (TG) menurunkan kenasaban perkiraan sdLDL-C Srisawasdi. Penurunan nilai kenasaban dapat mempengaruhi ketepatanyang mengakibatkan penurunan mutu pemeriksaan laboratorium. Diambil 88 sampel yang dilakukan pengukuran Total Cholesterol(TC), TG, high density lipoprotein-cholesetrol (HDL-C) dan direk low density lipoprotein-cholesetrol (dLDL-C) di RSUD Dr. Soetomo,sdLDL-C metode homogeneous enzymatic assay dilakukan di Laboratorium Parahita Dharmawangsa. Hasil analisis menunjukkan, tidakada perbedaan hasil periksaan sdLDL-C formula Srisawasdi dkk dengan metode homogeneous enzymatic assay (P=0,000). Penurunannilai kenasaban ditemukan di kelompok kepekatan TG <100 mg/dL sampai dengan kelompok kepekatan TG 200-299 mg/dL. Perbedaannilai kenasaban di setiap kelompok TG tidak mempengaruhi ketepatan pemeriksaan sdLDL-C formula Srisawasdi (P=0,720) hinggakepekatan TG <400 mg/dL, dengan nilai bias pada seluruh sampel yaitu 34,15%. Keterbatasan sdLDL-C formula Srisawasdi dkk hanyadapat digunakan di kepekatan TG kurang dari 200 mg/dL dengan pemantapan mutu intralaboratorium yang terkendali baik. Saranpenelitian, perlu diteliti lebih lanjut untuk menentukan nilai normal sdLDL-C formula Srisawasdi.
Effect of Dyslipidemia Therapy on Creatinine Kinase Activity Level in Patients with Heart Disease Waode Dila Sulistian; Muhamad Ro'biul Fuadi; Soebagijo Poegoeh Edijanto; Mochammad Yusuf
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1631

Abstract

Cardiovascular disease remains a significant health problem in the Asia Pacific region. Several studies have found that dyslipidemia is a cause of morbidity and mortality and requires high medical costs. Dyslipidemia is a risk factor for atherosclerosis. The most widely used therapy for dyslipidemia is statins. Statins often cause muscle disorders such as myalgia, myopathy, and rhabdomyolysis, which can cause death. A prospective cohort study design was carried out at Airlangga University Hospital, Surabaya, from April to November 2019. A total of 26 sample pairs containing 13 samples were treated with Atorvastatin, and 13 samples were treated with Simvastatin. The subjects were examined for the creatinine kinase activity level using enzymatic methods. The mean creatinine kinase levels in the atorvastatin group before and after treatment was 105.71 IU/L and 100.03 IU/L, respectively, because the subjects were diagnosed with acute coronary syndromes and blood was collected during acute conditions. Median creatinine kinase levels in the Simvastatin group were 85.5 IU/L before therapy and 118.1 IU/L after therapy, indicating significant differences in creatinine kinase levels before and after treatment. Simvastatin is very susceptible to certain drug interactions that can increase the concentration of statins in the serum. There were differences in levels of creatinine kinase activity before and after Simvastatin therapy but not Atorvastatin.
Correlation between Serum Endocan and HbA1c in Type 1 Diabetes Mellitus Patients Catur Suci Sutrisnani; Sidarti Soehita Satjadibrata; Soebagijo Poegoeh Edijanto; Anik Widijanti; Haryudi Aji Cahyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1676

Abstract

Endothelial dysfunction is a key mechanism in the pathogenesis of complications of cardiovascular disease in Diabetes Mellitus (DM) patients. One of the new biomarkers for inflammatory conditions and endothelial dysfunction is endocan. This study aimed to determine the correlation between endocan levels and HbA1c in type 1 DM patients. This study was an analytical observational study with a cross-sectional approach performed at the Dr. Saiful Anwar Hospital, Malang from May to August 2019. The research subjects were children aged 10-18 years with a diagnosis of type 1 DM who met the inclusion criteria. Students who underwent routine health checks participated as the control group. In both groups, serum endocan levels were measured using the ELISA method and HbA1c levels were measured by the HPLC method. Independent T-test analysis was used to determine the differences between both groups and the Pearson test was used to determine the correlation between serum endocan and HbA1c with SPSS version 23. In this study, there were 40 type 1 DM patients and 40 healthy controls with a mean age of 14.5 (3.16) years in the type 1 DM group and 14.7 (0.99) years in the healthy control group. There was a higher number of female subjects in both the type 1 DM group (57.5%) and the healthy control group (65%). The mean endocan level in the type 1 DM group was higher than the control group and was statistically significant with 1090.61 (150.84) pg/mL vs. 775.56 (8.91) pg/mL, p=0.000). The mean value for HbA1c levels in the type 1 DM group was also significantly higher compared to the control group 9.63 (2.22%) vs. 4.69 (0.251%), p <0.001), respectively. There was a significant positive correlation between endocan levels and HbA1c in DM patients (p=0.025, r=0.354). This study showed a correlation between serum endocan levels and HbA1c in patients with type 1 DM.
Differences in Erythrocytes Sedimentation Rate Results using Physiological Saline Solution and Phopshate Buffer Saline in Pulmonary Tuberculosis Patients Edijanto, Soebagijo Poegoeh; Layla Agustina, Nurul Ivada; Nugraha, Gilang; Anggraini, Rahayu; Sari, Nathalya Dwi Kartika; Lukiyono, Yauwan Tobing
Jurnal Analis Medika Biosains (JAMBS) Vol 11, No 2 (2024): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jambs.v11i2.353

Abstract

Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh mikroorganisme Mycobacterium tuberkulosis (MTB) pada paru-paru. Terjadi reaksi peradangan oleh sel fagositik dengan menekan bakteri, akibat dari reaksi tersebut terjadi penumpukan cairan eksudat pada alveolus sehingga membentuk granuloma yang berubah menjadi jaringan fibtosa yang dapat mengaktifkan bakteri dan kemudian merusak paru-paru. NaCl 0,9% adalah standar emas dalam Laju Sedimentasi Eritrosit (ESR) yang direkomendasikan oleh Komite Internasional untuk Standardisasi Hematologi (ICSH). Diketahui Saline Phosphate Buffer (PBS) mempunyai tekanan osmolaritas yang sama dengan cairan tubuh, dan bersifat isotonik sehingga mirip dengan NaCl 0,9%. Penelitian ini bertujuan untuk mengetahui perbedaan hasil ESR menggunakan pengencer PBS pH 7,2 dan pH 7,4 pada pasien tuberkulosis di Puskesmas Blega Kabupaten Bangkalan Madura. Sebanyak 30 sampel darah EDTA pasien tuberkulosis. Penelitian ini menggunakan metode eksperimen, dengan desain static group comparation pada perbedaan hasil ESR dengan menggunakan NaCl 0,9% sebagai kelompok kontrol dan PBS pH 7,2 dan pH 7,4 sebagai kelompok perlakuan, diperiksa dengan metode Westergren. . Hasil pengujian dengan menggunakan uji One Way Anova diperoleh p-value 0f 0,997. hasil Laju Sedimentasi Eritrosit menggunakan larutan Phosphate Buffer Saline pH 7,2 dan pH 7,4 dengan NaCl 0,9% pada pasien Tuberkulosis. Kesimpulan penelitian ini adalah hasil pemeriksaan ESR menggunakan larutan pengencer PBS pH 7,2 dan pH 7,4 tidak terdapat perbedaan hasil dengan kelompok kontrol (NaCl 0,9%).
Co-Authors Anik Widijanti Catur Suci Sutrisnani Edhi Rianto Fuadi, Muhamad Ro’biul Gilang Nugraha Haryudi Aji Cahyono Laurensia Goretti Layla Agustina, Nurul Ivada Mochammad Yusuf Mochammad Yusuf, Mochammad Muhamad Ro'biul Fuadi Nathalya Dwi Kartika Sari Rahayu Anggraini Sidarti Soehita Satjadibrata Sulistian, Waode Dila Waode Dila Sulistian