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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology
Mochammad Thaha
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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The Anti-Inflammatory Effect of ACE-I/ARBs Drug on hs-CRP and HDL-Cholesterol in CKD Patient Muhammad Iqbal Mubarok; Maftuchah Rochmanti; Mochamad Yusuf; Mochammad Thaha
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15878

Abstract

Chronic kidney disease (CKD) is progressive disease that closely related to the chronic inflammatory process.Angiotensin-Converting Enzyme Inhibitor (ACE-I)/Angiotensin Receptor Blockers (ARBs) is the main therapy in the management of CKD, based on the recent sudies stated that this drug have pleiotropic effects as anti-inflammation.The aim of this study is tosee the interaction of hs-CRP and HDL-Cholesterol to prove the role of ACE-I/ARBs as an anti-inflammatory treatment for CKD patient. In this study we compared hsCRP, HDL Cholesterol and HDL Cholesterol /hs-CRP ratio levels in CKD patients who consumeand do not consumeACE-I/ARBs. Forty eight samples of CKD patients were taken randomly and then separated into two group based on their consumption of ACE-I/ARBs, each group have 24 samples.There were significantly different of mean of hs-CRP, HDL Cholesterol, and HDL Cholesterol/hs-CRP ratio between group, the mean concentration of hs-CRP in the ACE-I/ARBs group was significantly lower than in non-ACE-I/ARBs group (1,48±0,81 vs 4,19±4,02; P= 0.038),the mean of HDL (48,95±13,05vs 41,50±12,31; P= 0,048).There were negative correlation between HDL Cholesterol and hs-CRP, positive correlation between HDL Cholesterol/hs-CRP ratio and eGFR.This result indicate that hs-CRP and HDL-Cholesterol monitoring very important in CKD patient.
ANTI-HIV DAN SUBTIPE HIV PADA PASIEN HEMODIALISIS Retno Handajani; Mochammad Thaha; Mochamad Amin; Citrawati Dyah Kencono Wungu; Edhi Rianto; Pranawa Pranawa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1124

Abstract

Anti-Human Immunodeficiency Virus (Anti-HIV) was performed from 100 plasma Chronic Kidney Disease (CKD) stage 5 patientswith continuous hemodialysis (HD) at the Hemodialysis Instalation Dr Soetomo hospital, Surabaya, Indonesia, using three (3) kind ofreagents: Tri-line HIV Rapid test Device from Acon for HIV 1/2/O as strips form, Foresight HIV 1/2/O Antibody EIA Test Kit from Aconand Anti-HIV 1+2/Subtype O ELISA from Axiom. HIV RNA and HIV subtype were detected by Reverse Transcription Polymerase ChainReaction (RT-PCR) based on HIV gag region and analysis of DNA result. Seventy three % patients were hemodialysed twice in a week andonly 14% with duration more than five (5) years. Most of the patients (43%) were hemodialysed between 100−300 times. From the 100plasma samples was obtained only one (1%) man patient plasma sample with positive anti-HIV. A weak positive of RT-PCR result wasnot succeed to be sequenced for determining the HIV subtype. This cause was suspected due to low levels of HIV RNA in blood. The resultsof this study was expected can be used as an additional management consideration of hemodialysis patients at the Hemodialysis Unit.
Co-Authors Edhi Rianto Mochamad Amin Mochamad Yusuf Muhammad Iqbal Mubarok Pranawa Pranawa Retno Handajani Rochmanti, Maftuchah Rochmanti Wungu, Citrawati Dyah Kencono