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All Journal Pharmaceutical Sciences and Research (PSR)
Syahdi, Rezi Riadhi
Fakultas Farmasi, Universitas Indonesia

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SARS-CoV-2: Virology and Drug Repurposing Approaches Rahmasari, Ratika; Setiawan, Heri; Syahdi, Rezi Riadhi; Arifianti, Ayun; Irianti, Marina Ika; Sauriasari, Rani; Makau, Juliann Nzembi; Raekiansyah, Muhareva
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

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An emerging coronavirus, SARS-CoV-2, is the causative agent for the ongoing pandemic of coronavirus disease 2019 (COVID-19), which has caused a worldwide social and economic disruption. Currently, no antiviral drugs with proven clinical efficacy, or vaccines for its prevention. Therefore, to combat the pandemic of this novel coronavirus, new effective treatments are urgently needed. In the process of traditional drug development, developing new drugs from scratch is a time- consuming process, requires high-investment, and is a high-risk process, which is impractical to face the immediate global challenge of the SARS-CoV-2 pandemic. Drug repurposing strategy is one of the effective ways to quickly find a therapeutic agent for COVID-19 Existing medicines, which already have been tested and proven safe in humans might work for COVID-19 offering a potentially faster approach for the disease management. Here, we review h the latest research progress in epidemiology, viral genome, and life cycles of SARS-CoV-2. Further, we describe and discuss some promising drugs repurposed to target SARS-CoV-2 that are being evaluated in clinical trials.
Synthesis of Polymer-Drug Conjugates Using Natural Polymer: What, Why and How? Sagita, Erny; Syahdi, Rezi Riadhi; Arrahman, Arif
Pharmaceutical Sciences and Research Vol. 5, No. 3
Publisher : UI Scholars Hub

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For years, natural polymers have played a significant role in pharmaceutical field due to their biocompatibility and biodegradability. In Indonesia, most research in natural polymers focus on application of the polymers as inert pharmaceutical excipients or as drug matrix in micro- and nano- particle. Meanwhile, research about polymers in the world (mostly synthetic polymers) have been progressed to advanced drug delivery system. In this system, the polymer can act as either pharmacologically active molecules, or sophisticated carrier in targeted prodrug delivery system. The latter is called polymer-drug conjugates, a system where the drugs are covalently attached to a polymeric carrier, rather than simply entrapped in polymer matrix. Natural polymers have been one of the materials to use for the carrier due to their biocompatibility and biodegradability. This review article emphasizes the opportunity, challenges and strategies to use natural polymers as carrier in polymer-drug conjugates. Moreover, we also discuss some aspects in regards of the synthesis and analysis, to give some perspectives and encouragement for the Indonesian researcher who are interested in exploring this research field.
Co-Authors Arif Arrahman Arif Arrahman, Arif Arifianti, Ayun Erny Sagita Erny Sagita, Erny Irianti, Marina Ika Makau, Juliann Nzembi Muhareva Raekiansyah Rahmasari, Ratika Rani Sauriasari, Rani RR. Ella Evrita Hestiandari