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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Jurnal Respirologi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Narra J Indonesian Journal of Health Science Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Farmasetis Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Malahayati International Journal of Nursing and Health Science Holistik Jurnal Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rani Sauriasari, Rani
Departement Of Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Fenomena Pengaruh Terapi Farmakologi Terhadap Kepatuhan Berobat dalam Perspektif Pasien Diabetes Melitus Tipe 2 Renaldi, Fransiskus Samuel; Sauriasari, Rani; Riyadina, Woro; Maulida, Irianti Bahana
Jurnal Farmasi Sains dan Terapan Vol 8, No 2 (2021): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v8i2.3044

Abstract

Diabetes melitus tipe 2 merupakan penyakit yang kompleks dan membutuhkan manajemen terapi yang serius. Kepatuhan menjadi masalah utama dalam pengobatan diabetes melitus tipe 2 tersebut dan dapat berdampak pada komplikasi yang akan sulit ditangani. Penelitian ini ditujukan untuk mengungkap berbagai permasalahan yang mendorong seorang pasien memilih untuk tidak patuh sehingga dapat membantu tenaga kesehatan dalam mencari akar masalah ketidakpatuhan pada penderita diabetes melitus tipe 2. Sebanyak 30 penderita diabetes melitus tipe 2 terbagi atas beberapa golongan kriteria, yaitu komplikasi, usia, dan tingkat kepatuhan. Pemilihan pasien dilakukan menggunakan metode sampling bola salju. Pengambilan data dilakukan dengan metode wawancara mendalam pada pasien yang dilakukan dengan teknik probing melalui telepon dan observasi langsung sebagai bentuk validasi. Data diolah dengan metode transkrip dan dianalisis secara tematik untuk kemudian diinterpretasikan dalam bentuk pernyataan hasil wawancara. Dari hasil penelitian didapatkan bahwa sebagian besar pasien menggunakan metformin. Hal ini dikarenakan banyak pasien merasa sesuai dengan metformin. Metformin dapat memberikan efek normalisasi gula darah yang diharapkan dengan efek samping ke sistem gastrointestinal yang masih dapat ditolerir. Di sisi lain, terdapat beberapa pasien yang sudah merasa jenuh dengan penggunaan obat secara terus-menerus, mereka ingin segera lepas dari obat. Perbandingan manfaat yang dirasakan ketika meminum obat dan tidak juga turut memotivasi pasien dalam menggunakan obat. Dari berbagai data yang telah dihimpun dalam penelitian ini, dapat disimpulkan bahwa kepatuhan berobat sangat dipengaruhi oleh efek yang diterima pasca penggunaan.
Prediktor Respons Tolvaptan Sebagai Strategi Optimalisasi Terapi pada Pasien Gagal Jantung: Kajian Naratif Hindun W. Risni; Rani Sauriasari; Oriza Satifa
Indonesian Journal of Clinical Pharmacy Vol 11, No 1 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.1.66

Abstract

Gagal jantung (GJ) merupakan kondisi tahap akhir dari semua penyakit jantung dan dikaitkan dengan mortalitas, morbiditas, dan pengeluaran kesehatan yang signifikan. Tolvaptan, antagonis reseptor V2, telah digunakan di berbagai negara sebagai terapi tambahan pada terapi diuretik untuk GJ. Walaupun tolvaptan telah terbukti efektif dan aman digunakan, masih terdapat beberapa pasien yang tidak merespons tolvaptan dengan baik. Terdapat indikasi bahwa efek optimal tolvaptan dapat dicapai oleh populasi yang spesifik sehingga identifikasi responder dan prediktor respons tolvaptan menjadi penting dalam mengembangkan rencana pengobatan individu. Tujuan kajian naratif ini adalah memberikan ulasan mengenai efektivitas tambahan tolvaptan serta prediktor-prediktor respons yang dapat digunakan sebagai strategi dalam optimalisasi terapi GJ. Pencarian artikel dilakukan melalui PubMed, Google Scholar, dan Scopus dengan kata kunci predictors, heart failure, dan tolvaptan. Prediktor status respons yang ditemukan dalam penelitian, yaitu osmolalitas urin, U-AQP2/PAVP, usia, kreatinin serum, BUN, BUN/Cr, UUN/BUN, UNa/UCr, BNP, AVP/PAC, CKD dan HFpEF, serta berbagai parameter ekokardiografik. Variasi temuan prediktor dapat disebabkan oleh adanya perbedaan definisi respons dan karakteristik pasien, serta jenis variabel yang dianalisis. Beberapa prediktor yang ditemukan sulit untuk diimplementasikan di beberapa negara dengan fasilitas rumah sakit dan cakupan asuransi kesehatan yang belum memadai. Pada akhirnya, penggunaan prediktor respons diharapkan dapat membantu tenaga kesehatan dalam mempertimbangkan risiko-manfaat suatu terapi individu pada pasien GJ. Kata kunci: Gagal jantung, prediktor, respons, tolvaptan Predictors of Tolvaptan Response as a Therapy Optimization Strategy in Heart Failure Patients: A Narrative Review AbstractHeart failure (HF) is an end-stage condition of all heart disease and is associated with significant mortality, morbidity, and health expenses. Tolvaptan, a V2 receptor antagonist, is being used in many countries as an adjunct to the diuretic therapy of HF. Although it has been proven effective and safe, some patients do not respond well to the medication. Since there are indications that a specific population can achieve this therapy’s optimal effect, it is essential to identify responders and predictors to develop individual treatment plans. Therefore, this study provides an overview of the effect of tolvaptan and predictors of response that can be used as a strategy in optimizing the treatment of HF. The article searching process was conducted through PubMed, Google Scholar, and Scopus, including predictors, heart failure, and tolvaptan. The predictors identified in the study were urine osmolality, U-AQP2/PAVP, age, serum creatinine, BUN, BUN/Cr, UUN/BUN, UNa/UCr, BNP, AVP/PAC, CKD, HFpEF, and echocardiographic parameters. The variation in results is caused by differences in response definition, patient characteristics, and the types of variables analyzed. Implementing some of these predictors in countries with inadequate hospital facilities and health insurance coverage is complicated. Therefore, the use of response predictors, at any rate, is expected to assist health professionals in considering the risks and benefits of HF therapy.Keywords: Heart failure, predictor, response, tolvaptan
Fenomena Aktivitas Fisik dan Olahraga dalam Perspektif Pasien Diabetes Melitus Tipe 2 Irianti Bahana Reyaan; Fransiskus Samuel Renaldi; Rani Sauriasari; Woro Riyadina
JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Vol 6 No 2 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/jskk.2021.6.2.2

Abstract

Diabetes melitus tipe 2 merupakan penyakit kronik dan membutuhkan tindakan khusus bagi pasien. Terapi untuk diabetes melitus tipe 2 dibedakan menjadi terapi farmakologi dan terapi non farmakologi. Contoh dari terapi non farmakologi untuk diabetes melitus tipe 2 adalah aktivitas fisik dan olahraga yang sesuai. Penelitian ini ditujukan untuk mengungkap berbagai aktivitas fisik dan olahraga yang dilakukan pasien untuk dapat membantu tenaga kesehatan dalam menyusun strategi edukasi yang sesuai. Penelitian ini merupakan studi kualitatif dengan menggunakan metode fenomenologi. Sebanyak 30 subjek terlibat dalam penelitian ini Pemilihan pasien dilakukan menggunakan metode sampling bola salju. Pengambilan data dari pasien dilakukan dengan metode wawancara mendalam (in-depth interviews). Wawancara mendalam dilakukan dengan menggunakan teknik probing untuk memvalidasi setiap pernyataan yang dikeluarkan oleh pasien.. Data diolah dengan metode transkrip dan dianalisis secara tematik untuk kemudian diinterpretasikan dalam bentuk pernyataan hasil wawancara. Dari penelitian ini, dapat disimpulkan bahwa sebagian besar pasien rutin melakukan aktivitas fisik dan olahraga. Beberapa pasien tidak dapat melakukan olahraga secara rutin akibat terhalang oleh waktu. Maka dari itu, diperlukan kolaborasi antara tenaga kesehatan untuk memberikan edukasi terkait aktivitas fisik dan olahraga yang sesuai bagi pasien Diabetes Melitus tipe 2.
The Efficacy of Remdesivir in Reducing SARS-CoV-2 Viral Load and Its Safety on COVID-19 Patients: A Systematic Review Afifah Fauziyyah; Ratika Rahmasari; Rani Sauriasari
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.211

Abstract

Background: This study aimed to examine the effectiveness of Remdesivir in reducing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viral load and its safety for antiviral therapy in Coronavirus disease 2019 (COVID-19) treatment.Methods: This systematic review used data sources from the PubMed, ProQuest, SpringerLink, and ClinicalTrial.gov databases for relevant observational and interventional studies during August 2020 to August 2021. Studies evaluating Remdesivir in adults hospitalized for COVID-19 were included in this review. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines.Results This review found 9 studies that were relevant to the study objectives. In total, 1,088 patients participated as subjects. Three studies demonstrated the effect of remdesivir in reducing SARS-CoV-2 viral load in upper and lower respiratory tract specimens. Six studies demonstrated that remdesivir was safe for use in a variety of baseline conditions (patients on hemodialysis and patients receiving kidney transplantation), had no significant hepatotoxicity, did not increase the risk of acute kidney injury, and did not increase eGFR or systemic symptoms in patients taking remdesivir.Conclusion: Remdesivir has been shown to reduce SARS-CoV-2 viral load and was safe for use as antiviral therapy in the treatment of COVID-19, but an assessment of randomized controlled trial for the effect of Remdesivir on viral load reduction was not available yet.
Safety of Favipiravir for Treatment of COVID-19: Latest Systematic Review Rizki Oktarini; Anna Rozaliyani; Ratika Rahmasari; Muhammad Alkaff; Rani Sauriasari
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.243

Abstract

Background: Adverse event studies of favipiravir use in treating COVID-19 have been ongoing since it was established as a treatment option. A better understanding of the side effects of favipiravir from recent studies is important in developing and assessing the recognition of effective treatments for COVID-19. Method: This was a systematic review based on studies and case reports on favipiravir monotherapy in COVID-19. Access to the included studies was gained via PubMed, SCOPUS, Science Direct, SpringerLink, and MedRxiv. Results: Twelve studies consisting of eight studies and four case reports were reviewed. The most common side effects were diarrhea, elevated liver enzyme levels, and hyperuricemia. None of which were significantly different from the comparison. Currently, various adverse event were reported in case reports such as drug fever,acute generalized exanthematous pustulosis (AGEP), and transient increase in viral load. The side effects would mostly be subsided after the treatment was discontinued.Conclusion: The use of favipiravir to treat COVID-19 caused dose-related side effects such as diarrhea, changes in liver enzymes, and increased level of uric acid. There were no serious side effectscompared to other antiviral drugs. To improve the efficacy and safety of COVID-19 therapy, it is important to prepare an incidence report of antiviral adverse events in special populations such as children, pregnant women, and  patients with organ dysfunction.
Analisis Zat Warna Merah Sintetik pada Selai Stroberi yang Dijual di Pasar Tradisional Kota Depok Ayuningtyas, Putri; Sauriasari, Rani; Kurniadi, Maryati
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Jam is a semi-solid food products made of fruit cooked with sugar that used as aflavoring on bakery including strawberry jam. Strawberry jam is added to food additives such as food dyes. The purpose of this study is to know about ponceau 4R, allura red, rodamin B, and amaran in the sample of strawberry jam in the traditional market at Depok City and to determine the levels of synthetic red dyes that are permitted on the sample strawberry jam. The method applied was dye isolation with wool and followed by analysis using a color reaction, then followed by paper chromatography using mobile phase n-butanol-eth-anol-water (3:4:4) and isobutanol-ethanol-water (3:2:4 ) and also TLC Densitometri using eluent ethanol-n-butanol-water (3:7:1). The result of study that from eight that has been investigated, it was found that six of them was contained ponceau 4R with levels of each sample at 0, 01164; 0, 00469; 0, 00974; 0, 00283; 0, 00482 and 0, 00435% still safe to consume.
SARS-CoV-2: Virology and Drug Repurposing Approaches Rahmasari, Ratika; Setiawan, Heri; Syahdi, Rezi Riadhi; Arifianti, Ayun; Irianti, Marina Ika; Sauriasari, Rani; Makau, Juliann Nzembi; Raekiansyah, Muhareva
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

An emerging coronavirus, SARS-CoV-2, is the causative agent for the ongoing pandemic of coronavirus disease 2019 (COVID-19), which has caused a worldwide social and economic disruption. Currently, no antiviral drugs with proven clinical efficacy, or vaccines for its prevention. Therefore, to combat the pandemic of this novel coronavirus, new effective treatments are urgently needed. In the process of traditional drug development, developing new drugs from scratch is a time- consuming process, requires high-investment, and is a high-risk process, which is impractical to face the immediate global challenge of the SARS-CoV-2 pandemic. Drug repurposing strategy is one of the effective ways to quickly find a therapeutic agent for COVID-19 Existing medicines, which already have been tested and proven safe in humans might work for COVID-19 offering a potentially faster approach for the disease management. Here, we review h the latest research progress in epidemiology, viral genome, and life cycles of SARS-CoV-2. Further, we describe and discuss some promising drugs repurposed to target SARS-CoV-2 that are being evaluated in clinical trials.
Interpersonal Relationship and Its Effect on Treatment Compliance in Patients with Type-2 Diabetes Mellitus Renaldi, Fransiskus Samuel; Riyadina, Woro; Qamar, Muhammad; Sauriasari, Rani
Pharmaceutical Sciences and Research Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Type-2 diabetes mellitus has become a chronic disease that can lead to serious complications and can only be prevented by compliant treatment of the patients. Compliance can be influenced by various factors, one of which is interpersonal factors. This study aimed to identify various interpersonal relationship problems between patients and healthcare workers that can affect their treatment compliance behavior. This study employed a qualitative design with phenomenological methods. This research was conducted in Central Bogor City in March-August 2020. The data were collected by conducting in-depth interviews with 20 type-2 diabetes mellitus patients who had been confirmed by the Community Health Center and focus group discussions with 12 healthcare workers consisting of doctors, pharmacists, nutritionists, and nurses. The data were then transcribed and content clouds analysis was carried out. The results showed that most of the patients (76%) followed the advice given by healthcare workers to carry out routine controls. This is a form of patients’ trust in healthcare workers as their health consultants. The trust arises from the convenience of interaction between the two parties. Providing adequate information will increase patients’ understanding and encourage them to take appropriate action for themselves. As many as 12 out of 20 patients chose the Community Health Center for their routine control because the services were sufficient in treating type 2 diabetes mellitus. From this study, it can be concluded that patients tend to comply if they feel trust in the health workers, which arises if they can feel the benefits during their therapy.
Evaluasi kesesuaian penulisan resep pada kasus ISPA non pneumonia di poli MTBS Puskesmas Kecamatan Cengkareng, Jakarta Sauriasari, Rani; Aulia, Annisa Azka Hikmawati; Swastika, Adisa
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Acute respiratory infections (ARI) is one of the major health problems in Indonesia. There are three classifications of cases of ARI, consist of pneumonia, severe pneumonia and non pneumonia. This study aimed to find an overview of the use of antibiotics and the evaluation of suitability prescriptions performed in cases of non pneumonia Acute Respiratory Infections (ARI) in IMCI Polyclinic, Cengkareng District Community Health Centre (Puskesmas Cengkareng), West Jakarta. Evaluation for the prescription suitability was useful to find the percentage of the suitability of prescribing on the existing management. This activity was done using retrospective method with data of 100 children patients suffered from non pneumonia cough obtained from registration book on IMCI Polyclinic during February 2016. The existing data was then matched to the patient status and prescription books that went into the dispensary unit at second floor. Furthermore, we evaluated the suitability of the reference book titled Integrated Management Scheme for Toddler Patients/Bagan Manajemen Terpadu Balita Sakit (MTBS), issued by the Ministry of Health of the Republic of Indonesia in 2011. The results showed that the percentage of antibiotic used in the sample was 59.6%, which the most frequent antibiotic used was amoxicillin. Therefore we concluded that the prescription compliance with IMCI guidelines in Puskesmas Cengkareng at February 2016 was inadequate yet.
Evaluasi Penerapan Booklet dan Edukasi Apoteker pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mayapada Tangerang Sagala, Radoti Merlin; Arozal, Wawaimuli; Sauriasari, Rani; Keban, Sesilia
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Type 2 diabetes mellitus is a degenerative disease with long-term treatment that requires knowledge and self-management to control blood sugar level. The purpose of this study was to evaluate the provision of booklet and pharmacist education in improving knowledge and behavior of self-management of type 2 diabetes mellitus patient at Mayapada Hospital Tangerang. This study respondents were 90 people who were divided into 3 groups. Group 1 got booklet and education, group 2 got booklet only and control group did not get any treatment. Fasting Blood Glucose (FBG) levels before the intervention were in poorly controlled category and after intervention there was no significant change. There was an increase in the level of knowledge and self-management in group 1 and group 2. There was no significant change in FBG. Provision of booklet with education by pharmacist showed a higher increase in knowledge (p=0.02) and self management behavior (p<0.001) than provision of booklet only. There was no relationship between knowledge and self-management behavior with blood sugar levels. It could be concluded that booklet and education by pharmacist could improve knowledge and behavior of self-management of DM type 2 patients in each intervention group. However, there was no relationship between knowledge and self-management behavior with FBG.
Co-Authors Abu Rachman Adisa Swastika Adisa Swastika, Adisa Afifah Fauziyyah Agusdini Banun Saptaningsih Ahmad Sahlan Baniu Anna Rozaliyani Annisa Azka Hikmawati Aulia Annisa Azka Hikmawati Aulia, Annisa Azka Hikmawati Annisa Lazuardi Larasati Arifianti, Ayun Ariska Deffy Anggarany, Ariska Deffy Arry Yanuar Atika Wahyu Puspitasari Baniu, Ahmad Sahlan Berna Elya Damayanti, Herni Dewi Danawati Dian Yudianto Dodi Sudiana Em Yunir, Em Evi Martha Fauziyyah, Afifah Fikria Adiputri Fitrianingsih Fitrianingsih Fonny Cokro Hadijah Tahir Haifa, Alifia Fauziyyah Hayatun Nufus Herni Damayanti Hindun W. Risni Hindun Wilda Risni Hindun Wilda Risni Hindun Wilda Risni I Gede Ketut Sajinadiyasa Indah Kusumawati Susanti Irianti Bahana Maulida Irianti Bahana Reyaan Ivans Panduwiguna Ivans Panduwiguna July Makau, Juliann Nzembi Marina Ika Irianti Maryati Kurniadi Maryati Kurniadi Maulida, Irianti Bahana Muh Ronike Yunus Muhammad Alkaff Muhammad Alkaff Muhareva Raekiansyah Nadia Farhanah Syafhan Novita Sari Nurwijayanti Oriza Satifa Panduwiguna, Ivans Paramita, Diana Pradana Soewondo Puji Astuti Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Puspitasari, Rara Merinda Putri Ayuningtyas Putri Ayuningtyas Putri, Risani Andalasia Putri, Widyana Sagita Qamar, Muhammad Qomariyanti, Khairunisa Qomariyanti, Khairunnisa Rachman, Abu Radoti Merlin Rahmasari, Ratika Ratika Rahmasari Ratu Ayu D Sartika Ratu Ayu Dewi Sartika Renaldi, Fransiskus Samuel Restu Anisa Putri Rina Novianti Siregar Risni, Hindun Wilda Rizki Oktarini RR. Ella Evrita Hestiandari Sagala, Radoti Merlin Sajinadiyasa, I Gede K Sarah Almira Septyowati, Priharika Sesilia Keban Sesilia Keban, Sesilia Soraya, Indana Ayu Syahdi, Rezi Riadhi Tahapary, Dicky L. Takhwifa, Famila Veryanti, Putu Rika Vincent Pratama Wawaimuli Arozal Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina