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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Narra J Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rani Sauriasari, Rani
Faculty of Pharmacy, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Fenomena Pengaruh Terapi Farmakologi Terhadap Kepatuhan Berobat dalam Perspektif Pasien Diabetes Melitus Tipe 2 Renaldi, Fransiskus Samuel; Sauriasari, Rani; Riyadina, Woro; Maulida, Irianti Bahana
Jurnal Farmasi Sains dan Terapan Vol 8, No 2 (2021): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v8i2.3044

Abstract

Diabetes melitus tipe 2 merupakan penyakit yang kompleks dan membutuhkan manajemen terapi yang serius. Kepatuhan menjadi masalah utama dalam pengobatan diabetes melitus tipe 2 tersebut dan dapat berdampak pada komplikasi yang akan sulit ditangani. Penelitian ini ditujukan untuk mengungkap berbagai permasalahan yang mendorong seorang pasien memilih untuk tidak patuh sehingga dapat membantu tenaga kesehatan dalam mencari akar masalah ketidakpatuhan pada penderita diabetes melitus tipe 2. Sebanyak 30 penderita diabetes melitus tipe 2 terbagi atas beberapa golongan kriteria, yaitu komplikasi, usia, dan tingkat kepatuhan. Pemilihan pasien dilakukan menggunakan metode sampling bola salju. Pengambilan data dilakukan dengan metode wawancara mendalam pada pasien yang dilakukan dengan teknik probing melalui telepon dan observasi langsung sebagai bentuk validasi. Data diolah dengan metode transkrip dan dianalisis secara tematik untuk kemudian diinterpretasikan dalam bentuk pernyataan hasil wawancara. Dari hasil penelitian didapatkan bahwa sebagian besar pasien menggunakan metformin. Hal ini dikarenakan banyak pasien merasa sesuai dengan metformin. Metformin dapat memberikan efek normalisasi gula darah yang diharapkan dengan efek samping ke sistem gastrointestinal yang masih dapat ditolerir. Di sisi lain, terdapat beberapa pasien yang sudah merasa jenuh dengan penggunaan obat secara terus-menerus, mereka ingin segera lepas dari obat. Perbandingan manfaat yang dirasakan ketika meminum obat dan tidak juga turut memotivasi pasien dalam menggunakan obat. Dari berbagai data yang telah dihimpun dalam penelitian ini, dapat disimpulkan bahwa kepatuhan berobat sangat dipengaruhi oleh efek yang diterima pasca penggunaan.
Analisis Zat Warna Merah Sintetik pada Selai Stroberi yang Dijual di Pasar Tradisional Kota Depok Ayuningtyas, Putri; Sauriasari, Rani; Kurniadi, Maryati
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Jam is a semi-solid food products made of fruit cooked with sugar that used as aflavoring on bakery including strawberry jam. Strawberry jam is added to food additives such as food dyes. The purpose of this study is to know about ponceau 4R, allura red, rodamin B, and amaran in the sample of strawberry jam in the traditional market at Depok City and to determine the levels of synthetic red dyes that are permitted on the sample strawberry jam. The method applied was dye isolation with wool and followed by analysis using a color reaction, then followed by paper chromatography using mobile phase n-butanol-eth-anol-water (3:4:4) and isobutanol-ethanol-water (3:2:4 ) and also TLC Densitometri using eluent ethanol-n-butanol-water (3:7:1). The result of study that from eight that has been investigated, it was found that six of them was contained ponceau 4R with levels of each sample at 0, 01164; 0, 00469; 0, 00974; 0, 00283; 0, 00482 and 0, 00435% still safe to consume.
SARS-CoV-2: Virology and Drug Repurposing Approaches Rahmasari, Ratika; Setiawan, Heri; Syahdi, Rezi Riadhi; Arifianti, Ayun; Irianti, Marina Ika; Sauriasari, Rani; Makau, Juliann Nzembi; Raekiansyah, Muhareva
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

An emerging coronavirus, SARS-CoV-2, is the causative agent for the ongoing pandemic of coronavirus disease 2019 (COVID-19), which has caused a worldwide social and economic disruption. Currently, no antiviral drugs with proven clinical efficacy, or vaccines for its prevention. Therefore, to combat the pandemic of this novel coronavirus, new effective treatments are urgently needed. In the process of traditional drug development, developing new drugs from scratch is a time- consuming process, requires high-investment, and is a high-risk process, which is impractical to face the immediate global challenge of the SARS-CoV-2 pandemic. Drug repurposing strategy is one of the effective ways to quickly find a therapeutic agent for COVID-19 Existing medicines, which already have been tested and proven safe in humans might work for COVID-19 offering a potentially faster approach for the disease management. Here, we review h the latest research progress in epidemiology, viral genome, and life cycles of SARS-CoV-2. Further, we describe and discuss some promising drugs repurposed to target SARS-CoV-2 that are being evaluated in clinical trials.
Interpersonal Relationship and Its Effect on Treatment Compliance in Patients with Type-2 Diabetes Mellitus Renaldi, Fransiskus Samuel; Riyadina, Woro; Qamar, Muhammad; Sauriasari, Rani
Pharmaceutical Sciences and Research Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Type-2 diabetes mellitus has become a chronic disease that can lead to serious complications and can only be prevented by compliant treatment of the patients. Compliance can be influenced by various factors, one of which is interpersonal factors. This study aimed to identify various interpersonal relationship problems between patients and healthcare workers that can affect their treatment compliance behavior. This study employed a qualitative design with phenomenological methods. This research was conducted in Central Bogor City in March-August 2020. The data were collected by conducting in-depth interviews with 20 type-2 diabetes mellitus patients who had been confirmed by the Community Health Center and focus group discussions with 12 healthcare workers consisting of doctors, pharmacists, nutritionists, and nurses. The data were then transcribed and content clouds analysis was carried out. The results showed that most of the patients (76%) followed the advice given by healthcare workers to carry out routine controls. This is a form of patients’ trust in healthcare workers as their health consultants. The trust arises from the convenience of interaction between the two parties. Providing adequate information will increase patients’ understanding and encourage them to take appropriate action for themselves. As many as 12 out of 20 patients chose the Community Health Center for their routine control because the services were sufficient in treating type 2 diabetes mellitus. From this study, it can be concluded that patients tend to comply if they feel trust in the health workers, which arises if they can feel the benefits during their therapy.
Evaluasi kesesuaian penulisan resep pada kasus ISPA non pneumonia di poli MTBS Puskesmas Kecamatan Cengkareng, Jakarta Sauriasari, Rani; Aulia, Annisa Azka Hikmawati; Swastika, Adisa
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Acute respiratory infections (ARI) is one of the major health problems in Indonesia. There are three classifications of cases of ARI, consist of pneumonia, severe pneumonia and non pneumonia. This study aimed to find an overview of the use of antibiotics and the evaluation of suitability prescriptions performed in cases of non pneumonia Acute Respiratory Infections (ARI) in IMCI Polyclinic, Cengkareng District Community Health Centre (Puskesmas Cengkareng), West Jakarta. Evaluation for the prescription suitability was useful to find the percentage of the suitability of prescribing on the existing management. This activity was done using retrospective method with data of 100 children patients suffered from non pneumonia cough obtained from registration book on IMCI Polyclinic during February 2016. The existing data was then matched to the patient status and prescription books that went into the dispensary unit at second floor. Furthermore, we evaluated the suitability of the reference book titled Integrated Management Scheme for Toddler Patients/Bagan Manajemen Terpadu Balita Sakit (MTBS), issued by the Ministry of Health of the Republic of Indonesia in 2011. The results showed that the percentage of antibiotic used in the sample was 59.6%, which the most frequent antibiotic used was amoxicillin. Therefore we concluded that the prescription compliance with IMCI guidelines in Puskesmas Cengkareng at February 2016 was inadequate yet.
Evaluasi Penerapan Booklet dan Edukasi Apoteker pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mayapada Tangerang Sagala, Radoti Merlin; Arozal, Wawaimuli; Sauriasari, Rani; Keban, Sesilia
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Type 2 diabetes mellitus is a degenerative disease with long-term treatment that requires knowledge and self-management to control blood sugar level. The purpose of this study was to evaluate the provision of booklet and pharmacist education in improving knowledge and behavior of self-management of type 2 diabetes mellitus patient at Mayapada Hospital Tangerang. This study respondents were 90 people who were divided into 3 groups. Group 1 got booklet and education, group 2 got booklet only and control group did not get any treatment. Fasting Blood Glucose (FBG) levels before the intervention were in poorly controlled category and after intervention there was no significant change. There was an increase in the level of knowledge and self-management in group 1 and group 2. There was no significant change in FBG. Provision of booklet with education by pharmacist showed a higher increase in knowledge (p=0.02) and self management behavior (p<0.001) than provision of booklet only. There was no relationship between knowledge and self-management behavior with blood sugar levels. It could be concluded that booklet and education by pharmacist could improve knowledge and behavior of self-management of DM type 2 patients in each intervention group. However, there was no relationship between knowledge and self-management behavior with FBG.
The Effect of Heparinoid as Systemic Prophylactic Anticoagulants on COVID-19 Patient Mortality and Its Safety Profiles: A Systematic Review and Meta-Analysis Anggarany, Ariska Deffy; Sauriasari, Rani; Alkaff, Muhammad; Takhwifa, Famila; Nufus, Hayatun; Paramita, Diana
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Coagulopathy is one of the complications of COVID-19 and is associated with a higher risk of mortality. However, evidence regarding the effectiveness and safety of anticoagulant therapy in various doses among COVID-19 patients is limited. This systematic review and meta-analysis aims to review and explore the effect of using heparinoids as a systemic anticoagulant at prophylactic doses on mortality in COVID-19 patients. Systematic searches were conducted of various databases (Pubmed, ScienceDirect, SpringerLink, Scopus, and ProQuest) covering the period 2019-2021. We assessed the quality of the articles using the STROBE checklist. Studies with a high risk of bias were excluded before pooled effect size was synthesized with 95% confidence intervals (CI) using random-effects models. From the 12 identified studies (N=8,968), six observational studies (N=7,176) were involved in the meta-analysis. The studies reviewed in the paper used a retrospective cohort design in various settings. The pooled effect size of mortality comparing prophylactic anticoagulant and no anticoagulant in three studies showed that there was an association between using prophylactic anticoagulant and a lower risk of in-hospital mortality (pooled OR= 0.47; 95% CI 0.19-0.76). A prophylactic dose of heparinoid anticoagulant was also associated with lower mortality (pooled OR= 0.51; 95% CI 0.21-0.82) and with lower bleeding events compared to intermediate-to-therapeutic dose anticoagulants. Administration of heparinoid anticoagulants at prophylactic doses was associated with reduced mortality risk in hospitalized COVID-19 patients. Due to the increased risk of bleeding with therapeutic doses, the use of prophylaxis anticoagulant is suggested in COVID-19 patients who are not critically ill.
The Association between Adherence to Oral Antihyperglycemic Agent and HbA1c Level Soraya, Indana Ayu; Sauriasari, Rani; Prawiroharjo, Pukovisa; Risni, Hindun Wilda
Pharmaceutical Sciences and Research Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Adherence to taking medication is essential for patients with chronic diseases such as Type 2 Diabetes Mellitus (T2DM). There have been many studies about the association between medication adherence and HbA1c levels, but few have used Adherence Refills and Medications Scale (ARMS) questionnaire and Proportion of Days Covered (PDC) method to measure adherence in Indonesian population. The aim of this study were to assess the association of medication adherence to HbA1c levels and compare two methods of adherence measurements. This research was conducted at Pasar Minggu Public Health Center, Jakarta using a cross-sectional design. The adherence assessment was conducted using a validated Indonesian version of the ARMS questionnaire and compared to the pharmacy refill adherence method using the PDC calculation. One hundred twenty-seven T2DM patients (75.6% female) with mean age of 58.69 years were recruited. The proportion of adhere patients as measured by ARMS was only 39.4% (50/127). Meanwhile, the proportion of adhere patients as measured by PDC was 77.2% (98/127). Adherence by both measurement showed significant associations with HbA1c <7% (ARMS, OR 4.000 (95% CI 1.705 – 9.386), p = 0.002; PDC, OR 5.674 (95% CI 1.266 – 25.438), p = 0.024). After controlled by covariates, the result remained significant (ARMS, aOR 4.281 (95% CI 1.785 – 10.267, p = 0.001; PDC, aOR 5.83 (95% CI 1.287 – 26.405), p = 0.022). Adherence and HbA1c levels was significantly associated even after controlling covariates. ARMS and PDC generated different proportions of adhere patients and may indicate the need of combining the two methods in measuring adherence.
Analysis of specialist doctors' behavior towards SGLT2 inhibitors prescription in Indonesia: A qualitative study Cokro, Fonny; Sauriasari, Rani; Tahapary, Dicky L.; Setiawan, Heri; Martha, Evi
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2089

Abstract

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have a broad range of clinical indications and are recommended by various guidelines for the management of diabetes, heart failure, and chronic kidney disease. However, prescribing rates for these agents are suboptimal towards various intended indications in many countries, including Indonesia. The aim of this study was to analyze the prescribing practices of SGLT2is among endocrinologists, cardiologists, and nephrologists in Indonesia. A qualitative method was utilized to provide a comprehensive understanding of this phenomenon. Semi-structured online interviews were performed with 18 participants, comprising seven specialized doctors as primary informants; eight key informants representing pharmacies, governmental bodies, and pharmaceutical marketing representatives; and three patients as supplementary informants. Furthermore, closed observations of two specialist doctors were undertaken as an additional data collection method. Informants were recruited using criterion and snowball sampling methods. The Theoretical Domains Framework was used as an interview guide; all interviews were audio visual-recorded, transcribed verbatim, and subsequently analyzed for thematic content with NVivo version 12. Seven themes emerged concerning the prescribing behavior of SGLT2is: socioeconomic status, therapeutic rationality, utilization barriers, utilization optimization, the urge to prescribe, therapeutic expectations and targets, and aspects of the health system and ethical considerations. Most informants possessed favorable perspectives regarding using SGLT2is when prescribed appropriately, yet specific elements necessitate enhancement to refine therapeutic justification, including initiatives to incorporate SGLT2is into the national formulary.
An Overview of Antiemetic Prophylaxis for Chemotherapy Induced Nausea and Vomiting in Head and Neck Cancer Patients at Dharmais National Cancer Hospital Sari, Novita; Sauriasari, Rani; Putri, Risani Andalasia
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1361

Abstract

Background: Chemotherapy-induced nausea and vomiting (CINV) are frequently experienced by cancer patients. One of the antineoplastic agents with high emetogenicity is cisplatin. Cisplatin is commonly used in the treatment of head and neck cancer (HNC). Therefore, the use of prophylactic antiemetics is recommended. This study aimed to examine the use of antiemetics as prophylaxis for CINV in HNC patients.Method: This study is a cross-sectional, using retrospective data from medical record observations at Dharmais National Cancer Hospital. Purposive sampling was used to collect data on antiemetic use between October and December of 2023. All patients with HNC who were undergoing chemotherapy and receiving antiemetics as prophylaxis during this period were included in the study and analyzed descriptively.Results: A total of 177 chemotherapy cycles in 96 head and neck cancer patients included in this study indicated that the most commonly used prophylactic antiemetic was a combination of ondansetron and dexamethasone (83.1%). The experience of CINV occurred more frequently in the delayed phase, with nausea occurring in 64.4% and vomiting in 44.6%. The highest severity level of nausea occurred at grade 2 (50.8%), meanwhile vomiting occurred at grade 1 (55.9%).Conclusion: The findings of this study show that the use of 5-HT3 RA (ondansetron) and dexamethasone alone is not sufficient to reduce the CINV response, thus requiring additional therapy such as D-2 RA, PPI, and H-2 Blockers.
Co-Authors Adisa Swastika, Adisa Annisa Azka Hikmawati Aulia, Annisa Azka Hikmawati Arifianti, Ayun Ariska Deffy Anggarany, Ariska Deffy Baniu, Ahmad Sahlan Cokro, Fonny Damayanti, Herni Evi Martha Hayatun Nufus Heri setiawan Irianti, Marina Ika Makau, Juliann Nzembi Maryati Kurniadi Maulida, Irianti Bahana Muhammad Alkaff Muhareva Raekiansyah Nadia Farhanah Syafhan Novita Sari Panduwiguna, Ivans Paramita, Diana Pradana Soewondo Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Putri Ayuningtyas Putri, Risani Andalasia Qamar, Muhammad Rachman, Abu Rahmasari, Ratika Ratu Ayu Dewi Sartika Renaldi, Fransiskus Samuel Risni, Hindun Wilda RR. Ella Evrita Hestiandari Sagala, Radoti Merlin Sajinadiyasa, I Gede K Sesilia Keban, Sesilia Soraya, Indana Ayu Syahdi, Rezi Riadhi Tahapary, Dicky L. Takhwifa, Famila Wawaimuli Arozal Woro Riyadina