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All Journal Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Journal Of Pharmacy
Rahmad Darmawan
Chemical Engineering Department, Syiah Kuala University Jl. Tgk. Syech Abdurrauf no. 7, Darussalam, Banda Aceh 23111
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Neutrophil Extracellular Traps as Potential Therapeutic Targets in Systemic Lupus Erythematosus: A Systematic Review of Current Evidence Primartati, Danny Meganingdyah; Fatmariza, Aulia Risqi; Darmawan, Rahmad; Fadillah, Noor
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 2 (2025): Desember 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i2.318

Abstract

Introduction: Systemic Lupus Erythematosus is an autoimmune disorder in which the immune system becomes increasingly dysregulated, inflamed, and involves multiple organ systems. While NETs play an essential role in antimicrobial defence, in SLE, they enhance immunopathological damage by driving type I interferon response, autoantibody production, and tissue damage. NETs, due to their unique capability of serving both as disease extraditional and as disease instigators, are a promising target in SLE. Methods: The current review is in accordance with PRISMA guidelines and registered in PROSPERO (CRD420251129386). Comprehensive searches were performed in PubMed, ScienceDirect, SpringerLink, and JSTOR, published between 2021 and 2025. Primary research investigating NETs or interventions aimed at them in SLE were included. Articles were excluded for non-originality, focus outside SLE and NETs, and lack of therapeutic focus. Documents were appraised for design, population, sample size, intervention, outcome, and therapeutic relevance for extraction. Results: A total of 1.065 articles were initially identified, of which six studies met inclusion criteria. Clinical studies consistently demonstrated elevated NET remnants, impaired NET degradation, and organ-specific deposition associated with lupus nephritis and vascular involvement. Preclinical models showed that PAD4 inhibition, DNase I supplementation, and mitochondrial-targeted antioxidants reduced NET formation, attenuated interferon-driven immune responses, and ameliorated renal and vascular pathology. Conclusion: Existing data underscore the role of NETs as critical pathogenic components of SLE and corroborate the possibility of NETs as therapeutic targets. There is, however, an immediate need for bespoke NET assays, active-signed NET biomarker stratification, NET-guided patient stratification, and rigorous clinical trial design.
Bioactive Profile and Health Benefits of Wedang Uwuh: A Narrative Mini-Review Darmawan, Rahmad; Primartati, Danny Meganingdyah; Puspa Dila Rohmaniar
The Journal Of Pharmacy Vol. 3 No. 2 (2026): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Background: Wedang uwuh is a traditional Indonesian herbal drink made from ginger, sappan wood, clove leaves, nutmeg leaves, rock sugar, and several other spices, and it is known for its health benefits. Objective: This review aims to summarize scientific evidence on the bioactive compounds, biological activities, and health potential of wedang uwuh. Methods: Literature was reviewed from scientific articles discussing the phytochemical composition and pharmacological activities of wedang uwuh. Results: The findings show that wedang uwuh contains polyphenols, flavonoids, gingerol, shogaol, and other bioactive metabolites with antioxidant, anti-inflammatory, and antidiabetic activities, and may also support weight management. Conclusion: Wedang uwuh has potential as a functional drink that supports health and represents part of Indonesia’s cultural heritage, although further studies, including toxicity tests and clinical research, are still needed to confirm its safety and effectiveness.
Co-Authors Aulia Risqi Fatmariza Danny Meganingdyah Primartati Noor Fadillah Puspa Dila Rohmaniar