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All Journal Judika (Jurnal Nusantara Medika) ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Biocaster : Jurnal Kajian Biologi JK Jurnal Kesehatan JENGGALA: Jurnal Riset Pengembangan dan Pelayanan Kesehatan Ficco Public Health Journal
Aulia Risqi Fatmariza
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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PERBEDAAN KADAR INTERLEUKIN-6 PADA PENDERITA DIABETES MELITUS TIPE 2 TERKONTROL DAN TIDAK Angga Eka Kurniawan; Aulia Risqi Fatmariza
Jurnal Kesehatan Vol. 2 No. 4 (2024): April
Publisher : CV. ADIBA AISHA AMIRA

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Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic, non-communicable disease that progresses slowly due to multifactorial etiology. Chronic low-grade inflammation plays an important role in the pathogenesis of T2DM, thereby linking diabetes to a number of common conditions thought to originate from inflammatory mechanisms. IL-6 is considered an independent risk factor and acts as a marker of insulin resistance and development of T2DM. High extracellular glucose levels will trigger an increase in oxidative stress which will increase ROS production and lead to inflammation. Objective: To prove that there are differences in IL-6 levels in controlled and uncontrolled T2DM sufferers. Research method: The type of research is analytical observational, with a cross sectional research design and non-probability sampling technique with a purposive sampling method in the laboratory of RSU Muhammadiyah Roemani Semarang in November-December 2022. Results: The results of the study showed that the mean value of IL-6 levels in T2DM controlled at 4.37 pg/ml and uncontrolled T2DM at 76.07 pg/ml. Based on Mann-Whitney U statistical analysis, it was found that the p value was <0.05, thus proving that there was a significant difference in IL-6 levels in controlled and non-controlled T2DM sufferers. Conclusion: There is a difference in IL-6 levels in controlled and uncontrolled T2DM sufferers, where IL-6 levels in uncontrolled T2DM sufferers are higher than in controlled T2DM sufferers.
COMPARISON OF HOMOGENEITY BETWEEN LYOPHILISED CONTROL MATERIAL AND IN-HOUSE CONTROL MATERIAL FOR GLUCOSE EXAMINATION Aulia Risqi Fatmariza; Angga Eka Kurnia; Danny Meganingdyah Primartati
ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Vol. 4 No. 2 (2024): APRIL
Publisher : CV. ADIBA ADISHA AMIRA

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Background: Internal Quality Assurance (IQA) is a continuous monitoring activity by the laboratory to reduce or prevent errors in examination results using control materials. Homogeneity of the control material is very important because homogeneity shows that the control material is the same. Objective: To find out whether there is a difference in homogeneity between the lyophilized control material and the in-house control material for glucose examination. Research method: The type of research used was a quasi experiment with a simple random sampling technique at the SMC Clinical Laboratory, Telogorejo Hospital, Semarang. Data analysis uses the homogeneity calculation formula. Results: Based on the results of homogeneity calculations, it is known that the Fcount for the lyophilized control material is 0.9538 while the in-house control material is 2.1883, where both are <Ftable (3.02) which means homogeneous. Conclusion: There is no difference in homogeneity between lyophilized control material and in-house control material for glucose examination.
Stabilitas Pooled Sera Etilen Glikol dan Pooled Plasma NaF Sebagai Bahan Kontrol Pemeriksaan Glukosa Fatmariza, Aulia Risqi; Kurniawan, Angga Eka; Sari, Nofita
Jenggala : Jurnal Riset Pengembangan dan Pelayanan Kesehatan Vol 3 No 2 (2024): DESEMBER 2024
Publisher : Fakultas Teknologi dan Manajemen Kesehatan

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Hubungan Upaya Pemberantasan Sarang Nyamuk dengan Kejadian Demam Berdarah Dengue di Indonesia Tahun 2023 Nofita Sari; Aulia Risqi Fatmariza
Ficco Public Health Journal Vol. 1 No. 03 (2024): December 2024
Publisher : Ficco Scientific Corner

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.14949247

Abstract

Background: This study aims to identify the relationship between mosquito nest eradication efforts and the prevalence of dengue fever in Indonesia. Methods: The study used a quantitative method with a descriptive analytic design and a cross-sectional approach, where the independent variables (sowing larvicide powder, installing mosquito screens on vents, draining bathtubs, closing water reservoirs, and destroying used items) were analysed against the dependent variable, which was the prevalence of DHF based on the Indonesian Health Survey data in 2023. Data were analysed univariately and bivariately with Spearman correlation test to see the relationship between variables. Results: The results showed that installation of mosquito screens on house ventilation and destruction of used goods had a significant association with the prevalence of DHF (p=0.006 and p=0.042, respectively), while sowing larvicidal powder, draining bathtubs, and closing water reservoirs did not show a significant association. Conclusions: This study concludes that mosquito nest eradication efforts, particularly mosquito screen installation and disposal of used items, can be effective in reducing the prevalence of DHF in Indonesia.
Analisis Korelasi Neutrophil-Lymphocyte Ratio (NLR) dengan Indikator Komplikasi Makrovaskular dan Mikrovaskular pada Diabetes Melitus Tipe 2 Hasanah, Fathul Hidayatul; Wahyuni, Sri; Primartati, Danny Meganingdyah; Fatmariza, Aulia Risqi; Sari, Fita
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.501

Abstract

Type 2 Diabetes Mellitus (DM type 2) is associated with low-grade systemic inflammation. Neutrophil-Lymphocyte Ratio (NLR) is a pro-inflammatory and oxidative stress biomarker in cardiometabolic diseases such as T2DM. This study aims to analyze the relationship of NLR with leukocyte count, random blood glucose, creatinine, total cholesterol, Serum Glutamic Pyruvic Transaminase (SGPT), and Serum Glutamic Oxaloacetic Transaminase (SGOT). The study design is a retrospective analysis with respondents of 162 uncomplicated T2DM patients treated at Mojowarno Christian General Hospital, Jombang. The results of the study showed that the average number of leukocytes was 12,688 cells/µl, neutrophils 75.3%, lymphocytes 17.2%, NLR 8.5, blood glucose 273.2 mg/dl, SGOT 40.88 U/l, SGPT 54.64 U/l, total cholesterol 196.3 mg/dl (<200), and creatinine 1.13 mg/dl. Correlation tests showed that NLR was significantly associated with leukocyte count (p = 0.000 < 0.05) and total cholesterol (p = 0.000 < 0.05), but not significantly correlated with random blood glucose (p = 0.064 > 0.05), SGOT (p = 0.089 > 0.05), SGPT (p = 0.929 > 0.05), or creatinine (p = 0.625 > 0.05). In conclusion, in patients with type 2 diabetes, NLR was significantly correlated with leukocyte count and total cholesterol, but not with random blood glucose, SGOT, SGPT, or creatinine.
Pengaruh Siklus Freeze-thaw Terhadap Akurasi dan Presisi Pooled sera Glukosa Fatmariza, Aulia Risqi; Primartati, Danny Meganingdyah; Danny Meganingdyah Primartati
Judika (Jurnal Nusantara Medika) Vol 9 No 2 (2025): Judika Volume 9 No. 2 Oktober 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/judika.v9i2.27073

Abstract

Siklus pembekuan dan pencairan (freeze–thaw) berulang sering kali tidak dapat dihindari dalam pengelolaan bahan kontrol laboratorium, terutama pada laboratorium dengan keterbatasan sumber daya. Glukosa merupakan salah satu parameter kimia klinik yang banyak diperiksa, sehingga penting untuk mengevaluasi stabilitasnya terhadap proses freeze–thaw. Tujuan: Penelitian ini bertujuan untuk menilai pengaruh siklus freeze–thaw terhadap akurasi dan presisi pooled sera glukosa. Metode: Penelitian eksperimental dilakukan menggunakan pooled sera dengan kadar glukosa tinggi yang dibagi menjadi aliquot dan melalui sepuluh kali siklus freeze–thaw. Pemeriksaan kadar glukosa dilakukan secara duplo pada setiap siklus. Analisis dilakukan dengan menghitung bias (%) terhadap nilai target awal, koefisien variasi (CV%), serta distribusi data (mean, median, minimum, maksimum). Hasil: Kadar glukosa rata-rata menunjukkan rentang 231,5–236 mg/dL dengan nilai mean 233,75 mg/dL, median 233,5 mg/dL, minimum 231,5 mg/dL, dan maksimum 236 mg/dL. Bias maksimum yang diperoleh adalah -1,91% dan nilai CV% ≤0,30%, yang keduanya masih memenuhi standar akurasi dan presisi berdasarkan ISO 15189 dan CLSI EP15-A3. Kesimpulan: Pooled sera glukosa terbukti stabil terhadap sepuluh kali siklus freeze–thaw tanpa penurunan signifikan pada akurasi maupun presisi, sehingga berpotensi digunakan sebagai alternatif bahan kontrol internal level tinggi yang efektif dan efisien di laboratorium klinik.
Co-Authors Danny Meganingdyah Primartati Fathul Hidayatul Hasanah, Fathul Hidayatul Fita Sari, Fita Kurniawan, Angga Eka Nofita Sari Sari, Nofita Sri Wahyuni