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All Journal Althea Medical Journal The Indonesian Biomedical Journal
Faisal Faisal
Department of Child Health Faculty of Medicine, Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The Pattern of Iodine Food Source Intake in Early Adolescents in Junior High School in Jatinangor Siti Nur Fatimah; Che Wan Nurdamia; Faisal Faisal
Althea Medical Journal Vol 6, No 4 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.393 KB) | DOI: 10.15850/amj.v6n4.1685

Abstract

Background: Iodine is one of the essential micronutrients for normal growth, development, and metabolism throughout life. Studies about the pattern of iodine food source intake in Indonesia are lacking. The aim of this study was to assess the current pattern of iodine food source intake among early adolescents.Methods: This was a cross-sectional study, the pattern of iodine food source intake in early adolescents aged 11–14 years attending Junior High School in Jatinangor Sumedang, Indonesia was assessed from September to October 2014, by validated food frequency questionnaire (FFQ). Eating patterns were divided into four categories based on Indonesian Recommended Dietary Allowance (RDA).Results: The average iodine daily intake of the subjects was 356.27 mcg. The highest frequency of the iodine intake category was adequate in students aged 11–12 years old (100%), compared to aged 13–14 years old (79.2%).Conclusions: The daily iodine intake in Junior High School students is sufficient. Further assessment in areas elsewhere in West Java needs to be conducted to have a better picture of the pattern of iodine food source intake in adolescents.
Antibodies to Glutamic Acid Decarboxylase-65 is Associated with Total Daily Dose of Insulin Requirement in Children with Type 1 Diabetes Faisal Faisal; Nur Rochmah; Muhammad Faizi; Novina Novina; Erni Nuraeni
The Indonesian Biomedical Journal Vol 15, No 4 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i4.2377

Abstract

BACKGROUND: Type 1 diabetes (T1D) mostly occurs due to the destruction of pancreatic beta cells due to autoimmune processes. Diagnosis of T1D can be established by examining the c-peptide levels and the markers of pancreatic autoantibodies, including glutamic acid decarboxylase 65 autoantibodies (GAD-65). However, the association between c-peptide and anti-GAD-65 toward patients’ clinical manifestations needs to be further explored. Hence, the aim of current study was to identify the association of anti-GAD65 with c-peptide and clinical characteristics in children with T1D.METHODS: Case-control study involving 47 T1D children (T1D group) and 41 healthy children (control group) younger than 18 years old was conducted. Secondary data regarding subjects’ demographic characteristics and medical history were collected from subjects, and serum blood was drawn from each subject for the anti-GAD65 and c-peptide measurement. Anti-GAD65 and c-peptide levels were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) methods.RESULTS: Anti-GAD65 antibody was detected in 78.7% T1D group, while only 2.43% were detected in control group subject (p=0.0000). The c-peptide level of T1D group was 0.07±0.19 nmol/L and control group was 1.5±0.77 nmol/L (p=0.0000). The total daily dose of insulin in subjects with positive anti-GAD65 was greater than in the negative anti-GAD65 (p=0.012). The sensitivity and specificity of the anti-GAD65 were 85.4% was 66.7%, respectively.CONCLUSION: The results of this study show that anti-GAD65 was associated with total daily dose of insulin requirement in children with T1D.KEYWORDS: diabetes mellitus, type 1 diabetes, anti-GAD65, c-peptide
Co-Authors Che Wan Nurdamia Erni Nuraeni Muhammad Faizi Novina Novina Nur Rochmah Siti Nur Fatimah