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All Journal Journal of Biomedicine and Translational Research Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Jurnal Medik Veteriner Indonesian Journal of Medicine ACADEMICS IN ACTION Journal of Community Empowerment JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Abdi Insani Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Journal of Applied Data Sciences AKSONA Asian Journal of Health Research MEDICINUS Folia Medica Indonesiana

Muhammad Faizi

Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga

Author-ID : 3272346

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Predispositions Factors Affecting Quality of Life in Children with T1DM During the Coronavirus Disease of 2019 Pandemic Nur Rochmah; Muhammad Faizi; Yuni Hisbiyah; Ike Wahyu Triastuti; Garindra Wicaksono; Anang Endaryanto; Soetjipto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17006

Height-for-age in Children under 5 Years Old with Down Syndrome and Hypothyroidism Muhammad Faizi; Nur Rochmah; Yuni Hisbiyah; Anang Endaryanto; Soetjipto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17604

Background: Children with Down syndrome tend to have accompanying comorbidities, such as hypothyroidism, and late detection of this ailment leads to reduced growth of the child. This study aimed to assess the growth patterns in children with Down Syndrome and hypothyroidism at diagnosis.Methods: This cross-sectional study was conducted from September to December 2020 with 56 subjects at the Pediatric Endocrine Outpatient Clinic of Dr. Soetomo Hospital. Diagnosis of Down Syndrome was confirmed by karyotyping, while the weights and heights were assessed using a standardized curve for children with Down Syndrome and then calculated using Peditools. Fifty-six children with Down Syndrome and hypothyroidism were included, comprising 32 boys and 24 girls (mean age, 37.75 ± 34.26 months). Majority of the subjects had normal weight, height, and Body Mass Index (36/56 [mean z-score, −1.62 ± 2.36], 33/56 [mean height-z-score, −0.43 ± 2.74], and 30/56 [mean z-score, −2.00 ± 2.06], respectively). Furthermore, the mean onset of diagnosis was 17.07 ± 32.23 months, where 23 out of the 56 children had short stature and had gotten diagnosed at over 12 months of age.Conclusion: From the results obtained, hypothyroidism can be said to be associated with reduced growth in children with DS.

Association of Growth Velocity with Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Children with a Vegan Diet Arie Purwana; Budiono Budiono; Jose RL Batubara; Muhammad Faizi
Journal of Biomedicine and Translational Research Vol 6, No 1 (2020): April 2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i1.5474

Background: The vegan diet in children provides the benefit of reducing the risk of being overweight and improving the fat profile. The risk that can occur in the provision of a vegan diet in children is anthropometric size below reference and low caloric intake. Growth hormone (GH) and Insulin like Growth Factors (IGFs) are powerful stimulators for longitudinal growth of bone and require insulin-like growth factor binding protein (IGFBPs) which acts as a transport protein for IGF-1. A vegan diet with lower calorie intake in children has lower IGF-I levels than children with an omnivorous diet.Objective: Examining the effect of vegan diets on IGF-1 levels, IGFBP-3 levels, and growth velocity.Methods: This study was done with a prospective cohort design. The study subjects were divided into two groups, namely the vegan group and the omnivorous group, then matched based on age and sex. During the study, anthropometric data collection, IGF-1 and IGFBP-3 levels measurements were done in both vegan children and omnivorous children.Results: During 6 months of observation, 22 subjects were divided into two groups, namely children with a vegan diet and children with an omnivorous diet. IGF-1 (ng / mL) in vegan children was 105.5 ± 47.3 compared to 102.7 ± 42.3 in omnivorous children with a value of p = 0.89. IGFBP-3 (ng / mL) in vegan children was 2146.4 ± 595.1 compared to 2142 ± 609.1 in omnivorous children with value of p = 0.99 and Growth Velocity (cm / 6 months) was 3.0 in vegan children (1.0-5.30), and 3.2 (2.6-6.5) in omnivorous children with value of p = 0.41.Conclusion:Children with vegan diet had IGF-1 level, IGFBP-3 level, and growth velocity that were the same as children with an omnivorous diet.

Risk Factor Related to Mortality of Diabetic Ketoacidosis Patients in Dr. Soetomo General Hospital Surabaya Alviano Satria Wibawa; Hermina Novida; Muhammad Faizi; Deasy Ardiany
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 1 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I12020.36-40

Introduction: Diabetic ketoacidosis (DKA) is a complication of diabetes mellitus which has a high risk of mortality. Mortality in DKA patients in developed countries is less than 5%, some other sources mention 5-10%, 2-10%, or 9-10%. Mortality events at clinics with simple facilities and elderly patients can reach 25-50%. The mortality rate of DKA patients is generally higher in infection conditions, especially in developing countries and in septic patients. Several factors such as age, sex, and high blood glucose can increase mortality risk of DKA patients. Other risk factors such as history of discontinued insulin therapy, impaired bicarbonate levels, pH, and increased leukocytes of DKA patients due to infection, abnormal albumin levels, electrolyte disturbances, and Serum Creatinine (SK) were thought to affect mortality of DKA patients. The purpose of this study was to determine the risk factors associated with mortality of DKA patients in Dr. Soetomo General Hospital Surabaya. Methods: The method used in this study was observational analytic involving 63 adult patients diagnosed with DKA with analysis using Chi-Square test. Results: From 63 patients included in this study, 37 patients diagnosed with DKA died and 26 patients lived. In a multivariate analysis, DKA severity with p = 0.001 (p < 0.005) was identified as having a relationship with mortality of DKA patients Dr. Soetomo General Hospital Surabaya. Conclusion: Severity is the only risk factor associated with mortality of DKA patients in Dr. Soetomo General Hospital Surabaya.

Diabetic ketoacidosis in children: an 11-year retrospective in Surabaya, Indonesia Nur Rochmah; Muhammad Faizi; Netty Harjantien
Paediatrica Indonesiana Vol 55 No 1 (2015): January 2015
Publisher : Indonesian Pediatric Society

Background Diabetic ketoacidosis (DKA) is a complication of type I diabetic mellitus (TIDM). Early recognition and prompt treatment can reduce mortality. Objective To evaluate the profiles of patients with diabetic ketoasidosis in Dr. Soetomo Hospital, Surabaya, Indonesia. Methods Retrospective medical records of patients admitted to the pediatric intensive care unit with DKA in Dr. Soetomo Hospital, Surabaya, Indonesia from January 2002 to June 2013 were reviewed. The data collected included clinical parameters, laboratory and imaging results, predisposing factors, complications and outcomes. Results During an 11 years period, there were 58 cases of DKA in children with T1DM. Eighteen subjects (31%) were boys. The severity of DKA was classified as follows: mild 13 (22.4%), moderate 23 (39.7%), and severe DKA 22 (37.9%). Recurrent DKA was diagnosed in 24 (41.4%) patients. Common clinical profiles recorded were dehydration 46 (79.3%), malaise 37 (63.8%), decreased consciousness 35 (60.3%), dyspnea 27 (46.6%), vomiting 26 (44.8%), fever 25 (43.1%), seizure 13 (22.4%), and decreased body weight 9 (15.5%). Laboratory results observed were as folllows: hyponatremia 19 (32.8%), hyperkalemia 12 (20.7%) and acute renal failure 3 (5.2%). Head CT scans showed that 2 (3.4%) patients suffered from cerebral edema. Infections, as triggers of DKA, were found in 12 (20.6%) patients: 4 caries and periodontitis, 3 urinary tract infections, 2 acute diarrhea, 2 acute pharyngitis, and 1 otitis externa. Four out of 24 patients with recurrent DKA failed to take their insulin dose prior to DKA. The average of length of patient stay in the PICU was 3.26 (SD 3.50) days. No patients died during the study. Conclusion Dehydration is the most common clinical profile of DKA in our study. More than half of the patients suffer from moderate to severe DKA.

Impact of growth hormone treatment on childrenâ€™s height Nur Rochmah; Muhammad Faizi
Paediatrica Indonesiana Vol 54 No 6 (2014): November 2014
Publisher : Indonesian Pediatric Society

Background The use of growth hormone (GH) is a routine treatment for growth hormone deficiency (GHD), small for gestational age (SGA), and Turner syndrome (TS). During the treatment, height measurement at regular intervals is a vital step to assess success. To date, there have been no previous studies on GH treatment in Dr. Soetomo Hospital, Surabaya, the referral hospital in East Indonesia. Objective To compare body height between pre- and post-growth hormone treatment in pediatric patients. Method This study was a non-randomized, pre-post clinical trial performed at Dr. Soetomo Hospital, Surabaya. The prospective cohort was accessed during January 2008-June 2013. The inclusion criteria was GH treatment for more than 3 months.Clinical data on GH treatment, including diagnosis, age, height pre-and post-treatment, height gain, duration of treatment, and parental satisfaction were collected. Two-tailed, paired T-test and Pearsonâ€™s test were used for statistical analyses. Result Nineteen patients underwent GH treatment during the study period, but only twelve patients had complete data and were included in the study. Eight subjects were female. Subjectsâ€™ meanage was 11 (range 8-15) years. Nine patients had GHD, 2 had TS, and 1 had SGA. Mean pre-treatment height was 121.05 cm, while mean post-treatment height was 130.5 cm. Mean duration of treatment was 10.5 (range 3-30) months. Mean height gain was 0.8 cm/month in GHD and SGA cases, and 0.78 cm/month for the TS cases. Eleven parents reported satisfaction with the results of GH treatment in their children. There is significant diffrent between pre- and post-treatment (P=0.001). Pearsonâ€™s correlation test (r=0.90) revealed a strong correlation between growth hormone treatment and height gain. Conclusion Growth hormone treatment has impact on heights in GH defficiency, Turner syndrome, and small for gestational age.

Anaphylactic Shock Associated with Scratch Testing Ariyanto Harsono; Muhammad Faizi
Paediatrica Indonesiana Vol 36 No 11-12 (1996): November - December 1996
Publisher : Indonesian Pediatric Society

A 10-year old boy with bronchial asthma referred to allergy clinic for allergy work-up. He complained of abdominal pain and blurred vision 20-rmnutes after undergoing allergy skin scratch test. Physical examination showed clammy and cyanoÂtic extremities, and hypotension. The skin test result showed positive rection for house dust, mite, and shrimp. Based on these findings the diagnosis of anaphylaxis associÂated with scratch test was made. The suggested offending extract was shrimp with possible interference of the other two extracts. Epinephnne 0.3 subcutaneously was initiated. The first dose gave a disappointing result, and then followed by the second dose which gave better result; dexamethasone was also administered. The eosinophilia, positive specific Ig E to shnmp, house dust and mite as indicated by RAST justify the atopic status of the patient. The management of the main disease consisted of house dust control, elimination diet, and symptomatic treatment were commenced.

Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus Nur Rochmah; Muhammad Faizi
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Background Children with type 1 diabetes mellitus (T1DM) are at risk of thyroid dysfunction. An association between diabetes duration and thyroid stimulating hormone level remains inconclusive. Objective To assess for a possible association between diabetes duration and thyroid stimulating hormone levels in children with T1DM. Methods We conducted a cross-sectional study from January to June 2017 in the Pediatric Endocrine Outpatient Clinic at Dr. Soetomo Hospital. Subjects were children with T1DM aged 7 to <18 years. Exclusion criteria were children with diabetic ketoacidosis, previously diagnosed thyroid problems, and hospitalization in the pediatric intensive care unit (PICU).Â Results From the 55 regular patients in our outpatient clinic, 34 patients were included in the study. Nineteen (54.3%) subjects were male, and the overall mean age was 11.3 years. Subjects' mean duration of diabetes was 3 years and their mean thyroid stimulating hormone concentration was 3.76mIU/L. Pearson's correlation test revealed no significant association between duration of diabetes and thyroid stimulating hormone level (rs=-0.068; P=0.703). Conclusion There is no significant association between duration of diabetes and thyroid stimulating hormone levels in children with T1DM.

lmmunomodulatory Effects of Human Milk upon Immune Functions in Infants Ariyanto Harsono; Anang Endaryanto; Muhammad Faizi
Paediatrica Indonesiana Vol 39 No 9-10 (1999): September - October 1999
Publisher : Indonesian Pediatric Society

Human milk is capable to modulate the immune system in infants in several ways. lmmunorestoration is mostly dominated by immunoglobulins content of human milks especially secretory lgA, although lgG antibody also plays important role. Nucleotide content of human milk is among substances widely investigated all over the world, capable to potentiate immune response in infants by increasing NK cell activity and production of lL-2. lmmunopotentiation also the result of cell content activity of human milk, interferon, and complement. Special feature of anti-inflammatory propertyÂ of human milk is its capability to prevent of allergic disease in infants. This because ofprotein in breast milk is species specific, instead the role of secretotry lgA inÂ preventing absorption of foreign macromolecules. Other substances also play an important role in the antiinflammatory properties of human milk and interestingly the paucity of initiators and mediators in human milk.

Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report Nur Rochmah; Muhammad Faizi; Adwina Nurlita Kusuma Wardhani
Paediatrica Indonesiana Vol 61 No 6 (2021): November 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.6.2021.356-8

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder commonly caused by mutation of the CYP21A2 gene, resulting in deficiency of an enzyme required for cortisol synthesis in the adrenal cortex. In 90-95% of cases, the deficient enzyme is 21-hydroxylase (21-OH), with an incidence ranging from 1 in 5,000 to 15,000 live births across various ethnic and racial backgrounds. In classical 21-OH deficiency (21-OHD) CAH, excessive androgen exposure in the fetus results in virilization at birth.1 The management of ambiguous genitalia in children with CAH presents a unique and ethically challenging decision-making dilemma for the medical team. Insensitive and poorly informed statements made in the delivery room may cause long-term psychological problems for the families. It is important to refrain from assigning gender until sufficient diagnostic information can be gathered. Parents, as guardians, and the supporting medical team must make decisions on behalf of the child, with the goal of enabling the child to grow into a healthy and happy adult with his or her assigned gender.2,3 We report a case of a child with CAH, focusing on the ethical challenges in management of ambiguous genitalia.

Co-Authors Adwina Nurlita Kusuma Wardhani AGUNG PRANOTO Ahmad Suryawan Alfaqih, Muhammad Subhan Alpha Fardah Athiyyah Alviano Satria Wibawa Aman Bhakti Pulungan, Aman Bhakti Anang Endaryanto Andi Cahyadi Andriani, Irwina Rahma Andy Darma Anny Hanifah Anugrah, Andreas Surya Arie Purwana Arifa Mustika Ariyanto Harsono Ariyanto Harsono Badriul Hegar Syarif Bagus Setyoboedi Bambang Permono Basuki, Mudjiani Bermanshah, Evita Karianni Bernie Endyarni Medise Budiono Budiono Deakandi, Wika Yuli Deasy Ardiany Dinda Chandra Yuliantari Dwiyanti Puspitasari, Dwiyanti Erni Nuraeni Evi Triandini Fadhil Abiyyu Yofi Faisal Faisal Faisal Faisal Fatimah Arief Fidiana Garindra Wicaksono Grawira Drana Putra Respati Hanifah, Anny Herman Kosasih Hermina Novida, Hermina I Dewa Gede Ugrasena I Gusti Ayu Putu Eka Pratiwi I Gusti Made Reza Gunadi Ranuh IDG Ugrasena Ike Wahyu Triastuti Irwina Rahma Andriani Ismi Citra Ismail, Ismi Citra Jose RL Batubara Juniastuti Juniastuti Khadijah Rizky Sumitro Khadijah Rizky Sumitro Kuswanto, Djoko Latifatu Choirunisa Leonardo Ferryanto Mak Samadhi Marcos, Imella Maria Christina Shanty Larasati Mia Ratwita Andarsini Minawati Minawati, Minawati Montolalu, Ivan Adrian Muji Retnaning Rini Nengcy Erlina Tasik Rerung Nesa, Ni Nyoman Metriani Netty Harjantien Neurinda Permata Kusumastuti Ni Nyoman Metriani Nesa Ni Nyoman Metriani Nesa Novina Novina Nur Rochmah Nur Rochmah Nur Rochmah, Nur Nurul Ima Suciwiyati Pasulu, Soraya Salle Perwitasari, Rayi Kurnia Praja, Nucky Indra Putu Adi Guna Permana Rendi Aji Prihaningtyas Reza Gunadi Ranuh Reza Gunadi Ranuh Roedi Irawan Samadhi, Leonardo Ferryanto Mak Sensusiati, Anggraini Dwi Shofwan Hanief Sidarti Soehita Soesanti, Frida Soetjipto SOETJIPTO . Soraya Salle Pasulu Steven Christian Susianto Steven Christian Susianto Sudarmo, Subijanto Marto Sukmawati Basuki Sumitro, Khadijah Rizky Susianto, Steven Christian Syahruna, Pradipta Reza Vinzy Yulina Wika Yuli Deakandi Yudhi Kurniawan Yuni Hisbiyah Yuri Pamungkas Zubaity Ardhanariswari

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