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All Journal Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Journal of Information Systems Engineering and Business Intelligence Majalah Obstetri dan Ginekologi Jurnal Bioteknologi & Biosains Indonesia (JBBI) Health Notions Radioterapi & Onkologi Indonesia Jurnal Respirasi (JR) Nusantara Science and Technology Proceedings Journal of Education and Culture Jurnal Cahaya Edukasi
Dyah Erawati, Dyah
Department Of Radiology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ANALISIS KERUSAKAN DNA PADA SEL LIMFOSIT PASIEN PASCA-RADIOTERAPI Darlina Yusuf; Devita Tetriana; Tur Rahardjo; Teja Kisnanto; Yanti Lusiyanti; Dyah Erawati; Nastiti Rahajeng
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 8 No. 1 (2021): June 2021
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.64 KB) | DOI: 10.29122/jbbi.v8i1.4598

Abstract

Analyses of DNA Damage in the Patient’s Lymphocyte Cells Post-Radiotherapy Radiotherapy given in high doses to kill cancer cells can also induce DNA damage in surrounding normal cells. The radiation dose is divided into smaller doses called fractionation to decrease the effect of radiation on normal tissue. For this reason, it is necessary to monitor the peripheral blood lymphocytes to evaluate the patient's DNA damage. The alkaline comet test is a simple and sensitive technique for detecting DNA instability. This study involved 11 patients who underwent radiotherapy up to 20 Gy, and 11 healthy subjects as controls. This study aims to see how much DNA damage is caused by a 20 Gy fractionated radiation dose in patients with various cancers. The results showed that the mean frequency of damaged cells in patients was 80.54 ± 12.52% with a mean comet tail length of 49.98 ± 12.93 µm. There was a significant difference in both the frequency of damaged cells and the mean value of the comet tail length against the control group (p < 0.001). It was concluded that high doses of radiation can cause DNA damage to peripheral blood lymphocytes. Radioterapi yang diberikan dalam dosis tinggi untuk mematikan sel kanker juga dapat menginduksi kerusakan DNA pada sel normal di sekitarnya. Dosis radiasi dibagi menjadi dosis yang lebih kecil yang disebut fraksinasi untuk menurunkan efek radiasi pada jaringan normal. Untuk itu perlu pemantauan pada limfosit darah tepi untuk mengevaluasi kerusakan DNA pasien. Uji komet alkali merupakan teknik yang sederhana dan sensitif untuk mendeteksi ketidakstabilan DNA. Penelitian ini melibatkan 11 pasien yang menjalani radioterapi hingga 20 Gy, dan 11 subyek sehat sebagai kontrol. Penelitian ini bertujuan untuk melihat seberapa besar kerusakan DNA akibat dosis radiasi fraksinasi 20 Gy pada pasien dengan variasi kanker. Hasil penelitian menunjukkan bahwa rerata frekuensi sel yang rusak pada pasien 80,54 ± 12,52% dengan rerata panjang ekor komet 49,98 ± 12,93 µm terdapat perbedaan nyata baik pada frekuensi sel yang rusak maupun nilai rerata panjang ekor komet terhadap kelompok kontrol (p < 0,001). Penelitian ini menyimpulkan bahwa radiasi dosis tinggi dapat menyebabkan kerusakan DNA sel limfosit darah tepi.
Characteristics of Renal Cell Carcinoma Patients in RSUD Dr Soetomo Surabaya in 2014-2017 Ferdiansyah Rusdhy; Wahjoe Djatisoesanto; Dyah Erawati; Dyah Fauziah
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn31206

Abstract

Renal Cell Carcinoma is a type of malignant renal tumour. According to GLOBOCAN 2012 data, it ranked 17th on the most common malignancy in Indonesia with an incidence rate of 1.5 per 100000 citizens. Mortality rates for men is 1.6 per 100000, while it is 0.8 per 100000 case for women. The clinical symptoms of flank pain, flank mass, and hematuria, are usually only found in patients with later stages of cancer development. This descriptive study aims to present data on characteristics of Renal Cell Carcinoma patients. Data were collected from histopathological medical records of RSUD Dr. Soetomo Surabaya. We found that 25 of 40 patients are male, with most patients aged between 50 to 59 at time of diagnosis. Majority of patients worked as a private sector worker, and had high school level education. They presented with stage 2 tumour, with Clear Cell Renal Cell Carcinoma subtype. All 40 patients were treated by Radical Nephroctomy. Keywords: renal cell carcinoma; characteristics
Differences Effectiveness of Percutaneous Nephrolithotomy and Open Surgery in Staghorn Stone Patients: Systematic Review Ramandita Duta Dewangga; Tarmono Djojodimedjo; Dyah Erawati
Health Notions Vol 4, No 11 (2020): November
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn41106

Abstract

This study purpose to analyze the differences in the effectiveness of PCNL and open surgery in patients with staghorn stones. We searched the literatures from PubMed and ScienceDirect from year 2005 until 2020. The method used in this study was a systematic review with a quantitative statistical approach (meta-analysis) using primary research data. From 4 studies there were 148 cases of PCNL and 98 cases of open surgery. PCNL had lower postoperative stone-free rate than open surgery (OR 0.168). PCNL had a lower final stone-free rate than open surgery (OR 0.603). The number of patients who had complications with PCNL was lower than open surgery (OR 0.451). The number of patients receiving blood transfusions on PCNL was lower than for open surgery (OR 0.494). Patients who received PCNL procedure required a shorter hospital stay than open surgery (MD -3,234). The number of patients who received additional therapy modalities on PCNL was lower than open surgery (OR 1.917). The conclusions obtained in this study indicate that there are differences in the effectiveness of PCNL and open surgery for patients with staghorn stones. Keywords: percutaneous nephrolithotomy; open surgery; staghorn stone
Perbandingan Algoritma Pengelompokan Non-Hierarki untuk Dataset Dokumen Dyah Herawatie; Eto Wuryanto; Purbandini Purbandini
Seminar Nasional Aplikasi Teknologi Informasi (SNATI) 2014
Publisher : Jurusan Teknik Informatika, Fakultas Teknologi Industri, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan penelitian ini adalah membandingkan beberapa algoritma pengelompokan non-hierarki : K-Means, Bisecting K-Means, K-Median dan K-Medoid untuk data dokumen. Perbandingan dilakukan dengan menggunakan Fmeasure dan akurasi sebagai ukuran kualitas ketepatan hasil pengelompokan. Dalam penelitian ini data yang dipakai untuk eksperimen adalah artikel media masa yang berbahasa Indonesia yang diambil dari website Kompas (www.kompas.com) dan Detik (www.detik.com). Tahapan yang digunakan dalam penelitian ini adalah sebagai berikut : Tahap pertama adalah pengambilan dan pemrosesan data. Sebelum dilakukan pengelompokan data, data dokumen terlebih dahulu harus melalui tahap pra proses, yaitu Detagging, Stopword removal, dan Stemming. Hal ini dimaksudkan agar kata-kata yang digunakan untuk membentuk term-document matrix hanyalah kata-kata khusus yang dapat merepresentasikan dokumen yang ada. Langkah selanjutnya adalah penentuan fitur dan penyusunan term-document matrix. Jumlah fitur yang digunakan untuk pengelompokan dinyatakan dengan persentase dari total fitur. Langkah terakhir : melakukan pengelompokan data set dokumen dengan menggunakan algoritma K-Mean, Bisecting K-Mean, K-Median, dan K-Medoid dengan menggunakan jarak Euclid dan cosinus. Dari hasil eksperimen dapat diambil kesimpulan bahwa algoritma pengelompokan yang memberikan hasil yang terbaik adalah K-Mean. Disamping itu Bi-secting K-Mean juga menghasilkan pengelompokan yang memuaskan. Selain itu jarak cosinus juga memberikan hasil yang paling baik dibandingkan dengan jarak Euclid. Dari hasil ekperimen, hanya dengan menggunakan 10% sampai 30% fitur yang digunakan telah menghasilkan pengelompokan yang memuaskan.
Sistem Pendukung Keputusan Pemilihan Mahasiswa Berprestasi dengan Metode Fuzzy TOPSIS Dyah Herawatie; Eto Wuryanto
Journal of Information Systems Engineering and Business Intelligence Vol. 3 No. 2 (2017): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.165 KB) | DOI: 10.20473/jisebi.3.2.92-100

Abstract

Abstrak—Pemilihan mahasiswa berprestasi adalah kegiatan untuk memilih dan memberikan penghargaan kepada siswa yang mencapai kinerja tinggi dalam kurikuler, ko-kurikuler, maupun ekstrakurikuler. Kegiatan ini dilaksanakan secara berjenjang mulai dari tingkat program studi, departemen, fakultas, perguruan tinggi, hingga di tingkat nasional. Mawapres secara langsung atau tidak langsung dapat mengangkat martabat mahasiswa dan perguruan tingginya. Dalam proses seleksinya melibatkan pertimbangan atau kriteria yang sifatnya crisp : IPK, karya ilmiah, prestasi unggulan dan kemampuan bahasa Inggris. Tetapi dalam kenyataannya kriteria tersebut ada yang bersifat fuzzy, dengan demikian memungkinkan adanya kriteria bersifat campuran antara crisp dan fuzzy sehingga timbul kesulitan dalam melakukan pengurutan. Untuk mengatasi permasalahan yang ada diperlukan sistem pendukung keputusan dengan multi kriteria. Penelitian ini bertujuan untuk merancang dan membangun sistem pengambilan keputusan pemilihan mahasiswa berprestasi di Fakultas Vokasi Universitas Airlangga. Dari aplikasi ini bisa diperoleh hasil perangkingan selain dengan metode standard (sesuai pedoman Dikti), juga ditampilkan hasil perangkingan dengan metode TOPSIS, dan Fuzzy TOPSIS. Dengan beberapa alternatif perangkingan, diharapkan dapat memberi masukan buat pimpinan fakultas sebelum melakukan pengambilan keputusan. Dari 10 kandidat yang mengikuti seleksi pada tahun 2016, menunjukkan bahwa dengan menggunakan ketiga metode memberikan hasil yang berbeda untuk beberapa rangking. Sedangkan beberapa rangking yang lain sama. Terjadinya perbedaan ini disebabkan karena nilai dari beberapa kriteria dari kandidat berdekatan. Adanya perbedaan hasil perangkingan, saat memberikan masukan kepada pimpinan fakultas sebagai dasar pengambilan keputusan.Kata Kunci— Fuzzy TOPSIS, Pemilihan Mahasiswa Vokasi Berprestasi , Sistem Pendukung KeputusanAbstract— Achievement student election is an activity to select and provide awards to students who reached high performance in curricular, co-curricular, and extracurricular. This activity is carried out gradually from the level of the study program, department, faculty, university, up to the national level. Achievement Student election directly or indirectly can raise the dignity of the students and the university. In the process of selection involves crisp consideration or criteria: GPA, scientific work, achievement seeded and English. Actually, there are one or more fuzzy criteria in this case. Since there are many criteria that is a mix between crisp and fuzzy cause difficulty in sorting process so that it becomes an interesting problem. To solve the problem, we need a decision support system with multi-criteria. This research aims to design and build a decision support system in achievement Student election at the Vocational Faculty of Airlangga University. From this application can be obtained the results of rank as an alternative to the standard method (according to the guidelines of Higher Education), also display a resulted rank from both TOPSIS method and Fuzzy TOPSIS. With some alternatives, rank can provide an important information for faculty leaders before making a decision. In 2016, the output of selection to 10 candidates shows that by using the three methods gave different results for some rank. There were differences are due to the value of some of the criteria of the adjacent candidate. The distinction of obtained rank can be a consideration to the faculty leaders in decision making.Keywords— Achievement Student Election, Vocational Faculty of Airlangga University, Fuzzy TOPSIS
Demografi, Respon Terapi dan Survival rate Pasien Kanker Serviks Stadium III-IVA yang Mendapat Kemoterapi Dilanjutkan Radioterapi Yuski Amin; Pungky Mulawardhana; Dyah Erawati
Majalah Obstetri dan Ginekologi Vol. 23 No. 3 (2015): September - Desember 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.506 KB) | DOI: 10.20473/mog.V23I32015.97-105

Abstract

 Tujuan: Mengetahui demografi pasien kanker serviks III-IVa, respon terapi dan survival rate pasien kanker serviks stadium III-IVA yang mendapat kemoterapi dilanjutkan radioterapi di RSUD Dr. Soetomo Surabaya tahun 2011-2013.Bahan dan Metode: Penelitian ini adalah penelitian deskriptif rektrospektif dengan menggunakan rekam medis Poli Onkologi Kandungan dan SMF/Instalasi Radioterapi RSUD Dr.Soetomo. Subyek penelitian adalah pasien kanker serviks III-IVA yang mendapat kemoterapi dilanjutkan radioterapi mulai Januari 2011 sampai Desember 2013. Analisis statistika pada penelitian ini menggunakan analisis deskriptif dan analisis survival meng-gunakan metode Kaplan Meier.Hasil: Selama tahun 2011-2013 didapatkan kunjungan pasien baru kanker serviks III-IVA sebanyak 648 pasien. Jumlah pasien kanker serviks IIIA sebanyak 48 kasus, stadium IIIB sebanyak 594 kasus dan stadium IVA sebanyak 6 kasus. Jumlah pasien kanker serviks III–IVA yang mendapat kemoterapi dilanjutkan radioterapi selama tahun 2011-2013 sebanyak 77 pasien. Pasien kanker serviks stadium IIIA sebanyak 8 pasien, stadium IIIB sebanyak 69 pasien. Tidak ada pasien kanker serviks stadium IVA yang mendapat kemoterapi dilanjutkan radioterapi. Respon terapi komplet sebesar 88,3% dan respon terapi inkomplet sebesar 11,7%. Analisis survival dengan metode Kaplan-Meier didapatkan 2-YSR dan 3-YSR kanker serviks stadium IIIA sebesar 86% dan 34%. Pada stadium IIIB didapatkan 2-YSR dan 3-YSR sebesar 47% dan 25%.Median survival pada semua kelompok pada penelitian ini adalah 25 bulan.Simpulan: Jumlah pasien kanker serviks III-IVA yang mendapat kemoterapi dilanjutkan radioterapi selama tahun 2011-2013 sebanyak 77 pasien. Respon terapi komplet pasca radioterapi sebesar 88,3% dan respon terapi inkomplet sebesar 11,7%. Hasil analisis survival didapatkan 2-YSR dan 3-YSR kanker serviks stadium IIIA sebesar 86% dan 34%. Pada stadium IIIB didapatkan 2-YSR dan 3-YSR sebesar 47% dan 25%. 
Diagnostic value of abdominal CT scan in ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 2017 to December 2018 Ida Bagus Gede Ramayuda; Lies Mardiyana; Dyah Erawati; Indra Yuliati
Majalah Obstetri dan Ginekologi Vol. 29 No. 2 (2021): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I22021.45-52

Abstract

HIGHLIGHTS1. Ovarian tumors diagnostic value has been determined using the tools on contrast-enhanced abdominal CT Scan.2. The tools including primary finding like mass size, septation, solid component, and additional finding such as ascites, peritoneal implants, lymph node enlargement.3. Most tumors were ovarian malignant tumors according to their histopathological results.4. Contrast-enhanced abdominal CT Scan of ovarian tumors evaluated by the tools gave better and more reliable diagnostic value than without using the tools.ABSTRACTObjectives: The purpose of this study was to determine the diagnostic value of contrast-enhanced abdominal CT scan in ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, to provide scientific and clinical benefits.Materials and Methods: Samples were taken retrospectively by contrast-enhanced abdominal CT scan raw data in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 2017 to December 2018. Using inclusion and exclusion criteria, a total of 88 samples were obtained and reviewed blindly by Female Organ Division of Radiology Department, Faculty of Medicine Universitas Airlangga, and by using "tools" (primary and additional findings of modified ovarian tumors malignancy). The data were correlated with histopathological findings and analyzed by statistical tests and the results with and without "tools" were compared.Results: Samples were grouped by age, distributed with a range of 20 years and the group of 41-60 years had the highest age of ovarian tumor samples (46.6%) with 84.1% being ovarian malignant tumors according to their histopathological results. It was dominated by serous, mucinous and endometroid types with sensitivity of 93.3%, specificity of 64.3%, positive predictive value of 93.3% negative predictive value of 69.2%, and accuracy value of 89.8%. More reliable results were obtained by using “tools”.Conclusion: Contrast-enhanced abdominal CT scan of ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, evaluated by “tools” still had a better and more reliable diagnostic value than without tools in determining policy steps in handling ovarian tumors with a note that more in-depth research on pitfalls is needed so it may enrich the characteristic findings in imaging.
Detection of Micronucleus, Nucleoplasmic Bridges, and Nuclear Buds Frequency in Peripheral Blood Lymphocytes of Cancer Patient Post-Radiation Fractionated Teja Kisnanto; Yanti Lusiyanti; Dyah Erawati; Suryadi
Nusantara Science and Technology Proceedings Bioinformatics and Biodiversity Conferences (BBC)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0707

Abstract

Simple measurement of cytogenetic damage would be of great value for studying genetic risk factors, especially in radiotherapy for cancer patients. One cytogenetic technique that is easy and simple to quantify the damage caused by radiation exposure in cultured human lymphocytes is the micronucleus (MN). This research was conducted to study the induction of micronucleus (MN), Nucleoplasmic Bridge (NPB), and Nuclear Buds (NBUDs) in cancer patients after administration of fractionated radiation exposure total of 20 Gy. Peripheral blood lymphocyte samples obtained from eleven cancer patients as the study group and eleven from the healthy people as the control group were assessed. Both samples were then cultured and added cytochalasin-B to arrest cells during the cytokinesis stage. Its characteristics were observed in binucleated cells (BNC) with cytochalasin blocked micronuclei (CBMN) assay procedure. The number of MN, NPB, and NBUDs was evaluated per 1000 BNC for both the study group and control. The results showed that there was a statistically signif- icant difference (P <0.05) between the frequency of MN in the study group (82.18±39.93) compared to controls (13.18±4.94). Besides, the number of NPB and NBUD in the study group is relatively low. In conclusion, the iden- tification of MN formation in peripheral blood lymphocytes of post-radiation cancer patients has other molecular mechanisms such as NPB and NBUD. Also, demographic factors such as age can influence the appearance of MN, NPB, and NBUDs.
Profil Pasien Kanker Paru Primer yang Dirawat Inap dan Rawat Jalan di Rumah Sakit Umum Daerah Dr Soetomo Surabaya : [Profile of Primary Lung Cancer Patients in Dr. Soetomo General Hospital Surabaya] Muhammad Rudy Chairudin; Isnin Anang Marhana; Dyah Erawati
Jurnal Respirasi Vol. 5 No. 3 (2019): September 2019
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.77 KB) | DOI: 10.20473/jr.v5-I.3.2019.65-71

Abstract

Background: Lung cancer is still one of the biggest contributors to cancer deaths. GLOBOCAN in 2012 reported that lung cancer causes 30% of cancer deaths in men and 11.1% in women. Objective: The purpose of this study was to determine the profile of lung cancer in the General Academic Hospital Dr. Soetomo.Method: This research uses a descriptive observasional type by taking one time  through medical record data from 186 primary lung cancer patients in Dr. Soetomo Hospital during January to December 2017. Results: Men (70.4%) more than women (29.6%). The most age group is 51-60 years (35.5%). Men and women suffer the most from adenocarcinoma (78.6% and 87.3%). Most jobs are private employees (38.2%). Most education is high school (70.4%). The most of patients live in East Java (97.3%) and the most specific are in Surabaya (39.2%). Most Histopathology is non-small cell lung cancer (95.9%) with adenocarcinoma is the most common type (81%). Lung cancer with small cell and non small cell type are mostly found in stage IV (82.3%) and extensive stage (3.8%). Local metastases are mostly found in the contralateral lung (58.1%), and most distant metastases in the brain organ (66.7%). The most common complication is pleural effusion (42.5%). Shortness of breath is the most common symptom (59.1%). The most widely used chemotherapy drug is pemetrexed-cisplatin (17.1%). Conclusion: Primary lung cancer patients at Dr. Soetomo Regional Academic Hospital majority of men aged 51-60 years. Most local metastases are in the contralateral lung and distant metastases in the brain. Most complications are pleural effusion.
Pendidikan Agama Islam dalam Tuntunan Syariat Rasulullah SAW Imam Tabroni; Dyah Erawati; Imam Maspiah; Hilma Sa’adatunnisa
Journal of Education and Culture (JEC) Vol. 2 No. 1 (2022): Journal of Education and Culture
Publisher : Indra institute Research & Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.342 KB) | DOI: 10.58707/jec.v2i1.141

Abstract

Islamic education is education that must be instilled as early as possible, even from the time of a mother’s womb. Because basically informal education is the beginning of the development of the child’s character is formed. Children who are happy in family care will bring up good character and are friendly to their environment when he enter the formal and non-formal education environment the will be more dominant and confident. Islamic religious in formal and non-formal schools must be further developed, especially in teaching the character of the personality of students. The problem formulation of this research is how Islamic religious education can be used as a reference in formal and non-formal educational institutions as a way to rediscover the character of students who excel and have good morals according to the guidance of the Prophet SAW. It is intended that Islamic religious education can be used as a benchmark for educational institutional in producing generation of good morals. This education uses the literature review method because in the process of collecting data it takes several book sources as a references. Then used descriptive qualitative to analyze the research that is in the form of a systematic systematic sentence according to the source of the reference.
Co-Authors Arif Maulana, Arif Darlina Yusuf Devita Tetriana DYAH FAUZIAH, DYAH Eto Wuryanto Ferdiansyah Mahyudin Hilma Sa’adatunnisa Ida Bagus Gede Ramayuda Imam Maspiah INDRA YULIATI, INDRA Isnin Anang Marhana Lies Mardiyana, Lies Muhammad Rudy Chairudin Nastiti Rahajeng Pasaribu, Ulinta Purwati Primasari, Mirna PUNGKY MULAWARDHANA, PUNGKY Purbandini Soeparman, Purbandini Ramandita Duta Dewangga Setiawan, Usep Suryadi Tarmono Djojodimedjo Teja Kisnanto Teja Kisnanto Tur Rahardjo wahjoe djatisoesanto Yanti Lusiyanti Yanti Lusiyanti Yuski Amin