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Hubungan antara Ekspresi Hsp 27 dan Hsp 70 Dengan Derajat Diferensiasi dan Angka Ketahanan Hidup Dua Tahun pada Penderita Kanker Endometrium Tipe I Pasca-Pembedahan di RSUD Dr. Soetomo YULIATI, INDRA; ASKANDAR, BRAHMANA; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 9, No 2 (2015): April-Juni 2015
Publisher : "Dharmais" Cancer Center Hospital

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This research was performed to know the relation between Hsp 27 and Hsp 70 expressions with degree of differentiation and two years survival rate in endometrial cancer type I that has undergone surgery in Dr. Soetomo Hospital, Surabaya. Methods: using observational analysis with retrospective Cohort study design to the endometrial cancer type I patients that had undergone surgery in Dr. Soetomo Hospital. As many as 30 subjects were examined, with dependent variable: Hsp 27 and Hsp 70 expressions and Dependent Variable: the type of endometrial cancer differentiation and 2 years survival rate of the endometrial cancer type I patients. In this research, 30 patients with endometrial cancer type I that had undergone surgery were obtained, with well differentiation (grade I) for 20 samples (66.7%), moderate differentiation (grade II) for 3 samples (10%) and poor differentiation (grade III) accounts for 7 samples (23.3%). Positive results for Hsp 27 are 13 samples, while negative Hsp 27 results are 17 samples. From the analysis, correlation coefficient is -0.218 and p value 0.248 (p > 0.05). Samples with positive Hsp 70 results are 19 (63.3%) and negative Hsp 70 results are 11 samples (36.7%), with correlation coefficient -0.099 and p value 0.603 (p > 0.05). Overall survival rate for Hsp 27 is 22.5 months (log rank 0.066), survival rate 1 year for positive Hsp 27 are 100%, and negative Hsp 27 are 88.2%, while in Hsp 70, the overall survival rate is 22.5 months (log rank 0.076), survival rate 1 year for positive Hsp 70 are 100% and negative Hsp 70 are 81.8%. There are no significant relations between Hsp 27 expression with tumor cells differentiation (grade) and the 2 years survival rate of the endometrial cancer type I patients. And also there are no significant relations between Hsp 70 expressions with tumor cells differentiation (grade). 2 years survival rate of the endometrial cancer type I with positive or negative Hsp expressions are not significantly correlated. And there are no significant relations between 2 years survival rate of the endometrial cancer type I with the cells differentiation degree.Keywords: Hsp 27, Hsp 70, differentiation degree, survival rate, endometrial cancer typeI.Â ABSTRAKPenelitian ini dilakukan untuk mengetahui hubungan antara ekspresi Hsp 27 dan Hsp 70 dengan derajat diferensiasi dan angka ketahanan hidup dua tahun pada penderita kanker endometrium tipe I pasca-pembedahan di RSUD Dr. Soetomo, Surabaya. Penelitian ini menggunakan penelitian analitik observasional dengan rancangan studi kohort retrospektif terhadap penderita kanker endometrium tipe 1 yang telah dilakukan pembedahan di RSUD Dr. Soetomo, Surabaya, sebanyak 30 subjek. Sebagai variabel bebas: ekspresi Hsp 27 dan Hsp 70. Variabel tergantung: jenis diferensiasi kanker endometrium dan angka ketahanan hidup 2 tahun penderita kanker endometrium tipe 1. Pada penelitian ini, didapatkan kanker endometrium tipe I yang telah dilakukan pembedahan sebanyak 30 penderita. Didapatkan sediaan dengan diferensiasi baik (grade I ) sebanyak 20 (66,7%), diferensiasi sedang (grade 2) 3 sediaan (10%), dan diferensiasi buruk (grade 3) sebanyak 7 sediaan (23,3%). Dengan ekspresi Hsp 27 positif sebanyak 13 sediaan, sedangkan dengan ekspresi Hsp 27 negatif sebanyak 17 sediaan. Dari hasil analisis didapatkan koefisienkorelasi -0,218 dan p value 0,248 (p>0,05). Sediaan dengan ekspresi Hsp 70 positif sebanyak 19 (63,3%), sedangkan Hsp 70 negatif 11 sediaan (36,7%), dengan koefisien korelasi -0,099 dan p value 0,603 (p > 0,05). Dengan overall survival sebesar 22,5 bulan (log rank 0,066), survival rate 1 tahun untuk Hsp 27 positif sebesar 100% dan Hsp 27 negatif sebesar 88,2%. Sedangkan pada Hsp 70, overall survival 22,5 bulan (log rank 0,076) dan survival rate 1 tahun untuk Hsp 70 positif sebesar 100% dan Hsp 70 negatif sebesar 81,8%. Tidak ada hubungan yang bermakna antara ekspresi Hsp 27 dengan diferensiasi sel tumor (grade) dan angka ketahanan hidup dua tahun penderita kanker endometrium tipe I. Tidak didapatkan hubungan yang bermakna juga antara ekspresi Hsp 70 dengan diferensiasi sel tumor (grade) dan angka ketahanan hidup dua tahun penderita kanker endometrium tipe I dengan ekspresi Hsp 70 positif ataupun negatif. Tidak ada hubungan antara angka ketahanan hidup dua tahun penderita kanker endometrium tipe I dengan derajat diferensiasi sel (grade).Â Kata Kunci: Hsp 27, Hsp 70, derajat diferensiasi, angka ketahanan hidup, kanker endometrium tipe 1.

Ekspresi CD44 (Penanda Sel Punca Kanker) sebagai Faktor Prognostik Kekambuhan pada Kanker Ovarium Tipe Epitel Stadium III MULAWARDHANA, PUNGKY; YULIATI, INDRA; SUDIANA, KETUT
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : Indonesian Journal of Cancer

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Epithelial ovarian cancer is a deadly cancer, cancer recurrence and resistance post surgical staging and chemotherapy are major problems which will eventually occur in most advanced stage ovarian cancer. Recent investigations have unravelled the role of CSC/ Cancer Stem Cell in the cancer recurrence and therapy resistance, CD44 has been reported as a CSC marker in ovarian cancer, investigator wanted to analyse CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Purpose: to analyse the role of CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Metode: Hystorical Cohort, ICH CD44 examination was performed on the pathological ovarian cancer sample which diagnosed with platinum resistant recurrence (study sample) and platinum sensitive recurrence (control sample). CD44 expression was measured, the role as recurrence prognostic factor evaluated, influence of CD44 expression increasetowards earlier recurrence analysed, and the CD44 expression differences between 2 groups based on grade; pathological type; and stadium were measured and analysed. Results: 40 research subjects were involved in the research, with 20 among them were platinum resistant and the other 20 were platinum sensitive. Mean CD44 expression in the platinum resistant group was 36,80+29,54; while in the resistant platinum was 7,05+9,58. There was a significant difference of CD44 expression between 2 groups (p=0,000). There was a strong correlation between CD44 expression with the timing of recurrence (p=0,894). With the cut off of12,5; 85% platinum resistant subject had CD44>12,5; 85% platinum sensitive subject had CD44<12,5; with 85% sensitivity and 85% specificity as a good recurrence prognostic factor. Relative Risk (RR) of CD44 Expression is 5,667, RRof tumor residue post surgical staging is 2,513. Through logistic regression analysis, it was concluded that high expression of CD44 and tumor residue are risk factors for recurrences, patient with CD44 expression of â¥ 12,50 has possibility of earlier recurrence (< 6 months) 48,487 times compared with patient with CD44 expression of < 12,50 and patient with tumor residue of < 1cm has possibility of earlier recurrence 13,013 times compared with patient without macroscopic residue.Conclusion: This research found that CD44 expression can be used as recurrence prognostic factor in stage III epithelial ovarian cancer, CD44 expression was significantly higher in the platinum resistant group, there was negative correlationbetween CD44 expression with the timing of recurrence. CD44 expression as recurrence prognostic factor was not influenced with grade and pathologic type, but influenced by stage. Expression of CD44 and tumor residue post surgical staging are good predictors for recurrence timing.ABSTRAKKanker ovarium tipe epitel adalah suatu kanker yang mematikan. Kekambuhan dan resistansi kanker pasca-surgical staging dan kemoterapi merupakan masalah utama yang akan terjadi pada sebagian besar kanker ovarium stadiumÂ lanjut. Penelitian-penelitian terbaru mengemukakan peran CSC (Cancer Stem Cell) dalam proses kekambuhan dan resistansi terapi. CD44 telah dilaporkan sebagai marker CSC pada kanker ovarium. Peneliti ingin meneliti ekspresi CD44 sebagai faktor prognostik kekambuhan kanker ovarium tipe epitel stadium III. Penelitian ini bertujuan menganalisis peran ekspresi CD44 sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III. Metode yang digunakan dalam penelitian ini adalah hystorical cohort, di mana dilakukan pemeriksaan IHC CD44 pada sampel PA pasien kanker ovarium yang mengalami kekambuhan resistan platinum (sampel studi) dan sensitif platinum (sampel pembanding). Ekspresi CD44 diukur, peran sebagai faktor prognostik kekambuhan dievaluasi, pengaruh peningkatan ekspresi CD44 pada kekambuhan yang lebih dini dianalisis, dan perbedaan ekspresi CD44 dinilai pada 2 kelompok berdasarkan grade, tipe PA, dan stadium. Sebanyak 40 subjek penelitian dengan rincian 20 kelompok resistan platinum dan 20 kelompok sensitif platinum diikutkan dalam penelitian ini. Rerata ekspresi CD44 pada kelompok resistan adalah 36,80+29,54 dan kelompok sensitif platinum 7,05+9,58. Didapatkan perbedaan signifikan ekspresi CD44 di antara dua kelompok (p=0,000). Didapatkan pula hubungan yang kuat antara ekspresi CD44 dengan waktu kekambuhan (p=0,894). Dengan cut off 12,5; 85% sampel resistan platinum memiliki CD44>12,5 dan 85% sampel sensitif platinum memiliki CD44<12,5 dengan sensitivitas 85% dan spesifisitas 85% sebagai faktor prognostik kekambuhan yang baik. Didapatkan RR ekspresi CD44 sebesar 5,667, RR residu tumor pasca-surgical staging sebesar 2,513. Melalui analisis regresi logistik, didapatkan bahwa ekspresi CD44 yang tinggi dan adanya residu merupakan faktor risiko kekambuhan. Penderita dengan ekspresi CD44 â¥ 12,50 berisiko kambuh <6 bulan sebesar 48,487 kali penderita dengan ekspresi CD44 < 12,50; dan penderita dengan residu < 1 cm berisiko kambuh <6 bulan sebesar 13,013 kali penderita tanpa residu makroskopik. Penelitian ini menyimpulkan bahwa ekspresi CD44 dapat dipakai sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III, ekspresi CD44 secara signifikan lebih tinggi pada kelompok resistan platinum, serta ada hubungan negatif antara ekspresi CD44 dengan waktu terjadinya kekambuhan. Ekspresi CD44 sebagai faktor prognostik tidak dipengaruhi oleh grade dan tipe PA, tetapi dipengaruhi oleh stadium kanker. Ekspresi CD44 dan residu tumor pasca-surgical staging merupakan indikator prediktif yang baik untuk kecepatan kekambuhan.

Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model Muninggar, Laili; Widjiati, Widjiati; Yuliati, Indra; Askandar, Brahmana; Hartono, Poedjo
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.

Ovarian Malignant Brenner Tumor Romi Alfianto; Alphania Rahniayu; Indra Yuliati
Majalah Obstetri dan Ginekologi Vol. 26 No. 3 (2018): December
Publisher : Universitas Airlangga

Objectives: To report one malignant Brenner tumor (MBT) case in Dr. Soetomo Hospital, Surabaya, Indonesia, that underwent therapy from August 2016 to August 2017.Case report: A woman aged 62 years underwent total abdominal hysterectomy and bilateral salphingo-oophorectomy surgery with histopathologic results of malignant Brenner Tumor. From immunohistochemical examination the expression of p63 was positive. The patient had been treated with Paclitaxel carboplatin chemotherapy for 5-cycles, with the results of the last post-chemotherapy evaluation showing no recidive mass.Conclusion:There was only one case of malignant ovarian Brenner Tumor in Dr Soetomo Hospital, Surabaya, Indonesia, in 2014- 2016. The diagnosis can only be based on anatomic pathology examination. The specific tumor markers for malignant Brenner tumors have so far not been found.

Diagnostic value of abdominal CT scan in ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 2017 to December 2018 Ida Bagus Gede Ramayuda; Lies Mardiyana; Dyah Erawati; Indra Yuliati
Majalah Obstetri dan Ginekologi Vol. 29 No. 2 (2021): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I22021.45-52

HIGHLIGHTS1. Ovarian tumors diagnostic value has been determined using the tools on contrast-enhanced abdominal CT Scan.2. The tools including primary finding like mass size, septation, solid component, and additional finding such as ascites, peritoneal implants, lymph node enlargement.3. Most tumors were ovarian malignant tumors according to their histopathological results.4. Contrast-enhanced abdominal CT Scan of ovarian tumors evaluated by the tools gave better and more reliable diagnostic value than without using the tools.ABSTRACTObjectives: The purpose of this study was to determine the diagnostic value of contrast-enhanced abdominal CT scan in ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, to provide scientific and clinical benefits.Materials and Methods: Samples were taken retrospectively by contrast-enhanced abdominal CT scan raw data in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 2017 to December 2018. Using inclusion and exclusion criteria, a total of 88 samples were obtained and reviewed blindly by Female Organ Division of Radiology Department, Faculty of Medicine Universitas Airlangga, and by using "tools" (primary and additional findings of modified ovarian tumors malignancy). The data were correlated with histopathological findings and analyzed by statistical tests and the results with and without "tools" were compared.Results: Samples were grouped by age, distributed with a range of 20 years and the group of 41-60 years had the highest age of ovarian tumor samples (46.6%) with 84.1% being ovarian malignant tumors according to their histopathological results. It was dominated by serous, mucinous and endometroid types with sensitivity of 93.3%, specificity of 64.3%, positive predictive value of 93.3% negative predictive value of 69.2%, and accuracy value of 89.8%. More reliable results were obtained by using “tools”.Conclusion: Contrast-enhanced abdominal CT scan of ovarian tumors in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, evaluated by “tools” still had a better and more reliable diagnostic value than without tools in determining policy steps in handling ovarian tumors with a note that more in-depth research on pitfalls is needed so it may enrich the characteristic findings in imaging.

Cervical Cancer Risk Factors Association in Patients at the Gynecologic-Oncology Clinic of Dr. Soetomo Hospital Surabaya Aisyiah Rahmi Putri; Siti Khaerunnisa; Indra Yuliati
Indonesian Journal of Cancer Vol 13, No 4 (2019): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cervical cancer ranks fourth of all cancers in women worldwide and linked to human papillomavirus (HPV) infection. Despite the evidence of methods for cervical cancer prevention, such as pap smear test and HPV vaccination, most of the women remain unscreened and never get HPV vaccination. Most cervical cancer cases are not diagnosed early enough, leading to poor outcomes. This study aims to examine the association of risk factors with cervical cancer incidence in Dr. Soetomo Hospital Surabaya and also records the patients’ knowledge of cervical cancer preventions, history of HPV vaccination, and pap smear screening test.Methods: This is a case-control study. Questionnaires were given to 60 newly diagnosed cervical cancer patients and 60 non-cervical cancer patients at The Gynecologic-Oncology Clinic of Dr. Soetomo Hospital Surabaya in the period of March 2016 until August 2016. The analysis was made using bivariate and multivariate logistic regression analysis.Results: The bivariate logistic regression analysis confirmed that parity more than two times (p=0.001), history of birth control pills consumption more than 10 years (p=0.04), passive smoking (p=0.001) and not knowing that cervical cancer can be prevented (p=0.001) were significantly associated to the incidence of cervical cancer. The multivariate logistic regression analysis confirmed that not knowing that cervical cancer can be prevented (OR=6.85), the history of passive smoking (OR=4.04), parity more than two times (OR=2.89) and history of birth control pills consumption more than 10 years (OR=6.52) were the independent factors that were associated with the cervical cancer incidence.Conclusions: Parity more than two times, history of birth control pills consumption more than 10 years, history of passive smoking, not knowing that cervical cancer can be prevented and never having a pap smear test were the factors associated with cervical cancer incidence.

Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model Laili Muninggar; Widjiati Widjiati; Indra Yuliati; Brahmana Askandar; Poedjo Hartono
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.

Ekspresi CD44 (Penanda Sel Punca Kanker) sebagai Faktor Prognostik Kekambuhan pada Kanker Ovarium Tipe Epitel Stadium III PUNGKY MULAWARDHANA; INDRA YULIATI; KETUT SUDIANA
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Epithelial ovarian cancer is a deadly cancer, cancer recurrence and resistance post surgical staging and chemotherapy are major problems which will eventually occur in most advanced stage ovarian cancer. Recent investigations have unravelled the role of CSC/ Cancer Stem Cell in the cancer recurrence and therapy resistance, CD44 has been reported as a CSC marker in ovarian cancer, investigator wanted to analyse CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Purpose: to analyse the role of CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Metode: Hystorical Cohort, ICH CD44 examination was performed on the pathological ovarian cancer sample which diagnosed with platinum resistant recurrence (study sample) and platinum sensitive recurrence (control sample). CD44 expression was measured, the role as recurrence prognostic factor evaluated, influence of CD44 expression increasetowards earlier recurrence analysed, and the CD44 expression differences between 2 groups based on grade; pathological type; and stadium were measured and analysed. Results: 40 research subjects were involved in the research, with 20 among them were platinum resistant and the other 20 were platinum sensitive. Mean CD44 expression in the platinum resistant group was 36,80+29,54; while in the resistant platinum was 7,05+9,58. There was a significant difference of CD44 expression between 2 groups (p=0,000). There was a strong correlation between CD44 expression with the timing of recurrence (p=0,894). With the cut off of12,5; 85% platinum resistant subject had CD44>12,5; 85% platinum sensitive subject had CD44<12,5; with 85% sensitivity and 85% specificity as a good recurrence prognostic factor. Relative Risk (RR) of CD44 Expression is 5,667, RRof tumor residue post surgical staging is 2,513. Through logistic regression analysis, it was concluded that high expression of CD44 and tumor residue are risk factors for recurrences, patient with CD44 expression of ≥ 12,50 has possibility of earlier recurrence (< 6 months) 48,487 times compared with patient with CD44 expression of < 12,50 and patient with tumor residue of < 1cm has possibility of earlier recurrence 13,013 times compared with patient without macroscopic residue.Conclusion: This research found that CD44 expression can be used as recurrence prognostic factor in stage III epithelial ovarian cancer, CD44 expression was significantly higher in the platinum resistant group, there was negative correlationbetween CD44 expression with the timing of recurrence. CD44 expression as recurrence prognostic factor was not influenced with grade and pathologic type, but influenced by stage. Expression of CD44 and tumor residue post surgical staging are good predictors for recurrence timing.ABSTRAKKanker ovarium tipe epitel adalah suatu kanker yang mematikan. Kekambuhan dan resistansi kanker pasca-surgical staging dan kemoterapi merupakan masalah utama yang akan terjadi pada sebagian besar kanker ovarium stadium lanjut. Penelitian-penelitian terbaru mengemukakan peran CSC (Cancer Stem Cell) dalam proses kekambuhan dan resistansi terapi. CD44 telah dilaporkan sebagai marker CSC pada kanker ovarium. Peneliti ingin meneliti ekspresi CD44 sebagai faktor prognostik kekambuhan kanker ovarium tipe epitel stadium III. Penelitian ini bertujuan menganalisis peran ekspresi CD44 sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III. Metode yang digunakan dalam penelitian ini adalah hystorical cohort, di mana dilakukan pemeriksaan IHC CD44 pada sampel PA pasien kanker ovarium yang mengalami kekambuhan resistan platinum (sampel studi) dan sensitif platinum (sampel pembanding). Ekspresi CD44 diukur, peran sebagai faktor prognostik kekambuhan dievaluasi, pengaruh peningkatan ekspresi CD44 pada kekambuhan yang lebih dini dianalisis, dan perbedaan ekspresi CD44 dinilai pada 2 kelompok berdasarkan grade, tipe PA, dan stadium. Sebanyak 40 subjek penelitian dengan rincian 20 kelompok resistan platinum dan 20 kelompok sensitif platinum diikutkan dalam penelitian ini. Rerata ekspresi CD44 pada kelompok resistan adalah 36,80+29,54 dan kelompok sensitif platinum 7,05+9,58. Didapatkan perbedaan signifikan ekspresi CD44 di antara dua kelompok (p=0,000). Didapatkan pula hubungan yang kuat antara ekspresi CD44 dengan waktu kekambuhan (p=0,894). Dengan cut off 12,5; 85% sampel resistan platinum memiliki CD44>12,5 dan 85% sampel sensitif platinum memiliki CD44<12,5 dengan sensitivitas 85% dan spesifisitas 85% sebagai faktor prognostik kekambuhan yang baik. Didapatkan RR ekspresi CD44 sebesar 5,667, RR residu tumor pasca-surgical staging sebesar 2,513. Melalui analisis regresi logistik, didapatkan bahwa ekspresi CD44 yang tinggi dan adanya residu merupakan faktor risiko kekambuhan. Penderita dengan ekspresi CD44 ≥ 12,50 berisiko kambuh <6 bulan sebesar 48,487 kali penderita dengan ekspresi CD44 < 12,50; dan penderita dengan residu < 1 cm berisiko kambuh <6 bulan sebesar 13,013 kali penderita tanpa residu makroskopik. Penelitian ini menyimpulkan bahwa ekspresi CD44 dapat dipakai sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III, ekspresi CD44 secara signifikan lebih tinggi pada kelompok resistan platinum, serta ada hubungan negatif antara ekspresi CD44 dengan waktu terjadinya kekambuhan. Ekspresi CD44 sebagai faktor prognostik tidak dipengaruhi oleh grade dan tipe PA, tetapi dipengaruhi oleh stadium kanker. Ekspresi CD44 dan residu tumor pasca-surgical staging merupakan indikator prediktif yang baik untuk kecepatan kekambuhan.

Maternal and neonatal outcomes in delivery with diagnosis of antepartum hemorrhage due to placenta previa at a tertiary hospital in Surabaya, Indonesia Sarah Nia Amru; Indra Yuliati; Philia Setiawan
Majalah Obstetri & Ginekologi Vol. 30 No. 3 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I32022.122-127

HIGHLIGHTS 1. To provide effective prevention and management of placenta previa, maternal and neonatal outcomes should be identified.2. Among mothers studied, no maternal mortality was found, but most newborns had prematurity and low birthweight. ABSTRACT Objective: To identify maternal and neonatal outcomes in delivery with diagnosis of antepartum hemorrhage (APH) due to placenta previa. Materials and Methods: This was a descriptive retrospective study with cross-sectional design. Samples were taken using medical records with convenience sampling technique. Deliveries with history of APH due to placenta previa at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, on January 1 until December 31, 2019, were included. Results: In our study, 36 mothers were included. Maternal characteristics included age of 20–35 years in 72.2%, overweight in 50%, referral visits in 69.4%, from out of town (66.7%), bleeding onset at 3rd trimester (97.2%), primigravida (8.3%), nulliparity (13.9%), 69.4% with history of C-section, and 83.3% no hospital readmissions. Maternal outcomes included 100% mothers diagnosed with complete placenta previa and performed C-section. The mothers were mostly (69.4%) diagnosed with placenta accreta spectrum (PAS). There were 36.1% hysterectomy, 33.3% postpartum hemorrhage, 50% blood transfusions, and zero maternal mortality. Neonatal outcomes included prematurity in 80%, low birth weight (LBW) in 51.5%, while 77.1% and 85.7% of newborns had no asphyxia at 1 and 5 minutes, consecutively. Conclusion: All mothers experienced complete placenta previa, and underwent C-section with most of the mothers were diagnosed with PAS. Less than half of them needed hysterectomy intervention because other patients with focal type PAS were planned for conservative surgery. Moreover, they mostly did not have postpartum hemorrhage with half of them needed blood transfusion. There was zero maternal mortality, with most newborns experienced prematurity, LBW but no significant asphyxia.

HUBUNGAN PIJAT BAYI TERHADAP KENAIKAN BERAT BADAN PADA BAYI BERAT LAHIR RENDAH (BBLR) : SYSTEMATIC REVIEW Yustika Ayustira Karim; Martono Tri Utomo; Indra Yuliati
Medika Respati : Jurnal Ilmiah Kesehatan Vol 16, No 4 (2021)
Publisher : Universitas Respati Yogyakarta

Relationship of Infant Massage to Weight Gains in Low Birth Weight Infant (LBWL): Systematic ReviewBackground: weight gain in LBW infants is very important in preventing an increase in mortality, morbidity, disability and long-term impact on infants. Weight gain is associated with tactile stimulation such as massage. Literally, there have been many studies that have proven the association between infant massage intervention and LBW weight gain, so the researchers conducted a systematic review. Objectives: : to identify the relationship between infant massage and weight gain in LBW infants. Methods: This study uses a systematic review with the PICOS framework, namely population, intervention, comparators, outcomes, study design and publication type. The research range is from 2011 to 2021 on English-language ProQuest, PubMed, ScienceDirect and ResearchGate searches using full text inclusion criteria using the keywords infant massage, weight gain, infant low birth weight. Results: these results were then screened using the criteria for the year and type of article to produce 253 literatures. The researcher excluded 214 literatures that were not in accordance with the topic or which could not be accessed by full text so that 39 full text literatures were obtained according to the topic. After 39 literatures were reviewed, there were 4 similar literatures, 3 non-English literature, 8 literatures with subjects other than infant low birth weight, 17 literatures that did not examine the relationship between infant massage and weight gain and 3 articles that discussed more than two intervention groups. Finally, there are four literatures analyzed in this systematic review. Assessment of literature quality using EPHPP found that all literature has been indexed by Scopus and is not a predatory journal. Based on data extraction from the four literatures, it was found that baby massage increased changes in infant weight by 619.06 ± 465.23. Conclusion: there is weight gain in infants who are given massage, changes in body weight in infants using massage interventions are higher than infants without massage interventions, and infant massage is associated with weight gain in low birth weight infants.

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