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All Journal Health Notions Majalah Farmasetika
Gabriella Septiani Nasution
Politeknik Kesehatan Kemenkes
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Sputum Conversion is Faster with Vitamin D Suplementation in Pulmonary TB Patients Nita Andriani Lubis; Gabriella Septiani Nasution
Health Notions Vol 3, No 11 (2019): November
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.267 KB) | DOI: 10.33846/hn31103

Abstract

Pulmonary tuberculosis (TB) is still a problem that must be resolved in Indonesia, especially North Sumatra. The study aims to determine the effect of vitamin D supplementation on the speed of sputum conversion in pulmonary TB patients. Randomized controlled trial study was conducted on 41 pulmonary TB patients according to inclusion criteria. Research subjects were given TB drug (DOTS program) and vitamin D treatment for 2 months. Sputum examination based on smear was carried out microscopically at 2nd week, 4nd week, 6nd week, and 8nd week after treatment. The results showed that all pulmonary TB patients who were given the intervention experienced sputum conversion. Research subjects with AFB +1 occurred the fastest conversion compared to the others. Statistical analysis using chi square obtained significant results (p = 0.0001). Sputum conversion evaluation based on the initial AFB status, there was a significant relationship between the time of sputum conversion with the initial AFB status with a very strong correlation level (r = 0.767). Vitamin D has been shown to have a significant effect on the patient's sputum conversion. Keywords: pulmonary TB; vitamin D; sputum conversion
Uji Antiseptik Sabun Cair Ekstrak Daun Lantana camara L. Terhadap Pertumbuhan Staphylococcus sp. Melia Sari; Adek Chan; Gabriella Septiani Nasution; Dewi Kristiani Mendrofa
Majalah Farmasetika Vol 7, No 3 (2022): Vol. 7, No. 3, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i3.37876

Abstract

Daun saliara (Lantana camara L.) termasuk gulma tahunan berbentuk perdu, berkayu dan berakar tunggang. Daun saliara mengandung senyawa aktif minyak atsiri, flavonoid, alkaloid, tanin, saponin merupakan senyawa yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui ekstrak etanol daun saliara dapat diformulasikan dalam bentuk sediaan sabun cair dan memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Staphylococcus epidermidis. Penelitian ini bersifat eksperimental yaitu ekstrak etanol daun saliara (Lantana camara L.) dengan konsentrasi 3%, 6% dan 9% dan dilakukan uji sifat fisik sediaan dengan uji organoleptis, uji homogenitas, uji pH, uji tinggi busa, uji viskositas dan uji aktivitas antibakteri. Pembuatan sediaan sabun cair ekstrak etanol daun saliara (Lantana camara L.) konsentrasi 3%, 6% dan 9% memenuhi kriteria uji organoleptis bewarna hijau dan tekstur cair, uji homogenitas menunjukkan sediaan homogen, uji pH sabun cair yaitu 8-9, uji tinggi busa yaitu 53-86 mm, uji viskositas 1073-2890 cps dan uji aktivitas antibakteri Staphylococcus aureus dengan konsentrasi 3%, memiliki daya hambat 5 mm, konsentrasi 6% memiliki daya hambat 5,5 mm dan konsentrasi 9% memiliki daya hambat 6 mm. Sedangkan pada uji aktivitas terhadap bakteri Staphylococcus epidermidis dengan konsentrasi 3% memiliki daya hambat 5 mm, konsentrasi 6% memiliki daya hambat 6 mm dan konsentrasi 9% memiliki daya hambat 7 mm. Berdasarkan hasil tersebut dapat disimpulkan bahwa sabun cair ekstrak etanol daun saliara (Lantana camara L.) memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus dan Staphylococcus epidermidis.
Co-Authors Adek Chan Dewi Kristiani Mendrofa Melia Sari Nita Andriani Lubis