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All Journal FIKkeS Jurnal Matematika & Sains The Journal of Pure and Applied Chemistry Research Jurnal Sains Teh dan Kina Molekul: Jurnal Ilmiah Kimia
Didin Mujahidin
Kelompok Keahlian Kimia Bahan Alam, Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology

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Aktifitas Antioksidan dan Inhibitor Tirosinase Beberapa Stilbenoid dari Tumbuhan Moraceae dan Dipterocarpaceae yang Potensial untuk Bahan Kosmetik Didin Mujahidin; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawati
Jurnal Matematika & Sains Vol 13, No 2 (2008)
Publisher : Institut Teknologi Bandung

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Abstract

In a drug discovery program to combat various diseases, many natural chemicals originating from Indonesian tropicalplants including Moraceae and Dipterocarpaceae have been investigated in our laboratory. These family of plants areknown as rich sources of stilbenoid type of compounds which have been shown to have various bioactivities, that arepotentially important in cosmetic bioindustry. In the course of our search for bioactive natural products from plants, wewere interested in the stilbenoid constituents of these plants. Thus, as part of this program, several stilbene derivativeswere successfully isolated from extracts of Morus macroura, a Moraceous plant locally named andalas, includingoxyresveratrol (1), lunularin (2) and new resveratrol dimers, namely andalasin A (3) and andalasin B (4). While,biotransformation of oxyresveratrol (1) using cell suspension culture of Solanum mammosum affordedtrans-oxyresveratrol-4-O-β-D-glucopyranoside (5). Similarly, some resveratrol derivatives have been isolated fromDipterocarpaceous plants, such as Shorea assamica, S. seminis, Vatica umbonata, and Dryobalanops oblongifolia.These species gave, among others, resveratrol (6), resveratrol-12-C-β-glucopyranoside (7), the resveratrol dimers(-)-ε-viniferin (8) and the new compound diptoindonesin A (9), in addition to resveratrol trimers (-)-α-viniferin (10), thenew compounds cis-diptoindonesin B (11) and trans-diptoindonesin B (12). Among these compounds oxyresveratrol (1),andalasin B (4), trans-oxyresveratrol-4-O-β-D-glucopyranoside (5), resveratrol (6), cis-diptoindonesin B (11) andtrans-diptoindonesin B (12) exhibited the most potent antioxidant activity [1,1-diphenyl-2-picrylhydrazil (DPPH)radical-scavenging activity]; moreover, andalasin A (3) have been reported to show a very strong tirosinase inhibitoractivity, thus valuable in cosmetic industry.
Synthesis of Eugenyl Cinnamate from Clove Oil (Syzygium aromaticum) via Bromination-Dehydrobromination Methods Anita Alni; Didin Mujahidin; Shinta Ellisya Fauzia
The Journal of Pure and Applied Chemistry Research Vol 8, No 2 (2019): Edition May-August 2019
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2019.008.02.458

Abstract

Synthesis of bioactive materials based on Indonesian natural products as precursors are potential to achieve a sustainable supply of modern medicines. Eugenyl cinnamate is a crucial building blocks in many bioactive compunds such as hepatoprotective silibinin. This research features simple synthesis of eugenyl cinnamate from eugenol, an essential oil presents as major constituent of clove oil (Syzygium aromaticum). The transformations were carried out via protection of hydroxyl group, bromination, and dehydrobromination reactions of eugenol (1) consecutively. The products of the synthesis were purified by gravity column chromatography and were characterized by FTIR and NMR spectroscopy. Benzylation of eugenol was carried out under basic condition with high yield (94.3%). Characterization by spectroscopic methods showed that eugenyl benzyl ether (2) was formed. Bromination of eugenyl benzyl ether yielded three products, namely: dibromo (3a and 3b), and tri-bromo eugenyl benzyl ether (3c). Compound 3a and 3b were epimers based on intensive NMR analysis (1H, 13C and DEPT). These epimers were separable using simple gravitational colomn chromatography. Bromination of eugenyl acetyl ether (4) yielded the targeted dibromo product (5). Dehydrobromination reaction of compound 5 with cinnamic acid yielded the eugenyl cinnamate (6) with yield of 23.2%. This compound is precursor in the hetero Diels-Alder reaction to form the dioxan unit of Silibinin. 
GAMBARAN PRAKTIK PENCEGAHAN PENULARAN TB PARU DI KELUARGA DI WILAYAH KERJA PUSKESMAS KEDUNGWUNI I KABUPATEN PEKALONGAN Didin Mujahidin
FIKkeS Vol 8, No 2 (2015): JURNAL KEPERAWATAN
Publisher : FIKkeS

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Abstract

Penularan utama TB Paru adalah bakteri yang terdapat dalam droplet yang dikeluarkan penderita sewaktu batuk, bersin, bahkan berbicara, sehingga pada lingkungan populasi yang padat angka kejadian TB Paru menjadi tinggi. Pencegahan TB Paru dapat dilakukan oleh keluarga. Peran dari keluarga sangat penting bagi setiap aspek perawatan kesehatan. Tujuan penelitian untuk mendeskripsikan praktik pencegahan penularan TB Paru di keluarga. Penelitian ini menggunakan metode deskriptif. Sampel penelitian ini adalah kelurga yang di dalamnya terdapat penderita TB Paru di wilayah Puskesmas Kedungwuni I Kabupaten Pekalongan pada bulan Juni 2013 sebanyak 31 keluarga. Alat pengumpulan data menggunakan kuesioner dengan teknik angket. Hasil uji statistik diperoleh kesimpulan sebagian besar (64,5%) kurang dalam melakukan praktik menutup mulut pada waktu batuk dan bersin, sebagian besar (51,6%) kurang dalam melakukan praktik meludah pada tempat khusus yang sudah diberi disinfektan, sebagian besar (51,6%) telah melakukan praktik imunisasi BCG pada bayi, sebagian besar (41,9%) telah melakukan dengan baik praktik mengusahakan sinar matahari dan udara segar masuk ke dalam rumah, sebagian besar (64,5%) kurang dalam melakukan praktik menjemur bantal dan kasur terutama di pagi hari, sebagian besar (67,7%) kurang dalam melakukan praktik memisahkan barang yang digunakan penderita, sebagian besar (58,1%) kurang dalam melakukan praktik pemberian makanan yang bergizi tinggi sebagian besar (74,2%) kurang dalam melakukan praktik pengadaan ventilasi rumah. Petugas kesehatan sebaiknya memberikan penyuluhan secara berulang tentang pencegahan penularan penyakit TB Paru pada penderita TB Paru dan melibatkan anggota keluarga dalam pencegahan penularan TB Paru di dalam keluarga.Kata kunci : Praktik Pencegahan, TB Paru
Time-Kill Assay of 4-Hydroxypanduratin A Isolated from Kaempferia Pandurata Against Foodborne Pathogens Soerya Dewi Marliyana; Didin Mujahidin; Yana M Syah; Yaya Rukayadi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.658 KB) | DOI: 10.20884/1.jm.2017.12.2.363

Abstract

Time–kill assay was performed for 4-hydroxypanduratin A that was isolated from Kaempferia pandurata rizhome against four important foodborne pathogens, namely Bacillus cereus ATCC 21772, Bacillu subtilis ATCC 6633, Staphylococcus aureus ATCC 29737,  and  Proteus mirabilis ATCC 21100. The methods have been investigated in term of Minimum Inhibitory Concentration (MIC) and killing time curve using methods of Clinical and Laboratory Standards Institute (CLSI) guidelines. The results showed that 4-hydroxypanduratin A rapid acting in killing bacteria as follow: B. cereus : 1×MIC for 4 h, P. mirabilis: 4×MIC for 0.5 h, meanwhile  B. subtilis and S. aureus were 1×MIC for 2 h. In conclusion, 4-hydroxypanduratin A showed strong antimicrobial activity against four important foodborne pathogens.
Synthesis of quinine N-oxide and an NMR tutorial in its structure determination Aisyah Aisyah; Nila Berghuis Tamaela; Joko Santoso; Yana Maolana Syah; Didin Mujahidin
Jurnal Penelitian Teh dan Kina Vol 17 No 1 (2014)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v17i1.45

Abstract

Cinchona alkaloids are one of abundant natural chiral pool for organocatalysts. The application of an N-oxide group containing molecule in asymmetric reaction is currently wide developed. The structure of quinine consist two amine groups that could be oxidized to the N-oxide groups at N-1’ of quinoline and at N-1 of quinuclidine moieties. The oxidation reaction took place selectively at quinuclidine moiety by controlling the concentration of oxidizing agents. In this study we showed that N-1-oxide quinine could be occurred chemo­selectively by using a low concentration of ozone thana palladium catalyzed oxidation. The structure of products N1-oxide quinine was elucidated by spectroscopy data including 1H-NMR, 13C-NMR, 2D-NMR, infra-red and mass spectrometry. The developed method is a chemoselectively and eco-friendly method for synthesis N1-oxide quinine.
Synthesis of 1-azabicyclo[3.2.2]nonane from cinchonidine Didin Mujahidin; Hans Martin Rudolf Hoffman
Jurnal Penelitian Teh dan Kina Vol 16 No 2 (2013)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v16i2.89

Abstract

The 1-azabicyclo[3.2.2]nonane is a potent building block which have important bio­logicaly activities including for Alzheimer and ashmatic treatment. The skeleton can be accessed by rearrangement of quinuclidine ring in Cinchona alkaloids. The rearrange­ment established three chiral center at C-2, C-3, and C-6. The rearrangement of qui­nuclidine moiety to azabicyclic[3.2.2]nonana system of mesylated cinchonidine took place by hydrolysis in a mixture of acetone–water (1:1) with 47% yields. The structure determination of the product and its absolute configuration of chiral centers were esta­blished by using spectroscopy data including, 1H NMR, 13C NMR, 1D NOE and HR-MS.
Co-Authors Aisyah Aisyah Anita Alni Euis Holisotan Hakim Hans Martin Rudolf Hoffman Joko Santoso Lia Dewi Juliawati Nila Berghuis Tamaela Shinta Ellisya Fauzia Soerya Dewi Marliyana Yana M Syah Yana Maolana Syah YAYA RUKAYADI