<![CDATA[Pendahuluan: Buah naga super merah (Hylocereus costaricensis) merupakan tanaman herbal namun sekitar 30-35% kulitnya seringkali dibuang sebagai sampah. Kulit buah naga super merah memiliki kandungan polifenol, alkaloid, terponoid, flavonoid, antosianin, dan antibakteri yang lebih tinggi dibandingkan jenis yang lain dan dagingnya. Penyebab kegagalan perawatan saluran akar salah satunya dapat disebabkan oleh bakteri Enterococcus faecalis (gram positif). Enterococcus faecalis adalah penyebab infeksi persisten pasca perawatan saluran akar. Tujuan penelitian ini untuk menganalisis potensi ekstrak etanol kulit buah naga super merah untuk menghambat pertumbuhan bakteri Enterococcus faecalis dalam perawatan saluran akar gigi. Metode: Penelitian ini merupakan penelitian eksperimental secara in vitro dengan hasil dianalisis secara statistik melalui uji one-way ANOVA menggunakan SPSS 2016, dilanjutkan dengan uji post-hoc Tukey untuk menguji kelompok yang paling optimal terhadap 6 kelompok yaitu ekstrak etanol kulit buah naga super merah dengan konsentrasi 120mg/L, 60mg/L, 30mg/L, 15mg/L (kelompok perlakuan), klorheksidin 2% (kontrol positif), dan akuades (kontrol negatif). Masing-masing kelompok dilakukan pengulangan sebanyak 5 kali pada media Mueller Hinton Agar (MHA) yang diaplikasikan menggunakan paper disc 6mm, kemudian dihitung diameter zona hambatnya menggunakan jangka sorong analitik. Hasil: Penelitian ini didapatkan ekstrak etanol kulit buah naga super merah berpotensi menghambat Enterococcus faecalis dengan konsentrasi 120mg/L paling efektif yaitu rerata diameter zona hambat sebesar 8,8mm dibandingkan dengan konsentrasi 60mg/L sebesar 8,62mm, konsentrasi 30mg/L sebesar 7,56mm, konsentrasi 15mg/L sebesar 6,68mm, kontrol positif sebesar 8,71mm, dan kontrol negatif sebesar 0 mm. Terdapat besar daya hambat minimum secara bermakna dengan nilai p=0,001 (p≤0,05) dan berpotensi sebagai cairan irigasi perawatan saluran akar. Simpulan: Ekstrak etanol kulit buah naga super merah berpotensi menghambat bakteri Enterococcus faecalis sebagai cairan irigasi dalam perawatan saluran akar gigi.Kata kunci: Daya hambat, ekstrak Hylocereus costaricensis, Enterococcus faecalis. ABSTRACTIntroduction: Super red dragon fruit (Hylocereus costaricensis) is a widely known natural remedy. However, about 30-35% of its peel of-ten disposed of as waste. Super red dragon fruit peel contains polyphenols, alkaloids, terpenoids, flavonoids, anthocyanins, and antibacterials higher than other red dragon fruits and the pulp. One of the causes of root canal treatment failure is En-terococcus faecalis (gram-positive bacteria). Enterococcus faecalis causes persistent infection after root canal treatment. The purpose of this study was to analyse the potential of the ethanol extract of super red dragon fruit peel to inhibit the growth of Enterococcus faecalis in root canal treatment. Methods: This research was an experimental in-vitro, in which the results were analysed statistically with the one-way ANOVA test using SPSS 2016 software, followed by Tukey post-hoc test to determine the most optimal group amongst six groups: the ethanol extract of super red dragon fruit peel with a concentration of 120 mg/L, 60mg/L, 30mg/L, 15mg/L, respectively (treatment groups); 2% chlorhexidine (positive control group); and distilled water (negative control). Each group was repli-cated five times on Mueller Hinton Agar (MHA) media, which was applied using a 6mm paper disc, then the inhibition zone diameter was measured using an analytic calliper. Results: The ethanol extract of super red dragon fruit peel has the potential to inhibit Enterococcus faecalis, with the most effective concentration of 120mg/L, with the average diameter of the inhibition zone was 8.8mm. The inhibition zone of the concen-tration of 60mg/L was 8.62mm, the concentration of 30mg/L was 7.56mm, the concentration of 15mg/L was 6.68mm, positive control was 8.71mm, and negative control was 0mm. There was a significant minimum inhibitory potential with the p-value=0.001 (p≤0.05); therefore, had the potential as a root canal treatment irrigation solution. Conclusion: Ethanol extract of super red dragon fruit peel has the potential to inhibit Enterococcus faecalis as an irrigation solution in root canal treatment.Keywords: Inhibition, Hylocereus costaricensis extract, Enterococcus faecalis.]]>
