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All Journal Medali Jurnal : Media Dental Intelektual Jurnal Kedokteran Gigi Universitas Padjadjaran Indonesian Journal of Dentistry
Indah Puti Rahmayani Sabirin
Universitas Jenderal Achmad Yani
Dentistry Health Professions Medicine & Pharmacology Public Health

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Hubungan jam tidur kurang optimal terhadap laju alir saliva pada dokter mudaThe relationship of less optimal sleep hour on the salivary flow rate in young doctor Indah Puti Rahmayani Sabirin; Ratih Widyasari; Nanda Denia Astika Putri
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 3 (2020): Desember 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i3.28958

Abstract

Pendahuluan: Saliva merupakan komponen di dalam mulut yang memiliki fungsi yang sangat penting dalam menentukan kondisi lingkungan di dalam rongga mulut. Jam tidur yang kurang optimal dapat memengaruhi irama sirkadian dan tingkat laju alir saliva mengikuti irama sirkadian. Kecepatan laju alir saliva yang tinggi dapat menurunkan risiko terjadinya karies. Penelitian ini bertujuan untuk menganalisispengaruh jam tidur yang kurang optimal terhadap laju alir saliva. Metode: Jenis penelitian ini adalah analitik dengan rancangan penelitian studi cross-sectional. Sampel penelitian ini adalah dokter muda di Rumah Sakit Dustira yang diambil secara total sampling dengan jumlah 55 sampel. Pemeriksaan laju alir saliva diambil menggunakan metode tanpa stimulasi yang diukur dengan stopwatch selama 60 detik. Data laju alir saliva dianalisis secara statistik menggunakan korelasi Spearman. Hasil: Terdapat hubungan antara jam tidur yang kurang optimal terhadap laju alir saliva (p=0,017, r=0,320). Simpulan: Jam tidur yang kurang optimal dapat memengaruhi kecepatan laju alir saliva menjadi lebih tinggi.Kata kunci : Irama sirkadian, jam tidur kurang optimal, laju alir saliva, saliva. ABSTRACTIntroduction: Saliva is a component in the oral cavity with a vital function in determining the environmental conditions. Less optimal sleep hours can affect the circadian rhythms and the salivary flow rates along with the circadian rhythms. High salivary flow rate can reduce the risk of caries. This study was aimed to analyse the effect of less optimal sleep hour on the salivary flow rate. Methods: This research was an analytic study with a cross-sectional study design. This study’s sample was young doctors at Dustira Hospital who were taken by total sampling, which obtained 55 samples. The salivary flow rate examination was taken using the non-stimulation method measured by a stopwatch for 60 seconds. The salivary flow rate data were statistically analysed using the Spearman correlation. Results: There was a relationship between less optimal sleep hour and the salivary flow rate (p=0.017; r=0.320). Conclusion: Less optimal sleep hour can increase the salivary flow rate.Keywords: Circadian rhythm, less optimal sleep hour, salivary flow rate, saliva.
Case report: drug-induced melanosis in 21-year-old woman treated by gingival depigmentation Indah Puti Rahmayani Sabirin; Zalfa Puspa Fakhira
Jurnal Medali Vol 5, No 1 (2023): Media Dental Intelektual March 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.5.1.49-53

Abstract

Background: Oral pigmentation can be caused by long-term consumption, smoking or physiology. Drug induced melanosis is one of the oral pigmentation caused by long-term medication use. Changes in the color of the oral mucosa can be and provide local or systemic diagnostics, it is necessary to carry out a significant examination and findings from the patient properly.Case Report: The method used is a case report with primary data analysis obtained through anamnesis, as well as intra-oral examinationConclusion: The diagnosis of patients with drug induced melanosis with clinical features found in the gingiva of the maxillary and mandibular anterior teeth, this is because the patient has a history of bronchitis and has been taking antibiotics for a long time. To overcome this pigmentation, the patient underwent OHI and gingival depigmentation treatment and the results showed reduced gingival pigmentation after 1 month postoperatively.
In Vitro Evaluation of NIH/3T3 Fibroblast Cell Viability After Treatment with Reundeu (Staurogyne Elongata) Leaf Extract Fifi Hafizhatul Nuraini; Indah Puti Rahmayani Sabirin; Rhabiah El Fithriyah; Euis Reni Yuslianti
Indonesian Journal of Dentistry Vol 6, No 2 (2026): August 2026
Publisher : Faculty of Dentistry Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v6i2.21000

Abstract

Background: Reundeu (Staurogyne elongata) is a plant traditionally used as food and medicine, especially in the Java region. It contains bioactive compounds that have the ability to improve health. Therefore, it may show potential for formulation into standardized herbal medicine.Objective: The aim of this study was to determine whether an ethanolic extract of reundeu (Staurogyne elongata) leaves exhibits a cytotoxic effect on NIH/3T3 fibroblast cells using a WST-8 assay.Method: In this in vitro laboratory examination, the NIH/3T3 cell line, cultured in 96-well plates, was treated with reundeu leaves ethanolic extract at 3.125%, 1.56%, 0.78%, 0.39%, and 0.19% concentrations, with DMEM and a cell-control as controls. Cell viability was assessed using the WST-8 assay and measured at 490 nm using a spectrophotometer. Data were analyzed using one-way ANOVA to assess differences among groups, followed by Tukey's post-hoc test for multiple pairwise comparisons.Outcome: The ethanolic extract at 3.125% concentration had mild toxicity to NIH/3T3 cells, but other concentrations showed high viability. One-way ANOVA demonstrated a significant effect of reundeu leaf extract concentration on NIH/3T3 cell viability (p < 0.05). Tukey's post-hoc analysis showed significant differences (p < 0.05) between the 3.13%, 1.56%, and 0.19% groups and other concentration groups.Conclusion: The study showed that reundeu leaf ethanolic extract can be considered safe but mildly cytotoxic to fibroblasts at a concentration of 3.125%.
Co-Authors Euis Reni Yuslianti, Euis Fifi Hafizhatul Nuraini Nanda Denia Astika Putri Ratih Widyasari Rhabiah El Fithriyah Zalfa Puspa Fakhira