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All Journal VALENSI Jurnal Penelitian Hasil Hutan ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Penelitian Hasil Hutan Helium: Journal of Science and Applied Chemistry

Ani Iryani

Universitas Pakuan

Author-ID : 2590131

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Energy Environmental Science Materials Science & Nanotechnology

Published : 14 Documents Claim Missing Document

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Articles

Title

STUDY OF REACTION KINETICS AND IDENTIFICATION OF CLOTRIMAZOLE DEGRADATION COMPOUNDS IN ANTI-FUNGAL CREAM PREPARATIONS Cellia Christiana Batubara; Ani Iryani; Linda Jati Kusumawardani
Helium: Journal of Science and Applied Chemistry Vol 1, No 2 (2021): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Fungal infections of the skin can be treated with antifungal compounds, one of which is clotrimazole. Under certain conditions, clotrimazole can be degraded to imidazole and (o-chlorophenyl) diphenyl methanol which can cause skin irritation. This is because the storage conditions of the drug product during or after use if it is not suitable, can interfere with the stability of the drug product. Therefore, this study was conducted to obtain information regarding changes in clotrimazole levels, reaction order, reaction constant value, half-life, activation energy, and the possibility of compounds formed after the clotrimazole degradation process to determine the good storage conditions of the product. Clotrimazole levels were tested in the open and closed state of the packaging every day at different storage temperatures for three months. Changes in clotrimazole levels were measured using HPLC every week. In addition, the identification of compounds resulting from degradation was also tested using HPLC every month and continued using LC-MS/MS in the last week. The results of the analysis of clotrimazole levels, there was a decrease in levels but still in accordance with the specifications required by the Indonesian Pharmacopoeia. The greatest decrease in levels occurred in samples stored at a temperature of 40±2oC which reached 9133%. The decrease in clotrimazole levels followed a first-order reaction with the shortest half-life of 90 weeks and activation energy of 18.9 kJ/mol. Identification of the degraded compounds using HPLC and LC-MS/MS found imidazole compounds and (o-chlorophenyl) diphenyl methanol in samples stored at 25±2oC and 40±2oC. These compounds can cause skin irritation, but these compounds may not have a serious impact because they have a fairly large body threshold value of 220 mg/kg. This shows that clotrimazole cream stored at various temperatures, both at 5±2oC, 25±2oC, and 40±2oC can still be used for three months after the packaging is opened according to the in-use shelf life.

Characterization of Batik Industrial Wastewater in Bogor City Siti Kholisoh; Intan Wulandari; Ani Iryani; Sutanto Sutanto; Siti Warnasih
Helium: Journal of Science and Applied Chemistry Vol 2, No 1 (2022): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Wastewater from the batik industry in Bogor City is the most waste produced from the dyeing process. The batik industry produces waste with concentrated color due to the high concentration of color content from the dyeing process. This affects water bodies as a direct disposal site for waste. Batik waste also has the potential to contain heavy metal compounds derived from the composition of dyes. This will have an impact on the disruption of the balance in the environment around the industry. Therefore, it is necessary to characterize batik wastewater to determine the pollutant content. This research aims to characterize the batik industry wastewater in the city of Bogor by measuring the levels of COD, BOD, TSS, pH, temperature, total chromium content, total phenol content, and sulfide content according to the parameters P.16/MENLKH/SETJEN /KUM.1/4/2019. The results showed the characteristics of the wastewater from the batik industry in Bogor City with levels of COD in dyeing waste at 797 mg/L and total waste at 52463 mg/L, BOD levels in dyeing waste at 431 mg/L, and total waste at 238 mg/L. TSS in the dyeing waste is 706.5 mg/L and the total waste is 3679 mg/L, the temperature in the dyeing waste is 26.9 °C and the total waste is 26.3°C, pH in staining waste at 1.62 and total waste at 6.82; the total chromium content in the staining waste was 2.62 mg/L and the total waste was 940.2 mg/L, the total phenol content and sulfide content in the dyeing waste and total waste was not detected. The characteristics of batik waste are not by the established quality standards, so there is a need for processing before the waste is discharged into the environment.

Chicken Bone Based Adsorbent for Adsorption of Pb(II), Cd(II), and Hg(II) Metals Ion Liquid Waste Uswatun Hasanah; Ani Iryani; Agus Taufiq; Dimas Apryandi Darma Putra
Helium: Journal of Science and Applied Chemistry Vol 1, No 1 (2021): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

High productivity of chicken meat for supplying society also make some impact in high productivity of chicken bone and because itâ€™s unraveling properties makes this become waste. Pharmaceuticalâ€™s Waste comes from production process, adstertion of production tools, laboratory activities and rejected product. Laboratoryâ€™s routine analysis also producing residual waste analysis, one of the source is come from heavy metals analysis of Pb, Cd, dan Hg. General process for waste treatment producing high quantity of sludge, mean while using third party service have impact in high costing of transportation and treatment process. An alternatif way for this case is using sorption treatment. Initial research starts from preparation of chicken bone-based adsorbent and its characterization using SEM and FTIR, followed by quality analysis of fresh waste (which is waste A and waste B) observed at pH, COD, TDS, TSS also Pb, Cd, dan Hg metals. Adsorption process was observed from adsorbentâ€™s graying temperature, adsorbentâ€™s particle size, contact time, pH of waste, and adsorbentâ€™s weight. Best result from adsorption process were applicated at fresh waste and simulation waste of Pb, Cd, and Hg metals also re-testing quality analysis of fresh waste and simulation waste for before-after result comparing purpose. The purpose of this research is for characterizing chicken bone-based adsorbent, observing adsorption process of Â Characterization of chicken bone ash based adsorbent has been carried out in adsorbing Pb, Cd, and Hg metals in pharmaceutical laboratory waste. Functional group analysis with Fourier Transform Infrared Spectrophotometer (FTIR) showed that the chicken bone ash adsorbent contained the mineral compound apatite carbonate. Surface morphology with a Scanning Electron Microscope (SEM) shows that the adsorbent surface is porous and appears to be adsorbing metals. From the adsorption observations, it was found that the best adsorption conditions were at an ashing temperature of 800 oC, particle size of 80 mesh, contact time of 30 minutes, waste conditions at pH 6 and an adsorbent weight of 600 mg. Application chicken bone-based adsorbent against pharmaceutical waste shows its existence improve the quality of waste but still do not meet the quality standard requirements for Hg metal.

Effectiveness Hydroxyapatite from Chicken Eggshells for Adsorption of Chromium (VI) Metal Ion Electroplating Waste Afifah Nur Ismawati; Ani Iryani; Linda Jati Kusumawadani
Helium: Journal of Science and Applied Chemistry Vol 3, No 1 (2023): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v3i1.7929

The largest source of waste comes from household activities. One of the wastes that comes from household activities is chicken eggshells waste. Chicken eggshells contain 94% CaCO3 and can be used as a source of calcium to synthesize hydroxyapatite (Ca10(PO4)6(OH)2) by the precipitation method. Hydroxyapatite can be used as an adsorbent material because it has pores, inert, and wear-resistant so it can adsorb dissolved metal ions Cr (VI) contained in liquid waste from electroplating process. This research aims to synthesize hydroxyapatite from chicken eggshells and determine the optimum pH, contact time, adsorbent mass, and initial concentration of waste which influence the adsorption efficiency using continuous system column adsorption method with fixed flow rate 25 mL/min. In this study, the metal ions Cr (VI) was chosen as adsorbate because Cr (VI) is the main component in electroplating process. This research started from preparation of chicken eggshells waste then synthesized into hydroxyapatite and characterized using XRD, FTIR, and SEM that known structure formed adsorbent is hydroxyapatite and measuring the initial Cr (VI) concentration in waste using AAS with wavelength 357,9 nm. The result of optimizing are the optimum pH 5, contact time of 60 minutes, 3,5 gram of adsorbent mass, and the initial concentration of waste is 10 ppm. The analyzed were done for Cr (VI) concentration. The result showed 99,48% adsorption efficiency with final concentration of Cr (VI) is 0,07 ppm. The adsorption process followed the Freundlich isotherm model with maximum adsorption capacity of 3,93 mg/g hydroxyapatite.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v1i1.2949

High productivity of chicken meat for supplying society also make some impact in high productivity of chicken bone and because its unraveling properties makes this become waste. Pharmaceuticals Waste comes from production process, adstertion of production tools, laboratory activities and rejected product. Laboratorys routine analysis also producing residual waste analysis, one of the source is come from heavy metals analysis of Pb, Cd, dan Hg. General process for waste treatment producing high quantity of sludge, mean while using third party service have impact in high costing of transportation and treatment process. An alternatif way for this case is using sorption treatment. Initial research starts from preparation of chicken bone-based adsorbent and its characterization using SEM and FTIR, followed by quality analysis of fresh waste (which is waste A and waste B) observed at pH, COD, TDS, TSS also Pb, Cd, dan Hg metals. Adsorption process was observed from adsorbents graying temperature, adsorbents particle size, contact time, pH of waste, and adsorbents weight. Best result from adsorption process were applicated at fresh waste and simulation waste of Pb, Cd, and Hg metals also re-testing quality analysis of fresh waste and simulation waste for before-after result comparing purpose. The purpose of this research is for characterizing chicken bone-based adsorbent, observing adsorption process of Â Characterization of chicken bone ash based adsorbent has been carried out in adsorbing Pb, Cd, and Hg metals in pharmaceutical laboratory waste. Functional group analysis with Fourier Transform Infrared Spectrophotometer (FTIR) showed that the chicken bone ash adsorbent contained the mineral compound apatite carbonate. Surface morphology with a Scanning Electron Microscope (SEM) shows that the adsorbent surface is porous and appears to be adsorbing metals. From the adsorption observations, it was found that the best adsorption conditions were at an ashing temperature of 800 oC, particle size of 80 mesh, contact time of 30 minutes, waste conditions at pH 6 and an adsorbent weight of 600 mg. Application chicken bone-based adsorbent against pharmaceutical waste shows its existence improve the quality of waste but still do not meet the quality standard requirements for Hg metal.

Study of Reaction Kinetics and Identification of Clotrimazole Degradation Compounds in Anti-Fungal Cream Preparations Cellia Christiana Batubara; Ani Iryani; Linda Jati Kusumawardani
Helium: Journal of Science and Applied Chemistry Vol 1, No 2 (2021): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v1i2.4540

Fungal infections of the skin can be treated with antifungal compounds, one of which is clotrimazole. Under certain conditions, clotrimazole can be degraded to imidazole and (o-chlorophenyl) diphenyl methanol which can cause skin irritation. This is because the storage conditions of the drug product during or after use if it is not suitable, can interfere with the stability of the drug product. Therefore, this study was conducted to obtain information regarding changes in clotrimazole levels, reaction order, reaction constant value, half-life, activation energy, and the possibility of compounds formed after the clotrimazole degradation process to determine the good storage conditions of the product. Clotrimazole levels were tested in the open and closed state of the packaging every day at different storage temperatures for three months. Changes in clotrimazole levels were measured using HPLC every week. In addition, the identification of compounds resulting from degradation was also tested using HPLC every month and continued using LC-MS/MS in the last week. The results of the analysis of clotrimazole levels, there was a decrease in levels but still in accordance with the specifications required by the Indonesian Pharmacopoeia. The greatest decrease in levels occurred in samples stored at a temperature of 40Â±2oC which reached 9133%. The decrease in clotrimazole levels followed a first-order reaction with the shortest half-life of 90 weeks and activation energy of 18.9 kJ/mol. Identification of the degraded compounds using HPLC and LC-MS/MS found imidazole compounds and (o-chlorophenyl) diphenyl methanol in samples stored at 25Â±2oC and 40Â±2oC. These compounds can cause skin irritation, but these compounds may not have a serious impact because they have a fairly large body threshold value of 220 mg/kg. This shows that clotrimazole cream stored at various temperatures, both at 5Â±2oC, 25Â±2oC, and 40Â±2oC can still be used for three months after the packaging is opened according to the in-use shelf life.

Comparison of Analysis Results pf pH, TSS, COD and Ammonia in Industry Wastewater with Sparing and SNI Methods Dessy Nur Indryastuti; Ani Iryani; Muhammad Fathurrahman
Helium: Journal of Science and Applied Chemistry Vol 2, No 2 (2022): Helium: Journal of Science and Applied Chemistry
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v2i2.6342

Sparing is a development of sensor technology to monitoring wastewater quality continuously and online, so it can be done in real time. Wastewater quality monitoring carried out in the laboratory using the SNI method still has several drawbacks, including large analysis costs, long analysis time and the use of chemicals that are not environmentally friendly. This study aims to determine the differences in the results of the analysis of the Sparing method with SNI on the parameters of pH, TSS, COD, and ammonia in the EWTP wastewater of PT "X" using statistical processing through the F-test and T-test. The research stages include sampling, sample storage and analysis in the laboratory. Based on the results of the study, it can be concluded that the differences in the method of Sparing analysis and SNI are not significantly different to the pH parameters in the measurement range 6.77 - 6.88; TSS in the measurement range 9.486 - 12.343 mg/L; COD in the measurement range of 55.402 - 59.274 mg/L and ammonia in the measurement range of 0.368 - 0.405 mg/L. This proves that the Sparing method can replace the SNI method for routinely monitoring the quality of EWTP wastewater of PT "X".

Co-Authors Afifah Nur Ismawati Agus Taufiq Angelica Paramasari Cellia Christiana Batubara Dessy Nur Indryastuti Diana Widiastuti Dimas Apryandi Darma Putra Djoko Hartanto Esya Juniar Hadi Nur Hery Widijanto Intan Wulandari Linda Jati Kusumawadani Linda Jati Kusumawardani Lisna Efiyanti Mardi Santoso Muhammad Fathurrahman Muhammad Fathurrahman Nela Rahmatisari Novitri Hastuti Poedji Hastuti Sherin Nurhafidza Ahmad Shinta Safitri Siti Kholisoh Siti Warnasih Sutanto Sutanto Usep Suhendar Uswatun Hasanah Yulian Syahputri

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