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All Journal Jurnal Ilmiah Farmasi AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdi Masyarakat Kita
Aulia Nurfazri Istiqomah
Universitas Bhakti Kencana
Medicine & Pharmacology Public Health

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Acute toxicity test ethanol extract of kerehau leaf (Callicarpa longifolia Lamk) using OECD 420 method Aulia Nurfazri Istiqomah; Shintya Safitri; Elis Susilawati
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art2

Abstract

AbstractBackground: Kerehau is empirically used as cooling powder to treat acne. Based on previous research, kerehau leaves have a number of activities, including wound healing, antidiabetic, and anti-inflammatory.Objectives: This study aimed to determine the safety level of a single dose of ethanol extract of kerehau leaves within a 24-hour administration period.Methods: Acute toxicity testing of ethanol extract of kerehau leaves was carried out on female Webster mice. Test animals were divided into 4 treatment groups, consisting of 1 control group and 3 test groups. The testing method referred to OECD (Organization of Economic Cooperation and Development) 420 with modified doses of 2000mg/kgBW, 5000 mg/kgBW, and 8000 mg/kgBW. The observations were made on the behaviour of animals towards toxicity symptoms for 4 hours after administration of the test substance as well as death. The death and weight gain were observed for 14 days. On the 15th day, animals were sacrificed, blood was taken, and biochemical parameters were measured. The heart, kidneys, liver, spleen, and lungs were harvested and weighed. Data was analysed using Oneway ANOVA continued with LSD and Post Hoc.Results: The results showed that ethanol extract of kerehau leaves did not cause death in all of the groups. There were significant differences in liver weight, SGPT, and SGOT levels (p< 0.05) at the dose of 5000 mg/kgBW. No toxicity symptoms and death were found until the end of the experiment.Conclusion: LD50 value of ethanol extract of kerehau leaves was above 8000 mg/kgBW with heart as the most affected organ.Keywords: Ethanol extract of kerehau leaves, acute toxicity test, OECD 420.Latar Belakang : Beragam  khasiat yang dimiliki daun kerehau menjadi dasar dilakukannya uji toksisitas akut untuk mengetahui adanya potensi toksik dan organ sasaran yang dipengaruhi.Metode : Metode pengujian toksisitas akut diadaptasi dari OECD 420 dengan dosis 2000 mg/kgbb, 5000 mg/kgbb dan 8000mg/kgbb. Pengamatan dilakukan  terhadap gejala toksik yang muncul, kematian dan berat badan. Pada hari ke-15 dilakukan pengukuran SGPT, SGOT , kreatinin dalam darah, indeks organ jantung, ginjal, hati, limpa dan paru-paru serta histopatologi organ hati dan ginjal.Hasil : Hasil penelitian menunjukkan ekstrak etanol daun kerehau mempengaruhi organ hati secara bermakna namun tidak menyebabkan kematian hingga dosis 8000mg/kgbb.Kata kunci : Ekstrak etanol, daun kerehau, toksisitas akut, OECD 420.
MEDICAL CHECK-UP (MCU) MINI MOBILE DI RW 01 DESA MAJASETRA KECAMATAN MAJALAYA KABUPATEN BANDUNG Aulia Nurfazri Istiqomah; Elis Susilawati; Wempi Budiana; Yani Mulyani
AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Vol. 4 No. 1 (2020): Amaliah: Jurnal Pengabdian Kepada Masyarakat
Publisher : LP2M UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v4i1.377

Abstract

Sindrom metabolik juga dikenal sebagai sindrom resistensi insulin. Prevalensi sindrom metabolisme secara global terus meningkat. Ada beberapa indikasi terkait sindrom metabolic yang patut diwaspadai. di antaranya adalah lingkar pinggang yang melebihi batas normal, tingginya tekanan darah, kadar trigliserida dalam darah, kadar glukosa dalam darah, dan rendahnya kadar HDL. Resiko terjadinya sindrom metabolik dipengaruhi oleh gaya hidup, stress yang berkepanjangan dan faktor genetic. Berdasarkan informasi yang diperoleh, kesadaran warga di Kp. Pangkalan RW.01 Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung akan kesehatan dan pola hidup sehat masih perlu ditingkatkan, oleh karena itu dilaksanakan Medical cek up (MCU) Mini Mobile untuk memberikan informasi terkait gejala sindrom metabolisme dan meningkatkan kesadaran masyarakat akan pentingnya pola hidup sehat.
Rehabilitasi Pasca Covid-19 Menjadi Kunci Untuk Meningkatkan Kesehatan Pada Masyarakat Sekar Wulan Apriliasari; Raihany Sholihatul; Ida Lisni; Aulia Nurfazri Istiqomah; Wahyu Wahdana
Jurnal Abdi Masyarakat Kita Vol 2 No 1 (2022): Jurnal Abdi Masyarakat Kita
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1827.656 KB) | DOI: 10.33759/asta.v2i1.197

Abstract

The pandemic due to Covid-19 can cause problems in Indonesia, especially on health problems that are mostly experienced by people who located in the Sukarindik Village area, Tasikmalaya City. Therefore, in order to solve the problem that occurred in Sukarindik Village, Tasikmalaya, carried out the 2021 Thematic PPM KKN activity program through post-Covid-19 physical rehabilitation measures in the form of breathing exercises, relaxation, exercise, exercise and jogging. The implementation of these activities is carried out online with the method of implementing webinar activities using the Zoom application. The results showed that the people of Sukarindik Village would carry out regular exercise every week to maintain physical fitness, improve heart and lung function. In conclusion, education related to post-covid-19 physical rehabilitation for the community is important. Because it can accelerate the healing of symptoms exposed to COVID-19, improve the quality of daily activities and improve health in the Sukarndik Village Community.
Co-Authors Ida Lisni Raihany Sholihatul Sekar Wulan Apriliasari Shintya Safitri Susilawati, Elis Wahyu Wahdana Wempi Budiana Yani Mulyani