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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ANNALES BOGORIENSES Jurnal Ilmiah Kesehatan Holistik Jurnal Kesehatan Jurnal Kesehatan Edu Masda Journal Medical Sains : Jurnal Ilmiah Kefarmasian Parapemikir Jurnal Ilmiah Farmasi Jurnal Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian
Nur Hasanah
Program Studi D3 Farmasi, STIKes Widya Dharma Husada Tangerang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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Journal : annales bogorienses

 1 
Potency of Curcuma aeruginosa as A Chemopreventive Candidate Agent on 7,12-Dimethylbenz[a]anthracene (DMBA)-Induced Rat Spleen Asri Sulfianti; Nur Hasanah; Agung Eru Wibowo; Kurnia Agustini; I Made Artika
ANNALES BOGORIENSES Vol 23, No 2 (2019): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.676 KB) | DOI: 10.14203/ann.bogor.2019.v23.n2.58-65

Abstract

Present investigation shows that the extract of C. aeruginosa attenuates DMBA-induced spleen carcinogenesis in Wistar rats. Three-week female Wistar rats were treated with three different C. aeruginosa extract doses (CA1: 40 mg/200 g body weight, BW; CA2: 80 mg/200 g BW; CA3: 160 mg/200 g BW) and were induced with DMBA after one-week administration of these doses. A commercial immunostimulant, and DMBA only were also given to each group as positive and negative control, respectively. The development of tumors was evaluated by investigating the incidence of tumor and tumor multiplicity during the experiment. Spleen mass index and histological parameters such as white pulp, centrum germinativum, and marginalis zone were also examined. Based on our study, the administration of C. aeruginosa extract during and after carcinogen induction gave several impacts on rat carcinogenesis. At the extract dose of 80 mg/200 g BW, tumor incidence of animals were least (P<0.05). However, all doses did not show any effect to the spleen mass index, though the highest dose (160 mg/200 g BW) was found to cause changes in white pulp and marginalis zone boards. This trend indicates that it takes higher dose to cause an immune response effect reaching the organs.
Co-Authors Agung Dewantoro Agung Eru Wibowo Ananda Eka Safitri Anggraini Karditiawati Asri Sulfianti Billy Arnanda Dede Anggraeni Diah Permata Sari Dony Mahendra Fadly Putajaya Fadly Putajaya Fajar Tri Kuncoroyekti Febrial Hikmah Fenita Purnama Sari Indah Fera Prasisca I MADE ARTIKA Ika Yulianti Kurnia Agustini Lela Kania Melda Yunisa Nanda Nurul Aini Nanda Nurul Aini Novian, Dede Rival Novita Rahmadhani Nur Wulan Adi Ismaya Nurwulan Adi Ismaya Oktavendriyastuti Tabrani Puji, Lela Kania Rahsa Sheila Meitania Utami Siti Novy Romlah Vini Irnia