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All Journal Nexus Kedokteran Translasional Health and Medical Journal Cermin Dunia Kedokteran
Annisa Marsha Evanti
Faculty of Medicine,Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efek Diuresis Ekstrak Seledri (Apium graviolens L.) pada Tikus Putih Jantan (Rattus norvegicus) Evanti, Annisa Marsha; Doewes, Muchsin; Murti, Bhisma
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background: Celery (Apium graviolens L.) is known has some biochemical substances effect such as kalium nitrat, manitol, and apigenin/flavonoid which can result diuretic effect. This research aims at finding out the diuretic effect of celery extract (Apium graviolens L.) on the male white rats (Rattus norvegicus). Methods: The research is a laboratory experimental analytic study using the Randomized Controlled Trial design. The research subject is a number of 30 male white rats of Wistar Strain, 200 grams of body weight. They were divided into five treatment groups randomly. Group I was given 3 mL aquadest as negative control, group II was given 0,32 mg/3 mL hydrochlorotiazid as positive control, group III was given 1,2g/3 mL celery extract as dose I, group IV was given 2,4g/3 mL celery extract as dose II, and group V was given 4,8g/3 mL celery extract as dose III. Rats urine volume was measured every 4 hours for 16 hours. Results:The result of statistic calculation using ANOVA test with p = 0.000 (p < 0.001) shows that there are significant differences in total rats urine volume between group I, II, III, IV, and V in every observation time. The Post-hoc test shows significant differences between negative control and three dosages of celery extract (p < 0.05), and the similarities between positive control and three dosages of celery extract (p > 0.05). Conclusions: Through observing amount of urine volume and statistic calculation, it can be concluded that there is diuretic effect of celery extract on the male white rats. Celery extract at dose 2,4 g/3 mL has the highest diuretic effect but celery extract at 1,2 g/3 mL has the optimum diuretic effect. Keywords: Celery extract, diuretic effect, hydrochlorotiazid
Korelasi Kadar Vitamin D Serum dan Derajat Keparahan Psoriasis Vulgaris Berdasarkan Skor PASI dan DLQI Pramudita, Adelia Wuri; Mulianto, Nur M Rachmat; Evanti, Annisa Marsha; Widyastuti, Zilpa; Asaduddin, Aiman Hilmi
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1476

Abstract

Latar Belakang: Derajat keparahan psoriasis vulgaris ditentukan berdasarkan skor Psoriasis Area and Severity Index (PASI) dan Dermatology Life Quality Index (DLQI). Perjalanan psoriasis dapat dipengaruhi oleh abnormalitas sistem imun, kerentanan genetik, lingkungan dan gaya hidup. Vitamin D juga diduga berperan pada perjalanan berbagai penyakit autoimun termasuk psoriasis. Tujuan: Untuk mengetahui korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan skor  PASI dan DLQI. Metode: Penelitian ini merupakan penelitian analitik eksperimental terhadap 10 subjek dan dilakukan pengukuran kadar vitamin D serum dengan metode Enzyme Linked Immunosorbent Assay (ELISA). Data klinis dan derajat keparahan psoriasis vulgaris dilakukan dengan skoring PASI dan DLQI. Data dianalisis secara deskriptif dan disajikan dalam tabel distribusi frekuensi. Pengolahan data menggunakan uji statistik Spearman untuk menilai korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan skor PASI dan DLQI. Hasil: Analisis data menunjukkan tidak ada korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan PASI (nilai p=0,751 dan koefisien korelasi r=-0,116) dan berdasarkan skor DLQI (nilai p=0,751 dan koefisien korelasi r=-0,116). Kesimpulan: Kadar vitamin D serum tidak berkorelasi dengan derajat keparahan psoriasis vulgaris.
Eritema Nodosum Leprosum Berat pada Pasien Kusta Lepromatosa: Laporan Kasus Pramudita, Adelia Wuri; Kariosentono, Harijono; Evanti, Annisa Marsha; Asaduddin, Aiman Hilmi
Cermin Dunia Kedokteran Vol 51 No 12 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i12.1116

Abstract

A case of a 58-year-old woman with lepromatous leprosy and severe ENL reaction is reported. The patient has symptoms of pustules for 1 year and the nodules were getting worse in the last week, accompanied by fever, joint pain, nausea, and vomiting. Physical examination revealed madarosis, infiltrates of both ears, and multiple painful erythematous nodules on the extremities and trunk. Slit skin smear examination showed bacterial index +3 and morphological index of 15%. Histopathological examination revealed neutrophil infiltration and vasculitis in the upper dermis. The patient was diagnosed with lepromatous leprosy and severe ENL reaction. The patient received multidrug therapy and methylprednisolone (62.5 mg/day), which was gradually reduced. The ENL reaction is caused by the deposition of M. leprae antigens and antibodies in small blood vessels, resulting in vasculitis and the release of enzymes that damage tissues. ENL reactions are commonly found in multibacillary MH and occur before, during, and after treatment. This reaction is mediated by cytokines produced by T-helper-2 (Th2). ENL reactions can cause disability.
Mekanisme Pertahanan Mukokutan terhadap Infeksi Candida: Analisis Pramudita, Adelia Wuri; Kariosentono, Harijono; Evanti, Annisa Marsha; Widyastuti, Zilpa
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1157

Abstract

Candida albicans is a commensal organism that can may become invasive and fatal under certain circumstances. Several genetic variations in the human genome towards susceptibility to Candida infections have been identified. There are a number of genes associated with Candida virulence factors, host environment, and immune response. C-type lectin receptors (CLRs) are characterized by leucine-rich and nucleotidebinding domains that can detect intracellular signals through various types of cytoplasmic domains. CLRs are family of PRRs that bind glycan through recognition of extracellular carbohydrate and mediate intracellular signaling through various type of cellular domains, resulting in a decrease of neutrophils and facilitating the occurrence of fungal infections. This study review the genetic determinant of defense mechanisms and immune deficiencies against Candida infection.
Co-Authors Asaduddin, Aiman Hilmi Bhisma Murti Kariosentono, Harijono Muchsin Doewes Mulianto, Nur M Rachmat Pramudita, Adelia Wuri Widyastuti, Zilpa