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All Journal UNEJ e-Proceeding Journal TABARO Agriculture Science JIAFE (Jurnal Ilmiah Akuntansi Fakultas Ekonomi) JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Jurnal Akademik Pengabdian Masyarakat Jurnal Manajemen Bisnis Era Digital Wissen: Jurnal Ilmu Sosial dan Humaniora
Yasmin Yasmin
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Nursing Social Sciences Veterinary

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Journal : UNEJ e-Proceeding

 1 
IN VITRO ALFA-GLUCOSIDASE INHIBITORY ACTIVITY OF VARIOUS TEA (Camellia sinensis L.) EXTRACTS Fransiska Maria Christianty; Diana Holidah; Yasmin Yasmin
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Diabetes mellitus is a group of metabolicdiseases characterized by hyperglycemia [1]. DM isclassified based on the pathogenic process that leadsto hyperglycemia as opposed to earlier criteria suchas age of onset or type of therapy. There are twobroad categories of DM, designated type 1 and type2 [2]. There were 10 million cases of diabetes inIndonesia in 2015. The number of these cases ispredicted to continue rising [3].Therapeutic approaches for the treatment oftype 2 diabetes, such as diet, sulphonylurea,metformin and insulin therapy, are all successful indecreasing fasting glucose levels. The importance ofpostprandial hyperglycaemia has led to thedevelopment of new agents to control this importantaspect of diabetes.Thus, α-glucosidase enzyme hasbecome one of important target in the treatment oftype-2 diabetes [4,5].α-glucosidase inhibition will slow thedigestion of carbohydrate and absorbtion ofmonosaccahrides in the proximal jejenum [6].Acarbose is an oligosaccharide which reversiblyinhibits intestinal α-glucosidase enzymes responsiblefor digestion of complex carbohydrates anddisaccharides to absorbable monosaccharides [7].The most common adverse effect of acarbose isabdominal discomfort associated with flatulence anddiarrhoea [8]. The undesirable side effects that existunderlie the emergence of research for alternativetherapy of type 2 diabetes, particularly through themechanism of inhibition enzyme α-glucosidase.Tea (Camellia sinensis L.) is annual plant thatwidely spread in Southest Asia, India, South China,Northwest Laos, Thailand and Burma. Tea is one ofthe most popular beverages consumed worldwide[9]. Various studies have reported beneficial effectof tea extract, including for diabetes mellitustherapy. Previous studies showed that tea extracthave antidiabetic activity in mice induced bystreptozotocin [10]. Antidiabetic activity of teaextract have been reported by Yang and Koh. Theresults showed that black tea extract had higheractivity to inhibit α-glucosidase than green teaextract. The present study was designed to comparein vitro α-glucosidase inhibitory activity of varioustea extracts, such as black tea, green tea, oolong tea,and white tea.
Co-Authors Diana Holidah Fransiska Maria Christianty Idawati Idawati Jabal Jabal Joko Irawan Kukuh Mujiono Muh Yusuf Idris Prakoso, Firza Agung Qurrotul A’yuni Rino Rino Rohmatul Nazila Ramadhani Rosnina Rosnina Sitti Maryam Yasin Sony Agung Santoso Sukriming Sapareng Taruna Shafa Arzam AR Yusrotul Latifa