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Sholikhah Deti Andasari
Program Studi DIII Farmasi, STIKES Muhammadiyah Klaten, Indonesia
Immunology & microbiology Medicine & Pharmacology

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Skrining Fitokimia Dari Infusa Dan Ekstrak Etanol 70% Daun Cincau Hijau(Cyclea barbata Miers) Siti Nur Oktavia; Endang Wahyuningsih; Sholikhah Deti Andasari; Normaidah
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Green grass jelly leaf (Cyclea barbata Miers) is a plant that has many benefits with the content of green grass jelly leaves (Cyclea barbata Miers) which are carbohydrates, fats, proteins and other compounds such as polyphenols, flavonoids and minerals such as calcium, phosphorus, vitamin A, and vitamin B. This study aims to determine the comparison of the results of the phytochemical screening of infusion and green grass jelly leaf extract (Cyclea barbata Miers). This research is a type of experimental research conducted at the Laboratory of Pharmaceutical Analysis STIKES Muhammadiyah Klaten. The research stages included sample preparation, extraction process, and phytochemical screening. The data analysis of this research is in the form of qualitative, the data is presented in tabular form and then the results are described. The results of phytochemical screening on green grass jelly leaves showed that the maceration and infusion processes of green grass jelly leaves contain flavonoids, alkaloids, saponins, and tannins. The difference is in the color change that occurs from the results of determining the flavonoid compounds, the results show that the color of the maceration extract is brownish yellow, while the color in the infusion is yellow. The conclusion of this study shows that green grass jelly leaf extract contains flavonoids, alkaloids, saponins, and tannins.
Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi PVP Sebagai Bahan Pengikat Nurul Hidayati; Ninda Meilany; Sholikhah Deti Andasari
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acetosal which at low doses can be efficacius as an antiplatelet. Acetosal chewable tablet thereby increasing compliance in taking the drug. The aim of this study was to know the effect of polivini pirolidone (PVP) concentration to physical properties and to find out the concentration of PVP which produces the best physical properties. Acetosal chewable tablet is made by direct compression method into 3 formulas with variations concentrations of PVP binder, the first (FI) is using PVP 1%, the second (FII) PVP 3%, the thirth (FIII) PVP 5%. The tablet evaluation included weight uniformity, hardness, friability, disintegration time, liking and responsiveness. The homogeneous analysis used the one-way ANOVA method and the post hoc LSD test, then if the data were not homogeneous, the Kruskall-Wallis test and the Mann-Whitney test. The results showed that the variation in the concentration of PVP as a binder had an effect on the physical properties of acetosal chewable tablets, namely the increase in PVP could increase the brittleness of the tablets, reduce the hardness and disintegration time of the tablets. The PVP 3% concentration in formula II produced the best physical properties of acetosal chewable tablets, namely fulfilling the requirements for weight uniformity, hardness 4,549 ± 0,306 kg, friability 0,183 ± 0,076 %, disintegration time 14,20 ± 0,255 minutes and can be accepted by consumers in the preference and taste response test.
Skrining Fitokimia Dari Infusa Dan Ekstrak Etanol 70% Daun Cincau Hijau(Cyclea barbata Miers) Siti Nur Oktavia; Endang Wahyuningsih; Sholikhah Deti Andasari; Normaidah
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.84

Abstract

Green grass jelly leaf (Cyclea barbata Miers) is a plant that has many benefits with the content of green grass jelly leaves (Cyclea barbata Miers) which are carbohydrates, fats, proteins and other compounds such as polyphenols, flavonoids and minerals such as calcium, phosphorus, vitamin A, and vitamin B. This study aims to determine the comparison of the results of the phytochemical screening of infusion and green grass jelly leaf extract (Cyclea barbata Miers). This research is a type of experimental research conducted at the Laboratory of Pharmaceutical Analysis STIKES Muhammadiyah Klaten. The research stages included sample preparation, extraction process, and phytochemical screening. The data analysis of this research is in the form of qualitative, the data is presented in tabular form and then the results are described. The results of phytochemical screening on green grass jelly leaves showed that the maceration and infusion processes of green grass jelly leaves contain flavonoids, alkaloids, saponins, and tannins. The difference is in the color change that occurs from the results of determining the flavonoid compounds, the results show that the color of the maceration extract is brownish yellow, while the color in the infusion is yellow. The conclusion of this study shows that green grass jelly leaf extract contains flavonoids, alkaloids, saponins, and tannins.
Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi PVP Sebagai Bahan Pengikat Nurul Hidayati; Ninda Meilany; Sholikhah Deti Andasari
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.89

Abstract

Acetosal which at low doses can be efficacius as an antiplatelet. Acetosal chewable tablet thereby increasing compliance in taking the drug. The aim of this study was to know the effect of polivini pirolidone (PVP) concentration to physical properties and to find out the concentration of PVP which produces the best physical properties. Acetosal chewable tablet is made by direct compression method into 3 formulas with variations concentrations of PVP binder, the first (FI) is using PVP 1%, the second (FII) PVP 3%, the thirth (FIII) PVP 5%. The tablet evaluation included weight uniformity, hardness, friability, disintegration time, liking and responsiveness. The homogeneous analysis used the one-way ANOVA method and the post hoc LSD test, then if the data were not homogeneous, the Kruskall-Wallis test and the Mann-Whitney test. The results showed that the variation in the concentration of PVP as a binder had an effect on the physical properties of acetosal chewable tablets, namely the increase in PVP could increase the brittleness of the tablets, reduce the hardness and disintegration time of the tablets. The PVP 3% concentration in formula II produced the best physical properties of acetosal chewable tablets, namely fulfilling the requirements for weight uniformity, hardness 4,549 ± 0,306 kg, friability 0,183 ± 0,076 %, disintegration time 14,20 ± 0,255 minutes and can be accepted by consumers in the preference and taste response test.
Co-Authors Endang Wahyuningsih Ninda Meilany Normaidah, Normaidah Nurul Hidayati Siti Nur Oktavia