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All Journal CERATA Jurnal Ilmu Farmasi Jurnal Farmasi Sains dan Praktis Urecol Journal. Part D: Applied Sciences Urecol Journal. Part G: Multidisciplinary Research Prosiding University Research Colloquium MOTORIK CERATA
Nurul Hidayati
Universitas Muhammadiyah Klaten
Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Optimasi Formula Masker Gel Peel Off Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl ) Dengan Variasi PVA Dan HPMC Menggunakan Metode Simplex Lattice Design Nurul Hidayati; Nanik Widyiastuti; Sutaryono
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) is an effectiveplant against bacteria the causes of acne. To facilitate the application, it formulated in a peel off gel mask preparation. This study aims to determine the effect of the concentration of PVA as film forming and HPMC as a gelling agent on the physical properties of the peel off gel mask and determine the concentration of PVA and HPMC which produce the optimum formula.The Mahkota Dewa fruit was extracted by soxletation with ethanol 70%. The extract was made into 5 runs with variations in the concentration of PVA (10-16%) and HPMC (2-4%). The fifth run in the test of physical properties include organoleptic tests, homogenity, pH, viscosity, spreadability, adhesion and drying time. The optimum formula of peel off gel mask is obtained from software design expert version 6.0.8. simplex lattice design method with the studied response to viscosity, spreadability, and drying time.The results show that increasing the concentration of PVA can increase viscosity and drying time, and increasing the concentration of HPMC can increase the value of dispersion of the preparation. The optimum formula was obtained with a variation of PVA 13.09% and HPMC of 2.97%.
Optimasi Formula Sirup Ekstrak Etanol Daun Sukun (Artocarpus altilis) Dengan Pemanis Sorbitol dan Co – Solvent Propilen Glikol Nurul Hidayati; Ivan Nuryanto; Saifudin Zukhri
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Breadfruit leaves (Artocarpus altilis) are effective in reducing high blood sugar levels. One of the uses of breadfruit is by making it into syrup. The manufacture of breadfruit leaf ethanol extract is expected to improve the bitter taste of breadfruit leaves. This study aims to determine the effect of variations of sorbitol and propylene glycol and to obtain the optimum value of sorbitol and propylene glycol on the physical properties and hedonic value of syrup preparations. Breadfruit leaveswas extracted by multilevel maceration with 70% ethanol. Thick breadfruit leaf extract made syrup preparations in 5 runs with variations of sorbitol: propylene glycol, namely Run 1 (20%: 25%), Run 2 (35%: 10%), Run 3 (31.25%: 13.75% ), Run 4 (27.5%: 17.5%) and Run 5 (23.75%: 21.25%). The syrups were tested for their physical properties including organoleptic, viscosity, pH and hedonic tests. The test results are optimized with Simplex Lattice Design. The optimum formula of the predicted results is verified by analysis of one sample t-test with a 95% confidence level.The results showed an increase in sorbitol and propylene glycol increased the pH and hedonic values but did not affect the viscosity value of syrup preparations. Sorbitol concentration of 30,0005% and propylene glycol 14.9995% produced syrup with pH and hedonic value optimum differed insignificantly with p-values> 0.05.
Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi PVP Sebagai Bahan Pengikat Nurul Hidayati; Ninda Meilany; Sholikhah Deti Andasari
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Acetosal which at low doses can be efficacius as an antiplatelet. Acetosal chewable tablet thereby increasing compliance in taking the drug. The aim of this study was to know the effect of polivini pirolidone (PVP) concentration to physical properties and to find out the concentration of PVP which produces the best physical properties. Acetosal chewable tablet is made by direct compression method into 3 formulas with variations concentrations of PVP binder, the first (FI) is using PVP 1%, the second (FII) PVP 3%, the thirth (FIII) PVP 5%. The tablet evaluation included weight uniformity, hardness, friability, disintegration time, liking and responsiveness. The homogeneous analysis used the one-way ANOVA method and the post hoc LSD test, then if the data were not homogeneous, the Kruskall-Wallis test and the Mann-Whitney test. The results showed that the variation in the concentration of PVP as a binder had an effect on the physical properties of acetosal chewable tablets, namely the increase in PVP could increase the brittleness of the tablets, reduce the hardness and disintegration time of the tablets. The PVP 3% concentration in formula II produced the best physical properties of acetosal chewable tablets, namely fulfilling the requirements for weight uniformity, hardness 4,549 ± 0,306 kg, friability 0,183 ± 0,076 %, disintegration time 14,20 ± 0,255 minutes and can be accepted by consumers in the preference and taste response test.
FORMULASI GEL EKSTRAK ETANOL BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) DENGAN VARIASI KONSENTRASI CARBOPOL DAN PROPILENGLIKOL Rahmi Nurhaini; Nurul Hidayati; Lisa Fidy Hapsari Hapsari
CERATA Jurnal Ilmu Farmasi Vol 9 No 2 (2018): Desember
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) was a plant that contains many chemical compounds one of which flavonoids. Flavonoids act as an antibacterial acne-causing Staphylococcus epidermidis. Acne can be overcome by using stocks that have good penetration one of which is a gel formulation. The purpose of experiment was to determine the effect of variations in the concentration of carbopol as a gelling agent and propylene glycol as a humectant to the physical properties of the gel and to know gel that produces the most excellent physical properties. This experiment uses ethanol extract of Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl) as the active ingredient and made five formulas with various concentration Carbopol: propylene glycol is formula I (0.5%: 15%), formula II (0.875%: 13.75%), the formula III (1.25 %: 12.5%), the formula IV (1.625%: 11.25%) and formula V (2%: 10%). Fifth tested formula physical properties and analyzed by ANOVA with confidence level of 95%. The results showed carbopol increase the viscosity and adhesion while propylene glycol improve dispersive power. Formula II and III produces the most excellent physical properties, with a pH test between 4.5 to 6.5, viscosity test 150-200 dPas, 5-7 cm dispersive power test, adhesion > 1 sec and power tests there are no red stain protection. Statistical analysis LSD formula II and III showed no significant differences. Viscosity test and dispersive power indicates with p value of 0.000 (<0.005) and adhesion with p value of 0.007 (<0.05).
Uji Stabilitas Formula Optimum Masker Gel Peel Off Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Nurul Hidayati; Anita Agustina Styawan; Ida Naim Muslimah
CERATA Jurnal Ilmu Farmasi Vol 11 No 2 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl was effective as an anti-acne agent and an optimization formula of Mahkota Dewa fruit extractpeel off gel mask has been carried out but the stability test has not been carried out. This study aims to determine the stability of the optimum formula of Mahkota Dewa fruit extract (Phaleria macrocarpa (Scheff.) Boerl)peel off gel mask. The fruit simplicia of Mahkota Dewa was extracted by soxhletation with 70% ethanol. The thick extract is made into a peel off gel mask with 13.09%PVA and 2.97% HPMC. Stability tests were carried out in 3 cycles using the freeze and thaw method. The evaluations carried out included organoleptic, homogeneity, pH, viscosity, dispersibility, adhesion and drying time. Analyzed data by One Way Anova followed by the LSD (Least Significance Difference) test. The results showed that the peel off gel mask optimization formula stable in storage for 3 cycles which overall meet the requirements of physical properties. The preparation was brown with rose aroma, thick, homogeneous with a pH value of 6 ± 0 and a viscosity value of 400 ± 0. The results of the drying time and spreadability test showed no difference in all cycles. Although the results of the adhesion test showed a significant difference, it was still within the range of good adhesion values.
PENETAPAN KADAR β-KAROTEN PADA WORTEL (Daucus carota, L) MENTAH DAN WORTEL REBUS DENGAN SPEKTROFOTOMETRI VISIBEL Anita Agustina Styawan; Nurul Hidayati; Putri Susanti
Jurnal Farmasi Sains dan Praktis Vol 5 No 1 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i1.2293

Abstract

Wortel (Daucus carota, L) adalah tumbuhan sayur yang ditanam sepanjang tahun yang banyak mengandung β-karoten. Dalam tubuh, β-karoten diubah menjadi vitamin A. β-karoten dalam wortel selain dapat memenuhi kebutuhan vitamin A, juga berfungsi sebagai antioksidan melawan radikal bebas. Akan tetapi, studi mengenai pengaruh pemasakan terhadap kandungan gizinya masih terbatas. Tujuan penelitian ini adalah untuk mengetahui kadar β-karoten pada wortel mentah dan wortel rebus. Sampel sebanyak 100 gram wortel (wortel mentah maupun wortel rebus) masing masing diekstraksi dengan heksan:aseton:etanol (2:1:1) sebanyak 200 mL. Ekstrak yang didapat kemudian dianalisis secara kualitatif dan kuantitatif. Analisis kualitatif menggunakan KLT silica gel 60 F254 dengan cairan pengelusi petroleum eter:benzen (9:1). Analisis kuantitatif menggunakan Spektrofotometri Visibel pada panjang gelombang 380–780 nm. Hasil kualitatif menunjukkan antara wortel mentah dan wortel rebus positif mengandung β-karoten yang ditunjukkan dengan hasil sama dengan baku pembanding, yaitu adanya 1 bercak noda kuning dengan nilai Rf 0,5 cm. Hasil analisis kuantitatif menunjukkan kadar rata-rata β-karoten wortel mentah adalah 34,94 ± 7,810 % b/b dan pada wortel rebus adalah 23,31 ± 4,246 % b/b. Besarnya kadar β-karoten kemudian dianalisa menggunakan uji sample paired t-test dan menunjukkan hasil nilai P value 0,06 (> 0,05) yang berarti tidak terdapat perbedaan bermakna antara kadar β-karoten pada wortel mentah dan wortel rebus. Kata Kunci: β-karoten; Wortel; Spektrofotometri Visibel.
Gel Formulation for Hand Sanitizer from Ethanol Extract of Mulberry Leaf (Morus Alba L.) Sutaryono Sutaryono; Hendra Budiman; Anita Agustina Styawan; Nurul Hidayati; Dayah Ainus
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.556 KB) | DOI: 10.53017/ujas.37

Abstract

During the Covid 19 pandemic, a handsanitizer product has emerged which functions as a hand washing disinfectant for the prevention of the Covid 19 virus. One of the ingredients that can be made handsanitizer gel is the mulberry plant (Morus alba L.) because it contains many flavonoids which act as antiseptics against bacteria. The research objective was to determine the handsanitizer gel formulation with the concentration of carbopol and propylenglycol which can produce good physical properties. The research design used an experiment, with the mulberry leaf preparation material macerated using 70% ethanol. Mulberry leaf ethanol extract (Morus alba L.) as the active substance and made 3 formulas with variations in the concentration of carbopol: propylenglycol formula I (0.5%: 15%), formula II (1.25%: 12.5%), formula III (2%: 10%). The three formulas were tested for physical properties and analyzed by ANOVA with a confidence level of 95%. The results showed that the handsanitizer gel formulation with carbopol increased viscosity and stickiness, while propylenglycol increased the dispersibility. The 1.25% formula: 12.5% ??produces the best physical properties, with a pH test of 6, a viscosity test of 150 dPas, a spreadability test of 6.5 cm, a sticky power test of 2.39 seconds and a protective power test without red stains.
Formulation and Physical Properties of Anti Foot Odor Spray from Lemon (Citrus limon Burm. F.) Nurul Hidayati; Maulida Kurniasari; Avanilla Fany Septyasari
Urecol Journal. Part G: Multidisciplinary Research Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.084 KB) | DOI: 10.53017/ujmr.35

Abstract

Lemon (Citrus limon Burm. F.) contains essential oil in the form of limonene which has antibacterial activity against Staphylococcus epidermidis which causes foot odor. To facilitate the application, it is made in the form of a spray, because the spray has a fast-drying profile so it is easy to use. This study aims to determine the effect of variations in the concentration of lemon essential oil on the physical properties of foot odor spray and to determine the concentration of lemon essential oil which produces an anti-foot odor spray with good physical properties. Spray made with variations in the concentration of essential oils 5%, 10%, and 15%. The spray was then tested for its physical properties including organoleptic, homogeneity, pH, and viscosity tests. The results of the organoleptic test and the homogeneity test were analyzed descriptively, while the results of the pH test and viscosity test were analyzed by one-way ANOVA with a 95% confidence level. The results showed that the increase in the concentration of lemon essential oil affected the organoleptics and increased the viscosity value. The 5% concentration spray produced the best physical properties with a liquid form, cloudy white color, distinctive lemon aroma, homogeneous with a pH value of 6 ± 0, and a viscosity value of 0.53 ± 0.06 dPas.
Gambaran Kepatuhan Minum Obat Pasien Tuberculosis di Balai Kesehatan Masyarakat (BALKESMAS) Wilayah Klaten Rahmi Nurhaini; Nurul Hidayati; Wiwit Nur Oktavia
Prosiding University Research Colloquium Proceeding of The 10th University Research Colloquium 2019: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Latar belakang: Tuberkulosis merupakan penyakit menular yang perlu diterapi dengan tepat dan dalam jangka waktu yang panjang. Obat anti tuberkulosis (OAT) harus dikonsumsi secara teratur untuk mencegah terjadinya pengoabatan ulang. Salah satu faktor keberhasilan pengobatan adalah adanya kepatuhan minum obat oleh pasien. Besarnya angka ketidakpatuhan pengobatan sulit dinilai, namun diperkirakan lebih dari seperempat pasien tuberkulosis gagal dalam menyelesaikan pengobatan 6 bulan. Ketidakpatuhan pengobatan meningkatkan risiko kegagalan pengobatan Tujuan: untuk mengetahui gambaran kepatuhan minum obat pasien tuberkulosis di Balai Kesehatan Masyarakat (BALKESMAS) Klaten. Jenis penelitian ini adalah penelitian deskriptif dengan rancangan pendekatan cross sectional. Penelitian menggunakan 32 pasien tuberkulosis di BALKESMAS Klaten yang sedang menjalankan pengobatan. Sampel diambil dengan teknik accidental sampling. Alat yang digunakan dalam penelitian adalah kuesioner untuk melihat tingkat kepatuhan pasien. Analisa data diolah secara komputerisasi. Hasil: penelitian tingkat kepatuhan minum obat pasien tuberkulosis di Balai Kesehatan Masyarakat (BALKESMAS) Klaten berdasarkan jenis kelamin paling tinggi yaitu laki-laki sebanyak 40,6% patuh, kelompok usia paling tinggi 40-60 tahun sebanyak 37,5% patuh, tingkat pendidikan paling tinggi adalah SMA sebanyak 40,6% patuh, dan tingkat pekerjaan paling tinggi adalah wiraswasta sebanyak 25% patuh. Kesimpulan: penelitian ini adalah tingkat kepatuhan minum obat pasien tuberkulosis di Balai Kesehatan Masyarakat (BALKESMAS) wilayah Klaten dari total 32 responden ditemukan 24 orang (75%) responden patuh.
FORMULASI DAN UJI SIFAT FISIS SIRUP EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg Nurul Hidayati; Anita Agustina Styawan; Anggit Khusnul Khotimah
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg merupakan salah satu tumbuhan obat tradisional yang banyak dimanfaatkan sebagai alternatif pengobatan untuk berbagai penyakit. Kandungan senyawa flavonoid di dalamnya dapat menurunkan kadar gula darah. Pembuatan sirup ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg dapat mempermudah penggunaan dan penutupan rasa pahit pada ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg terhadap sifat fisis sirup dan untuk mengetahui konsentrasi ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg yang menghasilkan sifat fisis sirup yang paling baik. Simplisia diekstraksi menggunakan metode maserasi bertingkat dengan etanol 70%. Ekstrak kental daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg dibuat sirup dalam 3 formula dengan variasi konsentrasi ekstrak, formula 1 (7,5%), formula 2 (15%), dan formula 3 (30%). Sirup diuji sifat fisis dan data dianalisis dengan One Way ANOVA dan dilanjutkan uji LSD (Least Significance Difference). Hasil penelitian menunjukkan peningkatan konsentrasi ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg mempengaruhi sifat fisis sirup, yaitu rasa sirup semakin pahit, baunya semakin khas, warnanya semakin pekat, serta peningkatan nilai pH, viskositas, dan waktu tuang. Sirup konsentrasi 15% menghasilkan sifat fisis yang paling baik, yaitu rasa manis, bau khas ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg, warna coklat, tingkat kejernihan sangat jernih, homogen, nilai pH 4 ± 0, viskositas 2,07 ± 0,06 dPas, serta nilai waktu tuang 2,99 ± 0,04 detik.
Co-Authors Agustina Styawan, Anita Anggit Khusnul Khotimah Anisa Dita Rahmawati Avanilla Fany Septyasari Dayah Ainus Hendra Budiman Ida Naim Muslimah Ivan Nuryanto Lisa Fidy Hapsari Hapsari Maulida Kurniasari Nanik Widyiastuti Ninda Meilany Putri Susanti Rahmi Nurhaini, Rahmi S.Pd. M Kes I Ketut Sudiana . saifudin zukhri - Sholikhah Deti Andasari Sutaryono Sutaryono Sutaryono Wiwit Nur Oktavia