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All Journal Pharmacology and Clinical Pharmacy Research Jurnal Global Ilmiah Journal Of Carbazon
Fathurrahmi Fathurrahmi
Chemistry Department, Faculty of Mathematics and Natural Sciences, Syiah Kuala University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Analysis of Potentially Inappropriate Prescriptions (PIP) Based on STOPP/START Criteria in Geriatric Patients with Cardiovascular Disorders at Hasan Sadikin Hospital, Bandung, West Java, Indonesia Fathurrahmi, Fathurrahmi; Wilar, Gofarana; Levita, Jutti; Winarni, Rina
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50436

Abstract

The geriatric population in Indonesia is increasing rapidly every year. The large number of drugs consumed by geriatric patients results in potentially inappropriate prescriptions (PIP) in the form of mis-prescribing drugs (potentially inappropriate medicines or PIM) and under-prescribing drugs (potentially prescription omission or PPO). In Indonesia, especially in Bandung, there is limited research on PIP in geriatric patients with cardiovascular disorders (CVDs). This study aims to identify PIP and factors that influence PIM and PPO based on STOPP/START criteria and the relationship between the incidence of PIM and kidney function in geriatric inpatients with CVDs at Hasan Sadikin Hospital, Bandung, West Java, Indonesia. The present retrospective study was cross-sectionally conducted from January to December 2022. The Chi-square tests were carried out to determine factors that were significantly related to PIM and PPO. Of the 192 patients, 33.4% patients experienced PIM with the most being NSAIDs with eGFR <30 mL/min/1.73 m2 (36%). As many as 35% of patients experienced PPO with the most frequent PPO not being given angiotensin-converting enzyme inhibitor (ACEi) in patients with systolic heart failure (41.8%). Factors that were significantly associated with PIM were comorbid kidney dysfunctions (OR 5; 95% CI: 2.367-10.342), and no factors were found that were significantly associated with PPO. Taking everything into consideration, it was found that PIM and PPO were common in hospitalized geriatric patients with CVDs. Kidney dysfunctions are a risk factor for PIM. These findings suggest that it is important to evaluate prescribing for geriatric patients during hospitalization using STOPP/START criteria to reduce the prevalence of PIP
Modification of Montmorillonite with Chitosan as Mercury Metal Adsorbent Julinawati, Julinawati; Nisa, Salasatun; Fathurrahmi, Fathurrahmi; Mustafa, Irfan; Saleha, Sitti; MZ., Kartika; Suryati, Suryati
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42230

Abstract

Modification of montmorillonite with chitosan as an adsorbent of mercury (Hg) metal has been carried out. This study aims to determine the characteristics of the adsorbent, the optimum adsorption capacity of Hg metal, and its adsorption isotherm equation. The optimum conditions for Hg metal adsorption are determined by varying the contact time and pH of the solution. Variations in adsorbate concentration are carried out to determine the adsorption isotherm. Characterization of the adsorbent using FTIR shows the presence of -OH, Si-O, Al-O, C-C, and N-H groups. The optimum conditions for mercury metal adsorption by montmorillonite modified with chitosan occur at a contact time of 80 minutes, and a pH of 4. The adsorption process of mercury metal ions using montmorillonite adsorbent modified with chitosan satisfies both isotherm models, namely the Langmuir and Freundlich isotherms with R2 values of 0.971 and 0.967 respectively, and a maximum adsorption capacity of 13.513 mg/g. The regeneration test showed that the adsorbent can be reused for the absorption of mercury metal ions.
Immobilisasi ?-Fe2o3/Bentonit Sebagai Fotokatalis Pada Fotodegradasi Zat Warna Methylene Blue Nurul Sakinah, Shofi; Julinawati, Julinawati; Fathurrahmi, Fathurrahmi; Sheilatina, Sheilatina
Jurnal Global Ilmiah Vol. 2 No. 3 (2024): Jurnal Global Ilmiah
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/jgi.v2i3.153

Abstract

Perkembangan industri tekstil di Indonesia memberikan dampak negatif terhadap lingkungan, terutama dari limbah cair yang mengandung zat warna berbahaya seperti Methylene Blue (MB). Zat warna ini bersifat toksik dan dapat merusak ekosistem perairan. Oleh karena itu, diperlukan metode yang efektif untuk mengurangi dampak limbah ini. Penelitian ini bertujuan untuk mengembangkan fotokatalis ?-Fe?O?/Bentonit yang diimmobilisasi pada plat kaca untuk mendegradasi zat warna Methylene Blue secara efisien. Immobilisasi fotokatalis ?-Fe2O3/Bentonit pada plat kaca telah dilakukan dengan metode brush coating menggunakan double-sided adhesive tape (DSAT) sebagai perekat. Formulasi komposit ?-Fe2O3/bentonit dibuat dengan mencampurkan ?-Fe2O3 dan bentonit dengan perbandingan 3:1 (w/w). Aktivitas fotokatalitik fotokatalis ?-Fe2O3/bentonit yang terimmobilisasi pada plat kaca dievaluasi pada penghilangan zat warna methylene blue (MB). Komposit ?-Fe2O3/bentonit dan ?-Fe2O3 dikarakterisasi menggunakan X-Ray Difrraction (XRD) untuk mengevaluasi struktur senyawa dan kristal dari komposit ?-Fe2O3/bentonit dan ?-Fe2O3. Morfologi permukaan fotokatalis ?-Fe2O3/bentonit dikarakterisasi menggunakan Scanning Electron Microscope (SEM). Hasil penelitian menunjukkan bahwa aktivitas fotokatalis dalam mendegradasi zat warna MB terjadi pada massa fotokatalis optimum 40 mg, pH 5 dan konsentrasi zat warna 5 mg/L dengan nilai kinetika reaksi yang diperoleh sebesar 0,0843 menit-1 dan persen kehilangan (%R) yang diperoleh sebesar 98,60% selama 60 menit penyinaran dengan lampu fluorescent. Penggunaan kembali (reusabilitas) fotokatalis komposit ?-Fe2O3/bentonit terhadap zat warna MB dilakukan sebanyak 5 kali dengan aktivitas fotokatalitik yang menurun seiring dengan pengulangan yang dilakukan yaitu 98,60 % hingga 94%.
Co-Authors Fadhli, Ashabul Gofarana Wilar Irfan Mustafa Julinawati, Julinawati Jutti Levita MZ., Kartika Nisa, Salasatun Nurul Sakinah, Shofi Sheilatina, Sheilatina Sitti Saleha, Sitti Suryati Suryati Winarni, Rina