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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Manuntung
Aisyah Fatmawaty
Faculty of Pharmacy, Hasanuddin University, Makassar.
Agriculture, Biological Sciences & Forestry Computer Science & IT Medicine & Pharmacology

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PENGARUH ISOPROPIL MYRISTAT SEBAGAI BAHAN PENINGKAT PENETRASI TERHADAP LAJU DIFUSI KRIM PEMUTIH EKSTRAK ETANOL DAUN MURBEI (Morus alba L) Yusuf, Nurul Arfiyanti; Fatmawaty, Aisyah
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.773 KB) | DOI: 10.51352/jim.v3i1.89

Abstract

The research has conducted research on the effectiveness of isopropyl myristat as a penetration enhancer on the diffusion rate of whitening cream mulberry leaf extract (Morus alba L) in vitro. This study aims to determine the effect of the use of isopropyl myristat. Mulberry leaf extract cream made with varying concentrations respectively 3%, 4%, 5% Isopropyl myristat as penetration enhancers made into 3 formulas (F1-F4) with the F1 without penetration enhancers. Evaluation of stability before and after accelerated storage includes observation of the organoleptic, emulsion type determination, measurement of pH, and viscosity. The evaluation results indicate four physically stable formula. In vitro diffusion studies conducted by Franz diffusion cells and footage is measured at a wavelength of 367.4 nm. The results of diffusion studies show that formula with the highest diffusion rate of 0.024 µg/minute on F4 (5% isopropyl myristat).
Anti-Acne Patch Formulation Silkworm Cocoon Waste with HPMC and PVP Variations Ulfa, Maria; Fatmawaty, Aisyah; Dambur, An M.R.
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.36951

Abstract

Some topical preparations for acne have been developed in the form of gels and creams. However,it is still rarely developed in the form of a patch dosage form. Waste from silkworm cocoons has theactivity of inhibiting the growth of acne-causing bacteria, can be formulated into patch preparations.This study aims to formulate anti-acne patches from silkworm cocoon waste with variations of HPMCand PVP. The formulation of the anti-acne patch from silkworm cocoon waste was made by mixingthe lyophilisate of silkworm cocoon waste with a patch base with variations of HPMC and PVP. Theformulations were divided into 3 with different concentrations of HPMC and PVP additives, namelyformulas 1 (4:1), 2 (2,3:1), and 3 (1:1), respectively, The evaluations carried out included organolepticexamination, patch thickness, weight uniformity, fold resistance, moisture absorption, drying shrinkage.The results obtained showed that the concentration of the combination of HPMC and PVP polymersin the patch preparation gave different results from all evaluations that had been carried out, includingorganoleptic evaluation, weight uniformity, fold resistance, and drying shrinkage were in accordancewith the requirements of a good patch. The optimum concentration of the combination of HPMC andPVP as a polymer in the anti-acne patch preparation from silkworm cocoons is formula 2 with a ratioof (2,3:1) as novelty in this study.
Co-Authors Abd Halim Umar Dambur, An M.R. Gemini Alam Latifah Rahman Maria Ulfa Marianti A Manggau Matias N Kolobani Muhammad Aswad Wahyu Hendrarti Yusuf, Nurul Arfiyanti Yusuf, Nurul Arfiyanti