Rapid advancements in science and technology require organizations to possess high-quality human resources to enhance effectiveness and efficiency in achieving organizational goals. Job satisfaction is a crucial aspect of human resource management, as it relates to employee morale, performance, and contributions to the organization. This study aims to examine the influence of work stress, communication, and the work environment on employee job satisfaction at the Purworejo Regency Education and Culture Office. Issues identified include high workloads causing employee stress and fatigue, ineffective communication leading to misunderstandings during task execution, and a work environment that is not conducive, coupled with limited work facilities. The study employs work stress as an independent variable (X1), communication as an independent variable (X2), the non-physical work environment as an independent variable (X3), and job satisfaction as the dependent variable (Y). The specific objectives are to examine the effects of work stress, communication, and the work environment on employee job satisfaction. The study population consists of all 105 employees of the Purworejo Regency Education and Culture Office. Data were collected using a questionnaire with Likert-scale response options; the instrument was pilot-tested and met validity and reliability requirements. Hypothesis testing was conducted using multiple linear regression analysis. The analysis results indicate that work stress has a significant negative effect on employee job satisfaction, while communication and the work environment have significant positive effects on employee job satisfaction.