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All Journal Chimica et Natura Acta Jurnal Pengabdian kepada Masyarakat Journal of Pharmaceutical and Sciences. JPS (Jurnal Pharma Saintika) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Nofita, Dewi
Akademi Farmasi Dwi Farma Bukitttinggi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Eksplorasi Aktivitas Antimikroba Bakteri Endofit Daun Betadine (Jatropha multifida L.) terhadap Patogen Staphylococcus aureus Arfiandi, Arfiandi; Fadjria , Neri; Nofita, Dewi; Rahmadini, Mutia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.899

Abstract

Background: Antibiotic resistance has spurred the exploration of novel antibacterial agents, including endophytic bacteria from medicinal plants like Jatropha multifida L. (Betadine leaves), traditionally used as antiseptics. Objective: To assess the antibacterial activity of endophytic bacterial isolates from Betadine leaves against Staphylococcus aureus. Methods: A laboratory-based experimental study employing the paper disc diffusion method. Endophytic isolates were cultured in Nutrient Broth, and centrifuged supernatants were tested for inhibition zones compared to positive (chloramphenicol) and negative (Na.CMC) controls. Results: The endophytic isolate produced a 16.11 mm inhibition zone (moderate activity), while chloramphenicol showed 27.63 mm (strong activity). No inhibition was observed in the negative control. Conclusion: Endophytic bacteria from Betadine leaves exhibit potential as natural antibacterial agents, though their efficacy is lower than standard antibiotics. Further development requires active compound characterization and toxicity studies.
ANALISIS FENOLIK DAN FLAVONOID DALAM EKSTRAK METANOL DAUN SUNGKAI (Peronema canescens Jack.) SECARA SPEKTROFOTOMETRI Nofita, Dewi; Setiawan, Budi; Marthia, Cut Mina; Putri, Desi Eka
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.967

Abstract

Sungkai (Peronema canescens Jack.) is an indigenous Indonesian plant traditionally used for the treatment of fever, enhancing immune function, and managing hypertension. This study aimed to determine the total phenolic and flavonoid contents of methanol extracts of Sungkai leaves using spectrophotometric analysis. Phenolic content was measured using the Folin–Ciocalteu reagent with gallic acid as the standard, while flavonoid content was quantified using quercetin as the reference compound. The results showed that the methanol extract of Sungkai leaves contained a total phenolic content of 255.760 ± 0.0146 mg GAE/g extract and a total flavonoid content of 52.014 ± 0.0301 mg QE/g extract. These findings indicate that Sungkai leaves represent a promising natural source of bioactive metabolites with potential health benefits.
Co-Authors Arfiandi Arfiandi Arfiandi Arfiandi Arfiandi Arfiandi Arfiandi Arfiandi Arfiandi, Arfiandi Budi Setiawan Budi Setiawan Budi Setiawan Delviona Friti Rahman Fadjria, Neri Hermansyah Aziz Husnatul Mardiah Marthia, Cut Mina Mazaya Fadhila Putri Nandinanti Putri, Desi Eka Rahmadini, Mutia Rahmat Dewangga Rahmiana Zein Refilda Refilda Renatalia Fika Shyntia Nofita Sari Yonrizon