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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Journal of Applied Science for Pharmaceuticals and Health
Nur Amalia Choironi
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Analisis Target Protein Pada Penyakit Kanker Serviks dari Senyawa Ethyl Para Methoxy Cinnamate Secara In Silico Ayunda Tasya Hapsari; Muhamad Salman Fareza; Nur Amalia Choironi
Journal of Applied Science for Pharmaceuticals and Health Vol 1 No 2 (2024): Journal of Applied Science for Pharmaceuticals and Health (Desember)
Publisher : Centre of Applied Science for Pharmaceutical Science Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jasph.2024.1.2.14999

Abstract

Kasus kanker serviks merupakan kanker tertinggi ke-5 diantara kanker lainnya di dunia. Amplifikasi DNA adalah salah satu mekanisme terjadinya kanker ini. Karena itu, keparahan penyakit ini bisa berkembang. Gen yang berperan dalam perkembangan kanker serviks adalah CCNB1, CCNB2, CDK, dan MMP. Terdapat masalah pada beberapa obat yang menargetkan beberapa protein tersebut seperti erlotinib, alvocidib, marimastat, dan lain-lain. Oleh karena itu, penemuan obat baru untuk mengatasi kasus ini perlu dilakukan. Senyawa Ethyl Para Methoxy Cinnamate (EPMC) mempunyai aktivitas sitotoksik IC50 sebesar 35 μg/ml yang bersifat sangat sitotoksik terhadap sel HeLa. Penelitian ini bertujuan untuk mengetahui potensi target dan profil docking molekul senyawa EPMC yang berpotensi menghambat kanker serviks. Pencarian data menggunakan database Pubchem, SWISS Target Prediction, PubMed, STRING, dan PDB. Situs Webgestalt dilakukan untuk analisis Geneontologi, jalur KEGG, dan asosiasi obat. Hasil PTTGs digunakan untuk melihat interaksi antara protein menggunakan STRING dan gen hub 10 teratas dengan cystoscape. Simulasi docking dilakukan untuk menentukan profil mooring. Hasil: Target potensial EPMC adalah EGFR, CCND1, CDK4, CDK2, CCNA1, HGF, MMP9, CCNE1, CCNB1, CDH1. Hasil simulasi docking menunjukkan MMP9 memiliki energi ikatan yang lebih rendah dibandingkan kontrol positif, yaitu sekitar -6,9 kkal/mol. Oleh karena itu, MMP9 berpotensi menjadi target EPMC melalui jalur persinyalan PI3K-Akt. Kesimpulan: Senyawa EPMC dapat menghambat pertumbuhan sel kanker dengan menargetkan MMP9 melalui jalur pensinyalan PI3K-Akt.
Bioinformatics Study on Curcuma mangga Diterpenoids as Potential Anticancer Agents for Breast Cancer Putri Khaerani Cahyaningrum; Indra Yudhawan; Binar Pratama; Nur Amalia Choironi
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.7363

Abstract

Breast cancer, with its aggresive subtypes and resistance, is a major cause of cancer-related mortality among women. Advancements of breast cancer drug discovery is great and survival rate is better than in the past, but still advanced breast cancer remain difficult to treat, emphasizing the need for searching of alternative therapeutic agents with proven efficacy and safety. Curcuma mangga contains diterpenoid compounds that have demonstrated cytotoxic potential against breast cancer cells. This study aimed to elucidate the molecular mechanisms and pharmacokinetic properties of diterpenoids from the n-hexane extract of C. mangga against ER-positive breast cancer using a network pharmacology approach. Four diterpenoids—(E)-Labda-8(17),12-diene-15,16-dial, (E)-15,16-Dinorlabda-8(17),11-dien-13-one, m-camphorene, and p-camphorene—were evaluated. Breast cancer-related genes were retrieved from the NCBI database, while compound targets were predicted using SwissTargetPrediction and SEA Search Server. Nineteen overlapping genes were identified as Potential Therapeutic Target Genes (PTTGs) and further analyzed through protein–protein interaction, Gene Ontology, and KEGG pathway enrichment analyses. Key targets included EGFR, AKT1, CYP19A1, and PGR, which are involved in cell proliferation, survival, and hormone-regulated signaling pathways. ADME and toxicity predictions indicated favorable oral bioavailability for labdane diterpenoids, although potential hepatotoxicity and mutagenicity were observed in certain compounds. Overall, (E)-Labda-8(17),12-diene-15,16-dial emerged as the most promising candidate, supporting its further investigation as a potential therapeutic agent for ER-positive breast cancer.
Perbedaan Pengetahuan dan Sikap Masyarakat Kabupaten Banyumas tentang Diabetes Melitus Tipe 2 Sebelum dan Setelah Edukasi Damairia Hayu Parmasari; Muhammad Salman Fareza; Lita Heni Kusumawardani; Pramesti Widya Hapsari; Nur Amalia Choironi; Aisyah Apriliciciliana Aryani
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 15 No 4 (2023): JIKM Vol. 15, Edisi 4, November 2023
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v15i4.475

Abstract

Latar Belakang: Diabetes melitus (DM) perlu dicegah karena tergolong penyakit silent killer. Sebagian kasus adalah DM Tipe 2. Berdasarkan hasil penelitian sebelumnya menunjukkan masyarakat di Banyumas sudah mempunyai tingkat pengetahuan cukup baik, tetapi belum mempunyai sikap yang cukup baik terhadap pencegahan DM Tipe 2. Perlu dilakukan edukasi kepada masyarakat serta deteksi dini DM melalui pemeriksaan gula darah. Tujuan penelitian ini untuk mengetahui perbedaan pengetahuan dan sikap masyarakat di Desa X, Kabupaten Banyumas terhadap DM Tipe 2 sebelum dan sesudah edukasi. Metode: Desain penelitian menggunakan quasi experiment dilakukan selama bulan Agustus 2023. Kuesioner digunakan untuk menilai pengetahuan dan sikap. Responden menjawab pertanyaan kuesioner pre-test, kemudian diberikan edukasi dan menjawab kuesioner post-test. Edukasi DM Tipe 2 dilakukan melalui penyampaian materi secara lisan dan tulisan melalui paparan menggunakan media slide Power Point dan modul. Sampel adalah masyarakat Desa X, Kabupaten Banyumas sebanyak 30 orang. Analisis perbedaan pengetahuan dan sikap menggunakan uji Wilcoxon.Hasil: Hasil uji Wilcoxon memperlihatkan bahwa tidak ada perbedaan signifikan pengetahuan dan sikap masyarakat Desa X tentang DM Tipe 2 sebelum dan sesudah edukasi dengan nilai p=0,07 dan p=0,948. Kesimpulan: Tidak ada perbedaan signifikan pengetahuan dan sikap masyarakat Desa X, Kabupaten Banyumas sebelum dan sesudah edukasi DM Tipe 2. Kata Kunci: Edukasi, Intervensi, Masyarakat, Pengetahuan, Sikap Introduction: Diabetes mellitus (DM) needs to be prevented because it is a silent killer disease. Some cases are Type 2 DM. Based on the results of previous research, it shows that the people in Banyumas already have a fairly good level of knowledge, but do not yet have a good enough attitude towards preventing Type 2 DM. Necessary to provide education to the community and early detection of DM through blood sugar checks. The study aimed to determine the differences in knowledge and attitudes of Village X community, Banyumas Regency towards Type 2 DM before and after education. Method: The research design used a quasi-experiment during August 2023. A questionnaire was used to measured knowledge and attitude. Respondents answered the pre-test, then were given education and answered the post-test. Type 2 DM education was carried out through the delivery of material orally and in writing through presentations using PowerPoint slides and modules. The sample were 30 people from Village X, Banyumas Regency. Analysis of differences in knowledge and attitudes using the Wilcoxon test. Results: The Wilcoxon test results show that there is no significant difference in the knowledge and attitudes of the people of Village X regarding Type 2 DM before and after education with a p-value of 0.07 and 0.948.Conclusion: There were no significant difference in the knowledge and attitudes of the people of Village X, Banyumas Regency pre and post Type 2 DM education.Keywords: Education, Intervention, Society, Knowledge, Attitude
Co-Authors Aisyah Apriliciciliana Aryani Ayunda Tasya Hapsari Binar Pratama Damairia Hayu Parmasari Fareza, Muhamad Salman Indra Yudhawan Lita Heni Kusumawardani Muhammad Salman Fareza Pramesti Widya Hapsari Putri Khaerani Cahyaningrum