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All Journal Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Jurnal Ekologi, Masyarakat dan Sains Jurnal Riset Multidisiplin Edukasi
M. Kanedi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Other

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Boosting Sperm Count Using Red Ginger in Mice Induced by Paraquat Dichloride (1.1-dimethyl-4.4 bipyridinium) Siti Umairoh; Sutyarso Sutyarso; M. Kanedi; Hendri Busman
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 6 No. 2 (2019)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v6i2.22

Abstract

Paraquat dichloride (1.1'-dimethyl-4.4'-bipyridinium dichloride) was commonly herbicide used by most farmers in Indonesia. It raises herbicide-free radicals and affects male reproductive organs. It caused infertility such as a decrease in the number of spermatogenic cells. Fortunately, red ginger has capable of dealing with infertility problems. This study aims to see whether the ethanol extract of red ginger can increase the number of spermatocyte and spermatid cells induced by paraquat dichloride. This study uses a completely randomized design with 24 male mice were divided into six treatment groups with four replications. Group K as a control (H2O), J (Ginger 18 mg / ml), Pq (Paraquat 20mg / BB), P1 (Pq 20 mg / BB + EEJM 6 mg / ml), P2 (Paraquat 20mg / BB + EEJM 12 mg / ml) and P3 (Paraquat 20mg / BB + EEJM 18 mg / ml). Paraquat is given 2 times a week for 21 days, while the ethanol extract of red ginger added for 35 days. The number of cells spermatocyte and spermatid cells of male mice and performed analysis of variance (ANOVA) and Least Significant Difference Test (BNT) level of 5% observed as the parameter. The results showed that ethanol extract of red ginger 6, 12 and 18 mg/ml increased the number of spermatocyte and spermatid cells of male mice induced by paraquat dichloride.
Organ-Protective Effect of Red Ginger Extracts in Male Mice Induced by Paraquat Kamiliah Tsany; Sutyarso Sutyarso; M. Kanedi; Hendri Busman
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 6 No. 2 (2019)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v6i2.24

Abstract

Paraquat is a toxic compound that disrupts biochemical processes in the body, cell death, and multi-organ failure. The liver and lung are the target organ of paraquat toxicity. The body needs antioxidants to counteract free radicals. Red ginger (Zingiber officinale Roxb. Var rubrum) is a spice that contains antioxidants. This study was conducted to determine the effect of ethanol extract of red ginger (Zingiber officinale Roxb. Var rubrum) on liver and lung histology male mice induced by paraquat. The research used completely randomized design and use of 6 treatment groups, i.e. control group (given distilled water and standard feed), PQ group (induced by paraquat 20 mg/kg per BW), group P1 (given paraquat and ethanol extracts of red ginger 200 mg/kg per BW), group P2 (given paraquat and ethanol extract of red ginger 400 mg/kg per BW), group P3 (given paraquat and ethanol extract of red ginger 600 mg/kg per BW), group P4 (given ethanol extract of red ginger extract 600 mg/kg per BW). The data obtained will be tested using One Way ANOVA and continued by Least Significant Difference (LSD) with a 95% confidence level. The results showed ethanol extract of red ginger effective against liver and lung histology male mice induced by paraquat. The results also showed ethanol extract of red ginger with a dose of 400 mg/kg per BW is effective in protecting the liver and lung from damage caused induced by paraquat.
Determination of Aedes Spp. Mosquito Breeding Spots as a High-Risk Area Through Maya Index Analysis in Way Halim Bandar Lampung Athiyya Nurfadhilah; Emantis Rosa; M. Kanedi; Tugiyono Tugiyono
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 6 No. 2 (2019)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v6i2.36

Abstract

Dengue Haemorrhagic Fever (DHF) is a disease that is transmitted through the Aedes aegypti and Aedes albopictus mosquito vectors. The Maya index (MI) is an indicator to identify whether an area is at high risk as a breeding site for mosquitoes. This study aims to determine the types of breeding places and types of mosquito larvae of DHF and MI vectors in the Way Halim District of Bandar Lampung. The method used was a survey method on 100 houses in 5 villages in Way Halim District, namely Jaga Baya 1, Jaga Baya 2, Jaga Baya 3, Way Halim Permai, and Gunung Sulah. Data analysis to determine MI uses the Breeding Risk Index (BRI) and Hygiene Risk Indicator (HRI) indicators. The results of this study indicate that there were 225 containers inside the house observed, where 51 containers of them were found to have Aedes mosquito larvae while outside the house found as many as 28 containers with 8 containers including larvae. The identification results found 2 types of Aedes mosquitoes namely, Ae. aegypti (88.24%) and Ae. albopictus (11.76%). The results of the MI analysis show that Way Halim District is classified as a District with a moderate MI category with an MI value of 46%
PENURUNAN LAJU PENUAAN REPRODUKSI MENCIT JANTAN (Mus muculus.Linn) DENGAN PEMBERIAN EKSTRAK JAHE (Zingiber officinale) DALAM PAKAN Sutyarso Sutyarso; Sumayyah Annida; M. Kanedi; Hendri Busman; Nuning Nurcahyani
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 5 No. 1 (2018)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v5i1.52

Abstract

The ginger rhizome contains antioxidants and is chemoprotective, therefore we suspect it can decrease the aging rate in the reproductive system. The purpose of this study, to determine the effect of ginger extract (Zingiber officinale) against reproductive aging of male mice (Mus musculus). This study, using 36 male mice (Mus musculus) aged 12-14 months, divided into three groups each 12 tails. Group 1 as controls, groups 2 and 3 were given 50 mg and 100 mg ginger extract / kg of pellets. The pellet is given for 70 days ad libitum. Next, observed the number of spermatogenic cells, as well as the number and quality of spermatozoa. The results showed that ginger extract had an effect on spermatogenic and spermatozoa (P <0,01) cells of mice. The results of preleptotene spermatocyte, pakhiten and spermatid spermatocyte counts were higher, as were the number of spermatozoa, the percentage of viability and motility, and the normal morphology of spermatozoa were more in the group given ginger extract than control (P <0.01). It was concluded that ginger rhizome extract given to mice entering the aging period could inhibit the rate of decline in reproductive function.
Pengaruh Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L.) Terhadap Penurunan Kadar Gula Darah dan Gejala Toksisitas Pada Mencit (Mus Musculus L.) Khatarina Septi Amelia Putri; Nuning Nurcahyani; Dzul Fithria Mumtazah; M. Kanedi
Jurnal Riset Multidisiplin Edukasi Vol. 2 No. 5 (2025): Jurnal Riset Multidisiplin Edukasi (Edisi Mei 2025)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v2i5.311

Abstract

Hyperglycemia refers to elevated blood glucose levels above the normal range. It is caused by glucose accumulation in the blood that fails to enter cells, insulin hormone dysfunction, and hereditary factors. This condition can impair organ function. Several studies have shown that Momordica charantia contains compounds that stimulate the regeneration of beta cells, thereby increasing insulin production. This study aims to evaluate the effectiveness of ethanol extract from M. charantia fruit in lowering blood glucose levels and to observe any toxicity symptoms induced by the extract in mice, to assess its safety. The research used a Completely Randomized Design (CRD) involving six treatment groups with five replications each: K(-) without alloxan or test substances, K(+) induced with alloxan and treated with glibenclamide, and P1 to P4 induced with alloxan and administered M. charantia extract at doses of 5, 50, 300, and 2000 mg/kg body weight, respectively. Observed parameters included mean body weight, blood glucose levels, toxicity symptoms (behavioral changes), organ weight, and macroscopic examination. Results indicated that the ethanol extract of M. charantia effectively reduced blood glucose levels in alloxan-induced male mice. Group P4 (2000 mg/kg BW) showed the most significant reduction (129.5 mg/dL). No significant toxicity symptoms were observed in organ weight or macroscopic structure, suggesting that the ethanol extract of M. charantia is safe for use.
Studi Bioassay Fly Ash Batubara Terhadap Dapnia magna Ramadan, Viki; M. Kanedi; Priyambodo; Tugiyono
Jurnal Ekologi, Masyarakat dan Sains Vol 5 No 1 (2024): Jan-Jun 2024
Publisher : ECOTAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55448/771d6z09

Abstract

Fly ash merupakan salah satu limbah pembakaran batubara. Fly ash mempunyai kandungan bahan anorganik yang memiliki unsur dan logam berat.  Fly ash dapat dimanfaatkan untuk bahan adsorben, tambahan pada industri semen dan pembenah lahan (soil conditioner). Namun kandungan logam berat pada fly ash tidak mampu diurai oleh lingkungan dan berpotensi terakumulasi pada organisme. Metode bioassay adalah metode yang digunakan untuk mengetahui pengaruh suatu bahan terhadap organisme. Metode ini memaparkan suatu bahan secara langsung terhadap organisme uji. Dapnia magna merupakan salah satu organisme yang digunakan sebagai organisme standar dalam uji bioassay. Penelitian ini bertujuan untuk mengetahui nilai LC50 96 jam pemaparan fly ash terhadap hewan uji. Konsentrasi yang digunakan pada uji sesungguhnya berupa 14.000, 21.000, 30.000, 45.000, 65.000, 94.000, 137.000, dan 199.000 ppm. Hasil penelitian menunjukan nilai LC50 96 jam berada pada estimasi kosentrasi 50.251 ppm.  Berdasarkan kriteria toksisitas, nilai LC yang didapatkan masuk ke dalam kategori almost non toxic.
Co-Authors Athiyya Nurfadhilah Dzul Fithria Mumtazah Emantis Rosa Hendri Busman Kamiliah Tsany Khatarina Septi Amelia Putri Nuning Nurcahyani Priyambodo Ramadan, Viki Siti Umairoh Sumayyah Annida Sutyarso Sutyarso Tugiyono Tugiyono Tugiyono