Articles
<![CDATA[Selecting Hormonal Contraceptives in Women Taking Antiepileptic Drugs : Review of Literature and Practical Recommendations ]]>
<![CDATA[Hendra Permana]]>;
<![CDATA[Restu Susanti]]>;
<![CDATA[Syamel Muhammad]]>
<![CDATA[ Andalas Obstetrics And Gynecology Journal Vol 4, No 2 (2020) ]]>
Publisher : <![CDATA[Universitas Andalas ]]>
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DOI: 10.25077/aoj.4.2.231-240.2020
<![CDATA[Contraception is a very important issue in women with epilepsy, since very broad questions taken in applying it to prevent unplanned pregnancy. The choice of contraceptive methods must be related to how the mechanism of action of antiepileptic drugs (AEDs), the contraceptive itself, and both interactions. Hormonal contraception can induce metabolism of AEDs and lead to increasing of seizure frequency, and in the other hand AEDs may decrease the blood levels of hormonal contraception. Therefore, physician must consider the type of contraception being used before prescribing AEDs. Additionally, they should emphasize the interaction between them in counseling, to assure that women with epilepsy have time to decide which type will be best use for them. This challenging matter needs better recommendation for practice, both neurologist and gynecologist.Keywords: antiepileptic drug, contraception, women with epilepsy]]>
<![CDATA[Premature Ovarian Failure and Epilepsy ]]>
<![CDATA[Hendra Permana]]>;
<![CDATA[Afriyeni Sri Rahmi]]>;
<![CDATA[Syamel Muhammad]]>
<![CDATA[ Andalas Obstetrics And Gynecology Journal Vol 5, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Andalas ]]>
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DOI: 10.25077/aoj.5.1.1-8.2021
<![CDATA[Premature ovarian failure (POF) or premature menopause refers to development of amenorrhoea due to cessation of ovarian function before the age of 40 years. The diagnosis is based on elevated FSH levels in menopausal range (usually above 40 IU/l) detected on at least two occasions a few weeks apart. The term “epilepsy” defines a group of disorders characterized by an enduring predisposition of the brain to produce seizures. The hypothalamic-pituitary-ovarian axis regulation is affected by the abnormal neurophysiology of seizures, and the hypothalamic-pituitary-ovarian associated hormones are affected by medications used to treat seizures in women with epilepsy. Ictal and interictal discharges can disrupt the normal activity of brain structures, including the limbic system, amygdala, hypothalamus, and pituitary gland. Management of epilepsy in women requires not only knowledge of epilepsy, but also recognition of the various roles and priorities women have in their lives (education, career development, child rearing, the role as carer within the extended family), and attention to gender-specific issues and their impact on patients’ wellbeing throughout life.Keywords: premature ovarian failure (POF), epilepsy]]>
<![CDATA[Hubungan Morfologi Plak pada Stenosis Arteri Karotis Ekstrakranial dengan Kejadian Stroke Iskemik ]]>
<![CDATA[Dedi Sutia]]>;
<![CDATA[Syarif Indra]]>;
<![CDATA[Hendra Permana]]>;
<![CDATA[Lenny Arinda]]>;
<![CDATA[Afriyeni Sri Rahmi]]>
<![CDATA[ Jurnal Kesehatan Andalas Vol 9, No 2 (2020): Online June 2020 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jka.v9i2.1274
<![CDATA[Stenosis arteri ekstrakranial bermanifestasi dalam berbagai kondisi, mulai dari asimptomatik hingga stroke iskemik. Salah satu modalitas diagnostik untuk mengevaluasi gambaran stenosis tersebut adalah carotid duplex. Terdapatnya plak pada stenosis arteri ekstrakranial mempengaruhi kejadian stroke iskemik. Namun masih belum jelas hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik. Tujuan: Menentukan hubungan morfologi plak pada stenosis arteri karotis ekstrakranial dengan kejadian stroke iskemik. Metode: Penelitian ini merupakan studi analitik dengan desain cross sectional yang dilakukan pada 20 orang sampel pada bulan Januari hingga September 2018 di RSUP Dr M Djamil, Padang. Kriteria inklusi adalah pasien yang telah didiagnosis stenosis arteri ekstrakranial dengan plak dari pemeriksaan carotid duplex dan kriteria eksklusi adalah pasien yang tidak datang kontrol atau tidak bisa dihubungi. Hubungan antar variable diuji dengan uji Chi-square. Hasil dianggap bermakna secara statistik jika nilai p<0,05. Hasil: Sebanyak 12 orang (60%) sampel adalah perempuan dan 8 orang (40%) adalah laki-laki. Median umur sampel adalah 56 tahun (37-71 tahun). Morfologi plak berupa plak nonulcerated sebanyak 11 orang (55%) dan plak ulcerated sebanyak 9 orang (45%). Kejadian stroke iskemik ditemukan sebanyak 9 orang (45%) dan tidak stroke sebanyak 11 orang (55%). Terdapat hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik (p = 0,02); RR = 5. Simpulan: Terdapat hubungan bermakna antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik.Kata Kunci: morfologi plak, stenosis arteri ekstrakranial, stroke iskemik]]>
<![CDATA[Relationship of Serum Tau Levels with Cognitive Functions and Factors Affecting The Cognitive Function Decrease in Parkinson's Disease Patients ]]>
<![CDATA[Meldayeni Busra]]>;
<![CDATA[Yuliarni Syafrita]]>;
<![CDATA[Hendra Permana]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i6.317
<![CDATA[Introduction: Cognitive impairment is a non-motor symptom of Parkinson's disease (PD) which occurs as the disease progresses and affects quality of life. Many efforts have been developed in early detection of cognitive disorders, one of which is the examination of tau protein biomarkers, where the tau protein that undergoes pathological changes to form neurofibrillary tangles (NFTs) is found in Alzheimer's disease and PD and plays a role in cognitive impairment. However, the role of tau in PD is still controversial. This study aims to assess the relationship between serum tau levels and cognitive function and the factors that affect cognitive function in PD patients. Methods: This cross-sectional design was conducted at the RSUP DR. M Djamil Padang. During the period March to August 2020, 62 research subjects were obtained. Cognitive function examination was carried out by using the MoCA-Ina test and examination of serum tau levels using the Elisa method. The relationship between categorical variables was tested by Chi square and differences in serum tau levels in the group with and without cognitive impairment were tested with the Mann Whitney test, considered statistically significant if the p value <0.05. Results: With Moca Ina examination, it was found that 67.7% of patients had impaired cognitive function. The mean serum tau level was 198.004 ± 162.69 ng / L.There was a significant relationship between education level and degree of disease with cognitive function (p <0.05) and there was no difference in mean serum tau levels between groups with and without cognitive impairment. Conclusion: There is a significant relationship between education level and degree of disease with cognitive function and there is no difference in mean serum tau protein levels between the cognitive impaired group and the cognitive normal group.]]>
<![CDATA[The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease ]]>
<![CDATA[Ahmad Afdal]]>;
<![CDATA[Syarif Indra]]>;
<![CDATA[Hendra Permana]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i9.350
<![CDATA[Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.]]>
<![CDATA[Factors Related To Outcome of Traumatic Brain Injury Patients at M Djamil Padang Hospital ]]>
<![CDATA[Nora Fitri]]>;
<![CDATA[Syarif Indra]]>;
<![CDATA[Hendra Permana]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i8.388
<![CDATA[Background: Traumatic brain injury is still a major threat because it can cause global morbidity and mortality. Many factors can affect the outcome of a traumatic brain injury. Some conditions that can exacerbate traumatic brain injury include GCS conditions, blood pressure variability, and pupillary reflexes.Methods: The research was conducted in M. Djamil Padang Hospital from October 2020 to March 2021. The study design was a cross-sectional study in traumatic brain injury patients with ≤ 48 hours of onset and the aged between 18-60 years. The subjects in this study consisted of 66 subjects. At 6 weeks after onset, a GOS assessment was performed to assess patient outcomes. Statistical analysis was performed computerized with SPSS 22.0. P-value <0.05 was considered statistically significant. Results: Most of the patients were male (71.2%) with an average age of 36.41 ± 14,275 years, and the most common injury mechanism was traffic accidents (95.5%). There was a significant relationship between onset of incidence, hypotension, pupillary reflexes, and Rotterdam score with the outcome of traumatic brain injury patients (p<0.05) and there was no significant relationship between age, gender, and mechanism of injury with the outcome patients with traumatic brain injury. Conclution: The onset of events, hypotension, pupillary reflexes, and Rotterdam scores significantly affect the outcome patients of traumatic brain injury.]]>
<![CDATA[Hubungan gangguan pendengaran dengan penurunan fungsi kognitif pada usia lanjut ]]>
<![CDATA[Ade Asyari]]>;
<![CDATA[Hendra Permana]]>;
<![CDATA[Al Hafiz]]>;
<![CDATA[Rossy Rosalinda]]>
<![CDATA[ Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Andalas ]]>
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DOI: 10.25077/mka.v43.i1.p8-14.2020
<![CDATA[Tujuan: Mengetahui hubungan antara gangguan pendengaran dengan penurunan fungsi kognitif pada usia lanjut. Metode: Menggunakan metode studi potong lintang pada kelompok usia lanjut yang menghuni panti sosial Tresna Werdha Kasih Sayang Ibu di Batusangkar dari bulan Juli sampai September 2017. Terdapat 38 orang usia lanjut lebih dari 60 tahun yang masing-masingnya dilakukan pemeriksaan fungsi kognitif dengan Mini Mental State Examination (MMSE) dan pemeriksaan fungsi pendengaran dengan Oto Acoustic Emission (OAE). Data kemudian dianalisis dengan Fisher Exact Test dimana nilai p<0,05 dianggap bermakna. Hasil: Didapatkan median umur 71 tahun (60-86 tahun), jenis kelamin laki-laki sebanyak 76,3%, fungsi kognitif terganggu sebanyak 68,4% dan pendengaran terganggu sebanyak 68,4%. Simpulan: Terdapat hubungan antara gangguan pendengaran dengan fungsi kognitif pada usia lanjut. ]]>
<![CDATA[Tingkat Pengetahuan, Sikap, dan Persepsi Mengenai Epilepsi antara Masyarakat Pedesaan dan Perkotaan di Padang ]]>
<![CDATA[Hendra Permana]]>
<![CDATA[ Health and Medical Journal Vol 3, No 1 (2021): HEME January 2021 ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/heme.v3i1.463
<![CDATA[Introduction: The Knowledge, perception and attitude about epilepsy in developing country, including Indonesia is still low. These problems can cause stigma and discrimination to the patient. Society still has the view that epilepsy is not a disease, but because of the inclusion of evil spirits, possessions, witches or a curse. Furthermore, the information gap between rural and urban society could contribute to the issues. Aims: This study was aimed to explore the knowledge, perception and attitude about epilepsy between rural and urban society in Padang. Method: This study used cross sectional comparative design. This study was conducted on February – June 2018 at Ulak Karang (urban) and Bungus (rural) public health center. The subjects of this study were 140 visitors of both public health centers. The inclusions criteria of this study was all visitors ≥ 17 years old and the exclusion criteria was all incomplete data. Data was taken by using questionnaire with 13 close questions. These data was analyzed with SPSS 22. Mannwhitney tests and Chi Square test were used to compare the knowledge, perception and attitude from the two groups. A P value below 0.05 was considered asstatistically significant. Result: From demographic data, there were no significant differences between urban and rural communities. In terms of knowledge about epilepsy, there are significant differences regarding the causes of epilepsy with a value of p = 0.002. In addition, perceptions of epilepsy stigma that differed significantly in urban and rural communities were regarding malformations in epilepsy patients with p = 0.046. As for community attitudes towards epilepsy patients, there were no significant differences between urban and rural areas Conclusion: Stigma is a frightening thing for people with epilepsy, because it can interfere with their social interactions and also reduce the opportunity to get a job and also the opportunity to get married. ]]>
<![CDATA[Hubungan Kadar Magnesium Serum Dan Hba1c dengan Severitas Neuropati Diabetik ]]>
<![CDATA[Andi Fadilah Yusran]]>;
<![CDATA[Yuliarni Syafrita]]>;
<![CDATA[Hendra Permana]]>
<![CDATA[ Jurnal Ilmu Kedokteran Vol 16, No 1 (2022): Jurnal Ilmu Kedokteran ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Riau ]]>
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DOI: 10.26891/JIK.v16i1.2022.22-29
<![CDATA[Low magnesium levels are known to be associated with increased risk of diabetes mellitus and its complications. In addition, HbA1c levels are also known to have a correlation with further diabetes complications such as diabetic neuropathy. Diabetic neuropathy is the most common microvascular complication in diabetes mellitus, whose incidence is associated with disability and mortality rates in diabetic patients. This study aimed to assess the correlation between serum magnesium levels and HbA1c with the severity of diabetic neuropathy. This was a cross-sectional study. Severity of diabetic neuropathy is classified according to the Baba's Diabetic Neuropathy Classification (BDC). All subjects were examined for serum magnesium and HbA1C levels. This study consisted of 46 diabetes mellitus subjects, with 69.6% of the subjects suffering from diabetic neuropathy. The average magnesium level in this study was 1.87 mg/dl ± 0.245 and the median HbA1c level was 8.6 %. There was no significant correlation between serum magnesium levels and HbA1c with the incidence and severity of diabetic neuropathy (p>0.05). However, there was a significant negative correlation between magnesium levels and HbA1c levels in diabetic neuropathy patients.]]>
<![CDATA[The Relationship between CC Ligand 5 Plasma Levels and Modic Changes in Low Back Pain Patients’ Severity ]]>
<![CDATA[Firstisa Nuzulia Krinseani]]>;
<![CDATA[Syarif Indra]]>;
<![CDATA[Hendra Permana]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.37275/bsm.v6i10.590
<![CDATA[Background: Low back pain (LBP) is one of the global health problems. The most common cause of LBP is disc degeneration. Modic changes (MC) are the most common MRI features in patients with disc degeneration. As a result of cartilage and disc tissue damage, CCL 5 is released and modulates pain responses in the dorsal root ganglion. This study aims to determine the relationship between CCL5 levels and the description of Modic changes on MRI with pain levels in patients with low back pain. Methods: This study is a cross-sectional study. The research subjects were LBP patients who were treated at the Neurology Polyclinic, Dr. M. Djamil General Hospital, Padang, in the range of March 2021-December 2021, who meets the inclusion and exclusion criteria. Subjects will be taken blood to assess CCL5 plasma levels, pain assessment using the McGill Pain Questionnaire, and undergo an MRI examination. Results: A total of 52 subjects consisted of 23 men and 29 women with an age range of 34-77 years. Most of the Modic changes were found in the type 2 group. Based on the pain scale, there were two groups with mild pain and moderate pain. On examination of plasma CCL 5 levels, the median value of plasma CCL5 levels was 303,271 ng/L. There was a significant relationship between plasma CCL5 levels and pain levels in patients with low back pain (p = 0.004). There was no significant relationship between Modic changes and the severity of pain. Conclusion: Plasma CCL5 levels are associated with pain levels in patients with low back pain, while Modic changes are not associated with pain severity.]]>
