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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Andalas obstetrics and gynecology journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Neurona
Hendra Permana
Universitas Andalas
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Selecting Hormonal Contraceptives in Women Taking Antiepileptic Drugs : Review of Literature and Practical Recommendations Hendra Permana; Restu Susanti; Syamel Muhammad
Andalas Obstetrics And Gynecology Journal Vol 4, No 2 (2020)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.231-240.2020

Abstract

Contraception is a very important issue in women with epilepsy, since very broad questions taken in applying it to prevent unplanned pregnancy. The choice of contraceptive methods must be related to how the mechanism of action of antiepileptic drugs (AEDs), the contraceptive itself, and both interactions. Hormonal contraception can induce metabolism of AEDs and lead to increasing of seizure frequency, and in the other hand AEDs may decrease the blood levels of hormonal contraception. Therefore, physician must consider the type of contraception being used before prescribing AEDs. Additionally, they should emphasize the interaction between them in counseling, to assure that women with epilepsy have time to decide which type will be best use for them. This challenging matter needs better recommendation for practice, both neurologist and gynecologist.Keywords: antiepileptic drug, contraception, women with epilepsy
Premature Ovarian Failure and Epilepsy Hendra Permana; Afriyeni Sri Rahmi; Syamel Muhammad
Andalas Obstetrics And Gynecology Journal Vol 5, No 1 (2021)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.1-8.2021

Abstract

Premature ovarian failure (POF) or premature menopause refers to development of amenorrhoea due to cessation of ovarian function before the age of 40 years. The diagnosis is based on elevated FSH levels in menopausal range (usually above 40 IU/l) detected on at least two occasions a few weeks apart. The term “epilepsy” defines a group of disorders characterized by an enduring predisposition of the brain to produce seizures. The hypothalamic-pituitary-ovarian axis regulation is affected by the abnormal neurophysiology of seizures, and the hypothalamic-pituitary-ovarian associated hormones are affected by medications used to treat seizures in women with epilepsy. Ictal and interictal discharges can disrupt the normal activity of brain structures, including the limbic system, amygdala, hypothalamus, and pituitary gland. Management of epilepsy in women requires not only knowledge of epilepsy, but also recognition of the various roles and priorities women have in their lives (education, career development, child rearing, the role as carer within the extended family), and attention to gender-specific issues and their impact on patients’ wellbeing throughout life.Keywords: premature ovarian failure (POF), epilepsy
Hubungan Morfologi Plak pada Stenosis Arteri Karotis Ekstrakranial dengan Kejadian Stroke Iskemik Dedi Sutia; Syarif Indra; Hendra Permana; Lenny Arinda; Afriyeni Sri Rahmi
Jurnal Kesehatan Andalas Vol 9, No 2 (2020): Online June 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1274

Abstract

Stenosis arteri ekstrakranial bermanifestasi dalam berbagai kondisi, mulai dari asimptomatik hingga stroke iskemik. Salah satu modalitas diagnostik untuk mengevaluasi gambaran stenosis tersebut adalah carotid duplex. Terdapatnya plak pada stenosis arteri ekstrakranial mempengaruhi kejadian stroke iskemik. Namun masih belum jelas hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik. Tujuan: Menentukan hubungan morfologi plak pada stenosis arteri karotis ekstrakranial dengan kejadian stroke iskemik. Metode: Penelitian ini merupakan studi analitik dengan desain cross sectional yang dilakukan pada 20 orang sampel pada bulan Januari hingga September 2018 di RSUP Dr M Djamil, Padang. Kriteria inklusi adalah pasien yang telah didiagnosis stenosis arteri ekstrakranial dengan plak dari pemeriksaan carotid duplex dan kriteria eksklusi adalah pasien yang tidak datang kontrol atau tidak bisa dihubungi. Hubungan antar variable diuji dengan uji Chi-square. Hasil dianggap bermakna secara statistik jika nilai p<0,05. Hasil: Sebanyak 12 orang (60%) sampel adalah perempuan dan 8 orang (40%) adalah laki-laki. Median umur sampel adalah 56 tahun (37-71 tahun). Morfologi plak berupa plak nonulcerated sebanyak 11 orang (55%) dan plak ulcerated sebanyak 9 orang (45%). Kejadian stroke iskemik ditemukan sebanyak 9 orang (45%) dan tidak stroke sebanyak 11 orang (55%). Terdapat hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik (p = 0,02); RR = 5. Simpulan: Terdapat hubungan bermakna antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik.Kata Kunci: morfologi plak, stenosis arteri ekstrakranial, stroke iskemik
Relationship of Serum Tau Levels with Cognitive Functions and Factors Affecting The Cognitive Function Decrease in Parkinson's Disease Patients Meldayeni Busra; Yuliarni Syafrita; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.317

Abstract

Introduction: Cognitive impairment is a non-motor symptom of Parkinson's disease (PD) which occurs as the disease progresses and affects quality of life. Many efforts have been developed in early detection of cognitive disorders, one of which is the examination of tau protein biomarkers, where the tau protein that undergoes pathological changes to form neurofibrillary tangles (NFTs) is found in Alzheimer's disease and PD and plays a role in cognitive impairment. However, the role of tau in PD is still controversial. This study aims to assess the relationship between serum tau levels and cognitive function and the factors that affect cognitive function in PD patients. Methods: This cross-sectional design was conducted at the RSUP DR. M Djamil Padang. During the period March to August 2020, 62 research subjects were obtained. Cognitive function examination was carried out by using the MoCA-Ina test and examination of serum tau levels using the Elisa method. The relationship between categorical variables was tested by Chi square and differences in serum tau levels in the group with and without cognitive impairment were tested with the Mann Whitney test, considered statistically significant if the p value <0.05. Results: With Moca Ina examination, it was found that 67.7% of patients had impaired cognitive function. The mean serum tau level was 198.004 ± 162.69 ng / L.There was a significant relationship between education level and degree of disease with cognitive function (p <0.05) and there was no difference in mean serum tau levels between groups with and without cognitive impairment. Conclusion: There is a significant relationship between education level and degree of disease with cognitive function and there is no difference in mean serum tau protein levels between the cognitive impaired group and the cognitive normal group.
The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease Ahmad Afdal; Syarif Indra; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.350

Abstract

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.
Factors Related To Outcome of Traumatic Brain Injury Patients at M Djamil Padang Hospital Nora Fitri; Syarif Indra; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.388

Abstract

Background: Traumatic brain injury is still a major threat because it can cause global morbidity and mortality. Many factors can affect the outcome of a traumatic brain injury. Some conditions that can exacerbate traumatic brain injury include GCS conditions, blood pressure variability, and pupillary reflexes.Methods: The research was conducted in M. Djamil Padang Hospital from October 2020 to March 2021. The study design was a cross-sectional study in traumatic brain injury patients with ≤ 48 hours of onset and the aged between 18-60 years. The subjects in this study consisted of 66 subjects. At 6 weeks after onset, a GOS assessment was performed to assess patient outcomes. Statistical analysis was performed computerized with SPSS 22.0. P-value <0.05 was considered statistically significant. Results: Most of the patients were male (71.2%) with an average age of 36.41 ± 14,275 years, and the most common injury mechanism was traffic accidents (95.5%). There was a significant relationship between onset of incidence, hypotension, pupillary reflexes, and Rotterdam score with the outcome of traumatic brain injury patients (p<0.05) and there was no significant relationship between age, gender, and mechanism of injury with the outcome patients with traumatic brain injury. Conclution: The onset of events, hypotension, pupillary reflexes, and Rotterdam scores significantly affect the outcome patients of traumatic brain injury.
Hubungan gangguan pendengaran dengan penurunan fungsi kognitif pada usia lanjut Ade Asyari; Hendra Permana; Al Hafiz; Rossy Rosalinda
Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.57 KB) | DOI: 10.25077/mka.v43.i1.p8-14.2020

Abstract

Tujuan: Mengetahui hubungan antara gangguan pendengaran dengan penurunan fungsi kognitif pada usia lanjut. Metode: Menggunakan metode studi potong lintang pada kelompok usia lanjut yang menghuni panti sosial Tresna Werdha Kasih Sayang Ibu di Batusangkar dari bulan Juli sampai September 2017. Terdapat 38 orang usia lanjut lebih dari 60 tahun yang masing-masingnya dilakukan pemeriksaan fungsi kognitif dengan Mini Mental State Examination (MMSE) dan pemeriksaan fungsi pendengaran dengan Oto Acoustic Emission (OAE). Data kemudian dianalisis dengan Fisher Exact Test dimana nilai p<0,05 dianggap bermakna. Hasil: Didapatkan median umur 71 tahun (60-86 tahun), jenis kelamin laki-laki sebanyak 76,3%, fungsi kognitif terganggu sebanyak 68,4% dan pendengaran terganggu sebanyak 68,4%. Simpulan: Terdapat hubungan antara gangguan pendengaran dengan fungsi kognitif pada usia lanjut. 
Relationship of Serum Tau Levels with Cognitive Functions and Factors Affecting The Cognitive Function Decrease in Parkinson's Disease Patients Meldayeni Busra; Yuliarni Syafrita; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.317

Abstract

Introduction: Cognitive impairment is a non-motor symptom of Parkinson's disease (PD) which occurs as the disease progresses and affects quality of life. Many efforts have been developed in early detection of cognitive disorders, one of which is the examination of tau protein biomarkers, where the tau protein that undergoes pathological changes to form neurofibrillary tangles (NFTs) is found in Alzheimer's disease and PD and plays a role in cognitive impairment. However, the role of tau in PD is still controversial. This study aims to assess the relationship between serum tau levels and cognitive function and the factors that affect cognitive function in PD patients. Methods: This cross-sectional design was conducted at the RSUP DR. M Djamil Padang. During the period March to August 2020, 62 research subjects were obtained. Cognitive function examination was carried out by using the MoCA-Ina test and examination of serum tau levels using the Elisa method. The relationship between categorical variables was tested by Chi square and differences in serum tau levels in the group with and without cognitive impairment were tested with the Mann Whitney test, considered statistically significant if the p value <0.05. Results: With Moca Ina examination, it was found that 67.7% of patients had impaired cognitive function. The mean serum tau level was 198.004 ± 162.69 ng / L.There was a significant relationship between education level and degree of disease with cognitive function (p <0.05) and there was no difference in mean serum tau levels between groups with and without cognitive impairment. Conclusion: There is a significant relationship between education level and degree of disease with cognitive function and there is no difference in mean serum tau protein levels between the cognitive impaired group and the cognitive normal group.
The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease Ahmad Afdal; Syarif Indra; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.350

Abstract

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.
Factors Related To Outcome of Traumatic Brain Injury Patients at M Djamil Padang Hospital Nora Fitri; Syarif Indra; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.388

Abstract

Background: Traumatic brain injury is still a major threat because it can cause global morbidity and mortality. Many factors can affect the outcome of a traumatic brain injury. Some conditions that can exacerbate traumatic brain injury include GCS conditions, blood pressure variability, and pupillary reflexes.Methods: The research was conducted in M. Djamil Padang Hospital from October 2020 to March 2021. The study design was a cross-sectional study in traumatic brain injury patients with ≤ 48 hours of onset and the aged between 18-60 years. The subjects in this study consisted of 66 subjects. At 6 weeks after onset, a GOS assessment was performed to assess patient outcomes. Statistical analysis was performed computerized with SPSS 22.0. P-value <0.05 was considered statistically significant. Results: Most of the patients were male (71.2%) with an average age of 36.41 ± 14,275 years, and the most common injury mechanism was traffic accidents (95.5%). There was a significant relationship between onset of incidence, hypotension, pupillary reflexes, and Rotterdam score with the outcome of traumatic brain injury patients (p<0.05) and there was no significant relationship between age, gender, and mechanism of injury with the outcome patients with traumatic brain injury. Conclution: The onset of events, hypotension, pupillary reflexes, and Rotterdam scores significantly affect the outcome patients of traumatic brain injury.
Co-Authors Ade Asyari Afriyeni Sri Rahmi Ahmad Afdal Al Hafiz Andi Fadilah Yusran Andi Fadilah Yusran Putri Arina Widya Murni Dea Rika Putri Purba Dedi Sutia Dedi Sutia Eldi Sauma Firstisa Nuzulia Krinseani Lenny Arinda Meldayeni Busra Nora Fitri Restu Susanti Ribka Ankashima Sembiring Rika Susanti Rossy Rosalinda Syamel Muhammad Syarif Indra Syarif Indra Syarif Indra Syarif Indra Syarif Indra Yuliarni Syafrita