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All Journal Indonesian Journal of Rheumatology Health and Medical Journal Andalas obstetrics and gynecology journal Jurnal Health Sains Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran
Yessy Setiawati
Anatomical Pathology Department, Faculty Of Medicine, Andalas University, Dr. M. Djamil Central General Hospital Padang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Difficulty in Diagnosing Peritoneal Fluid Cytology in Ovarian Yolk Sac Tumor Cases Haris Pemuda; Yenita Yenita; Pamelia Mayorita; Yessy Setiawati; Syamel Muhammad
Andalas Obstetrics And Gynecology Journal Vol 5, No 2 (2021)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.278-286.2021

Abstract

Objective : This article objective is to describe cytology diagnosis difficulties of yolk sac tumors of the ovary.Method : Case reports and literature review.Case : The author reports the case of a 24 year old woman who complained of an enlarged stomach. Serum AFP increased to 16,519.7 U/mL. Ultrasound examination revealed solid and irregular mass of ovarian, so the conclusion was suspect ovarian carcinoma. Conclusion of CT scan examination was a solid ovarian tumor. The working diagnosis was suspect ovarian carcinoma. Optimal debulking was performed, accompanied by taking a sample from the peritoneal rinse fluid. Microscopic examination of peritoneal fluid showed the distribution and group of cells with pleomorphic nuclei, partly hyperchromatic, partly vesicular with coarse chromatin and prominent nucleoli. There were also cells with polygonal nuclei, small nuclei, basophilic and vacuole cytoplasm with a mucoid background. These cells formed a solid arrangement. Conclusion from these features was carcinoma metastases to the peritoneal fluid. Microscopic examination from tumor tissue sample showed an ovarian yolk sac tumor appearance.Conclusion : Cytologic examination of peritoneal fluid in cases of ovarian yolk sac tumor is quite difficult to determine the diagnosis. This is due to the microscopic appearance of tumor cells which often looks like a carcinoma and limited literature about this tumors in the peritoneal fluid.Keywords: Yolk sac tumor, ovary, 
Cytomorphological Characteristics Of Ameloblastoma By Fine Needle Aspiration Biopsy Procedure Confirmed With Histopathological Examination Dewi Safnita; Noza Hilbertina; Yessy Setiawati
Jurnal Health Sains Vol. 3 No. 12 (2022): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v3i12.696

Abstract

Background: Ameloblastoma is the most common benign epithelial odontogenic tumor with malignant potential and is usually located in the jaw. It constitutes about 1-3% of all tumors and cysts of jaws. This entity has a very high recurrence rate of over 50% even after wide excision. Preoperative diagnosis of ameloblastoma can be made by fine-needle aspiration biopsy (FNAB) which is used as a guide for surgical planning. Case report: We report a case of a tumor in the mandible of a 41-year-old man with a preoperative diagnosis of ameloblastoma from a fine needle aspiration biopsy. Cytological examination of FNAB was confirmed by histopathological preparation of tumor tissue. Conclusion: The fine needle aspiration biopsy cytology is a reliable procedure for the pre-operative diagnosis of ameloblastoma. Pre-operative diagnosis of ameloblastoma can be used for planning therapy and early diagnosis of recurrence cases that can improve patient survival
MUCINOUS CARCINOMA OF THE OVARY IN PERITONEAL FLUID Prima Adelia Rachmita; Rachmadijah Zuryati Nizar; Yessy Setiawati
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 5, No 2 (2022): ILMU KEDOKTERAN
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v5i2.7613

Abstract

Peritoneal cytology is crucial in the diagnosis and staging of abdominal and pelvic malignancies. Diagnostic pitfalls can be avoided by having an understanding of the different methods of sampling, a familiarity with cytomorphology of the various specimen types, adequate clinical history, and an ability to prepare cell blocks and/or review other prior or concurrent specimens. Ovarian cancer is the second most frequent type of gynecological malignancy but the most lethal. While high-grade serous carcinoma is the most common histological subtype, mucinous carcinoma of the ovary (MCO) was believed to constitute around 4% of ovarian malignancies.  It is critical to diagnose these rare tumors correctly to ensure proper treatment, avoid mortality, and preserve fertility for young women.
Adenokarsinoma Paru yang Didiagnosis dari Histopatologi Metastasis di Otak dan Perikardium Dewi Safnita; Hera Novianti; Yessy Setiawati; Pamelia Mayorita
Health and Medical Journal Vol 5, No 1 (2023): HEME January 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i1.1246

Abstract

Latar belakang: Adenokarsinoma paru merupakan keganasan tersering dan dilaporkan sekitar 40% dari keganasan paru. Adenokarsinoma paru umumnya terdeteksi pada stadium lanjut dengan metastasis multipel sehingga tindakan pembedahan tidak dianjurkan. Tumor ini umumnya terletak di bagian pinggir paru. Tumor metastasis adenokarsinoma yang dapat direseksi merupakan spesimen berharga untuk menegakkan diagnosis dan menentukan terapi yang tepat. Laporan kasus: Seorang pria non-perokok berusia 24 tahun dengan penglihatan kabur yang dicurigai dengan tumor primer otak dari pemeriksaan fisik dan radiografi. Tindakan bedah kraniotomi dilakukan dan pemeriksaan histopatologi tumor menunjukkan metastasis adenokarsinoma pada otak. Pasien mengalami tamponade jantung dengan efusi perikardial massif dan limfadenopati leher. Pemeriksaan radiografi toraks menunjukkan adanya lesi paru kanan yang semakin jelas dalam empat bulan perjalanan penyakit. Pemeriksaan histopatologi dari semua tumor yang ditemukan termasuk di kelenjar getah bening leher, tumor perikardial, dan cairan efusi perikardial mengarah pada metastasis adenokarsinoma. Pewarnaan imunohistokimia untuk Epithelial Membrane Antigen (EMA) dan Thyroid Transcription Factor-1 (TTF-1) dilakukan untuk mendeteksi tumor primer dengan hasil mengarah tumor primer berasal dari paru. Pemeriksaan mutasi Epidermal Growth Factor Receptor (EGFR) dan pewarnaan imunohistokimia Programmed Death Ligand-1 (PDL-1) dilakukan untuk tujuan terapeutik. Pasien diterapi dengan kemoterapi konvensional dan menunjukkan perbaikan klinis. Kesimpulan: Dalam kasus ini, spesimen tumor metastasis pada otak dan perikardial merupakan spesimen yang sangat berharga untuk mengidentifikasi tumor primer dan menentukan manajemen terapi. Pemeriksaan histopatologi, imunohistokimia, dan molekuler diperlukan untuk menegakkan diagnosis.
Embryonal Rhabdomyosarcoma: Rare Case Reports with Middle Ear Location Runky Pebranka; Salmiah Agus; Yessy Setiawati
Indonesian Journal of Rheumatology Vol. 13 No. 3: Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v13i3.264

Abstract

Background: Patients with embryonal rhabdomyosarcoma (EMRS) are dominated by boys. The peak incidence occurs in the small age group from one year to 4 years. Approximately 35% of all pediatric RMS occur in the head and neck. Case presentation: A 3-year-old male patient came to the ear, nose, throat-head neck (ENT-HNS) polyclinic at Dr. M. Djamil General Hospital Padang on February 25th, 2021, with complaints of a lump appearing in his right ear canal for 4 months. The patient also complained of slanting on the right side of his face and pain in his right ear since 2 weeks ago. History of bleeding from the ear 1 week ago. On the examination of House-Brackmann, the patient obtained a category House-Brackmann V. Histopathological results, microscopically visible pieces of tissue with part of the surface covered with keratinized squamous epithelium, part of the surface not keratinized. There are dense groups consisting of a proliferation of cells with round, oval nuclei, small to medium size, little cytoplasm, some cells with pleomorphic nuclei, hyperchromatic, irregular nuclear membranes, lots of eosinophilic cytoplasms, with the appearance of "tadpole”, atypical mitoses may be found. The underlying tissue stroma appears myxoid. Among them, fibrotic connective tissue septa containing partially hyperemic capillaries are visible. Necrotic areas and clusters of PMN leukocytes and cellular debris were also seen. This description is consistent with EMRS. Conclusion: The patient was diagnosed with right middle ear EMRS stage III with right peripheral facial nerve paresis House-Brackmann V.
Co-Authors Dewi Safnita Dewi Safnita Haris Pemuda Hera Novianti Noza Hilbertina Pamelia Mayorita Prima Adelia Rachmita Rachmadijah Zuryati Nizar Runky Pebranka Salmiah Agus Syamel Muhammad Yenita Afriyeni