Garuda - Garba Rujukan Digital

Cytomorphological Characteristics Of Ameloblastoma By Fine Needle Aspiration Biopsy Procedure Confirmed With Histopathological Examination Dewi Safnita; Noza Hilbertina; Yessy Setiawati
Jurnal Health Sains Vol. 3 No. 12 (2022): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v3i12.696

Background: Ameloblastoma is the most common benign epithelial odontogenic tumor with malignant potential and is usually located in the jaw. It constitutes about 1-3% of all tumors and cysts of jaws. This entity has a very high recurrence rate of over 50% even after wide excision. Preoperative diagnosis of ameloblastoma can be made by fine-needle aspiration biopsy (FNAB) which is used as a guide for surgical planning. Case report: We report a case of a tumor in the mandible of a 41-year-old man with a preoperative diagnosis of ameloblastoma from a fine needle aspiration biopsy. Cytological examination of FNAB was confirmed by histopathological preparation of tumor tissue. Conclusion: The fine needle aspiration biopsy cytology is a reliable procedure for the pre-operative diagnosis of ameloblastoma. Pre-operative diagnosis of ameloblastoma can be used for planning therapy and early diagnosis of recurrence cases that can improve patient survival

Potensi Ekstrak Daun Sirsak Dalam Menginduksi Apoptosis Sel Kanker Serviks HeLa Nadya Mirenda Putri; Dessy Arisanty; Noza Hilbertina
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.722

Latar Belakang: Kanker serviks merupakan kanker dengan tingkat kematian tertinggi pada wanita di Indonesia. Sebagian besar penderita kanker serviks datang pada stadium lanjut yang menyebabkan pengobatan menjadi kurang optimal sehingga memerlukan penelitian untuk mencari modalitas terapi, termasuk terapi alternatif. Setiap sel kanker mempunyai karakteristik khusus akibat mutasi genetik (hallmark of cancer) seperti sel kanker serviks yang memiliki kemampuan untuk menghindar dari apoptosis. Pada penelitian terdahulu, ekstrak daun sirsak berpotensi menginduksi apoptosis pada sel kanker. Objektif: Penelitian ini bertujuan untuk mengetahui potensi ekstrak daun sirsak dalam menginduksi apoptosis pada sel kanker serviks HeLa. Metode: Penelitian in vitro ini dilakukan dengan sel kanker serviks HeLa. Sel HeLa yang konfluens diinkubasi selama 24 jam setelah diberi perlakuan ekstrak daun sirsak dengan konsentrasi IC50 15,8 µg/ml. Apoptosis dilihat dengan pewarnaan Acridine Orange dan Propidium Iodide dan dilihat dibawah mikroskop fluoresens. Analisis data dilakukan menggunakan uji T independen. Hasil: Persentase apoptosis sel HeLa lebih tinggi pada kelompok perlakuan dibandingkan kelompok kontrol. (p< 0,001) Kesimpulan: ekstrak daun sirsak dapat menginduksi apoptosis pada sel HeLa.

Hubungan Ekspresi Sodium Iodide Symporter dengan Varian Histopatologi dan Stadium Papillary Thyroid Carcinoma Rini Purnama Sari; yenita - yenita; Noza - Hilbertina; tofrizal - tofrizal; Daan - Khambri; Husna - Yetti
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1280-1288.2024

Abstrak Tujuan: Mengetahui hubungan ekspresi sodium iodide symporter dengan varian histopatologi dan stadium papillary thyroid carcinoma. Metode: Penelitian ini merupakan penelitian observasional dengan pendekatan cross sectional. Sampel penelitian ini adalah kasus papillary thyroid carcinoma dari laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang periode Januari 2022-Desember 2022 sebanyak 37 kasus. Varian histopatologi papillary thyroid carcinoma dinilai berdasarkan WHO 2017 dan stadium klinis dinilai berdasarkan TNM American Joint Committee on Cancer edisi ke VIII. Ekspresi NIS dinilai melalui pulasan imunohistokimia. Analisis bivariat dilakukan dengan uji Chi-square dengan hasil uji statistik dianggap bermakna jika p < 0,05. Hasil: Penelitian ini menunjukkan ekspresi NIS positif sebesar 13,5%. Analisis statistik menunjukkan adanya hubungan yang bermakna antara ekspresi NIS dengan varian histopatologi papillary thyroid carcinoma (p=0,03). Varian histopatologi tertentu menunjukkan tingkat ekspresi NIS yang lebih tinggi dibandingkan dengan varian lainnya. Namun, penelitian ini tidak menemukan hubungan antara ekspresi NIS dengan stadium papillary thyroid carcinoma (p =0,61). Kesimpulan: Terdapat hubungan antara ekspresi NIS dengan varian histopatologi. Ekspresi NIS tidak berhubungan dengan stadium papillary thyroid carcinoma.Kata kunci: sodium iodide symporter; papillary thyroid carcinoma; varian histopatologi; stadium

A Rare Case of Multiple Hereditary Exostosis: Making The Correct Diagnosis with Triple Diagnosis Rahmi Ramadhani; Noza Hilbertina; Yenita; Tofrizal; Pamelia Mayorita; Loli Devianti; Meta Zulyati O ktora
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.248

Background: A rare genetic disorder characterized by the development of multiple benign bone tumors called osteochondromas. This condition is primarily hereditary and follows an autosomal dominant pattern of inheritance, with mutations in the EXT1 and EXT2 genes being the most common genetic. Case report: This case report describes an 12-year-old boy with lumps in all four extremities accompanied by intermittent pain. Femur x-rays concluded MHE of the femur, tibia, and bilateral fibula. Histopathological examination shows that the cartilage tissue contains chondrocyte cells that form the cartilage cap. There is a transition of cartilage to bone trabeculae through endochondral ossification and bone marrow between the bone trabeculae. Discussion and Conclusion: MHE is a rare condition, with an incidence of approximately 1 in 50,000 to 100,000 live births. MHE is closely related to genetic mutations that occur in the EXT1, EXT2, and EXT3 genes. These genes code for enzymes involved in the biosynthesis of heparan sulfate, which is necessary for normal bone growth. Mutations in any of these genes disrupt the regulation of bone growth and lead to osteochondroma formation. Symptoms of MHE can range from mild to severe, and they tend to appear in childhood or adolescence. The main clinical manifestations include the formation of a hard lump on the bone, which can cause deformity, pain, and limitation of movement. Osteochondroma can also compress nerves or blood vessels, causing complications such as circulatory disorders or paralysis. We report a rare case emphasizing the typical morphology of multiple hereditary exostosis of the long bones to establish the final diagnosis without immunohistochemistry and molecular examination. In low-resource settings where molecular analysis is not available, histopathological examination are key tools to establish a correct diagnosis.

Fine Needle Aspiration Biopsy as A Useful Diagnostic Adjunct in The Management of Ameloblastoma: A Cytology Case Report Rum Affida Rasfa; Shinta Ayu Intan; Noza Hilbertina; Meta Zulyati Oktora
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.249

Background: Ameloblastoma is one of the most common benign odontogenic tumors, known for its slow growth but locally invasive behavior, often leading to extensive bone destruction if not diagnosed and treated early. Preoperative diagnosis of ameloblastoma can be made by Fine Needle Aspiration Biopsy (FNAB) which is used as a guide for surgical planning. Diagnosis of ameloblastoma from cytology is challenging due to many pitfalls and differential diagnosis with other odontogenic lesions, but proper sampling and accurate diagnosis are very useful inpatient management Understanding its cytomorphological features can greatly assist in early differentiation from other maxillofacial neoplasms. This case report aims to describe the appearance of ameloblastoma on FNAB and reveal the contribution of the FNAB examination in the preoperative diagnosis of ameloblastoma so that adequate surgery can be carried out and the results are more optimal. Case report: We report a case of a tumor in the mandible of a 16-year-old man with a diagnosis of right mandibular tumor. The patient was sent for FNAB to the anatomical pathology laboratory. Preoperative cytology examination showed benign odontogenic lesions indicating ameloblastoma from FNAB. Furthermore, tumor resection was performed on the patient and histopathology tissue examination was performed with results consistent with ameloblastoma. Discussion: The FNAB procedure can be performed to establish for a pre-operative diagnosis of ameloblastoma. Cytological characteristics of ameloblastoma include basaloid cells or epithelial cells resembling ameloblasts with nuclei arranged palisade at the periphery and in the middle consisting of cells resembling stellate reticulum cells. False-negative results in the FNAB procedure can occur due to inadequate specimens or inaccurate sampling, mostly related to cystic tumors. To avoid this, FNAB tissue sampling can be performed at multiple sites and the deeper aspects of the tumor can assist in establishing an accurate preoperative diagnosis. Conclusion: The FNAB cytology is a reliable procedure for the pre-operative diagnosis of ameloblastoma. Pre-operative diagnosis of ameloblastoma can be used for planning therapy and early diagnosis of recurrence cases that can improve patient survival. The correlation between t

Tumor Budding Grade Based on the ITBCC 2016 Criteria is Associated with Lymphovascular Invasion and Lymph Node Involvement in Invasive Breast Carcinoma Nelzima, Maisyah; Asri, Aswiyanti; Tofrizal, Alimuddin; Hilbertina, Noza; Mulyani, Henny; Devianti, Loli; Fadila, Zurayya
Jurnal Penelitian Kesehatan SUARA FORIKES 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf17a03

Invasive breast carcinoma is a malignant neoplasm with metastatic potential influenced by various histopathological parameters, including tumor budding (TB). TB has emerged as a potential indicator of tumor aggressiveness; however, differences in assessment criteria may affect its clinical relevance. This study aimed to evaluate the association between TB grade and lymphovascular invasion (LVI) as well as lymph node involvement in invasive breast carcinoma using three different assessment criteria. A cross-sectional study was conducted on 44 cases of invasive breast carcinoma that met the inclusion criteria. TB was assessed at the invasive front using the International Tumor Budding Consensus Conference (ITBCC) 2016 criteria, as well as the criteria proposed by Usta et al. and Manimaran et al. LVI and lymph node status were determined through histopathological examination. The associations between variables were analyzed using the chi-square test or Fisher’s exact test, as appropriate. Tumor budding grade based on one standardized assessment system demonstrated a significant association with both LVI and lymph node involvement. In contrast, the other two grading approaches did not show statistically significant associations. As conclusion, within the context of this study, the ITBCC 2016 criteria appear to be more representative in reflecting tumor invasive activity in invasive breast carcinoma. These findings support the potential role of tumor budding as an additional indicator of tumor aggressiveness and highlight the importance of standardizing its assessment method in invasive breast carcinoma.Keywords: invasive breast carcinoma; tumor budding; lymphovascular invasion; lymph node involvement

The Large-Mass Phenotype of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Clinicopathological Analysis of 37 Cases in Indonesia Using WHO 2021 and Modified Stanford Criteria Yuliza Ariani; Henny Mulyani; Noza Hilbertina; Yenita; Aswiyanti Asri; Tofrizal; Loli Devianti; Hera Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1565

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) presents a diagnostic dilemma, especially in Southeast Asian populations, where delayed presentation often leads to advanced tumor burden. This study aimed to characterize the clinicopathological profile of STUMP in Indonesia using the 2021 WHO Classification and modified Stanford parameters. Methods: A descriptive study analyzed 37 STUMP cases diagnosed between 2023 and 2025 at a tertiary referral center in West Sumatra. A panel of pathologists re-evaluated archival slides for atypia, mitotic activity, necrosis, and growth patterns, establishing inter-observer reliability. Fisher’s Exact Test was employed to correlate tumor size with morphological markers of aggression. Results: The cohort demonstrated a distinct large-mass phenotype, with 54.1% of tumors exceeding 10 cm and a median diameter of 14.5 cm. Pathological review classified 56.8% of cases into WHO Group 4 (atypia with ambiguous mitosis). A statistically significant correlation was identified between tumor size >10 cm and the presence of infiltrative growth margins (81.1%; p=0.034). Conclusion: Indonesian STUMP cases are distinctively characterized by massive size and high rates of infiltrative growth, likely driven by prolonged natural history. The prevalence of ambiguous mitotic figures underscores the utility of the WHO Group 4 category in resource-limited settings. These findings advocate for aggressive surgical management and wider resection margins in large-mass variants to mitigate local recurrence risk.

Pengaruh Pemberian Ekstrak Buah Pohon Andalas (Morus Macroura Miq.) terhadap Gambaran Histopatologi Miokardium pada Tikus Model Aterosklerosis Intan Putri Syamtoni; Henny Mulyani; Rita Hamdani; Noza Hilbertina; Miftah Irramah; Endrinaldi Endrinaldi
CENDEKIA : Jurnal Penelitian dan Pengkajian Ilmiah Vol. 3 No. 6 (2026): CENDEKIA : Jurnal Penelitian Dan Pengkajian Ilmiah, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/cendekia.v3i6.2698

Atherosclerosis is an inflammation that occurs in blood vessels, especially arteries, it could be developed by an accumulation of lipids in the body, which is atherosclerosis causes this to become a major factor of cardiovascular disease. The fruit of the andalas contains flavonoid, morasin C and M for anti-inflammatory. The purpose of this experimental is to see the effect of extract andalas fruits to histologial changes in myocardium of rats with aterosclerosis model. This research was an experimental study with a randomized post test only control group design with using 29 mice which have been divided into 5 groups, there is negative control group (K-), positive control group (K+), treatment group 1 (P1), treatment group 2 ( P2), and treatment group 3 (P3). The results measurement of the weight rat's heart after analysis used the One Way ANOVA test were p = 0.000, that’s mean there was a significant difference of weight rat's heart in each other groups. Measuring the thickness of myocardial cell size used the One Way Anova test, the resulted is p = 0.632, that’s mean there was no relationship between the groups. Measuring the blood vessel thickness were used by One Way ANOVA analysis, the resulted is p = 0.301, that’s mean there was no significant difference in arterial blood vessel thickness in all groups. The conclusion of this study is there was changes in rat heart weight in all groups, there was no significant change in the histopathological size of the myocardium in all groups, lipofuscin was found in 1 sample, necrosis wasn’t found, sicatric tissue wasn’t found, and there was no significant change in the histopathological picture of arterial thickness in this experience.

The Large-Mass Phenotype of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Clinicopathological Analysis of 37 Cases in Indonesia Using WHO 2021 and Modified Stanford Criteria Yuliza Ariani; Henny Mulyani; Noza Hilbertina; Yenita; Aswiyanti Asri; Tofrizal; Loli Devianti; Hera Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1565

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) presents a diagnostic dilemma, especially in Southeast Asian populations, where delayed presentation often leads to advanced tumor burden. This study aimed to characterize the clinicopathological profile of STUMP in Indonesia using the 2021 WHO Classification and modified Stanford parameters. Methods: A descriptive study analyzed 37 STUMP cases diagnosed between 2023 and 2025 at a tertiary referral center in West Sumatra. A panel of pathologists re-evaluated archival slides for atypia, mitotic activity, necrosis, and growth patterns, establishing inter-observer reliability. Fisher’s Exact Test was employed to correlate tumor size with morphological markers of aggression. Results: The cohort demonstrated a distinct large-mass phenotype, with 54.1% of tumors exceeding 10 cm and a median diameter of 14.5 cm. Pathological review classified 56.8% of cases into WHO Group 4 (atypia with ambiguous mitosis). A statistically significant correlation was identified between tumor size >10 cm and the presence of infiltrative growth margins (81.1%; p=0.034). Conclusion: Indonesian STUMP cases are distinctively characterized by massive size and high rates of infiltrative growth, likely driven by prolonged natural history. The prevalence of ambiguous mitotic figures underscores the utility of the WHO Group 4 category in resource-limited settings. These findings advocate for aggressive surgical management and wider resection margins in large-mass variants to mitigate local recurrence risk.

HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP IBU TERKAIT INISIASI MENYUSUI DINI, PEMBERIAN ASI EKSKLUSIF, DAN MAKANAN PENDAMPING ASI DENGAN KEJADIAN STUNTING PADA ANAK DI WILAYAH KERJA PUSKESMAS YANGMEMILIKI ANGKA KEJADIAN STUNTING TERTINGGI DI KOTA PADANG Artes Putri Melayu; Nice Rachmawati; Noza Hilbertina
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 1 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i1.2446

Stunting is a condition of malnutrition that persists for a long period of time in children, characterized by the child's height growth not being in accordance with age. The cause of stunting is multifactorial, low nutritional intake is the main cause of stunting. This nutritional intake includes Early Breastfeeding Initiation, exclusive breastfeeding and complementary feeding. Providing nutritional intake to children influenced by the mother's knowledge and attitudes. This study aims to determine the relationship between mothers' knowledge and attitudes regarding early initiation of breastfeeding, exclusive breastfeeding and complementary foods with the incidence of stunting in children. The type of research is analytical observational research with a cross sectional research design with a sample of 67 mothers who had children aged 24-59 months in the work area of the health center which had the highest incidence of stunting in Padang City, namely the Ikur Koto Health Center, Air Children's Health Center and Seberang Padang Health Center . The number of samples was taken based on propotional random sampling technique. This research instrument uses a questionnaire and microtoise. The data analysis using the Chi Square test. The results of the study showed that the frequency of stunting incidents in children aged 24-59 months in the three health center work areas studied was 47,8%. The level of knowledge of respondents was good at 44.8%, and the attitude of respondents was positive at 62.7%. Bivariate analysis obtained a value of p = 0.004 (p value < 0.05) for the relationship between maternal knowledge level and the incidence of stunting and a value of p = 0.005 (p value < 0.05) for the relationship between maternal attitudes and the incidence of stunting. The conclusion of this study is that the level of knowledge and attitudes of mothers regarding IMD, exclusive breastfeeding and MPASI show a statistically significant relationship

Title

Found 13 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 13 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 13 Documents
Search