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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmagazine Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Ulil Albab
Okpri Meila
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ERITROPOETIN (HEMAPO® , EPOTREX®, NEORECORMON®) PADA PASIEN HEMODIALISIS DI RSUP PERSAHABATAN Chandra Widianti; Yusi Anggriani; Tri Kusumaeni; Okpri Meila
Jurnal Kedokteran Syiah Kuala Vol 18, No 3 (2018): Volume 18 Nomor 3 Desember 2018
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v18i3.18017

Abstract

Abstrak. Penerapan INA-CBGs (Indonesia Case Base Groups) di era JKN mendorong penyedia layanan kesehatan, untuk menghitung biaya yang dikeluarkan agar tidak merugi. Pada pasien Gagal Ginjal Kronis (GGK) yang menjalani hemodialisis, prevalensi anemia cukup tinggi, sehingga diberikan eritropoetin (EPO). Dibutuhkan penelitian untuk mengetahui dari beberapa jenis EPO, mana yang lebih cost-effective. Penelitian deskriptif non-eksperimental dilakukan di Unit Hemodialisa Rumah Sakit Persahabatan. Efektivitas terapi ditentukan oleh peningkatan kadar hemoglobin (Hb) setelah 3 (tiga) bulan berturut-turut mendapatkan terapi EPO yang sama. Analisis efektivitas-biaya diperoleh dengan menghitung nilai CER (Cost-Effectiveness Ratio). Hasil menunjukkan penggunaan Neorecormon® memiliki efektivitas yang lebih tinggi dengan persentase jumlah pasien yang mengalami peningkatan Hb sebesar 56,41% dibandingkan Hemapo® (54%) dan Epotrex® (52,63%). Total biaya pengobatan rata-rata dengan Hemapo® , Epotrex® dan Neorecormon® masing-masing Rp. 32.552.117, Rp. 34.787.487 dan Rp. 32.866.969. Hasil perhitungan nilai CER dalam penggunaan Neorecormon® untuk pasien yang mengalami peningkatan Hb adalah Rp 58.264.437, lebih kecil daripada Hemapo® (Rp. 60.281.698) and Epotrex® (Rp. 66.098.208). Berdasarkan nilai CER dan tabel efektivitas-biaya, menunjukkan bahwa Neorecormon® adalah pilihan terapi yang lebih cost-effective daripada Hemapo® dan Epotrex®.Kata-kata kunci: Analisis efektivitas-biaya, hemodialisis, eritropoetinAbstract. INA-CBGs (Indonesia Case Base Groups) in JKN era, encourages health care providers to calculate costs incurred so as not to lose money. In Chronic Renal Failure (CRF) patients who undergo hemodialysis, anemia prevalence is high enough to require administration of erythropoietin (EPO). It’s necessary to investigate the therapeutic treatment from several types of EPO, which is more cost-effective. Descriptive non-experimental research conducted in the Hemodialysis Unit in Persahabatan Hospital. The effectiveness determined by an increased in hemoglobin (Hb) levels after three (3) months earned the same EPO therapy. Cost-effectiveness analysis is obtained by calculated the CER (Cost-Effectiveness Ratio). The results shows that Neorecormon® have a higher effectiveness with the percentage of patients whose Hb level increase by 56.41% comparing to Hemapo® (54%) and Neorecormon® (52.63%). The average total cost with Hemapo®, Epotrex® and Neorecormon® each successive Rp. 32.552.117, Rp. 34.787.487 and Rp. 32.866.969. The CER value of Neorecormon® show cost-effectiveness of Rp 58.264.437 for a patient with an increase in Hb, smaller than Hemapo® (Rp. 60.281.698) and Epotrex® (Rp. 66.098.208). Based on CER value and cost effectiveness grid, shows that Neorecormon® is the choice that is more cost-effective than Hemapo® and Epotrex®. Keywords : Cost effectiveness analysis, hemodialysis, erythropoetin
Uji Aktivitas Antidiabetes dari Ekstrak Metanol Buah Kiwi (Actinidia deliciosa) melalui Penghambatan Aktivitas α-Glukosidase: Antidiabetic Activity of Kiwi Fruit (Actinidia deliciosa) Extract through Inhibition of α-Glucosidase Activity Okpri Meila; Noraini Noraini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.28 KB) | DOI: 10.22487/j24428744.0.v0.i0.8814

Abstract

Diabetes melitus (DM) is defined as a chronic metabolic disease or disorder with multiple etiologies characterized by high blood sugar levels. One way to treat diabetes mellitus is inhibiting the α-glucosidase enzyme. This study aims to determine the inhibition of α-glucosidase of methanol extract of kiwi fruit (Actinidia deliciosa) . Kiwi fruit (Actinidia deliciosa) contains saponins characterized by the formation of foam, positive flavonoid characterized by the formation of a yellow color (orange) and positive alkaloid which is characterized by brown color in wagner test. The inhibition activity test of α-glucosidase enzyme was performed by using spectrophotometric method. The results of the inhibition activity test of α-glucosidase enzyme in acarbose showed the value of 13,672 mg/L, while the methanol extract of kiwi fruit showed IC50 value of 7.219 mg/L. It demonstrated that themethanol extract of kiwi fruit has the inhibition activity greater than acarbose.
UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK ETANOL 70% BUAH KIWI (Actinidia deliciosa) MELALUI PENGHAMBATAN AKTIVITAS ENZIM α- GLUKOSIDASE Okpri Meila; Deviya Purwandarie
Jurnal Farmagazine Vol 4, No 1 (2017): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v4i1.71

Abstract

Prevalensi penyakit diabetes terus meningkat di seluruh dunia. WHO memprediksikan peningkatan jumlah penyandang diabetes yang cukup besar untuk tahun-tahun mendatang. Buah kiwi memiliki banyak kandungan nutrisi, bahkan jumlahnya tersimpan lebihbanyak dibanding buah-buahan lain.Penelitian yang mendukung buah kiwi sebagai antidiabetes yaitu dari Buku Healts Secret of Kiwi Fruits tahun 2010 yang menyatakan bahwa buah kiwi bagus untuk dikonsumsi bagi penderita diabetes. Buah kiwi (Actinidia deliciosa) mengandung senyawa flavanoid, alkaloid, dan saponin, yang berarti senyawa tersebut dapat menghambat aktivitas enzim α-glukosidase. Tujuan penelitian ini untuk mengetahui penghambatan α-glukosidase pada ekstrak etanol 70% buah kiwi (Actinidia deliciosa) sebagai pengobatan diabetes melitus. Simplisia di maserasi dengan etanol 70% sebanyak 3.500 ml pekatkan dengan rotary evaporator suhu 40ºCz. Berdasarkan hasil uji tersebut maka didapatkan IC50 4,251 ppm dan akarbose 13,672 ppm. Kata kunci: Prevalensi penyakit diabetes, buah kiwi (Actinidia deliciosa), enzim α-glukosidase, etanol70%.
TINGKAT KEPUASAN PASIEN RAWAT JALAN TERHADAP PELAYANAN KEFARMASIAN DI INSTALASI FARMASI RUMAH SAKIT MARINIR CILANDAK JAKARTA Jenny Pontoan; Okpri Meila; Yuli Asnanik; Muhammad Azhar Muharam
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.298

Abstract

Measuring the quality dimensions of health service is essential and should be done along with patient satisfaction surveys. The level of patient satisfaction with hospital health services may use the five-dimensional Service Quality (ServQual) method, that is, reliability, responsiveness, assurance, concern and tangible form. The study was conducted to determine the level of outpatient satisfaction with the quality of services provided by The Cilandak Marinir Hospital Pharmacy Installation. The research design is Observational by survey methods, conducted on JKN outpatients, with a total sample of 106 respondents. Inclusion criteria; patients who redeem a prescription at a hospital pharmacy installation at least 2 times; patients who are willing to fill out the questionnaire, sign the questionnaire, and approve the informed consent; patients aged ≥ 15 years. Exclusion criteria are patients who are hospital employees; HIV / AIDS patients. This study was also complemented with data collection permits from the hospital and ethical approval from the ethics research committee of the Universitas Pembangunan Veteran Jakarta. The instrument used is in the form of a questionnaire to measure patient satisfaction about pharmacy services at the pharmacy. The results of the validity test of 0.383-0.950 (components of expectations) and 0.362-0.928 (components of performance) are declared valid. The reliability test results are 0.954-0.961 (expectation component) and 0.951-0.960 (performance component); these results indicate that the questionnaire can be used because all questions are reliable (> 0.60 Cronbach Alpha scores). Data analysis uses the Service Quality method (Service Quality score = Performance - Expectation). A positive score indicates that customer expectations are met so that services on specific dimensions can be perceived as high quality and vice versa. Ideally, the value of the gap between expectations and perceptions is zero. ServQual analysis results based on the gap showed that the most significant value of the gap in the dimensions of reliability -0.18, responsiveness (responsiveness) -0.12, awareness (empathy) -0.08, assurance -0, 07, and tangible form (tangible) -0.03. Based on these results, It can be concluded that pharmaceutical services still need improvement because they still have a negative gap value for the five dimensions.
Profile of The Use of Prophilacic Antibiotics in Heart Surgery Patients Jenny Pontoan; Okpri Meila; Alisyah Riefla Indriyani
ULIL ALBAB : Jurnal Ilmiah Multidisiplin Vol. 2 No. 6: Mei 2023
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/jim.v2i6.1660

Abstract

Coronary Artery Bypass Graft (CABG) is a surgical procedure that aims to remove blocked coronary arteries and maximize blood vessel flow. Heart valve surgery is a treatment option recommended by doctors to prevent complications from occurring more severe to the heart with the main indication of valve stenosis and regurgitation. For the use of prophylactic antibiotics, studies have shown that prophylactic antibiotics with first- and second-generation cephalosporins can effectively reduce the incidence of surgical wound infection and postoperative infectious complications in cardiac surgery patients. This study aims to determine the use of prophylactic antibiotics in cardiac surgery patients. This research uses descriptive research type with retrospective data collection cross-sectional, by collecting secondary data derived from medical records of cardiac surgery patients who used prophylactic antibiotics and met the study inclusion criteria. The results showed that the majority of the prophylactic antibiotics Cefuroxime in 317 patients (88.06%) consisted of 206 patients (57.2%) and 111 patients (30.8%) of patented Cefuroxime. The majority of preoperative length of stay ≤ 1 day 331 patients (91.9%), and there was no incidence of surgical wound infection in the whole sample (100%). Based on the results of the study, it can be concluded that the most use of prophylactic antibiotics is Cefuroxime
Co-Authors Alisyah Riefla Indriyani Chandra Widianti Deviya Purwandarie Muhammad Azhar Muharam Noraini Noraini Pontoan, Jenny Tri Kusumaeni Yuli Asnanik Yusi Anggriani