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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Pharmascience
Nurdin Saidi
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Aphorpines and benzylisoquinoline alkaloids from bark of Cryptocarya crassinervia Nurdin Saidi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 2 (2011): Engineering
Publisher : Syiah Kuala University

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Abstract

Two aphorpine alkaloids, (+)-lirinine 1 and (+)-lirioferine 2 and two bezylisoquinoline alkaloids (+)-reticuline 3 and (-)-N-Methylisococlaurine 4 were isolated from bark of Cryptocarya crassinervia. The structures were  elucidated by spectral analysis, including 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, HMQC, HMBC), UV, IR, and MS and comparison with the published data.
Antibacterial activity of secondary metabolite compounds from leaf of Eclipta alba L. Hassk Kartini Hasballah; . Murniana; Nurdin Saidi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Two secondary metabolite compounds of steroid and triterpenoid derivates had been extracted from the leaf of Eclipta alba L. Hassk. The extraction of the compounds was carried out by maceration and then isolated by column chromatography. Structural elucidation was established using GC-MS. Both of the compounds showed antibacterial activity against S. mutans, A. viscosus, and L. kaesal at the concentration of 5%, 10%, and 25%. 
β-Sitosterol From Bark Of Artocarpus Camansi And Its Antidiabetic Activity Rosnani Nasution; . Marianne; Muhammad Bahi; Nurdin Saidi; Isni Junina
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 1 (2015): Engineering
Publisher : Syiah Kuala University

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Research compound betasitosterol from the bark of plant of Artocarpus camansi (kulu) and test its antidiabetic has been done. The study begins by extracting samples (3.5 kg),w in the solvent of hexane, hexane extracts obtained,then separated by gravity column chromatography, and was characterized by GC-MS. The results obtained are groups of fractions A, and B. From phytochemical test results, the fraction of group B, has a steroid framework. Group fractions B after rechromatographed is obtained a pure isolates of B. Characterization by 1H-NMR and MS (from GC-MS), pure isolate of B is β-sitosterol. Antidiabetic activity test results showed that the extract of n-hexane, fraction group A and fraction group of B  (containing βsitosterol), can lower blood sugar levels male Swiss Webster mice were performed by the method of glucose tolerance. Dose of extract of n-hexane is  50 mg/dL at minute 30th, 60th and 90th can lower glucose as much as 103 mg/dL; 71 mg/dL; and 49.33 mg/dL. Group of  fraction A of a dose 50 mg/dL at 60th minutes and 90th can lower blood glucose of mice are: 116 mg/dL; and 58 mg/dL. Group B fraction (containing β-sitosterol) at a dose of 50 mg/dL at minute 30th, 60th and 90th can lower glucose by 73 mg/dL; 87 mg/dL; and 73.33 mg/dL. Group fraction of B is the highest in lowering blood glucose average compared with n-hexane extract and group A. Analysis of variance of this fraction were performed by using ANOVA Post hoc analysis procedures one-way of, significant differences (p0.05) and (p 0.01) conducted using Tukey.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Gaharu (Aquilaria Malaccensis Lamk.) Dan Identifikasi Senyawa Dengan Metode GC-MS Misrahanum Misrahanum; Cut Aja Dian Zahira; Nurdin Saidi
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13803

Abstract

Gaharu (Aquilaria malaccensis L.) merupakan salah satu tumbuhan yang memiliki aktivitas antibakteri. Pada umumnya resin gaharu digunakan menjadi sediaan parfum. Penelitian ini bertujuan untuk mengetahui senyawa kimia dan aktivitas antibakteri ekstrak etanol daun gaharu. Senyawa yang diperoleh dari hasil analisis GC-MS sebanyak 23 senyawa dengan persentase area terbesar adalah Squalene, Phytol, Heneicosane, 9,12,15-Octadecatrienoic acid, methyl ester, 1,2-Benzenedicarboxylic acid, mono (2-ethylhexyl) ester, beta. –Sitosterol, ICOSANE (4,57%), Vitamin E dan Hexadecanoic acid, methyl ester. Aktivitas antibakteri menggunakan metode sumuran pada variasi konsentrasi 5; 10; 15; 20 dan 30 % terhadap bakteri Escherichia coli dan Staphylococcus aureus zona hambat yang diperoleh sebesar 6,09; 6,72; 7,78; 8,65; dan 9,63 mm pada bakteri E. coli sedangkan zona hambat S. aureus sebesar 10,37; 10,44; 11,63; 12,21; dan 13,34 mm. Hasil menunjukkan ekstrak etanol daun gaharu aktif dalam menghambat pertumbuhan bakteri E. coli dan S. aureus. Kata Kunci: Gaharu, Senyawa Kimia, E. coli, S. aureus  Agarwood (Aquilaria malaccensis L.) is a plant that has antibacterial activity. Generally, resin to gaharu is used to make perfume. This research was conducted to determine the compound content and antibacterial activity of ethanol extracts of agarwood. The results of the Analysis of the compound content using the GC-MS instrument the ethanol extract contained 23 components with a larger area Squalene, Phytol, Heneicosane, 9,12.15-Octadecatrienoic acid, methyl ester, 1,2-Benzenecarboxylic acid, mono (2-Ethylhexyl) ester, beta. – Sitosterol , ICOSAN, Vitamin E  and Hexadecanoic acid, methyl ester. Testing of antibacterial activity using the well method at various concentrations of 5; 10; 15; 20 and 30%. The results activity against Escherichia coli and Staphylococcus aureus bacteria. Agarwood leaves ethanol extract obtained inhibition zone diameters of 6.09; 6.72; 7.78; 8.65; and 9.63 mm on E. coli bacteria while on S. aureus the inhibition zones were 10.37; 10.44; 11.63; 12.21; and 13.34 mm. The result showed that ethanol Agarwood extract is active in inhibiting the growth of E. coli and S. aureus bacteria. 
Co-Authors . Marianne . Murniana Cut Aja Dian Zahira Isni Junina Kartini Hasballah Misrahanum Misrahanum Muhammad Bahi Rosnani Nasution