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All Journal Ganendra: Majalah IPTEK Nuklir Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology)

Muhamad Basit Febrian

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Author-ID : 2792518

Biochemistry, Genetics & Molecular Biology Computer Science & IT Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Other

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Articles

PENENTUAN KONDISI OPTIMUM DALAM PENANDAAN LIGAN EDTMP DENGAN RADIOISOTOP 170Tm Azmairit Aziz; Muhamad Basit Febrian
GANENDRA Majalah IPTEK Nuklir Volume 14 Nomor 1 Januari 2011
Publisher : Website

PENENTUAN KONDISI OPTIMUM DALAM PENANDAAN LIGAN EDTMP DENGAN RADIOISOTOP 170Tm.Tulium-170 (170Tm) merupakan salah satu radioisotop yang dapat digunakan untuk terapi paliatif karena merupakanpemancar-b yang memiliki T1/2 = 128,4 hari dan Eb (maksimum) sebesar 0,968 MeV. Radioisotop 170Tm selain pemancar-b juga memancarkan sinar-g dengan energi sebesar 84 keV (3,26%) yang dapat dimanfaatkan untuk penyidikan(imaging) selama terapi berlangsung. Ligan etilendiamintetrametilen fosfonat (EDTMP) dapat ditandai denganradioisotop 170Tm sebagai radiofarmaka alternatif untuk penghilang rasa sakit (paliatif) akibat metastase kanker ketulang menggantikan 89SrCl2. Telah dilakukan penentuan kondisi optimum dalam penandaan ligan EDTMP denganradioisotop 170Tm berdasarkan variasi beberapa parameter yang berpengaruh dalam reaksi penandaan, yaitu jumlahligan EDTMP, pH penandaan dan waktu inkubasi. Senyawa bertanda 170Tm-EDTMP yang diperoleh ditentukanefisiensi penandaan melalui pemeriksaan kemurnian radiokimianya dengan cara kromatografi kertas danelektroforesis kertas. Kondisi optimum penandaan diperoleh pada pH 7 dengan jumlah ligan EDTMP sebanyak 2 mgdan waktu inkubasi selama 15 menit pada temperatur kamar. Kompleks yang terbentuk memberikan efisiensipenandaan maksimum sebesar 99,23 ± 0,27%. Berdasarkan hasil yang diperoleh, ligan EDTMP dapat ditandaidengan radioisotop 170Tm dengan efisiensi penandaan yang tinggi (di atas 95%).Kata kunci : radioisotop, tulium-170 (170Tm), etilendiamintetrametilen fosfonat (EDTMP), paliatif.

SYNTHESIS AND CHARACTERIZATION OF BENZOTRIAZOLIUM-BASED IONIC LIQUIDS FOR TECHNETIUM-99M SEPARATION FROM MOLYBDENUM BY IL-MEDIATED EXTRACTION PROCESS Yanuar Setiadi; Muhamad Basit Febrian; Ahmad Mudzakir; Azmairit Aziz; Duyeh Setiawan; Anna Kurnia Illahi; Dwi Ayu Rahmawati
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 20, No 2 (2019): Agustus 2019
Publisher : BATAN

Various separation techniques for separation of technetium-99m (99mTc) from molybdenum-99 (99Mo) are being developed to overcome the drawbacks of using 99Mo from neutron activation technique. Ionic liquids (ILs) were used in many extraction processes in metal separation due to their high selectivity. In this research, two benzotriazolium-based ionic liquids were used as co-extractant in 99mTc/ Mo separation process via liquid-liquid extraction. 1-octyl-3-methyl-benzotriazolium iodide ([MeOcBtu]I) and 1-octyl-3-methyl-benzotriazolium bis (trifluoromethanesulfonyl) imide ([MeOcBtu]TF2N) were successfully synthesized and analyzed by FTIR, 1H-NMR and 13C-NMR. Extraction processes were conducted in various organic solvents, pH, and extraction time without/ with ionic liquids addition. The data of ratio between 99mTc distribution coefficient compared to Mo distribution coefficient showed that the addition of ionic liquids exhibited significant improvement of separation factor. The separation factor of extraction using conventional water immiscible solvent ranged between 0 – 8 and increased to 30 – 600 as ILs were added. The optimum conditions which achieved highest separation factor were pH 14 using [MeOcBtu]I-chloroform. Benzotriazolium-based ionic liquid potential to be developed as extractant in the separation of 99mTc from 99Mo. Keywords: Ionic liquids, benzotriazolium, technetium-99m, molybdenum, liquid-liquid extraction.

SYNTHESIS OF BUTHYL BROMIDE LABELED 82Br FOR LEAKAGE DETECTION APPLICATION IN INDUSTRIAL PIPELINE SYSTEM Ade Suherman; Titin Sri Mulyati; Iswahyudi Iswahyudi; Badra Sanditya Rattyananda; Dessy Cartika; Winda Putri Silpia; Mentik Hulupi; Duyeh Setiawan; Muhamad Basit Febrian
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 20, No 2 (2019): Agustus 2019
Publisher : BATAN

The detection of a leakage in an installation or pipeline in industrial complex is difficult to be done because related to security, safety, and operation condition. With expanded radioisotope application as a tracer in industry, hence a leakage in a pipe can be detected easily and qiuickly without needed excavation or stop the production process. The selection of radioisotope labeled compound as radiotracer should be examined carefully to determine the appropriate and well mixed radiotracer with the material passing through the pipeline system. Radioisotope labeled compound butyl bromide-82 (C4H982Br) as a radiotracer can be synthesized by reacting K82Br with 1-butanol and sulphuric acid (H2SO4) as a catalyst. The experiment result shows that synthesized C4H982Br by composition of 15 mL K82Br solution (0.1 gr/mL KBr) and 10 mL 1-butanol gave the highest percentage of reactions amount 50,00% and 40,95%. Characterization by FTIR showed that the product has absorption band for C-Br at 514,99-738,74 cm-1. GCMS analysis showed the peak of C4H982Br together with other 7 peaks of impurities with 43.03% percentage of C4H982Br peak. In distribution coefficient determination of C4H982Br in the test solution from industry (ethylene dichloride), Kd value of 5,1350 was obtained and more than 98% C4H982Br distilled together with ethylene dichloride in 110°C distillation process whereas no radioactivity detected in distillation flask if K82Br was used. Based on these results, C4H982Br is suitable to be applied as radiotracer for leakage detection in pipeline system with organic compounds as passing liquid including ethylene dichloride.

Co-Authors Ade Suherman Ahmad Aminudin Anna Kurnia Illahi Azmairit Aziz Badra Sanditya Rattyananda Dessy Cartika Duyeh Setiawan Dwi Ayu Rahmawati Iswahyudi Iswahyudi Mentik Hulupi Titin Sri Mulyati Winda Putri Silpia Yanuar Setiadi

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