RB. Soeherman Herdiningrat
Department Of Anatomy And Cell Biology, Faculty Of Medicine Universitas Padjadjaran

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Effects of White Turmeric Infusion on the Liver Cells in Carbon Tetrachloride-Induced Mice Oktaviani, Fitria; Herdiningrat, RB. Soeherman; Yulianti, Herry
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Background: The liver is an organ that has important functions in the body. Liver damage can be caused by oxidative stress and free radicals. White turmeric (Curcuma zedoaria L) contains antioxidants that can be used to neutralize the effects of free radicals. This study was conducted to determine the effect of white turmeric infusion on histological appearance of liver cells in male mice induced by carbon tetrachloride (CCl4).Methods: This laboratory experimental study was conducted using male mice (Mus musculus) with Balb/c strain. Thirty-three mice were randomly divided into 3 groups i.e.,group 1 as a control group was given standard food and drink, group 2 was given 10% of CCl4 0.1 ml by intraperitoneal injection on the first day and group 3 was given 10% of CCl4 0.1 mL by  ntraperitoneal injection on the first day, followed by the administration of 50% of white turmeric infusion 0.2 mL. Kruskal-Wallis test method was used to analyse the significant differences of the average percentage of damaged liver cells in the group given CCl4 alone with the group given CCl4 and white turmeric infusion and control group.Results: The percentage of damaged liver cells between groups of mice given CCl4 alone and the group given CCl4 followed by white turmeric infusion were respectively(p <0.05) compared to group1.Conclusions: Administration of white turmeric infusion gave an influence by decreasing the percentage of damaged liver cells in CCl4-induced mice. White turmeric can serve as an alternative antioxidants that can be used to neutralize the effects of free radicals. [AMJ.2015;2(4):506–10] DOI: 10.15850/amj.v2n4.498
Success Rate of Trabeculectomy in Primary Glaucoma at Cicendo Eye Hospital on January–December 2013 Saputro, Erva Monica; Rifada, Maula; Herdiningrat, RB. Soeherman
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Trabeculectomy is a surgical therapy for glaucoma to preserve visual function by lowering intraocular pressure (IOP). In some studies, the success of trabeculectomy in lowering IOP is greater than medication. Success is defined by IOP <21 mmHg, with or without glaucoma medication. Primary glaucoma based on the mechanism of aquous humor outflow is divided into primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). This study aimed to know the success rate of trabeculectomy in POAG and PACG.Methods: This study was a descriptive study conducted at Cicendo Eye Hospital using medical record of POAG and PACG patients who underwent trabeculectomy surgery on January–December 2013 with minimal one month follow-up. Data collection was conducted during September 2014. Data processed in this study were 100 eyes from 76 patients with diagnosis POAG and PACG.Results: The success rate for trabeculectomy in POAG was 79% and PACG was 86%, failure (IOP ≥ 21 mmHg) 21% in POAG, and 14% in PACG for period 2013 at Cicendo Eye Hospital.Conclusions: The success rate of trabeculectomy at Cicendo Eye Hospital is good in one month, with or without glaucoma medication after surgery. [AMJ.2016;3(1):110–4] DOI: 10.15850/amj.v3n1.723
Allergic Rhinitis Patient Characteristics in Dr. Hasan Sadikin General Hospital Bandung Indonesia Moeis, Raisa Mentari; Sudiro, Melati; Herdiningrat, RB. Soeherman
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Althea Medical Journal

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Abstract

Background: Allergic rhinitis affects 500 million people worldwide, especially children and adolescents. This disease interferes with daily activities and productivity, leading to decreased quality of life. Allergic rhinitis is often accompanied by co-morbid conditions such as asthma, conjunctivitis, rhinosinusitis, urticaria and othersthat may worsen the disease. This study aimed to investigate the characteristics of patients with allergic rhinitis during the period of 2010-2011 in Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was a descriptive study with a cross-sectional design using medical records of allergic rhinitis patients  who visited the allergy clinic of the Otorhinolaryngology ‒ Head and Neck Surgery ( ORL ‒ HNS ) Department of Dr. Hasan Sadikin General Hospital Bandung.Results: There were 167 patients diagnosed as suffering from allergic rhinitis during the study time with more women (53.3%) affected compared to men (46.7%). Most of them were in the age group of 18-34 years old (52.7%) and their were student (53.3%). Most  were suffered from moderate-severe persistent allergic rhinitis based on the Allergic Rhinitis and its Impact on Asthma-World Health Organization (ARIA-WHO) classification (52.7%). Co-morbid conditions were found in 73.7% of subjects and the allergic conjunctivitis (59.9%) was the most common.Conclusions: Allergic rhinitis is most commonly found in people at school age and productive age. Most allergic rhinitis patients are classified into persistent moderate/severe, showing that the rhinitis symptom has already interfered with their daily activities and decreased their quality of life.Key words: Allergic Rhinitis, Co-morbid Condition, school age  Karakteristik Pasien Rinitis Alergi di Rumah Sakit Dr Hasan Sadikin Bandung Indonesia Abstrak Latar Belakang: Rinitis alergi memengaruhi 500 juta orang di seluruh dunia, terutama anak-anak dan remaja. Penyakit ini mengganggu kegiatan dan produktivitas sehari-hari serta menyebabkan kualitas hidup menurun. Rinitis alergi sering disertai dengan penyakit penyerta seperti asma, konjungtivitis, rhinosinusitis, urtikaria dan lain-lain yang dapat memperburuk penyakit. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dengan riinitis alergi periode 2010-2011 di Rumah Sakit Dr. Hasan Sadikin Bandung.Metode: Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang dengan menggunakan rekam medis pasien rinitis alergi yang mengunjungi klinik alergi Departemen Telinga, Hidung, Tenggorokan - Kepala dan Leher (THT-KL)) RS Dr. Hasan Sadikin Bandung.Hasil: Ada 167 pasien yang didiagnosa menderita rinitis alergi selama usia sekolah. Perempuan lebih banyak yang terkena dampak (53,3%) dibandingkan dengan laki-laki (46,7%). Sebagian besar dari mereka berada di kelompok usia 18-34 tahun (52,7%) dan mereka adalah siswa (53,3%). Berdasarkan klasifikasi Organisasi Allergic Rhinitis and its Impact on Asthma-World Health Organization (ARIA-WHO) (ARIA-WHO) sebagian besar menderita rinitis alergi persisten sedang-berat (52,7%). Kondisi co-morbid ditemukan di 73,7% dari subyek dan yang paling umum adalah konjungtivitis alergi (59,9%).Simpulan: Rinitis alergi paling sering ditemukan pada orang di usia sekolah dan usia produktif. Sebagian besar pasien rinitis alergi diklasifikasikan menjadi persisten sedang/berat. Hal ini menunjukkan bahwa gejala rinitis telah mengganggu kegiatan sehari-hari dan menurunkan kualitas hidup mereka. Kata kunci: Rinitis alergi, Kondisi Co-morbid, usia sekolah DOI: 10.15850/amj.v1n2.350
Clinical Profile and Mortality in Children with Pneumonia Manivel, Ashvinii; Sudarwati, Sri; Herdiningrat, RB. Soeherman
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: Pneumonia is the leading killer in under-five children. Therefore, by identifying the danger signs, we are able to predict children who are at higher risk of mortality. The objective of the study is to identify the relationship between the clinical profile and mortality in children with pneumonia at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This was an analytical study with a retrospective case control approach using medical records with patient’s age limitation of 1–60 month. The study period started on January 1st 2010 and ended on December 31st 2011. All types of pneumonia included whereas congenital anomalies, immunocompromised and Down’s syndrome patients were excluded in this study. Data were presented as frequency distribution.Results: During the study period, there were 653 children under age of 5 with pneumonia. Only 56 subjects met the inclusion and exclusion criteria. Twenty-eight patients with pneumonia were cured and 28 died. Based on the phi’s coefficient, tachycardia (α-value = 0.019) and hepatomegaly (α-value = 0.001) were significant predictors of death and based on the Mantel-Haenszel analysis, hepatomegaly (OR=9.62, CI 95% 2.349–39.35) was significant as a risk for mortality. Inability to drink, cyanosis, tachypnea, grunting, vomiting, convulsion, and unconsciousness were not related to mortality.Conclusion: Tachycardia and hepatomegaly have a significant relationship with mortality in under-five children with pneumonia. [AMJ.2015;2(1):235–40]
Success Rate of Trabeculectomy in Primary Glaucoma at Cicendo Eye Hospital on January–December 2013 Erva Monica Saputro; Maula Rifada; RB. Soeherman Herdiningrat
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.363 KB)

Abstract

Background: Trabeculectomy is a surgical therapy for glaucoma to preserve visual function by lowering intraocular pressure (IOP). In some studies, the success of trabeculectomy in lowering IOP is greater than medication. Success is defined by IOP <21 mmHg, with or without glaucoma medication. Primary glaucoma based on the mechanism of aquous humor outflow is divided into primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). This study aimed to know the success rate of trabeculectomy in POAG and PACG.Methods: This study was a descriptive study conducted at Cicendo Eye Hospital using medical record of POAG and PACG patients who underwent trabeculectomy surgery on January–December 2013 with minimal one month follow-up. Data collection was conducted during September 2014. Data processed in this study were 100 eyes from 76 patients with diagnosis POAG and PACG.Results: The success rate for trabeculectomy in POAG was 79% and PACG was 86%, failure (IOP ≥ 21 mmHg) 21% in POAG, and 14% in PACG for period 2013 at Cicendo Eye Hospital.Conclusions: The success rate of trabeculectomy at Cicendo Eye Hospital is good in one month, with or without glaucoma medication after surgery. [AMJ.2016;3(1):110–4] DOI: 10.15850/amj.v3n1.723
Clinical Profile and Mortality in Children with Pneumonia Ashvinii Manivel; Sri Sudarwati; RB. Soeherman Herdiningrat
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.976 KB)

Abstract

Background: Pneumonia is the leading killer in under-five children. Therefore, by identifying the danger signs, we are able to predict children who are at higher risk of mortality. The objective of the study is to identify the relationship between the clinical profile and mortality in children with pneumonia at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This was an analytical study with a retrospective case control approach using medical records with patient’s age limitation of 1–60 month. The study period started on January 1st 2010 and ended on December 31st 2011. All types of pneumonia included whereas congenital anomalies, immunocompromised and Down’s syndrome patients were excluded in this study. Data were presented as frequency distribution.Results: During the study period, there were 653 children under age of 5 with pneumonia. Only 56 subjects met the inclusion and exclusion criteria. Twenty-eight patients with pneumonia were cured and 28 died. Based on the phi’s coefficient, tachycardia (α-value = 0.019) and hepatomegaly (α-value = 0.001) were significant predictors of death and based on the Mantel-Haenszel analysis, hepatomegaly (OR=9.62, CI 95% 2.349–39.35) was significant as a risk for mortality. Inability to drink, cyanosis, tachypnea, grunting, vomiting, convulsion, and unconsciousness were not related to mortality.Conclusion: Tachycardia and hepatomegaly have a significant relationship with mortality in under-five children with pneumonia. [AMJ.2015;2(1):235–40]
Allergic Rhinitis Patient Characteristics in Dr. Hasan Sadikin General Hospital Bandung Indonesia Raisa Mentari Moeis; Melati Sudiro; RB. Soeherman Herdiningrat
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (721.412 KB)

Abstract

Background: Allergic rhinitis affects 500 million people worldwide, especially children and adolescents. This disease interferes with daily activities and productivity, leading to decreased quality of life. Allergic rhinitis is often accompanied by co-morbid conditions such as asthma, conjunctivitis, rhinosinusitis, urticaria and othersthat may worsen the disease. This study aimed to investigate the characteristics of patients with allergic rhinitis during the period of 2010-2011 in Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was a descriptive study with a cross-sectional design using medical records of allergic rhinitis patients  who visited the allergy clinic of the Otorhinolaryngology ‒ Head and Neck Surgery ( ORL ‒ HNS ) Department of Dr. Hasan Sadikin General Hospital Bandung.Results: There were 167 patients diagnosed as suffering from allergic rhinitis during the study time with more women (53.3%) affected compared to men (46.7%). Most of them were in the age group of 18-34 years old (52.7%) and their were student (53.3%). Most  were suffered from moderate-severe persistent allergic rhinitis based on the Allergic Rhinitis and its Impact on Asthma-World Health Organization (ARIA-WHO) classification (52.7%). Co-morbid conditions were found in 73.7% of subjects and the allergic conjunctivitis (59.9%) was the most common.Conclusions: Allergic rhinitis is most commonly found in people at school age and productive age. Most allergic rhinitis patients are classified into persistent moderate/severe, showing that the rhinitis symptom has already interfered with their daily activities and decreased their quality of life.Key words: Allergic Rhinitis, Co-morbid Condition, school age  Karakteristik Pasien Rinitis Alergi di Rumah Sakit Dr Hasan Sadikin Bandung Indonesia Abstrak Latar Belakang: Rinitis alergi memengaruhi 500 juta orang di seluruh dunia, terutama anak-anak dan remaja. Penyakit ini mengganggu kegiatan dan produktivitas sehari-hari serta menyebabkan kualitas hidup menurun. Rinitis alergi sering disertai dengan penyakit penyerta seperti asma, konjungtivitis, rhinosinusitis, urtikaria dan lain-lain yang dapat memperburuk penyakit. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dengan riinitis alergi periode 2010-2011 di Rumah Sakit Dr. Hasan Sadikin Bandung.Metode: Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang dengan menggunakan rekam medis pasien rinitis alergi yang mengunjungi klinik alergi Departemen Telinga, Hidung, Tenggorokan - Kepala dan Leher (THT-KL)) RS Dr. Hasan Sadikin Bandung.Hasil: Ada 167 pasien yang didiagnosa menderita rinitis alergi selama usia sekolah. Perempuan lebih banyak yang terkena dampak (53,3%) dibandingkan dengan laki-laki (46,7%). Sebagian besar dari mereka berada di kelompok usia 18-34 tahun (52,7%) dan mereka adalah siswa (53,3%). Berdasarkan klasifikasi Organisasi Allergic Rhinitis and its Impact on Asthma-World Health Organization (ARIA-WHO) (ARIA-WHO) sebagian besar menderita rinitis alergi persisten sedang-berat (52,7%). Kondisi co-morbid ditemukan di 73,7% dari subyek dan yang paling umum adalah konjungtivitis alergi (59,9%).Simpulan: Rinitis alergi paling sering ditemukan pada orang di usia sekolah dan usia produktif. Sebagian besar pasien rinitis alergi diklasifikasikan menjadi persisten sedang/berat. Hal ini menunjukkan bahwa gejala rinitis telah mengganggu kegiatan sehari-hari dan menurunkan kualitas hidup mereka. Kata kunci: Rinitis alergi, Kondisi Co-morbid, usia sekolah DOI: 10.15850/amj.v1n2.350
Effects of White Turmeric Infusion on the Liver Cells in Carbon Tetrachloride-Induced Mice Fitria Oktaviani; RB. Soeherman Herdiningrat; Herry Yulianti
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (494.69 KB)

Abstract

Background: The liver is an organ that has important functions in the body. Liver damage can be caused by oxidative stress and free radicals. White turmeric (Curcuma zedoaria L) contains antioxidants that can be used to neutralize the effects of free radicals. This study was conducted to determine the effect of white turmeric infusion on histological appearance of liver cells in male mice induced by carbon tetrachloride (CCl4).Methods: This laboratory experimental study was conducted using male mice (Mus musculus) with Balb/c strain. Thirty-three mice were randomly divided into 3 groups i.e.,group 1 as a control group was given standard food and drink, group 2 was given 10% of CCl4 0.1 ml by intraperitoneal injection on the first day and group 3 was given 10% of CCl4 0.1 mL by  ntraperitoneal injection on the first day, followed by the administration of 50% of white turmeric infusion 0.2 mL. Kruskal-Wallis test method was used to analyse the significant differences of the average percentage of damaged liver cells in the group given CCl4 alone with the group given CCl4 and white turmeric infusion and control group.Results: The percentage of damaged liver cells between groups of mice given CCl4 alone and the group given CCl4 followed by white turmeric infusion were respectively(p <0.05) compared to group1.Conclusions: Administration of white turmeric infusion gave an influence by decreasing the percentage of damaged liver cells in CCl4-induced mice. White turmeric can serve as an alternative antioxidants that can be used to neutralize the effects of free radicals. [AMJ.2015;2(4):506–10] DOI: 10.15850/amj.v2n4.498
Literature Review: Trombositopenia sebagai Deteksi Dini pada Pasien Sepsis Neonatorum Qintana Dianissa Sutomo; Annisa Rahmah Furqaani; RB. Soeherman Herdiningrat
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5976

Abstract

Abstract. Sepsis is a life-threatening organ dysfunction caused by immune dysregulation against infection. The purpose of this literature review is to collect previous research data on thrombocytopenia as early detection in neonatal sepsis patients. The results of this study showed that the standard diagnosis is based on bacterial culture from body fluids, but bacterial culture is hampered by low sensitivity, high false negative results due to high potential contamination, and slow analysis time. The high mortality rate of sepsis makes early detection essential. Monitoring and assessment of risk factors and hematologic profile is an attempt at early detection. Thrombocytopenia occurs 24 hours after infection. The activation of platelets causes clot formation which increases platelet utilization, leading to thrombocytopenia. Thus it can be concluded that thrombocytopenia can be used as early detection in patients with neonatal sepsis. Keywords: neonatal, sepsis, thrombocytopenia Abstrak. Sepsis adalah disfungsi organ yang mengancam kehidupan yang disebabkan oleh disregulasi imun terhadap infeksi. Tujuan studi literatur ini untuk mengumpulkan data penelitian terdahulu mengenai trombositopenia sebagai deteksi dini pada pasien sepsis neonatorum. Hasil dari studi ini menunjukan standar baku diagnosis didasarkan pada kultur bakteri dari cairan tubuh, namun kultur bakteri ini terhambat oleh sensitivitas yang rendah, hasil negatif palsu yang tinggi karena tingginya potensi kontaminasi, dan waktu analisis yang lambat. Angka kematian sepsis yang tinggi sehingga penting dilakukan deteksi dini. Pemantauan dan penilaian faktor risiko dan profil hematologi merupakan upaya deteksi dini. Trombositopenia terjadi 24 jam setelah infeksi. Adanya aktivasi trombosit menyebabkan pembentukan clot sehingga meningkatkan pemakaian trombosit, sehingga menyebabkan trombositopenia. Dengan demikian dapat disimpulkan bahwa trombositopenia dapat digunakan sebagai deteksi dini pada pasien sepsis neonatorum. Kata Kunci: neonatorum, sepsis, trombositopenia
Hubungan Usia terhadap Derajat Keparahan Hipertensi di Puskesmas Imbanagara Ciamis Tahun 2023 Angga Angrayama; Yulianti, Arief Budi; Herdiningrat, RB. Soeherman
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10333

Abstract

Abstract. Hypertension is a non-communicable disease that continues to increase both in Indonesia and the world. Hypertension is defined as an increase in systolic pressure of more than 140 mmHg and/or diastolic pressure of more than 90 mmHg. The causes of hypertension can be caused by factors that non-modifiable such as genetics, age, gender, and factors modifiable such as lack of physical activity, obesity, smoking, excessive salt consumption, and stress. Age is a non-modifiable risk factor for hypertension because it is related to the senescence process which causes the elasticity of blood vessels to decrease. This study aims to analyze the relationship between age and the severity of hypertension in hypertensive patients at the Imbinagara Ciamis Health Center, West Java in 2023. This research is researchcross sectional which was carried out at the Imbanegara Ciamis Health Center on 90 patients. Data was collected using a questionnaire in the form of characteristics of age, gender, educational history, employment, sources of information, compliance with antihypertensive medication consumption and blood pressure. Data were analyzed using univariate and bivariate tests and statistical tests were carried out ChiSquare. Results: this study found that the characteristics of hypertensive patients were female, a history of primary school education with the highest occupation being a housewife and the most information was obtained from health workers. Most respondents experienced grade II hypertension, 50 patients (55.5%). with the majority of patients aged 40-55 years, UjiChiSquare shows a p value of 0.00 (<0.05). There is a significant relationship between age and the severity of hypertension in hypertensive patients at the Imbinagara Ciamis Health Center, West Java in 2023. Abstrak. Hipertensi merupakan salah satu penyakit tidak menular yang terus mengalami peningkatan baik di Indonesia maupun di Dunia. Hipertensi didefinisikan kenaikan tekanan sistolik lebih dari 140 mmHg dan atau tekanan diastolik lebih dari 90 mmHg. Penyebab hipertensi dapat disebabkan oleh faktor yang tidak dapat dirubah seperti genetik, usia, jenis kelamin, dan faktor yang dapat dirubah seperti kurangnya aktivitas fisik, obesitas, merokok, konsumsi garam berlebih, dan stress. Usia menjadi salah satu faktor risiko hipertensi yang tidak dapat dirubah karena berhubungan dengan proses penuaan yang menyababkan elastisitas pembuluh darah mengalami penurunan. Sehingga penelitian ini bertujuan untuk menganalisis hubungan antara usia dengan derajat keparahan hipertensi pada pasien hipertensi di Puskesmas Imbanagara Ciamis Jawa Barat tahun 2023. Penelitian ini merupakan penelitian cross sectional yang dilakukan di Puskesmas Imbanegara Ciamis pada 90 pasien. Data dikumpulkan menggunakan kuesioner berupa karakteristik usia, jenis kelamin, Riwayat pendidikan, pekerjaan, sumber informasi, kepatuhan konsumsi obat antihipertensi dan tekanan darah. Data dianalisis dengan uji univariat dan bivariat dan dilakukan uji statistik ChiSquare. Penelitian ini didapatkan karakteristik pasien hipertensi berjenis kelamin perempuan, Riwayat pendidikan terakhir SD dengan pekerjaan terbanyak ibu rumah tangga dan informasi terbanyak didapat dari tenaga kesehatan. Responden paling banyak mengalami hipertensi grade II sebanyak 50 pasien (55,5%). dengan mayoritas pasien berada di usia 40-55 tahun, Uji ChiSquare menunjukan nilai p sebesar 0.00 (<0.05). Terdapat hubungan yang sginifikan antara usia dengan derajat keparahan hipertensi pada pasien hipertensi di Puskesmas Imbanagara Ciamis Jawa Barat tahun 2023.