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All Journal Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology)
Yanuar Setiadi
PSTNT - BATAN
Biochemistry, Genetics & Molecular Biology Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics

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SYNTHESIS AND CHARACTERIZATION OF BENZOTRIAZOLIUM-BASED IONIC LIQUIDS FOR TECHNETIUM-99M SEPARATION FROM MOLYBDENUM BY IL-MEDIATED EXTRACTION PROCESS Yanuar Setiadi; Muhamad Basit Febrian; Ahmad Mudzakir; Azmairit Aziz; Duyeh Setiawan; Anna Kurnia Illahi; Dwi Ayu Rahmawati
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 20, No 2 (2019): Agustus 2019
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.854 KB) | DOI: 10.17146/jstni.2019.20.2.5588

Abstract

Various separation techniques for separation of technetium-99m (99mTc) from molybdenum-99 (99Mo) are being developed to overcome the drawbacks of using 99Mo from neutron activation technique. Ionic liquids (ILs) were used in many extraction processes in metal separation due to their high selectivity. In this research, two benzotriazolium-based ionic liquids were used as co-extractant in 99mTc/ Mo separation process via liquid-liquid extraction. 1-octyl-3-methyl-benzotriazolium iodide ([MeOcBtu]I) and 1-octyl-3-methyl-benzotriazolium bis (trifluoromethanesulfonyl) imide ([MeOcBtu]TF2N) were successfully synthesized and analyzed by FTIR, 1H-NMR and 13C-NMR. Extraction processes were conducted in various organic solvents, pH, and extraction time without/ with ionic liquids addition. The data of ratio between 99mTc distribution coefficient compared to Mo distribution coefficient showed that the addition of ionic liquids exhibited significant improvement of separation factor. The separation factor of extraction using conventional water immiscible solvent ranged between 0 – 8 and increased to 30 – 600 as ILs were added. The optimum conditions which achieved highest separation factor were pH 14 using [MeOcBtu]I-chloroform. Benzotriazolium-based ionic liquid potential to be developed as extractant in the separation of 99mTc from 99Mo. Keywords: Ionic liquids, benzotriazolium, technetium-99m, molybdenum, liquid-liquid extraction.
PENGEMBANGAN TEKNOLOGI PROSES RADIOISOTOP MEDIS 131I MENGGUNAKAN METODE KOLOM RESIN PENUKAR ION UNTUK APLIKASI KEDOKTERAN NUKLIR Duyeh Setiawan, MT; Azmairit Aziz; Muhamad Basit Febrian; Yanuar Setiadi; Iwan Hastiawan
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 18, No 1 (2017): Februari 2017
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.563 KB) | DOI: 10.17146/jstni.2017.18.1.3138

Abstract

.  Penyakit kanker merupakan salah satu penyebab kematian utama di seluruh dunia.  Upaya untuk mengatasi penyakit kanker dilakukan dengan cara diagnosis dan terapi.  Teknik kedokteran nuklir menggunakan radioisotop iodium-131 (131I) merupakan salah satu teknik yang dapat digunakan dalam diagnosis dan terapi beberapa jenis kanker terutama kanker endokrin. Diagnosis dan terapi menggunakan radioisotop 131I telah banyak digunakan di beberapa rumah sakit di Indonesia, namun pasokan 131I saat ini terhambat. Pusat Sains dan Teknologi Nuklir Terapan – Badan Tenaga Nuklir Nasional telah memiliki kemampuan untuk memproses radioisotop 131I menggunakan metode destilasi basah.  Untuk meningkatkan yield proses dan memperbaiki aspek keselamatan, perlu dilakukan suatu penelitian untuk mengembangkan teknologi proses radioisotop 131I.  Salah satu metode yang dapat diaplikasikan pada teknologi proses adalah metode pemisahan menggunakan kolom resin penukar ion.  Pada penelitian menggunakan metode kolom, target telurium hasil iradiasi dilarutkan bersama dengan 131I yang terbentuk, telurium dan 131I dipisahkan menggunakan kolom berisi resin penukar ion.  Kondisi optimasi hasil penelitian menggunakan pelarut NaOH 2 N, jenis resin Dowex 1x8  (Cl- form), 100 – 200 mesh dan eluen NH4NO3 0,5 N. Karakteristik produk akhir yang memenuhi standar acuan kedokteran nuklir hasil proses pemisahan diperoleh yield lebih besar 70 %, kemurnian radionuklida > 99 %, kemurnian radiokimia > 95 %, radioisotop 131I berupa larutan jernih pada pH 7.
SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM CONTENT IN 99mTc SOLUTION VIA Mo-TGA-KSCN COMPLEXES FORMATION Muhamad Basit Febrian; Titin Sri Mulyati; Ade Suherman; Natalia Adventini; Yanuar Setiadi; Duyeh Setiawan; Azmairit Aziz
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 19, No 2 (2018): Agustus 2018
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.814 KB) | DOI: 10.17146/jstni.2018.19.2.4109

Abstract

SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM CONTENT IN 99mTc SOLUTION VIA Mo-TGA-KSCN COMPLEXES FORMATION. Quality of Technetium-99m solution is determined from its radiochemical, radionuclidic and chemical purity. One of the major concern about chemical purity of Tc-99m from irradiated natural molybdenum is its molybdenum content or Mo breaktrough. Spectrophotometric method is one of method that could be applied for Mo determination in Tc-99m solution. Molybdenum (V) could form a colored complexes with potassium thiocyanate (KSCN) but Molybdenum (VI) must be reduced before formed a complexes with KSCN. Thioglycolic Acid (TGA) was used as reducing agent to obtain reduced Mo (Mo(V)). A series of optimization process was carried out to find optimum condition of complex formation for analysis purposes. Optimized condition were 3 mL of 25% HCl was added into a volume of Mo sample, followed by 200 µL  of 10% TGA, 1 mL of 10% KSCN, and water addition up to 10 mL total volume. The method is linear over 2 ppm to 30 ppm Mo with regression coeffisient 0.9988±0.0007. The detection limit was 0.212 ppm Mo. Color of the complex has a stability of absorbance up to 120 minutes while stored at room temperature. No significant deviation occured when 1000 ppm of oxalic acid, methyl ethyl ketone and iron added into sample solution. This complexing method is suitable for spectrophotometric determination of molybdenum content in Tc-99m solution as a part of quality control process.
Co-Authors Ade Suherman Ahmad Aminudin Anna Kurnia Illahi Azmairit Aziz Azmairit Aziz Duyeh Setiawan Duyeh Setiawan Duyeh Setiawan, MT Dwi Ayu Rahmawati Iwan Hastiawan Muhamad Basit Febrian Muhamad Basit Febrian Natalia Adventini Titin Sri Mulyati