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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Plexus Medical Journal
Novan Adi Setyawan
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Association of Keloid Site with its Histopathological Features: an Analytical Observational Study Wibisono Nugraha; Muhammad Eko Irawanto; Moerbono Mochtar; Nur Rachmat Mulianto; Novan Adi Setyawan; Nugrohoaji Dharmawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.47-52

Abstract

Background: Keloid is a growth of fibrous tissue in the wound tissue of susceptible individuals. This tissue extends beyond the boundaries of the previous wound. The site of keloids commonly appears on a high-tension area, such as the chest, shoulders, and neck. Histopathologically keloids show thickened the epidermis and the vascularization and infiltration of inflammatory cells in the dermis. Purpose: This study aims to determine the relationship between the site of keloids and the histopathological appearance of keloids. Methods: An analytical observational study was conducted on keloid patients visiting the Dermatovenereology outpatient clinic of Dr.Moewardi Hospital. The sample collection used consecutive sampling techniques Result: The majority of keloid patients are >30 years old (46.4%). Most patients with keloids were female (53.6%). Keloids were mostly found on the chest (25.0%). Tounge-like appearance of the epidermis at the edges of the lesions was mostly on the shoulders and chest (33.3% each, p=0.048); flattened appearance was found on the middle epidermis of the lesions, which were mostly on the ears, shoulders, and upper extremities (22.7% each, p=0.011). Increased vascularity was found in the dermis at the edges of the lesions, especially in the ear and chest areas (31.3% each, p=0.046). Moderate-severe inflammatory infiltrates in the dermis at the edges of the lesions were commonly found on the chest (p=0.04). Conclusion: There is a significant relationship between the site of the lesion and the histopathological appearance of the keloid in epidermal as well as dermal layers.
Ethanolic Extract of Moringa oleifera Leaves Reduces The Expression of ICAM-1 in Aortic Tissues of Metabolic Syndrome Induced Rattus norvegicus Ikhsan, Muhammad Nouval; Riza novierta pesik; Dyah Ratna Budiani; Novan Adi Setyawan
Plexus Medical Journal Vol. 2 No. 4 (2023): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i4.866

Abstract

Introduction: Metabolic syndrome poses a risk for the development of atherosclerotic lesions, which are associated with various cardiovascular diseases. Moringa leaves are known for their antioxidant and anti-inflammatory properties. ICAM-1 serves as an early marker of atherosclerosis. This study aims to investigate how the dosage of ethanolic extract from Moringa leaves affects the expression of ICAM-1 in the aortic tissue of Wistar rats with metabolic syndrome. Methods: This study employed a laboratory experimental design with a posttest only control group. The research involved 30 Wistar rats, divided into five groups: the normal control group (G1), the positive control group (G2), and three experimental groups (G3, G4, and G5). The experimental groups (G3, G4, and G5) were induced with metabolic syndrome and administered ethanolic extract of Moringa leaves at doses of 150 mg/kg, 250 mg/kg, and 350 mg/kg, respectively. The expression of aortic ICAM-1 was evaluated using the Intensity Distribution Score (IDS) and analyzed using one-way ANOVA and Post-hoc Tukey HSD test. Results: Increasing the dosage of ethanolic leaf extract of Moringa oleifera reduces the IDS value of ICAM-1 in the aortic tissue of Wistar rats with a significance of p<0.05.. Conclusion: The higher dosage of ethanolic leaf extract from Moringa oleifera Lamk has the potential to decrease ICAM-1 expression in the aortic tissue of Wistar rats with metabolic syndrome. The author hopes that Moringa leaf extract can be utilized as a supplement to prevent the formation of atherosclerotic plaques and cardiovascular diseases resulting from atherosclerotic plaques, such as thromboembolism and stroke.  
Co-Authors Balgis . Balgis . Dharmawan, Nugrohoaji Dyah Ratna Budiani Ikhsan, Muhammad Nouval Irene Ardiani Pramudya Wardhani Moerbono Mochtar Muhammad Eko Irawanto Nur Rachmat Mulianto Riza Novierta Pesik Shelly Lavenia Sambodo Sri Haryati Wibisono Nugraha