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Hubungan Karakteristik Penderita dengan Gambaran Sitopatologi pada Kasus Karsinoma Paru yang Dirawat di RSUP Dr. M. Djamil Padang Metha Arsilita Hulma; Masrul Basyar; Henny Mulyani
Jurnal Kesehatan Andalas Vol 3, No 2 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i2.86

AbstrakKarsinoma paru merupakan tumor ganas epitel primer saluran nafas terutama bronkus yang dapat menginvasi struktur jaringan di sekitarnya dan berpotensi menyebar ke seluruh tubuh. Karakteristik penderita karsinoma paru dipengaruhi oleh berbagai faktor, diantaranya jenis kelamin, usia, status sosial ekonomi, kebiasaan merokok, dan gambaran sitopatologi. Penelitian ini bertujuan untuk mengetahui distribusi penderita karsinoma paru serta melihat hubungan antara karakteristik penderita dengan gambaran sitopatologi. Penelitian ini adalah deskriptif analitik dengan desain cross-sectional pada 128 penderita. Data yang digunakan adalah data sekunder dari laboratorium Patologi Anatomi dan Instalasi Rekam Medik. Data dianalisis dengan uji chi-square. Hasil analisis univariat menunjukkan penderita karsinoma paru sebagian besar laki-laki (71,1%), kelompok usia > 40 tahun (85,2%), berlatar belakang pendidikan dasar (49,2%), memiliki pekerjaan yang terpapar karsinogen (53,9%), frekuensi terbesar pada penderita dengan Indeks Brikman berat (49,2%), merupakan perokok aktif (66,4%), dan jenis sel terbanyak adalah adenocarcinoma (47,7%). Hasil analisis bivariat menunjukkan terdapat hubungan antara jenis kelamin dan riwayat merokok dengan gambaran sitopatologi (p=0,022 dan p=0,000). Selain itu, tidak terdapat hubungan antara usia, latar belakang pendidikan, jenis pekerjaan, dan derajat berat merokok dengan gambaran sitopatologi (p=0,812; p=0,498; p=0,931; dan p=0,054).Kata kunci: karsinoma paru, gambaran sitopatologi, karakteristik penderitaAbstractLung carcinoma is a malignant epithelial tumors in airway, especially primary bronchial that can invade surrounding tissue and potentially spread throughout the body. Characteristics of patient with lung carcinoma are influenced by various factors, including sex, age, socioeconomic status, smoking habits, and cytopathology overview. This study aimed to evaluate the distribution of patients with lung carcinoma and assess the relationship between the characteristics of patient with cytopathology overview. This study was descriptive analytical using cross-sectional study in 128 patients. We used secondary data derived from the Anatomic Pathology laboratory and the Medical Record Department. The data were analyzed by chi-square test. Results of univariate analysis showed patients with lung carcinoma mostly are male (71.1%), > 40 years age group (85.2%), background in basic educated people (49.2 %), had occupation contacted carcinogenic compound (53,9%), the greatest frequency was found in patients with severe Brikman Index (49.2%), active smokers (66.4%), and most of cytopathology cell type are adenocarcinoma (47.7 %). Results of bivariate analysis showed there are significant relationship between sex and smoking history with the overview of cytopathology (p=0,022 dan p=0,000). In addition, there are no significant relationship between age, educational background, occupational history, and the degree of smoking with the overview of cytopathology (p=0,812; p=0,498; p=0,931; dan p=0,054).Keywords: lung carcinoma, cytopathology overview, characteristics of the patient

Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatolo Aisha Rahmatya; Daan Khambri; Henny Mulyani
Jurnal Kesehatan Andalas Vol 4, No 2 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i2.277

AbstrakKanker payudara merupakan kanker yang paling sering mengenai perempuan dan menjadi penyebab kematian terbanyak akibat kanker pada perempuan. Angka kejadian kanker payudara bervariasi secara global dimana terjadi peningkatan insiden di negara berkembang tetapi cenderung menurun di negara maju. Gambaran klinikopatologi kanker payudara dapat bervariasi sesuai kelompok usia dan memiliki peran penting dalam faktor prognostik penyakit. Tujuan penelitian ini adalah untuk mengetahui hubungan usia dengan gambaran klinikopatologi kanker payudara. Gambaran klinikopatologi meliputi stadium klinis, subtipe histologi, dan gradasi histologi. Penelitian ini adalah penelitian analitik menggunakan metode cross sectional dengan teknik total sampling. Sampel penelitian yaitu data pasien kanker payudara primer di bagian bedah RSUP Dr. M. Djamil Padang periode Januari 2012 – Desember 2012. Dari 112 penderita kanker payudara primer hanya 46 yang memenuhi kriteria. Sampel penelitian dianalisis dengan uji chi square (p ≤ 0,05). Hasil penelitian ditemukan bahwa sebagian besar penderita berusia ≥ 40 tahun (78,3%) dan <50 tahun (67,4%), datang pada stadium lanjut (69,6%) dengan tipe invasive ductal carcinoma (87%) dan bergradasi rendah (78,3%). Analisis bivariat menunjukkan bahwa tidak terdapat hubungan yang bermakna antara usia dengan gambaran klinikopatologi kanker payudara.Kata kunci: kanker payudara, gambaran klinikopatologi, stadium klinis, subtipe histologi, gradasi histologi AbstractBreast cancer is now become the most common cancer diagnosed in women and the leading cause of deaths from cancer among women. The incidences of the disease vary globally, it has been reported to be increasing in developing countries while slightly down in developed countries. The clinicopathologic features of breast cancer may vary from each age groups and it has an important role as a prognostic factors. The objective of this study was to determine the relationship between age of the breast cancer patients and their clinicopathologic features. The clinicopathologic features i.e. staging, histologic subtypes, and histologic grades. This was an analythical study by using cross sectional method with total sampling technique. Samples were patients with primary breast cancer in Dr. M. Djamil General Hospital period January 2012 – December 2012. From 112 patients with primary breast cancer there were only 46 who fulfilled the criteria. The samples were analyzed by chi square test (p ≤ 0.05). The result of this study has revealed that most of the patients ≥ 40 years of age (78.3%) and < 50 years of age (67.4%), diagnosed in late stage (69.6%) with invasive ductal carcinoma (87%) and low histologic grade (78.3%). Bivariat analyze found that there is no significant relation between age and clinicopathologic features of breast cancer.Keywords: breast cancer, clinicopathologic features, staging, histologic subtypes, histologic grades

Hubungan Faktor Risiko Terhadap Kejadian Sindroma Koroner Akut pada Pasien Dewasa Muda di RSUP Dr. M. Djamil Padang Anggita Tiara Pramadiaz; Muhammad Fadil; Henny Mulyani
Jurnal Kesehatan Andalas Vol 5, No 2 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i2.517

AbstrakSumatera Barat merupakan provinsi dengan prevalensi penyakit jantung tertinggi ke-4 di Indonesia. Sindroma Koroner Akut (SKA) merupakan suatu spektrum perjalanan aterosklerosis pada Penyakit Jantung Koroner (PJK). Prevalensi penyakit ini meningkat diperkirakan karena faktor risiko seperti; jenis kelamin, riwayat keluarga, diabetes melitus, hipertensi, dislipidemia dan merokok. Tujuan penelitian ini adalah menentukan hubungan faktor risiko dengan kejadian SKA pada dewasa muda..Ini merupakan penelitian analitik observasional dengan desain potong lintang yang dilakukan di RSUP.M. Djamil Padang dari Juni 2014 sampai Oktober 2014. Populasi penelitian ini adalah seluruh pasien SKA berusia < 45 tahun yang dirawat dari 1 Januari 2011 – 31 Desember 2013 sebanyak 66 orang sebagai subjek penelitian. Data pasien didapatkan dari rekam medik. Data dideskripsikan dengan tabel dan dianalisis dengan uji chi-square dan regresi logistik.Distribusi frekuensi terbanyak pasien SKA terdapat pada laki-laki (74,2%), riwayat merokok (63,6%) dan hipertensi (37,9%). Hasil uji chi-square menunjukan terdapat hubungan antara hipertensi dan riwayat keluarga dengan kejadian SKA pada dewasa muda.Pasien dewasa muda dengan hipertensi berisiko terkena SKA 0,301 kali lebih besar.Hipertensi merupakan faktor yang paling berpengaruh terhadap kejadian SKA pada pasien dewasa muda.Kata kunci: sindroma koroner akut, penyakit jantung koroner, faktor risiko AbstractWest Sumatra is the 4th highest province in prevalence of heart disease in Indonesia. Acute Coronary Syndromes (ACS) is a spectrum of atherosclerosis in Cardiac Heart Disease (CHD). The prevalence of this disease has increased related to risk factors,such as; gender, family history, diabetes mellitus, hypertension and smoking. The objective of tthis study was to determine the relationship of risk factors of ACS in young adults.This was an analytic observational cross-sectional design conducted at Dr.M. Djamil Padang Hospital from June 2014 - October 2014. The populations were ACS patients age < 45 years old which hodpitalized from January 1st 2011 - December 31st 2013 to 66 samples as research subject.The data was retrieved from medical record. Data described in tables and analyzed with the chi-square test and logistic regression.The frequency distributions of most ACS patients are males (74,2%), smoking history (63,6%), and hypertension (37,9%). Chi-square test result shows that hypertension and family history are related to ACS events in young adults. ACS events are more likely to occur 0,301 times in young adults with hypertension. Hypertension is the most influencing factor of ACS events in young adults.Keywords: acute coronary syndromes, coronary heart disease, risk factors

HUBUNGAN PERSENTASE DAN POLA STROMA REAKTIF DENGAN DERAJAT HISTOPATOLOGI LESI PROSTAT Noza Hilbertina; Henny Mulyani
Majalah Kedokteran Andalas Vol 35, No 2 (2011): Published in August 2011
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakAktivasi dari lingkungan mikro stromal pada pejamu diperkirakan merupakan tahapan kritis dalam pertumbuhan dan progresi dari adenokarsinoma. Stroma reaktif ini sangat penting dalam merangsang invasi, progresi dan metastasis tumor. Kanker prostat adalah kanker yang tersering pada laki-laki.. Elemen pembeda pada prostat adalah fenotipe otot polos yang ada pada jaringan prostat normal sulit dibedakan dengan stroma reaktif pada pewarnaan rutin yaitu hematoksilin eosin. Dengan aplikasi pulasan Masson trichrome maka stroma normal dan stroma reaktif dapat dibedakan secara jelas. Penelitian ini bertujuan untuk mengetahui persentase dan pola distribusi stroma reaktif berdasarkan derajat histopatologi lesi prostat.Seratus sepuluh kasus lesi prostat yang telah didiagnosis di Laboratorium Patologi FK-Unand, Padang dilakukan review ulang terhadap derajat histopatologi lesi. Selanjutnya blok parafin dari kasus yang bersangkutan dipotong ulang untuk pewarnaan Masson trichrome dan dinilai secara mikroskopik persentase dan pola stroma reaktif tersebut.Analisis statistik menunjukkan hubungan yang kuat dan bermakna secara statistik antara persentase stroma reaktif dengan derajat histopatologi lesi prostat dengan nilai r = 0,679 dan p < 0,05 dan juga terdapat hubungan yang bermakna secara statistik antara pola distribusi stroma reaktif dengan derajat histopatologi lesi prostat dengan nilai p < 0,05Kata Kunci : Derajat histopatologi, persentase stroma reaktif, pola stroma reaktifAbstractActivation of the host stromal microenvironment is predicted to be a critical step in adenocarcinoma growth and progression. Reactive stroma in cancer would be predicted to enhance tumor progression, stimulating invasion and metastasis. Prostat cancer is the most cancer in men. Prostat cancer reactive stroma is composed of a myofibroblast/fibroblast mix. A simple trichrome stain makes the process of distinguishing normal stroma and reactive stroma more obvious. We examined the association of percentage and pattern of reactive stroma to histopatologic grading from the prostate lesions.A hundred and ten of prostate lesion were obtain from the Pathological Anatomic Laboratorium, Medical Faculty of Andalas University in Padang. The hematoxilinARTIKEL PENELITIAN107eosin slides were reviewed by two viewer for histopathologic grading and than whole mount thin section were stained with Masson trichrome. To evaluate the reactive stromal interpretation classified in to percentage (+, ++, +++) and pattern of reactive stroma (regular and irregular).There were significant association between percentage of reactive stroma with histopathologic grading statistically (p<0,05 and r=0,679) and significant association between pattern of reactive stroma with histopathologic grading statistically (p<0,05).Key word : histopathologic grading, percentage, pattern

Differential Roles of CD117 and Ki67 in Gastrointestinal Stromal Tumors: Diagnostic Utility Versus Prognostic Power Fitri Nur Handriyani; Noza Hilbertina; Henny Mulyani; Loli Devianti; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1337

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, primarily driven by mutations in KIT or PDGFRA genes. CD117 (c-KIT) expression is a key diagnostic marker, while the Ki67 labeling index reflects cellular proliferation. Risk stratification, often using modified NIH criteria based on tumor size, mitotic rate, and location, guides prognosis and treatment. This study investigated the distinct roles of CD117 and Ki67 expression in relation to risk stratification in GIST patients. Methods: This cross-sectional analytical study examined 27 GIST cases diagnosed between January 2021 and December 2024 from three Indonesian hospitals. Formalin-fixed paraffin-embedded tissues were analyzed using immunohistochemistry for CD117 (clone YR145) and Ki67 (clone K2). CD117 positivity was defined as ≥5% tumor cell staining, and high Ki67 expression as >10% nuclear staining. Risk stratification utilized the modified NIH criteria. The Chi-square test assessed correlations (p<0.05 significance). Results: The cohort predominantly comprised patients >50 years (66.7%), males (59.3%), with gastric tumors (51.9%), large tumor size (>5cm in 96.3%), spindle cell morphology (77.8%), and high mitotic rates (74.1%). Most cases (85.2%) were classified as high-risk. CD117 was positive in 81.5% (22/27) of cases but showed no significant correlation with risk stratification (p=0.561). High Ki67 expression was found in 74.1% (20/27) of cases and demonstrated a significant positive correlation with high-risk stratification (p=0.002). The combination of CD117 and Ki67 status also showed a significant association with risk stratification (p=0.001). Conclusion: While CD117 expression remains a cornerstone for GIST diagnosis and targeted therapy selection, it did not correlate significantly with risk stratification in this cohort. Conversely, a high Ki67 labeling index was significantly associated with high-risk GIST, underscoring its potential as a valuable prognostic marker alongside established risk stratification parameters.

Investigating the Landscape of Programmed Death-Ligand 1 (PD-L1) in Thymic Tumors: Implications for Histopathological Classification and Staging Rio Hendra; Noza Hilbertina; Henny Mulyani; Tofrizal; Afriani; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1338

Background: Thymic epithelial tumors (TETs) are uncommon malignancies originating in the mediastinum, characterized by considerable histopathological diversity and variable clinical trajectories. Programmed Death-Ligand 1 (PD-L1), an immune checkpoint protein, is implicated in mechanisms of tumor immune evasion. This study aimed to investigate the correlation between PD-L1 immunoexpression and distinct histopathological types, as well as the Masaoka-Koga stage, in TETs. Methods: This cross-sectional investigation analyzed 29 archival cases of TETs diagnosed between January 2019 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Samples were procured via consecutive sampling from formalin-fixed paraffin-embedded (FFPE) tumor tissues. Histopathological classification was reassessed according to the WHO 2021 criteria. PD-L1 expression was evaluated immunohistochemically and quantified using the Tumor Proportion Score (TPS). Masaoka-Koga staging was determined from clinical records. Statistical analysis of correlations was performed using the Chi-square test. Results: PD-L1 immunoexpression was detected in the preponderance of cases. Low positive PD-L1 expression (TPS 1-49%) was observed in 82.8% of TETs, while high positive expression (TPS ≥50%) was noted in 10.3%. Thymic carcinoma constituted the most prevalent histopathological category (51.7%), and the majority of patients (91.7%) presented at an advanced Masaoka-Koga stage. Statistical analysis did not demonstrate a significant correlation between PD-L1 expression levels and histopathological type (p=0.195). Furthermore, no significant association was identified between PD-L1 expression and Masaoka-Koga stage (p=0.800). Conclusion: This study indicated that while PD-L1 is frequently expressed in TETs within this cohort, its expression level did not exhibit a significant correlation with specific histopathological subtypes or the Masaoka-Koga clinical stage. Further investigations incorporating larger sample sizes are warranted to delineate the precise role of PD-L1 within the complex biological spectrum of thymic neoplasms.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

Differential Roles of CD117 and Ki67 in Gastrointestinal Stromal Tumors: Diagnostic Utility Versus Prognostic Power Fitri Nur Handriyani; Noza Hilbertina; Henny Mulyani; Loli Devianti; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1337

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, primarily driven by mutations in KIT or PDGFRA genes. CD117 (c-KIT) expression is a key diagnostic marker, while the Ki67 labeling index reflects cellular proliferation. Risk stratification, often using modified NIH criteria based on tumor size, mitotic rate, and location, guides prognosis and treatment. This study investigated the distinct roles of CD117 and Ki67 expression in relation to risk stratification in GIST patients. Methods: This cross-sectional analytical study examined 27 GIST cases diagnosed between January 2021 and December 2024 from three Indonesian hospitals. Formalin-fixed paraffin-embedded tissues were analyzed using immunohistochemistry for CD117 (clone YR145) and Ki67 (clone K2). CD117 positivity was defined as ≥5% tumor cell staining, and high Ki67 expression as >10% nuclear staining. Risk stratification utilized the modified NIH criteria. The Chi-square test assessed correlations (p<0.05 significance). Results: The cohort predominantly comprised patients >50 years (66.7%), males (59.3%), with gastric tumors (51.9%), large tumor size (>5cm in 96.3%), spindle cell morphology (77.8%), and high mitotic rates (74.1%). Most cases (85.2%) were classified as high-risk. CD117 was positive in 81.5% (22/27) of cases but showed no significant correlation with risk stratification (p=0.561). High Ki67 expression was found in 74.1% (20/27) of cases and demonstrated a significant positive correlation with high-risk stratification (p=0.002). The combination of CD117 and Ki67 status also showed a significant association with risk stratification (p=0.001). Conclusion: While CD117 expression remains a cornerstone for GIST diagnosis and targeted therapy selection, it did not correlate significantly with risk stratification in this cohort. Conversely, a high Ki67 labeling index was significantly associated with high-risk GIST, underscoring its potential as a valuable prognostic marker alongside established risk stratification parameters.

Investigating the Landscape of Programmed Death-Ligand 1 (PD-L1) in Thymic Tumors: Implications for Histopathological Classification and Staging Rio Hendra; Noza Hilbertina; Henny Mulyani; Tofrizal; Afriani; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1338

Background: Thymic epithelial tumors (TETs) are uncommon malignancies originating in the mediastinum, characterized by considerable histopathological diversity and variable clinical trajectories. Programmed Death-Ligand 1 (PD-L1), an immune checkpoint protein, is implicated in mechanisms of tumor immune evasion. This study aimed to investigate the correlation between PD-L1 immunoexpression and distinct histopathological types, as well as the Masaoka-Koga stage, in TETs. Methods: This cross-sectional investigation analyzed 29 archival cases of TETs diagnosed between January 2019 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Samples were procured via consecutive sampling from formalin-fixed paraffin-embedded (FFPE) tumor tissues. Histopathological classification was reassessed according to the WHO 2021 criteria. PD-L1 expression was evaluated immunohistochemically and quantified using the Tumor Proportion Score (TPS). Masaoka-Koga staging was determined from clinical records. Statistical analysis of correlations was performed using the Chi-square test. Results: PD-L1 immunoexpression was detected in the preponderance of cases. Low positive PD-L1 expression (TPS 1-49%) was observed in 82.8% of TETs, while high positive expression (TPS ≥50%) was noted in 10.3%. Thymic carcinoma constituted the most prevalent histopathological category (51.7%), and the majority of patients (91.7%) presented at an advanced Masaoka-Koga stage. Statistical analysis did not demonstrate a significant correlation between PD-L1 expression levels and histopathological type (p=0.195). Furthermore, no significant association was identified between PD-L1 expression and Masaoka-Koga stage (p=0.800). Conclusion: This study indicated that while PD-L1 is frequently expressed in TETs within this cohort, its expression level did not exhibit a significant correlation with specific histopathological subtypes or the Masaoka-Koga clinical stage. Further investigations incorporating larger sample sizes are warranted to delineate the precise role of PD-L1 within the complex biological spectrum of thymic neoplasms.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

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