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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Komunitas Jurnal Respirologi Indonesia Unri Conference Series: Community Engagement Respiratory Science
Yessy Susanty Sabri
Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas
Humanities Health Professions Medicine & Pharmacology Public Health

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CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF PULMONARY FUNGUS BALL RELATED TUBERCULOSIS Fenty Anggrainy; Irvan Medison; Deddy Herman; Sabrina Ermayanti; Yessy Susanty Sabri
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.1025

Abstract

Fungus Ball paru merupakan komplikasi yang sering terjadi pada Tuberkulosis (TB) paru dengan kavitas, terutama pada bekas TB paru. Agen penyebab selain Aspergilus sp yaitu Candida sp. Terapi definitif untuk penyakit ini adalah terapi bedah. Pada kondisi khusus dapat digunakan tatalaksana lainnya. Penelitian ini mengevaluasi 6 pasien Fungus Ball paru dengan riwayat obat anti tuberkulosis, dengan beberapa metode diagnosis dari tahun 2010 sampai 2013. Tatalaksana dan hasil pengobatan pasien dianalisis pada penelitian ini. Hemoptisis terdapat pada seluruh pasien dan tiga diantaranya dengan hemoptisis masif. Semua pasien memiliki gambaran yang khas untuk Fungus Ball paru dari radiologi toraks. Spesies jamur terkonfirmasi pada 5 pasien: pemeriksaan serologis (1), kultur jamur (2) dan pemeriksaan histopatologi (2). Spesies yang didapatkan adalah Aspergilosis sp = 3, Candida paraspilosis = 1 dan Candida sp = 1. Dua pasien mendapatkan terapi bedah dengan tidak adanya keluhan hemoptisis setelah itu. Empat pasien yang hanya mendapatkan anti jamur, ternyata 75% memberikan respon yang baik secara klinis dan radiologis. Kavitas yang menetap pada TB paru dan bekas TB paru, dapat menimbulkan insiden Fungus Ball paru yang membutuhkan lobektomi sebagai terapi definitif. Pada kondisi tertentu dimana terapi pembedahan tidak dapat dilakukan, anti jamur dapat menjadi terapi alternatif dan memberikan hasil yang baik.
Correlation between N-Acetyltransferase 2 (NAT2) Polymorphism Genotype with Plasma Isoniazid (INH) Concentration in MDR TB Patients Receiving Short Regimen in West Sumatera Mega Senja; Masrul Basyar; Yessy Susanty Sabri; Afriani Afriani
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.283

Abstract

Background: Isoniazid (INH) is one of the most potent TB drug. High dose INH is used in short regimen MDR TB drugs. The genetic polymorphism of NAT2 affects the acetylation status. Awareness of the patients’ acetylator status is important to determine the risk of toxicity, treatment failure and drug resistance. The aim of this study was to demonstrate NAT2 genotype association with INH plasma concentration after 2 hours of oral INH therapy. Methods: This was a cross sectional study of MDR TB patients who received short term combination therapy at RSUP Dr. M.Djamil Padang, Achmad Muchtar Hospital Bukittinggiand West Sumatra Pulmonary Hospital from September 2019 to February 2020. Patients were examined for NAT2 genotype and plasma INH concentration. The results of the plasma INH concentrations obtained were evaluated based on the NAT2 acetylator phenotype group.Results: The majority of the subjects weremen (62.5%), aged 40-64 years (50%), had the most common comorbid of diabetes mellitus (31.25%), were normoweight (75%) and had negative HIV status (93.8%). A total of 7 alleles consisting of 7 SNPs and 7 variations of the NAT2 genotype were found in MDR TB patients who received short-term therapy. The NAT2*12A alleles (56.25%) was the most common allele and was a fast acetylator. Based on the bimodal distribution, the median concentration of INH in the fast and slow acetylator were 1.25 µg/ml and 5.24 µg/ml, respectively. The median values of INH concentration based on the trimodal distribution for fast, intermediate, and slow acetylators were 1.25 µg/ml, 2.17 µg/ml and 5.24 µg/ml. Conclusion: There were no correlations between the type of NAT2 acetylator phenotype and plasma INH concentrations.
Pengaruh Progressive Muscle Relaxation (PMR) dalam Menurunkan Skala Nyeri pada Pasien Kanker Paru yang Mendapatkan Pengobatan Kemoterapi Defi Eka Kartika; Yessy Susanty Sabri; Reni Prima Gusty
Jurnal Kesehatan Komunitas Vol 8 No 1 (2022): Jurnal Kesehatan Komunitas
Publisher : STIKes Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol8.Iss1.1094

Abstract

Progressive Muscle Relaxation (PMR) is a technique that focuses on maintaining a state of muscle relaxation, involving contraction and relaxation of various muscle groups from the head to the lower extremities. This study aimed to examine the effectiveness of PMR in reducing pain in lung cancer patients receiving chemotherapy. The research design used is quantitative research with a quasi-experiment approach with control group pre-test-post-test design with purposive sampling technique so that the number of respondents as many as 34 people (17 people control group and 17 people intervention group). The pain scale data collection technique uses a numeric rating scale. the results of the study found that there was a difference in the scale of pain before and after the administration of PMR in cancer patients in the intervention group with p = 0,000 (p<0.05). it is hoped that health services, especially nurses, can make PMR as an independent intervention and one of the establishments of telenursing programs in terms of monitoring pain scales in lung cancer patient receiving chemotherapy treatment.
Layanan Hotline Konsultasi Masalah Kesehatan Pasca COVID-19 Sabrina Ermayanti; Russilawati Russilawati; Fenty Anggraini; Afriani Afriani; Irvan Madison; Oea Khairsyaf; Masrul Basyar; Deddy Herman; Yessy Susanty Sabri; Dewi Wahyu Fitrina; Dessy Mirzati; Elsa Purnama Sari; Dimas Bayu Firdaus
Unri Conference Series: Community Engagement Vol 3 (2021): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.3.296-302

Abstract

Pandemy of Corona virus disease 2019 (Covid-19) has overwhelmed the word for nearly two years. Indonesia is one countries that been hit hard by Covid-19. Even though most of patients with positive test of Covid-19 had no symptoms or mild some of them reported persistent clinical symptoms months after test negative. This population with disorder whose terminology Long Covid-19 need health care to help them cope with this condition. In this need Department of Pulmonology and Respiratory medicine initiate community service activity for Covid-19 survival with Long Covid-19 in the formulation Hotline Service on Post Covid-19 Health Problem. Survivors of Covid-19 who accessed this service originated from variety geographic region in Indonesia. This Activity reached 60 survivors were mostly female (57%), in age group of young adult (62%) and dominant with mild symptoms (58%). Recommendation for these survivors whose mild symptoms was self care observation. There were still about 25 survivors (42%) who need further health care with appropriate speciality.
Factors Affecting the Outcomes of COVID-19 Patients Treated at Dr. M. Djamil Padang General Hospital Yessy Susanty Sabri; Dewi Wahyu Fitrina; M. Hari Nandi Pinto; Lusi Agustini Arda; Nova Indriyani; Kornelis Aribowo; Ilham Ilham; Dimas Bayu Firdaus
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.273

Abstract

Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality. This study aimed to determine the factors that influenced the outcomes of COVID-19 patients treated at RSUP. Dr. M. Djamil Padang.Methods: This was an observational analytic study conducted with a retrospective cohort design on COVID-19 patients at RSUP Dr. M. Djamil Padang. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients were analyzed using Chi- Square/Fisher Exact Test.Results: Majority of the patients were female (56.4%) and aged above 50 years (64.3%). Hypertension was the most common comorbidity (41.1%). Diabetes mellitus affected the final outcome of treatment. The number of comorbidities the patients had was associated with a worse outcome for COVID-19.Conclusion: Most of COVID-19 patients at RSUP Dr. M. Djamil Padang were male and more than 50 years old. There was a correlation between age, gender, and comorbidities in COVID-19 patients with the outcomes.
The Relationship Between Smoking Status and Smoking Index Against COVID-19 Disease Course in Treated Patients at Dr. M Djamil General Hospital, Padang Yulia Helexandra; Yessy Susanty Sabri; Fenty Anggrainy
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.58

Abstract

Background: Smoking is a risk factor for the development and worsening of respiratory diseases, including COVID-19 infection. Smoking can increase the risk of the severity of COVID-19 by two times because in smokers there is an increase in the expression of the ACE-2 gene by 25% compared to non-smokers. The purpose of this study was to determine the relationship between smoking status and smoking index on the course of COVID-19 disease treated at Dr. M Djamil General Hospital. Method: An observational analytic study with a retrospective cohort approach on COVID-19 patients who were treated at Dr. M. Djamil General Hospital. Data were taken from January to March 2021. The relationship between smoking status and smoking index on the course of COVID-19 was analyzed by Chi-Square. Results: This study found the most age was above 50 years with a vulnerable age of 50-59 years (28.4%) and female gender (56.7%). Non-smoker status (64.2%) and moderate smoking index (51.4%) were the most commonly found in this study. Clinically non-progressive COVID-19 (53.7%) was the most common. This study found that the maximum length of stay for COVID-19 patients was less than 21 days (53.7%) and the outcome of patients recovered (62.2%). This study found a significant relationship between the smoking index on the clinical progress of COVID-19 patients and there was a significant relationship between smoking status and the outcome of COVID-19 patients. This study found that smoking status and the smoking index had no significant relationship with the length of stay of COVID-19 patients. Conclusion: Smoking status is related to outcomes in COVID-19 patients and the smoking index is related to a progression in COVID-19 patients treated at Dr. M. Djamil General Hospital.
Association Between Comorbidities and Outcome of COVID-19 Patients at dr. M. Djamil General Hospital Padang Nova Indriyani; Yessy Susanty Sabri; Afriani Afriani
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.59

Abstract

Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality estimated up to 20%. This number will increase with the presence of comorbidities. Comorbidities were associated with complex clinical management and impacted on COVID-19 disease outcomes. This study aims to determine the association between comorbidities and the outcome of COVID-19 patients at Dr. M. Djamil Hospital. Method: We conducted an observational study with a retrospective cohort design on COVID-19 patients treated at Dr. M. Djamil Hospital. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients was analyzed by Chi-Square or Fisher Exact Test. Results: The majority patientss were female (56.4%) and ages above 50 years old (64.3%) were the majority of patients. The most common was hypertension (36.56%). The longest length of stay of COVID-19 patients was more than 21 days (52.9%).  The outcomes of COVID-19 patients were recovered (59.5%), recovered with sequelae (5.7%), and died (34.8%). Diabetes mellitus affected the end of treatment outcome. There was no relationship of type of comorbidity with length of stay. The more co-morbidities a patient suffers, the condition when infected with COVID-19 will get worse. Conclusion: The number of comorbidities affects the outcome of COVID-19 patients. Diabetes mellitus is most common that affects the end of treatment outcome for COVID-19 patients at Dr. M. Djamil Hospital.
Association of the Vaccination Status of Health Workers of COVID-19 Survivors with The Outcomes of Treatment of COVID-19 At General Hospital in Padang City Kornelis Aribowo; Masrul Basyar; Yessy Susanty Sabri
Jurnal Respirologi Indonesia Vol 43, No 3 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i3.351

Abstract

Background: Health workers are on the front lines of treating and fighting the COVID-19 pandemic. Health workers face COVID-19 patients at work. Health workers are at increased risk of infection if they are not properly protected. Increased risk for health workers can be caused by contact with patients without personal protective equipment (PPE) and surfaces contaminated with the virus. Infected health workers can infect other people around them and will increase the workload of other health workers. One of the efforts to reduce the risk of transmission to health workers is vaccination. Vaccines against COVID-19 are considered very important to prevent and control COVID-19. The aim is to determine the relationship between the COVID-19 vaccine status and the outcomes of healthcare workers treated for confirmed COVID-19 at hospitals throughout Padang.Methods: This observational study was conducted using a retrospective cohort method. The study was conducted from August 2021 to May 2022 in hospitals across Padang by completing a questionnaire in the form of a Google form link. Results: Vaccination status of health workers who survived COVID-19 who were treated at Padang City General Hospital (66.97%) were not vaccinated, aged 26–35 years (57.80%), female (80.73%), worked as paramedics (63, 55%), symptom onset 3 to 7 days (44.95%), number of symptoms 3 (55.96%), most fever (24.68%), number of comorbid 1 to 2 (66.06%), obesity (66.67%), length of stay <21 days (84.40%), and mild clinical (55.96%) and recovered (92.66%). The highest degree of COVID-19 severity for health workers who were not vaccinated was moderate clinical, 42 samples (57.53%), and vaccinated, predominantly mild clinical, 34 samples (94.44%). The duration of stay of health workers vaccinated was higher than that who were not vaccinated (97.22% vs. 78.08%).Conclusion: The vaccination status of health workers who have survived COVID-19 relates to a clinical degree, length of stay, and outpatient treatment.
Differences in IL-6 Levels Based on Clinical Severity and Outcome of COVID-19 Patients at Dr. M. Djamil Hospital Chicy Widya Morfi; Yessy Susanty Sabri; Dessy Mizarti
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.94

Abstract

ground: A cytokine storm is defined by elevated levels of proinflammatory cytokines such as interleukin-6 (IL-6). In COVID-19 infection, IL-6 is superior to C-reactive protein (CRP) and other inflammatory markers in predicting respiratory failure. The IL-6 is the main cytokine triggered by T cells when a cytokine storm occurs. IL-6 is the most important driver of immune dysregulation and ARDS in COVID-19 infection. The purpose of this study is to assess differences of IL-6 levels based on clinical severity and outcomes in COVID-19 patients at Dr. M. Djamil Hospital. Method: The study took place at Dr. M. Djamil Hospital from November 2021 to November 2022. This is a retrospective cohort study in which patients were tested for IL-6 levels between January 1st, 2021 and December 31, 2021. The distribution of the frequency and proportion of each variable is included in univariate analysis; bivariate analysis determines the correlation between the independent variables (clinical severity, length of stay, and final status of hospitalization) and the dependent variable (IL-6 levels in COVID-19 patients). Results: Patients' characteristics in this study, the majority of patients aged 18-49 years. Women and patients with moderate disease were more common. The majority of patients were treated for less than 14 days, and the final status of hospitalization the patients showed that most of the patients recovered. IL-6 levels with median (min-max) was 32.00 (1.50-589.00). The IL-6 levels were higher in clinically critical COVID-19 patients (77.20 mg/L), in patients with a shorter length of stay (14 days) (36.00 mg/L), and at final status of hospitalization were death (58.90 mg/L). Conclusion: There were differences of IL-6 level based on clinical severity and final hospitalization status of COVID-19 patients, but not from the length of stay in COVID-19 patients at Dr. M. Djamil Hospital.
Co-Authors Afriani Afriani Afriani Afriani Afriani Afriani Chicy Widya Morfi Defi Eka Kartika Dessy Mirzati Dessy Mizarti Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dimas Bayu Firdaus Dimas Bayu Firdaus Elsa Purnama Sari Ermayanti, Sabrina Fenty Anggraini Fenty Anggrainy Herman, Deddy Ilham Ilham Irvan Madison Irvan Medison Kornelis Aribowo Kornelis Aribowo Lusi Agustini Arda M. Hari Nandi Pinto Masrul Basyar Masrul Basyar Mega Senja Nova Indriyani Nova Indriyani Oea Khairsyaf Reni Prima Gusty Russilawati, Russilawati Yulia Helexandra